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• 主な研究費取得状況

口腔癌が浸潤・転移する過程では種々の遺伝子異常が起こります。しかしながら、口腔癌における遺伝子異常の多くはがんの進展に伴い付随的に生じたパッセンジャー変異であり、口腔癌の発生や進展に必須なドライバー変異を引き起こす遺伝子はよく分かっていません。当研究室では、口腔癌の分子機構を解明すべく病理学と分子生物学を融合させた研究を行っています。

臨床面では、鹿児島大学病院の病理部門として顎口腔や唾液腺領域の病理診断を行っています。医学部の病理学分野とも密に連携しており、口腔病理専門医、細胞診専門歯科医を取得しやすい環境を構築しています。私たちとともに、実践的な外科病理学の知識に裏付けられた分子生物学研究が行える科学者を目指しましょう。　　　　　　　　　　　　　　　　　　　　　　　　　　　　　　　　　　　　　　　　　　　　　　　　　　　　　　　　　　　　　　　　　　　　　　　　

研究室概要

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主な研究実績

2023年　原著論文

• Hoang TH, Nguyen PT, Huynh CNN, Nguyen TTT, Trang THT, Botelho MG, Nguyen VL, Shima K, Sasahira T . Reliability of online dental final exams in the pre and post COVID-19 era: A comparative study. PLOS ONE 18(5): e0286148, 2023

2022年　原著論文

• Sasahira T, Kurihara-Shimomura M, Shimojjukoku Y, Shima K, Kirita T. Searching for new molecular targets for oral squamous cell carcinoma with a view to clinical implementation of precision medicine. J Pers Med 12(3): 413, 2022

2021年　原著論文

• Sasahira T, Kurihara-Shimomura M, Shimomura H, Bosserhoff AK, Kirita T. Identification of oral squamous cell carcinoma markers MUC20 and SPRR1B downstream of TANGO. J Cancer Res Clin Oncol 147(6): 1659-1672, 2021
• Sasahira T, Kurihara-Shimomura M, Shimomura H, Kirita T. SERPINE2 is an oral cancer-promoting factor that induces angiogenesis and lymphangiogenesis. Int J Clin Oncol 26(10): 1831-1839, 2021

2020年　原著論文

• Kurihara-Shimomura M, Sasahira T, Shimomura H, Bosserhoff AK, Kirita T. Mast cell chymase promotes angiogenesis and lymphangiogenesis mediated by activation of melanoma inhibitory activity gene family members in oral squamous cell carcinoma. Int J Oncol 56(5): 1093-1100, 2020
• Ikeda M, Shima K, Kondo T, Semba I. Atypical immunohistochemical patterns can complement the histopathological diagnosis of oral premalignant lesions. Journal of Oral Biosciences 62: 93-98, 2020
• Nguyen PT, Kanno K, Pham QT, Kikuchi Y, Kakimoto M, Kobayashi T, Otani Y, Kishikawa N, Miyauchi M, Arihiro K, Ito M, Tazuma S. Senescent hepatic stellate cells caused by deoxycholic acid modulates malignant behavior of hepatocellular carcinoma. Journal of Cancer Research and Clinical Oncology, 146: 3255-3268, 2020
• Kobayashi T, Kanno K, Nguyen PT, Sugiyama A, Kawahara A, Otani Y, Kishikawa N, Ito M, Tazuma S. Periostin antisense oligonucleotide prevents hepatic steatosis and fibrosis in a mouse model of non-alcoholic steatohepatitis. Journal of Gastroenterology and Hepatology, 35: 2140-2150, 2020

