研究テーマ(研究室紹介)

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平成31年4月1日より社会医療法人義順顕彰会の御寄附により心血管病予防分析学講座が発足しました。
種子島を舞台として先制医療の確立と健康寿命の延伸を目指した疫学研究「健康アイランド種子島」を遂行するための寄附講座です。

研究室概要

部局 大学院医歯学総合研究科 Graduate School of Medical and Dental Sciences
  寄附講座 Endowed Courses
講座 心血管病予防分析学講座 Department of Prevention and Analysis of Cardiovascular Diseases

分野サイト

連絡先

TEL.099-275-5318 / FAX.099-265-8447

主要研究テーマ

特定健診データ利用による心血管リスクの抑制、健康寿命延伸に関する研究 Research on suppression of cardiovascular risk and extension of healthy life expectancy by using Specific Health Checkup data
特定健診の受診率向上に関する取り組み Improvement of the consultation rate of Specific Health Checkup
学校健診データ利用による子供の肥満、血圧上昇抑制に関する研究 Suppression of obesity and blood pressure increase in children by using school medical examination data

スタッフ

大石 充

教授(兼任)
氏名 大石 充 Mitsuru OHISHI
専門分野 循環器学, 虚血性心疾患, 動脈硬化, 高血圧
研究テーマ ・循環器レジストリを駆使した病態把握と心血管疾患治療seeds探索(KIDSレジストリなど)
・AI・deep learning・LAMP法を用いたBig Data(健診データやDPCデータ)解析
・垂水研究(多職種によるチーム医療コホート研究)
・高血圧ゼロの街 枕崎(高血圧治療が予後及び社会経済に与える影響を見るコホート研究)
・健康アイランド 種子島(既存の健診(学校健診や特定健診)を120%生かすことに島民全員の健康を維持することができるかを見るコホート研究
・高血圧・心不全をターゲットとした新しい創薬・治療法の開発
・受容体連関を基軸としたtranslational research

研究者総覧


川添 晋

特任講師
氏名 川添 晋 Shin KAWASOE
専門分野 循環器学、心不全、心臓リハビリテーション、臨床疫学
研究テーマ ・種子島健康アイランドプロジェクト
・健診データによる心血管リスク因子探索
・心不全の病態、運動耐容能及び予後に関する研究

研究者総覧


徳重 明央

特任講師
氏名 徳重 明央 Akihiro TOKUSHIGE
専門分野 循環器学、虚血性心疾患、腫瘍循環器、臨床研究、臨床薬理、生物統計
研究テーマ ・種子島健康アイランドプロジェクト
・透析患者の心血管予後調査(KIDSレジストリー)
・腫瘍循環器におけるミトコンドリアダイナミクス
・臨床研究ワークショップ主催

