分子口腔病理学
口腔癌が浸潤・転移する過程では種々の遺伝子異常が起こります。しかしながら、口腔癌における遺伝子異常の多くはがんの進展に伴い付随的に生じたパッセンジャー変異であり、口腔癌の発生や進展に必須なドライバー変異を引き起こす遺伝子はよく分かっていません。当研究室では、口腔癌の分子機構を解明すべく病理学と分子生物学を融合させた研究を行っています。
臨床面では、鹿児島大学病院の病理部門として顎口腔や唾液腺領域の病理診断を行っています。医学部の病理学分野とも密に連携しており、口腔病理専門医、細胞診専門歯科医を取得しやすい環境を構築しています。私たちとともに、実践的な外科病理学の知識に裏付けられた分子生物学研究が行える科学者を目指しましょう。
研究室概要
| 部局 | 医歯学総合研究科 | Graduate School of Medical and Dental Sciences |
|---|---|---|
| 専攻 | 先進治療科学専攻 | Advanced Therapeutics Course |
| 大講座 | 腫瘍学 | Oncology |
| 分野 | 分子口腔病理学 | Molecular Oral Pathology and Oncology |
| 分野サイト | http://w3.hal.kagoshima-u.ac.jp/dental/op/index.html | |
連絡先
TEL.099-275-6142 / FAX.099-275-6148
主要研究テーマ
| 口腔癌の進展に関与する新規マーカーの探索 | Search for novel molecular markers involved in the development and progression of oral cancer |
| 口腔癌におけるDNAメチル化状態の研究 | Study of DNA methylation status in oral cancer |
| 口腔癌における腫瘍微小環境に関する研究 | Study on tumor microenvironmet of oral cancer |
スタッフ
教授
| 氏名 |
笹平智則 Tomonori SASAHIRA |
|---|---|
| 専門分野 | 口腔病理学 |
| 研究テーマ |
・口腔癌の新規腫瘍マーカーの探索 |
准教授
| 氏名 | 嶋 香織 Kaori SHIMA |
|---|---|
| 専門分野 | 口腔病理学 |
| 研究テーマ | ・多発性口腔扁平上皮癌におけるDNAメチル化に関する研究 |
助教
| 氏名 | Phuong Thao NGUYEN |
|---|---|
| 専門分野 | 口腔病理学 |
| 研究テーマ | 口腔病理、口腔がん、肝臓がん、代謝 |
技術職員
| 氏名 | 加治屋由佳 Yuka KAJIYA |
|---|
主な研究実績
2023年
- Hoang TH, Nguyen PT, Huynh CNN, Nguyen TTT, Trang THT, Botelho MG, Nguyen VL, Shima K, Sasahira T . Reliability of online dental final exams in the pre and post COVID-19 era: A comparative study. PLOS ONE 18(5): e0286148, 2023
- Shima K, Nguyen PT, Shimojukkoku Y, Sasahira T. Two cases of primordial odontogenic tumor in the maxilla. Japanese Journal of Diagnostic Pathology 40 (3) 265-71, 2023
- Miyakoshi M, Abe H, Hagimoto A, Kawashima Y, Kawabata Y, Indo H, Hijioka H, Shima K, Sugiura T, Sasahira T, Tanaka T. Mucoepidermoid Carcinoma of the Maxilla with Multiple Spreading Patterns: A case report. Dental Radiology 63(1) 20-24, 2023
2022年
- Sasahira T, Kurihara-Shimomura M, Shimojjukoku Y, Shima K, Kirita T. Searching for new molecular targets for oral squamous cell carcinoma with a view to clinical implementation of precision medicine. J Pers Med 12(3): 413, 2022
2021年
- Sasahira T, Kurihara-Shimomura M, Shimomura H, Bosserhoff AK, Kirita T. Identification of oral squamous cell carcinoma markers MUC20 and SPRR1B downstream of TANGO. J Cancer Res Clin Oncol 147(6): 1659-1672, 2021
- Sasahira T, Kurihara-Shimomura M, Shimomura H, Kirita T. SERPINE2 is an oral cancer-promoting factor that induces angiogenesis and lymphangiogenesis. Int J Clin Oncol 26(10): 1831-1839, 2021
2020年
- Kurihara-Shimomura M, Sasahira T, Shimomura H, Bosserhoff AK, Kirita T. Mast cell chymase promotes angiogenesis and lymphangiogenesis mediated by activation of melanoma inhibitory activity gene family members in oral squamous cell carcinoma. Int J Oncol 56(5): 1093-1100, 2020
- Ikeda M, Shima K, Kondo T, Semba I. Atypical immunohistochemical patterns can complement the histopathological diagnosis of oral premalignant lesions. Journal of Oral Biosciences 62: 93-98, 2020