2019年　原著論文

• Kusuyama J, Amir MS, Albertson BG, Bandow K, Ohnishi T, Nakamura T, Noguchi K, Shima K, Semba I, Matsuguchi T. JNK inactivation suppresses osteogenic differentiation, but robustly induces osteopontin expression in osteoblasts through the induction of inhibitor of DNA binding 4 (Id4). FASEB J. 33(6):7331-7347, 2019
• Kusuyama J, Seong CH, Makarewicz NS, Ohnishi T, Shima K, Semba I, Bandow K, Matsuguchi T. Low intensity pulsed ultrasound (LIPUS) maintains osteogenic potency through the increased expression and stability of Nanog through spleen tyrosine kinase (Syk) activation. Cellular Signalling 62: 109345, 2019
• Kusuyama J, Seong CH, Nakamura T, Ohnishi T, Amir MS, Shima K, Semba I, Noguchi K, Matsuguchi T. BMP9 prevents induction of osteopontin in JNK-inactivated osteoblasts via Hey1-Id4 interaction. Int J Biochem Cell Biol 116, 105614, 2019
• Nguyen PT, Kanno K, Pham T, Kobayashi T, Tazuma S. Deoxycholic acid-Induced senescent hepatic stellate cell promote malignant behaviors of hepatocellular carcinogenesis. Gastroenterology, 156(6), 2019 
• Kobayashi T, Kanno K, Nguyen PT, Kishikawa N, Tazuma S. Molecular mechanism in which periostin induces hepatic steatosis in vivo and in vitro. Hepatology, 2019
• Ohigashi T, Kanno K, Sugiyama A, Nguyen PT, Kishikawa N, Otani Y, Kobayashi T, Matsuo H, Tazuma S. Protective effect of phosphatidylcholine on lysophosphatidylcholine-induced cellular senescence in cholangiocyte. J Hepatobiliary Pacreat Sci, 26(12), 568-577, 2019

2018年　原著論文

• Sasahira T, Nishiguchi Y, Kurihara-Shimomura M, Nakashima C, Kirita T. NIPA-like domain containing 1 is a novel tumor-promoting factor in oral squamous cell carcinoma. J Cancer Res Clin Oncol 144(5): 875-882, 2018
• Kurihara-Shimomura M, Sasahira T, Nakamura H, Nakashima C, Kirita T. Zinc finger AN1-type containing 4 is a novel marker for predicting metastasis and poor prognosis in oral squamous cell carcinoma. J Clin Pathol 71(5): 436-441, 2018 
• Nakashima C, Yamamoto K, Fuiwara-Tani R, Matsushima S, Fujii K, Ohnmori H, Sasahira T, Sasaki T,  Kitadai Y, Kirita T, Kuniyasu H. Expression of cytosolic malic enzyme (ME1) is associated with disease progression in human oral squamous cell carcinoma. Cancer Sci 109(6): 2036-2045, 2018
• Shimomura H, Sasahira T, Nakashima C, Shimomura-Kurihara M, Kirita T. Downregulation of DHRS9 is associated with poor prognosis in oral squamous cell carcinoma. Pathology 50(6): 642-647, 2018
• Sasahira T, Bosserhoff AK, Kirita T. The importance of melanoma inhibitory activity gene family in the tumor progression of oral cancer. Pathol Int 68(5): 278-86, 2018.
• Sasahira T, Kirita T. Hallmarks of cancer-related newly prognostic factors of oral squamous cell carcinoma. Int J Mol Sci　19(8): E2413, 2018
• Ma S, Ogino S, Parsana P, Nishihara R, Qian Z, Shen J, Mima K, Masugi Y, Cao Y, Nowak JA, Shima K, Hoshida Y, Giovannucci EL, Gala MK, ChanAT, Fuchs CS, Parmigiani G, Huttenhower C, Waldron L. Continuity of Transcriptomes Among Colorectal Cancer Subtypes Based on Meta-analysis. Genome Biology, 19: 142, 2018
• Kobayashi T, Kanno K, Sugiyama A, Nguyen PT, Kishikawa N, Otani Y, Tazuma S. Periostin Antisense Oligonucleotide Prevents Hepatic Steatosis and Fibrosis in Mice: A novel strategy for Nonalcoholic Steatohepatitis Treatment. Hepatology, 68, 2018 
• Nguyen PT, Nguyen D, Chea C, Miyauchi M, Fujii M, Takata T. Interaction between N-cadherin and decoy receptor-2 regulates apoptosis in head and neck cancer. Oncotarget 9: 31516-31530, 2018 
• Oka H, Ishida Y, Hong G, Nguyen PT. Perceptions of dental students in Japanese national universities about studying abroad. Eur J Dent Educ, 22: e1-e6, 2018 
• Chea C, Miyauchi M, Inubushi T, Okamoto K, Haing S, Nguyen PT, Imanaka H, Takata T. Bovine lactoferrin reverses programming of epithelial-to-mesenchymal transition in oral squamous cell carcinoma. Biochem Biophys Res Commun, 502:142-147, 2018
• Chea C, Miyauchi M, Inubushi T, N, Subarnbhesaj A, Nguyen PT, Shestha M, Haing S, Ohta K, Takata T. Molecular mechanism of inhibitory effects of bovine lactoferrin on the growth of oral squamous cell carcinoma. PLOS ONE,13: e0191683, 2018 