研究者総覧


主な研究実績

大石 充
  1. Ohishi M, Yoshida T, Nishigaki N, Oh A, Shimasaki Y.
    Antihypertensive treatment for hypertensive patients with heart failure using real-world Japanese data: subanalysis of the retrospective study of antihypertensives for lowering blood pressure (REAL) study.
    Clin Exp Hypertens 2020; 42: 139-145.
  2. Ikeda Y, Sasaki T, Kuwahata S, Imamura M, Tanoue K, Komaki S, Hashiguchi M, Kuroda A, Akasaki Y, Ohishi M.
    Management instructions for elderly patients with hypertension.
    Clin Exp Hypertens 2020; 42: 295-301.
  3. Kubota K, Miyanaga S, Iwatani N, Higo K, Tokushige A, Ikeda Y, Ohishi M.
    Geriatric Nutritional Risk Index is associated with prognosis in patients with pulmonary arterial hypertension and chronic thromboembolic pulmonary hypertension.
    Circ Rep 2020; 2: 372-377.
  4. Kawasoe S, Kubozono T, Ojima S, Kawabata T, Miyahara H, Tokushige K, Ohishi M.
    Sex differences in the effects of weight reduction on future blood pressure elevation in a mildly obese middle-aged population.
    Circ Rep 2020; 2: 385-392.
  5. Kanda D, Ikeda Y, Sonoda T, Tokushige A, Kosedo I, Yoshino S, Takumi T, Ohishi M.
    Malnutrition and non-use clopidogrel additively aggravate prognosis of critical limb ischemia patients who underwent revascularization.
    Circ Rep 2020; 2: 121-127.
  6. Kosedo I, Tokushige A, Takumi T, Yoshikawa A, Teraguchi K, Takenouchi K, Shiraishi K, Ikeda D, Imamura M, Sonoda T, Kanda D, Ikeda Y, Ido A, Ohishi M.
    Use of proton pump inhibitors is associated with an increase in adverse cardiovascular events in patients with hemodialysis: insight from the KIDS Registry.
    Eur J Intern Med 2020; 72: 79-87.
  7. Sasaki Y, Ikeda Y, Miyauchi T, Uchikado Y, Akasaki Y, Ohishi M.
    Estrogen-SIRT1 axis plays a pivotal role in protecting arteries against menopause-induced senescence and atherosclerosis.
    J Atheroscler Thromb 2020 Jan 1; 27: 47-59.
  8. Ojima S, Kubozono T, Kawasoe S, Kawabata T, Miyata M, Miyahara H, Maenohara S, Ohishi M.
    Association of risk factors for atherosclerosis, including high-sensitivity C-reactive protein, with carotid intima-media thickness, plaque score, and pulse wave velocity in a male population.
    Hypertens Res 2020;43: 422-430.
  9. Makizako H, Nakai Y, Tomioka K, Taniguchi Y, Sato N, Wada A, Kiyama R, Tsutsumimoto K, Ohishi M, Kiuchi Y, Kubozono T, Takenaka T.
    Effects of a multicomponent exercise program in physical function and muscle mass in sarcopenic/pre-sarcopenic adults.
    J Clin Med 2020; 9: 1386.
  10. Maruta M, Makizako H, Ikeda Y, Miyata H, Nakamura A, Han G, Shimokihara S, Tokuda K, Kubozono T, Ohishi M, Tomori K, Tabira T.
    Associations between depressive symptoms and satisfaction with meaningful activities in community-dwelling Japanese older adults.
    J Clin Med 2020; 9: 795.
  11. Hirase T, Makizako H, Okubo Y, Lord SR, Okita M, Nakai Y, Takenaka T, Kubozono T, Ohishi M.
    Falls in community-dwelling older adults with lower back or knee pain are associated with cognitive and emotional factors.
    Int J Environ Res Public Health 2020; 17: 4960.
  12. Kario K, Chirinos JA, Townsend RR, Weber MA, Scuteri A, Avolio A, Hoshide S, Kabutoya T, Tomiyama H, Node K, Ohishi M, Ito S, Kishi T, Rakugi H, Li Y, Chen CH, Park JB, Wang JG.
    Systemic hemodynamic atherothrombotic syndrome (SHATS) - Coupling vascular disease and blood pressure variability: proposed concept from pulse of Asia.
    Prog Cardiovasc Dis 2020; 63: 22-32.
  13. Nakajima T, Oh A, Saita S, Yoshida T, Ohishi M, Nishigaki N.
    Comparative effectiveness of angiotensin II receptor blockers in patients with hypertension in Japan: a systematic review and network meta-analysis.
    Circ Rep 2020; 2: 576-586.
  14. Tanaka A, Taguchi I, Teragawa H, Ishizaka N, Kanzaki Y, Tomiyama H, Sata M, Sezai A, Eguchi K, Kato T, Toyoda S, Ishibashi R, Kario K, Ishizu T, Ueda S, Maemura K, Higashi Y, Yamada H, Ohishi M, Yokote K, Murohara T, Oyama J, Node K, on behalf of the PRIZE study investigators.
    Febuxostat does not delay progression of carotid atherosclerosis in patients with asymptomatic hyperuricemia: A randomized, controlled trial.
    PLOS Med 2020; 17: e1003095.

川添 晋
  1. Kawasoe S, Kubozono T, Ojima S, Kawabata T, Miyahara H, Tokushige K, Ohishi M.
    Sex differences in the effects of weight reduction on future blood pressure elevation in a mildly obese middle-aged population.
    Circ Rep 2020; 2: 385-392.
  2. Ojima S, Kubozono T, Kawasoe S, Kawabata T, Miyata M, Miyahara H, Maenohara S, Ohishi M.
    Association of risk factors for atherosclerosis, including high-sensitivity C-reactive protein, with carotid intima-media thickness, plaque score, and pulse wave velocity in a male population.
    Hypertens Res 2020;43: 422-430.
  3. Kawasoe S, Ide K, Usui T, Kubozono T, Yoshifuku S, Miyahara H, Maenohara S, Ohishi M, Kawakami K.
    Distribution and characteristics of hypouricemia within the japanese general population: a cross-sectional study.
    Medicina (Kaunas) 2019; 55: E61.
  4. Miyanaga S, Kubota K, Iwatani N, Higo K, Miyata M, Horizoe Y, Ojima S, Kawasoe S, Kubozono T, Ohishi M.
    Predictors of exercise-induced pulmonary hypertension in patients with connective tissue disease.
    Heart Vessels 2019; 34: 1509-1518.
  5. Ojima S, Kubozono T, Saihara K, Miyauchi T, Kawasoe S, Kubota K, Shigemizu S, Ohtsubo H, Miyata M, Ohishi M.
    Significant clinical indexes of exercise-induced pulmonary hypertension in patients with connective tissue disease.
    Circulation Reports 2019; 1: 610-616.
  6. Ojima S, Kubozono T, Kawasoe S, Kawabata T, Miyata M, Miyahara H, Maenohara S, Ohishi M.
    Association of risk factors for atherosclerosis, including high-sensitive C-reactive protein, with carotid intima-media thickness, plaque score and pulse wave velocity in male population.
    Hypertens Res 2020 May;43(5):422-430.
  7. Kawasoe S, Kubozono T, Yoshifuku S, Ojima S, Miyata M, Miyahara H, Maenohara S, Ohishi M.
    Uric acid level and new-onset atrial fibrillation in the japanese general population - longitudinal study.
    Circ J 2018; 83: 156-163.
  8. Kawasoe S, Kubozono T, Ojima S, Miyata M, Ohishi M.
    Combined assessment of the red cell distribution width and B-type natriuretic peptide: a more useful prognostic marker of cardiovascular mortality in heart failure patients.
    Intern Med 2018; 57: 1681-1688.
  9. Kawasoe S, Ide K, Usui T, Kubozono T, Yoshifuku S, Miyahara H, Maenohara S, Ohishi M, Kawakami K. Association of serum triglycerides with arterial stiffness in subjects with low levels of low-density lipoprotein cholesterol.
    Cir J 2018; 82: 3052-3057.
  10. Kubozono T, Miyata M, Kawasoe S, Ojima S, Yoshifuku S, Miyahara H, Maenohara, S, Ohishi M.
    High pulse wave velocity has a strong impact on early carotid atherosclerosis in a Japanese general male population.
    Circ J 2017; 81: 310-315.

