研究テーマ(研究室紹介)

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平成31年4月1日より社会医療法人義順顕彰会の御寄附により心血管病予防分析学講座が発足しました。
種子島を舞台として先制医療の確立と健康寿命の延伸を目指した疫学研究「健康アイランド種子島」を遂行するための寄附講座です。

研究室概要

部局 大学院医歯学総合研究科 Graduate School of Medical and Dental Sciences
  寄附講座 Endowed Courses
講座 心血管病予防分析学講座 Department of Prevention and Analysis of Cardiovascular Diseases

分野サイト

連絡先

TEL.099-275-5318 / FAX.099-265-8447

主要研究テーマ

特定健診データ利用による心血管リスクの抑制、健康寿命延伸に関する研究 Research on suppression of cardiovascular risk and extension of healthy life expectancy by using Specific Health Checkup data
特定健診の受診率向上に関する取り組み Improvement of the consultation rate of Specific Health Checkup
学校健診データ利用による子供の肥満、血圧上昇抑制に関する研究 Suppression of obesity and blood pressure increase in children by using school medical examination data

スタッフ

大石 充

教授(兼任)
氏名 大石 充 Mitsuru OHISHI
専門分野 循環器学, 虚血性心疾患, 動脈硬化, 高血圧
研究テーマ ・循環器レジストリを駆使した病態把握と心血管疾患治療seeds探索(KIDSレジストリなど)
・AI・deep learning・LAMP法を用いたBig Data(健診データやDPCデータ)解析
・垂水研究(多職種によるチーム医療コホート研究)
・高血圧ゼロの街 枕崎(高血圧治療が予後及び社会経済に与える影響を見るコホート研究)
・健康アイランド 種子島(既存の健診(学校健診や特定健診)を120%生かすことに島民全員の健康を維持することができるかを見るコホート研究
・高血圧・心不全をターゲットとした新しい創薬・治療法の開発
・受容体連関を基軸としたtranslational research

研究者総覧


川添 晋

特任講師
氏名 川添 晋 Shin KAWASOE
専門分野 循環器学、心不全、心臓リハビリテーション、臨床疫学
研究テーマ ・種子島健康アイランドプロジェクト
・健診データによる心血管リスク因子探索
・心不全の病態、運動耐容能及び予後に関する研究

研究者総覧


徳重 明央

助教(兼任)
氏名 徳重 明央 Akihiro TOKUSHIGE
専門分野 循環器学、虚血性心疾患、腫瘍循環器、臨床研究、臨床薬理、生物統計
研究テーマ ・種子島健康アイランドプロジェクト
・透析患者の心血管予後調査(KIDSレジストリー)
・腫瘍循環器におけるミトコンドリアダイナミクス
・臨床研究ワークショップ主催