2017年　原著論文

• Sasahira T, Kurihara M, Nishiguchi Y, Nakashima C, Kirita T. Pancreatic adenocarcinoma upregulated factor has oncogenic functions in oral squamous cell carcinoma. Histopathology 70(4):539-48, 2017
• Kusuyama J, Ohnishi T, Bandow K, Amir MS, Shima K, Semba I, Matsuguchi T. Constitutive activation of p46JNK2 is indispensable for C/EBPdelta induction in the initial stage of adipogenic differentiation. Biochem J 2017; 474(20): 3421-3437.
• Kusuyama J, Bandow K, Ohnishi T, Hisadome M, Shima K, Semba I, Matsuguchi T. Osteopontin inhibits osteoblast responsiveness through the downregulation of focal adhesion kinase mediated by the induction of low molecular weight-protein tyrosine phosphatase. Mol Biol Cell 2017; (10): 1326-1236.
• Subarnbhesaj A, Miyauchi M, Mikuriya A, Nguyen PT, Chanbora C, Ayunintyas NF, Fujita M, Niida S, Takata T. Roles of VEGF-Flt-1 signaling in malignant behaviors of oral squamous cell carcinoma. PLOS ONE,22: e0187092, 2017

2016年　原著論文

• Sasahira T, Kurihara M, Nakashima C, Kirita T. LEM domain containing 1 promotes oral squamous cell carcinoma invasion and endothelial transmigration. Br J Cancer 115(1):52-8, 2016
• Sasahira T, Kurihara M, Nishiguchi Y, Fujiwara R, Kirita T. NEDD 4 binding protein 2-like 1 promotes cancer cell invasion in oral squamous cell carcinoma. Virchows Archiv 469(2):163-72, 2016
• Nagata M, Kanie T, Shima K. Cemental tear in an autotransplanted tooth that had been functioning for 15 years. Clinical Advances in Periodontics 2016; 6 (3): 111-7.
• Nagata M, Nagata M, Kanie T, Shima K. Clinical and histologic aspect of cervical cemental tears as a risk for periodontal diseases. Clinical Advances in Periodontics 2016; 6 (4): 167-74

2015年　原著論文

• Nguyen PT, Subarnbhesaj A, Miyauchi M, Ogawa I, Takata T. The FGFR1 inhibitor PD173074 reduces osteoclastogenesis in gingival squamous cell carcinoma. Oral Surgery, Oral Medicine, Oral Pathology and Oral Radiology 119: e172, 2015 
• Subarnbhesaj A, Miyauchi M, Chea C, Nurina FA, Nguyen PT, Takata T. Role of VEGF-Flt-1 Signaling in Oral Cancer Progression. Oral Surgery, Oral Medicine, Oral Pathology and Oral Radiology, 119: e136-7, 2015

2013年　原著論文

• Nguyen PT, Tsunematsu T, Yanagisawa S, Kudo Y, Miyauchi M, Kamata N and Takata T. The FGFR-1 inhibitor PD173074 induces mesenchymal-epithelial transition through the transcription factor AP-1. British Journal of Cancer,109: 2248-58, 2013

2012年　原著論文

• Kudo Y, Iizuka S, Yoshida M, Nguyen PT, Takata T. Periostin Directly and Indirectly Promotes Tumor Lymphangiogenesis of Head and Neck Cancer. PLOS ONE, 7: 1-14, 2012 

2011年　原著論文

• Nguyen PT, Kudo Y, Yoshida M, Takata T. N-cadherin expression is involved in malignant behavior of head and neck cancer in relation to epithelial-mesenchymal transition. Histol Histopathol 26: 147-156, 2011
• Nguyen PT, Kudo Y, Yoshida M, Iizuka S, Ogawa I, Takata T. N-cadherin expression is correlated with metastasis of spindle cell carcinoma of head and neck region. Journal of Oral Pathology and Medicine 40:77-82, 2011

2010年　原著論文

• SL Priebe, J Aleksejūnienė, C Zed, S Dharamsi, DHQ Thinh, NT Hong, TTK Cuc, Nguyen PT. Oral squamous cell carcinoma and cultural oral risk habits in Vietnam. International Journal of Dental Hygiene 8: 159-168, 2010 

Research Grant List

Tomonori SASAHIRA

Kaori SHIMA

Phuong Thao Nguyen

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