徳重 明央
  1. Kubota K, Miyanaga S, Iwatani N, Higo K, Tokushige A, Ikeda Y, Ohishi M.
    Geriatric Nutritional Risk Index is associated with prognosis in patients with pulmonary arterial hypertension and chronic thromboembolic pulmonary hypertension.
    Circ Rep 2020; 2: 372-377.
  2. Kanda D, Ikeda Y, Sonoda T, Tokushige A, Kosedo I, Yoshino S, Takumi T, Ohishi M.
    Malnutrition and non-use clopidogrel additively aggravate prognosis of critical limb ischemia patients who underwent revascularization.
    Circ Rep 2020; 2: 121-127.
  3. Kosedo I, Tokushige A, Takumi T, Yoshikawa A, Teraguchi K, Takenouchi K, Shiraishi K, Ikeda D, Imamura M, Sonoda T, Kanda D, Ikeda Y, Ido A, Ohishi M.
    Use of proton pump inhibitors is associated with an increase in adverse cardiovascular events in patients with hemodialysis: insight from the KIDS Registry.
    Eur J Intern Med. 2020 Feb;72:79-87.
  4. Kinjo T, Tadokoro T, Tokushige A, Zamami T, Taira S, Ikehara Y, Tsuhako C, Ohtsu H, Ueda S, Kakinohana M.
    Effects of perioperative administration of acetaminophen on postoperative shivering: a randomized, triple-blind, placebo-controlled trial.
    Anesth Analg 2020; 130: 983-990.
  5. Nagata M, Ito H, Yoshida T, Tokushige A, Ueda S, Yokose T, Nakayama H.J
    Risk factors for progressive sarcopenia 6 months after complete resection of lung cancer: what can thoracic surgeons do against sarcopenia?
    Thorac Dis 2020; 12: 307-318.
  6. Shinoura S, Tokushige A, Chinen K, Mori H, Kato S, Ueda S.
    Association between contrast-induced nephrotoxicity and contrast enhanced computed tomography followed by endoscopic retrograde cholangiopancreatography.
    Eur J Radiol 2020; 129: 109074.
  7. Shinoura S, Tokushige A, Chinen K, Mori H, Kato S, Ueda S.
    Endosonographic finding of the simultaneous depiction of bile and pancreatic ducts can predict difficult biliary cannulation on endoscopic retrograde cholangiopancreatography.
    PLoS One 2020; 15: e0235757.
  8. Higo K, Tokushige A, Tezuka A, Ojima S, Miyauchi T, Saihara K, Sunahara N, Taketomi E, Ohishi M.
    Isolated distal deep vein thrombus detected before orthopedic surgery: Is preoperative anticoagulation preferable?
    Ann Vasc Dis 2019; 12: 354-361.
  9. Nagata M, Ito H, Yokose T, Tokushige A, Ueda S, Nakayama H.
    Effect of progressive sarcopenia during postoperative 6 months on long-term prognosis of completely resected lung cancer.
    J Thorac Dis 2019; 11: 3411-3420.
  10. Morimoto T, Sakuma I, Sakuma M, Tokushige A, Natsuaki M, Asahi T, Shimabukuro M, Nomiyama T, Arasaki O, Node K, Ueda S.
    Randomized evaluation of anagliptin vs sitagliptin on low-density lipoprotein cholesterol in diabetes (reason) Trial: A 52-week, open-label, randomized clinical trial.
    Sci Rep 2019; 9: 8537.

主な研究費取得状況

大石 充
事業・種目/期間詳細
日本学術振興会
科学研究費 基盤研究(C) 代表 / 2016年度~2018年度
大規模検診から高浸透率家系を抽出する新しい高血圧遺伝子同定法の確立

徳重 明央
事業・種目/期間詳細
日本学術振興会
科学研究費 若手研究 代表  / 2020年度〜2022年度
がん患者におけるミトコンドリア関連miRNAを介した心血管機能への影響の解明
新ニーズに対応する九州がんプロ養成プラン
GPなど(医歯学)
鹿児島大学
鹿児島大学病院
附属施設等
公開講座のご案内