- Nguyen PT, Kanno K, Pham QT, Kikuchi Y, Kakimoto M, Kobayashi T, Otani Y, Kishikawa N, Miyauchi M, Arihiro K, Ito M, Tazuma S. Senescent hepatic stellate cells caused by deoxycholic acid modulates malignant behavior of hepatocellular carcinoma. Journal of Cancer Research and Clinical Oncology, 146: 3255-3268, 2020
- Kobayashi T, Kanno K, Nguyen PT, Sugiyama A, Kawahara A, Otani Y, Kishikawa N, Ito M, Tazuma S. Periostin antisense oligonucleotide prevents hepatic steatosis and fibrosis in a mouse model of non-alcoholic steatohepatitis. Journal of Gastroenterology and Hepatology, 35: 2140-2150, 2020
2019年
- Kusuyama J, Amir MS, Albertson BG, Bandow K, Ohnishi T, Nakamura T, Noguchi K, Shima K, Semba I, Matsuguchi T. JNK inactivation suppresses osteogenic differentiation, but robustly induces osteopontin expression in osteoblasts through the induction of inhibitor of DNA binding 4 (Id4). FASEB J. 33(6):7331-7347, 2019
- Kusuyama J, Seong CH, Makarewicz NS, Ohnishi T, Shima K, Semba I, Bandow K, Matsuguchi T. Low intensity pulsed ultrasound (LIPUS) maintains osteogenic potency through the increased expression and stability of Nanog through spleen tyrosine kinase (Syk) activation. Cellular Signalling 62: 109345, 2019
- Kusuyama J, Seong CH, Nakamura T, Ohnishi T, Amir MS, Shima K, Semba I, Noguchi K, Matsuguchi T. BMP9 prevents induction of osteopontin in JNK-inactivated osteoblasts via Hey1-Id4 interaction. Int J Biochem Cell Biol 116, 105614, 2019
- Nguyen PT, Kanno K, Pham T, Kobayashi T, Tazuma S. Deoxycholic acid-Induced senescent hepatic stellate cell promote malignant behaviors of hepatocellular carcinogenesis. Gastroenterology, 156(6), 2019
- Kobayashi T, Kanno K, Nguyen PT, Kishikawa N, Tazuma S. Molecular mechanism in which periostin induces hepatic steatosis in vivo and in vitro. Hepatology, 2019
- Ohigashi T, Kanno K, Sugiyama A, Nguyen PT, Kishikawa N, Otani Y, Kobayashi T, Matsuo H, Tazuma S. Protective effect of phosphatidylcholine on lysophosphatidylcholine-induced cellular senescence in cholangiocyte. J Hepatobiliary Pacreat Sci, 26(12), 568-577, 2019
2018年
- Sasahira T, Nishiguchi Y, Kurihara-Shimomura M, Nakashima C, Kirita T. NIPA-like domain containing 1 is a novel tumor-promoting factor in oral squamous cell carcinoma. J Cancer Res Clin Oncol 144(5): 875-882, 2018
- Kurihara-Shimomura M, Sasahira T, Nakamura H, Nakashima C, Kirita T. Zinc finger AN1-type containing 4 is a novel marker for predicting metastasis and poor prognosis in oral squamous cell carcinoma. J Clin Pathol 71(5): 436-441, 2018
- Nakashima C, Yamamoto K, Fuiwara-Tani R, Matsushima S, Fujii K, Ohnmori H, Sasahira T, Sasaki T, Kitadai Y, Kirita T, Kuniyasu H. Expression of cytosolic malic enzyme (ME1) is associated with disease progression in human oral squamous cell carcinoma. Cancer Sci 109(6): 2036-2045, 2018
- Shimomura H, Sasahira T, Nakashima C, Shimomura-Kurihara M, Kirita T. Downregulation of DHRS9 is associated with poor prognosis in oral squamous cell carcinoma. Pathology 50(6): 642-647, 2018
- Sasahira T, Bosserhoff AK, Kirita T. The importance of melanoma inhibitory activity gene family in the tumor progression of oral cancer. Pathol Int 68(5): 278-86, 2018.