研究者総覧


主な研究実績

大石 充
  1. Kubozono T, Akasaki Y, Kawasoe S, Ojima S, Kawabata T, Makizako H, Kuwahata S, Takenaka T, Maeda M, Ohno M, Kijimuta M, Fujiwara S, Miyagawa K, Ohishi M.
    The relationship between home blood pressure measurement and room temperature in a Japanese general population.
    Hypertens Res 2021; 44: 454-463.
  2. Kuwahata S, Takenaka T, Motoya T, Masuda K, Yonezawa H, Shinchi S, Kawashima Y, Mohri S, Ohishi M.
    Effect of QT prolongation in patients taking cholinesterase inhibitors (Donepezil) for alzheimer's disease.
    Circ Rep 2021; 3: 115-121.
  3. Ninomiya Y, Kawasoe S, Kubozono T, Tokushige A, Ichiki H, Miyahara H, Tokushige K, Ohishi M.
    Sex-specific relationship between abdominal obesity and new-onset atrial fibrillation in the general Japanese population.
    Heart Vessels 2021; 36: 1879-1884.
  4. Ninomiya Y, Inoue K, Tanaka N, Okada M, Tanaka K, Onishi T, Hirao Y, Oka T, Inoue H, Takayasu K, Nakamaru R, Kitagaki R, Koyama Y, Okamura A, Iwakura K, Ohishi M, Fujii K.
    Absence of first-pass isolation is associated with poor pulmonary vein isolation durability and atrial fibrillation ablation outcomes.
    J Arrhythm 2021; 37: 1468-1476.
  5. Kawasoe S, Kubozono T, Ojima S, Kawabata T, Miyahara H, Tokushige K, Ohishi M.
    J-shaped curve for the association between serum uric acid levels and the prevalence of blood pressure abnormalities.
    Hypertens Res 2021; 44: 1186-1193.
  6. Arikawa R, Kanda D, Ikeda Y, Tokushige A, Sonoda T, Anzaki K, Ohishi M.
    Prognostic impact of malnutrition on cardiovascular events in coronary artery disease patients with myocardial damage.
    BMC Cardiovasc Disord 2021; 21: 479.
  7. Ojima S, Kubozono T, Kawasoe S, Kawabata T, Miyahara H, Tokushige K, Ohishi M.
    Gender differences in the risk factors associated with atherosclerosis by carotid intima-media thickness, plaque score, and pulse wave velocity.
    Heart Vessels 2021; 36: 934-944.
  8. Sasaki Y, Ikeda Y, Uchikado Y, Akasaki Y, Sadoshima J, Ohishi M.
    Estrogen plays a crucial role in Rab9-dependent mitochondrial autophagy, delaying arterial senescence.
    J Am Heart Assoc 2021; 10: e019310.
  9. Iwatani N, Kubota K, Ikeda Y, Tokushige A, Miyanaga S, Higo K, Ohishi M.
    Different characteristics of mitochondrial dynamics-related miRNAs on the hemodynamics of pulmonary artery hypertension and chronic thromboembolic pulmonary hypertension.
    J Cardiol 2021; 78: 24-30.
  10. Shimono H, Kajiya T, Takaoka J, Miyamura A, Inoue T, Kitazono K, Ninomiya T, Atsuchi Y, Atsuchi N, Ohishi M.
    Characteristics of recurrent in-stent restenosis (ISR) after second and third generation drug-eluting stent (DES) implantation.
    Cor Art Dis 2021; 32: 36-41.
  11. Yoshimoto I, Iriki Y, Oketani N, Okui H, Ichiki H, Maenosono R, Namino F, Miyata M, Ohishi M.
    A randomized comparison of two direct oral anticoagulants for patients undergoing cardiac ablation with a contemporary warfarin control arm.
    J Interv Card Electrophysiol 2021; 60: 375-385.
  12. Uchikado Y, Ikeda Y, Sasaki Y, Iwabayashi M, Akasaki Y, Ohishi M.
    Association of lectin-like oxidized low-density lipoprotein receptor-1 with angiotensin II type 1 receptor impacts mitochondrial quality control, offering promise for the treatment of vascular senescence.
    Front Cardiovasc Med 2021; 8: 788655.
  13. Nakamura M, Hamada T, Tanaka A, Nishi K, Kume K, Goto Y, Beppu M, Hijioka H, Higashi Y, Tabata H, Mori K, Mishima Y, Uchino Y, Yamashiro K, Matsumura Y, Makizako H, Kubozono T, Tabira T, Takenaka T, Ohishi M, Sugiura T.
    Association of oral hypofunction with frailty, sarcopenia, and mild cognitive impairment: A cross-sectional study of community-dwelling Japanese older adults.
    J Clin Med 2021; 10: 1626. J Clin Med 2021; 10 (8): 1626.
  14. Nakajo M, Ojima S, Kawakami H, Tani A, Hirayama A, Jinguji M, Kubozono T, Ohishi M, Yoshiura T.
    Value of patlak ki images from 18F-FDG-PET/CT for evaluation of the relationships between disease activity and clinical events in cardiac sarcoidosis.
    Sci Rep 2021; 11: 2729.
  15. Kiuchi Y, Makizako H, Nakai Y, Tomioka K, Taniguchi Y, Kimura M, Kanouchi H, Takenaka T, Kubozono T, Ohishi M.
    The association between dietary variety and physical frailty in community-dwelling older adults.
    Healthcare 2021; 9: 32.
  16. Kaimoto K, Yamashita M, Suzuki T, Makizako H, Koriyama C, Kubozono T, Takenaka T, Ohishi M, Kanouchi H, Tarumizu Study Diet Group.
    Association of protein and magnesium intake with prevalence of prefrailty and frailty in community-dwelling older Japanese women.
    J Nutr Sci Vitaminol 2021; 67: 39-47.
  17. Maruta M, Makizako H, Ikeda Y, Miyata H, Nakamura A, Han G, Shimokihara S, Tokuda K, Kubozono T, Ohishi M, Tabira T.
    Association between apathy and satisfaction with meaningful activities in older adults with mild cognitive impairment: A population-based cross-sectional study.
    Int J Geriatr Psychiatry 2021; 36: 1065-1074.
  18. Maenosono R, Mizukami N, Ichiki H, Oketani N, Namino F, Masamoto I, Yuasa T, Yamakuchi M, Ohishi M, Hashiguchi T.
    Total atrial conduction time as a possible predictor of atrial fibrillation recurrence after catheter ablation for paroxysmal atrial fibrillation: relationship between electrical atrial remodeling and structural atrial remodeling time courses.
    J Med Ultrason 2021; 48: 295-306.
  19. Sugimoto T, Araki A, Fujita H, Honda K, Inagaki N, Ishida T, Kato J, Kishi M, Kobayashi K, Kouyama K, Noma H,Ohishi M, Satoh-Asahara N, Shimada H, Sugimoto K, Suzuki S, Takeya Y, Tamura Y, Tokuda H, Umegaki H, Watada H, Yamada Y, Sakurai T.
    The multi-domain intervention trial in older adults with diabetes mellitus for prevention of dementia in Japan: study protocol for a multi-center, randomized, 18-month controlled trial.
    Front Aging Neurosci 2021; 13: 680341.
  20. Inoue K, Hirao K, Kumagai K, Kimura M, Miyauchi Y, Tsushima E, Ohishi M, Kimura K, Yasaka M, Yamaji H, Okawa K, Fujimoto M.
    Long-term efficacy and safety of anticoagulation after atrial fibrillation ablation: data from the JACRE registry.
    J Cardiol 2021; 77: 263-270.
  21. Salim Anwar A, Kawasoe S, Kubozono T, Ojima S, Kawabata T, Ikeda Y, Miyahara H, Tokushige K, Ohishi M.
    Assessment of future hypertension risk by sex using combined body mass index and waist-to-height ratio.
    Circ Rep 2021 Nov 20;4: 9-16.

川添 晋
  1. Kubozono T, Akasaki Y, Kawasoe S, Ojima S, Kawabata T, Makizako H, Kuwahata S, Takenaka T, Maeda M, Ohno M, Kijimuta M, Fujiwara S, Miyagawa K, Ohishi M.
    The relationship between home blood pressure measurement and room temperature in a Japanese general population.
    Hypertens Res 2021; 44: 454-463.
  2. Ninomiya Y, Kawasoe S, Kubozono T, Tokushige A, Ichiki H, Miyahara H, Tokushige K, Ohishi M.
    Sex-specific relationship between abdominal obesity and new-onset atrial fibrillation in the general Japanese population.
    Heart Vessels 2021; 36: 1879-1884.
  3. Kawasoe S, Kubozono T, Ojima S, Kawabata T, Miyahara H, Tokushige K, Ohishi M.
    J-shaped curve for the association between serum uric acid levels and the prevalence of blood pressure abnormalities.
    Hypertens Res 2021; 44: 1186-1193.
  4. Ojima S, Kubozono T, Kawasoe S, Kawabata T, Miyahara H, Tokushige K, Ohishi M.
    Gender differences in the risk factors associated with atherosclerosis by carotid intima-media thickness, plaque score, and pulse wave velocity.
    Heart Vessels 2021; 36: 934-944.
  5. Seki T, Takeuchi M, Kawasoe S, Takeuchi K, Miki R, Ueshima K, Kawakami K.
    Survival benefits of outpatient cardiac rehabilitation after acute myocardial infarction: propensity analysis using japanese administrative database.
    Ann Clin Epidemiol 2021: 3; 10-26.
  6. Salim Anwar A, Kawasoe S, Kubozono T, Ojima S, Kawabata T, Ikeda Y, Miyahara H, Tokushige K, Ohishi M.
    Assessment of future hypertension risk by sex using combined body mass index and waist-to-height ratio.
    Circ Rep 2021; 4: 9-16.
  7. Kawasoe S, Kubozono T, Ojima S, Kawabata T, Miyahara H, Tokushige K, Ohishi M.
    Sex differences in the effects of weight reduction on future blood pressure elevation in a mildly obese middle-aged population.
    Circ Rep 2020; 2: 385-392.
  8. Ojima S, Kubozono T, Kawasoe S, Kawabata T, Miyata M, Miyahara H, Maenohara S, Ohishi M.
    Association of risk factors for atherosclerosis, including high-sensitivity C-reactive protein, with carotid intima-media thickness, plaque score, and pulse wave velocity in a male population.
    Hypertens Res 2020;43: 422-430.
  9. Ojima S, Kubozono T, Kawasoe S, Kawabata T, Miyata M, Miyahara H, Maenohara S, Ohishi M.
    Association of risk factors for atherosclerosis, including high-sensitive C-reactive protein, with carotid intima-media thickness, plaque score and pulse wave velocity in male population.
    Hypertens Res 2020 May;43(5):422-430.
  10. Kawasoe S, Ide K, Usui T, Kubozono T, Yoshifuku S, Miyahara H, Maenohara S, Ohishi M, Kawakami K.
    Distribution and characteristics of hypouricemia within the japanese general population: a cross-sectional study.
    Medicina (Kaunas) 2019; 55: E61.