- Sasahira T, Kirita T. Hallmarks of cancer-related newly prognostic factors of oral squamous cell carcinoma. Int J Mol Sci 19(8): E2413, 2018
- Ma S, Ogino S, Parsana P, Nishihara R, Qian Z, Shen J, Mima K, Masugi Y, Cao Y, Nowak JA, Shima K, Hoshida Y, Giovannucci EL, Gala MK, ChanAT, Fuchs CS, Parmigiani G, Huttenhower C, Waldron L. Continuity of Transcriptomes Among Colorectal Cancer Subtypes Based on Meta-analysis. Genome Biology, 19: 142, 2018
- Kobayashi T, Kanno K, Sugiyama A, Nguyen PT, Kishikawa N, Otani Y, Tazuma S. Periostin Antisense Oligonucleotide Prevents Hepatic Steatosis and Fibrosis in Mice: A novel strategy for Nonalcoholic Steatohepatitis Treatment. Hepatology, 68, 2018
- Nguyen PT, Nguyen D, Chea C, Miyauchi M, Fujii M, Takata T. Interaction between N-cadherin and decoy receptor-2 regulates apoptosis in head and neck cancer. Oncotarget 9: 31516-31530, 2018
- Oka H, Ishida Y, Hong G, Nguyen PT. Perceptions of dental students in Japanese national universities about studying abroad. Eur J Dent Educ, 22: e1-e6, 2018
- Chea C, Miyauchi M, Inubushi T, Okamoto K, Haing S, Nguyen PT, Imanaka H, Takata T. Bovine lactoferrin reverses programming of epithelial-to-mesenchymal transition in oral squamous cell carcinoma. Biochem Biophys Res Commun, 502:142-147, 2018
- Chea C, Miyauchi M, Inubushi T, N, Subarnbhesaj A, Nguyen PT, Shestha M, Haing S, Ohta K, Takata T. Molecular mechanism of inhibitory effects of bovine lactoferrin on the growth of oral squamous cell carcinoma. PLOS ONE,13: e0191683, 2018
2017年
- Sasahira T, Kurihara M, Nishiguchi Y, Nakashima C, Kirita T. Pancreatic adenocarcinoma upregulated factor has oncogenic functions in oral squamous cell carcinoma. Histopathology 70(4):539-48, 2017
- Kusuyama J, Ohnishi T, Bandow K, Amir MS, Shima K, Semba I, Matsuguchi T. Constitutive activation of p46JNK2 is indispensable for C/EBPdelta induction in the initial stage of adipogenic differentiation. Biochem J 2017; 474(20): 3421-3437.
- Kusuyama J, Bandow K, Ohnishi T, Hisadome M, Shima K, Semba I, Matsuguchi T. Osteopontin inhibits osteoblast responsiveness through the downregulation of focal adhesion kinase mediated by the induction of low molecular weight-protein tyrosine phosphatase. Mol Biol Cell 2017; (10): 1326-1236.
- Subarnbhesaj A, Miyauchi M, Mikuriya A, Nguyen PT, Chanbora C, Ayunintyas NF, Fujita M, Niida S, Takata T. Roles of VEGF-Flt-1 signaling in malignant behaviors of oral squamous cell carcinoma. PLOS ONE,22: e0187092, 2017
2016年
- Sasahira T, Kurihara M, Nakashima C, Kirita T. LEM domain containing 1 promotes oral squamous cell carcinoma invasion and endothelial transmigration. Br J Cancer 115(1):52-8, 2016
- Sasahira T, Kurihara M, Nishiguchi Y, Fujiwara R, Kirita T. NEDD 4 binding protein 2-like 1 promotes cancer cell invasion in oral squamous cell carcinoma. Virchows Archiv 469(2):163-72, 2016
- Nagata M, Kanie T, Shima K. Cemental tear in an autotransplanted tooth that had been functioning for 15 years. Clinical Advances in Periodontics 2016; 6 (3): 111-7.