徳重 明央
  1. Ninomiya Y, Kawasoe S, Kubozono T, Tokushige A, Ichiki H, Miyahara H, Tokushige K, Ohishi M.
    Sex-specific relationship between abdominal obesity and new-onset atrial fibrillation in the general Japanese population.
    Heart Vessels 2021; 36: 1879-1884.
  2. Arikawa R, Kanda D, Ikeda Y, Tokushige A, Sonoda T, Anzaki K, Ohishi M.
    Prognostic impact of malnutrition on cardiovascular events in coronary artery disease patients with myocardial damage.
    BMC Cardiovasc Disord 2021; 21: 479.
  3. Iwatani N, Kubota K, Ikeda Y, Tokushige A, Miyanaga S, Higo K, Ohishi M.
    Different characteristics of mitochondrial dynamics-related miRNAs on the hemodynamics of pulmonary artery hypertension and chronic thromboembolic pulmonary hypertension.
    J Cardiol 2021; 78: 24-30.
  4. Kawabe A, Yasu T, Morimoto T, Tokushige A, Momomura SI, Sakakura K, Node K, Inoue T, Ueda S; CHD Collaborative Investigators.
    WBC count predicts heart failure in diabetes and coronary artery disease patients: a retrospective cohort study.
    ESC Heart Fail 2021; 8: 3748-3759.
  5. Kubota K, Miyanaga S, Iwatani N, Higo K, Tokushige A, Ikeda Y, Ohishi M.
    Geriatric Nutritional Risk Index is associated with prognosis in patients with pulmonary arterial hypertension and chronic thromboembolic pulmonary hypertension.
    Circ Rep 2020; 2: 372-377.
  6. Kanda D, Ikeda Y, Sonoda T, Tokushige A, Kosedo I, Yoshino S, Takumi T, Ohishi M.
    Malnutrition and non-use clopidogrel additively aggravate prognosis of critical limb ischemia patients who underwent revascularization.
    Circ Rep 2020; 2: 121-127.
  7. Kosedo I, Tokushige A, Takumi T, Yoshikawa A, Teraguchi K, Takenouchi K, Shiraishi K, Ikeda D, Imamura M, Sonoda T, Kanda D, Ikeda Y, Ido A, Ohishi M.
    Use of proton pump inhibitors is associated with an increase in adverse cardiovascular events in patients with hemodialysis: insight from the KIDS Registry.
    Eur J Intern Med. 2020 Feb;72:79-87.
  8. Kinjo T, Tadokoro T, Tokushige A, Zamami T, Taira S, Ikehara Y, Tsuhako C, Ohtsu H, Ueda S, Kakinohana M.
    Effects of perioperative administration of acetaminophen on postoperative shivering: a randomized, triple-blind, placebo-controlled trial.
    Anesth Analg 2020; 130: 983-990.
  9. Nagata M, Ito H, Yoshida T, Tokushige A, Ueda S, Yokose T, Nakayama H.J
    Risk factors for progressive sarcopenia 6 months after complete resection of lung cancer: what can thoracic surgeons do against sarcopenia?
    Thorac Dis 2020; 12: 307-318.
  10. Shinoura S, Tokushige A, Chinen K, Mori H, Kato S, Ueda S.
    Association between contrast-induced nephrotoxicity and contrast enhanced computed tomography followed by endoscopic retrograde cholangiopancreatography.
    Eur J Radiol 2020; 129: 109074.

主な研究費取得状況

大石 充
事業・種目/期間詳細
日本学術振興会
科学研究費 基盤研究(C) 代表(分担 窪薗琢郎, 川添 晋, 牧迫飛雄馬) / 2021年度~2023年度
高齢者コホートデータ人工知能解析によるフレイルネットワーク分析及び予後因子の同定.

川添 晋
事業・種目/期間詳細
日本学術振興会
科学研究費 基盤研究(C) 代表 (分担 大石 充, 窪薗琢郎) / 2021年度〜2023年度
70万人, 43年の大規模健診データによる心血管病発症AI予測モデルの構築と実装

徳重 明央
事業・種目/期間詳細
日本学術振興会
科学研究費 若手研究 代表  / 2020年度〜2022年度
がん患者におけるミトコンドリア関連miRNAを介した心血管機能への影響の解明
新ニーズに対応する九州がんプロ養成プラン
GPなど(医歯学)
鹿児島大学
鹿児島大学病院
附属施設等
公開講座のご案内