- Nagata M, Nagata M, Kanie T, Shima K. Clinical and histologic aspect of cervical cemental tears as a risk for periodontal diseases. Clinical Advances in Periodontics 2016; 6 (4): 167-74
2015年
- Nguyen PT, Subarnbhesaj A, Miyauchi M, Ogawa I, Takata T. The FGFR1 inhibitor PD173074 reduces osteoclastogenesis in gingival squamous cell carcinoma. Oral Surgery, Oral Medicine, Oral Pathology and Oral Radiology 119: e172, 2015
- Subarnbhesaj A, Miyauchi M, Chea C, Nurina FA, Nguyen PT, Takata T. Role of VEGF-Flt-1 Signaling in Oral Cancer Progression. Oral Surgery, Oral Medicine, Oral Pathology and Oral Radiology, 119: e136-7, 2015
2013年
- Nguyen PT, Tsunematsu T, Yanagisawa S, Kudo Y, Miyauchi M, Kamata N and Takata T. The FGFR-1 inhibitor PD173074 induces mesenchymal-epithelial transition through the transcription factor AP-1. British Journal of Cancer,109: 2248-58, 2013
2012年
- Kudo Y, Iizuka S, Yoshida M, Nguyen PT, Takata T. Periostin Directly and Indirectly Promotes Tumor Lymphangiogenesis of Head and Neck Cancer. PLOS ONE, 7: 1-14, 2012
2011年
- Nguyen PT, Kudo Y, Yoshida M, Takata T. N-cadherin expression is involved in malignant behavior of head and neck cancer in relation to epithelial-mesenchymal transition. Histol Histopathol 26: 147-156, 2011
- Nguyen PT, Kudo Y, Yoshida M, Iizuka S, Ogawa I, Takata T. N-cadherin expression is correlated with metastasis of spindle cell carcinoma of head and neck region. Journal of Oral Pathology and Medicine 40:77-82, 2011
2010年
- SL Priebe, J Aleksejūnienė, C Zed, S Dharamsi, DHQ Thinh, NT Hong, TTK Cuc, Nguyen PT. Oral squamous cell carcinoma and cultural oral risk habits in Vietnam. International Journal of Dental Hygiene 8: 159-168, 2010
Research Grant List
Tomonori SASAHIRA
| Project・Event / Span | Research |
|---|---|
|
Grant-in-aid for Scientific research (C) PI: 吉村 卓也 |
運動によるmyokineを介した口腔癌微小環境・免疫機能改善と癌細胞への直接作 |
|
Grant-in-aid for Scientific research (C) PI: 栗原 都 |
PXDNによるがん代謝と微小環境を標的とした口腔癌の治療ストラテジー |
|
Grant-in-aid for Scientific research (C) PI: Tomonori SASAHIRA |
新規口腔癌特異的遺伝子であるSTOX2の機能解明と診断・治療への応用の模索 |
|
Grant-in-aid for Scientific research (C) PI: 栗原 都 |
MIA2関連シグナルを標的とした口腔癌の分子診断・治療の新展開 New Developments in Molecular Diagnosis and Therapy of Oral Cancer by Targeting MIA2-related Signals |
|
Grant-in-aid for Scientific research (C) PI: Tomonori SASAHIRA |
TANGOによる口腔癌の転移前ニッチ形成機構の解明 Elucidation of the pre-metastasis niche formation mechanism of oral cancer by TANGO |
|
Grant-in-aid for Scientific research (C) PI: Tomonori SASAHIRA |
新規口腔癌関連遺伝子による新たな血管·リンパ管新生機構の解明 Elucidation of angio and lymphangiogenesis mechanism by novel oral cancer-related gene |
|
Grant-in-aid for Scientific research (C) PI: 大森 斉 |
大腸癌肝転移を促進する骨髄間葉系幹細胞を標的とする治療 Targeting of mesenchymal stem cell associated with colorectal cancer liver metastasis |
|
Grant-in-aid for Scientific research (C) PI: Tomonori SASAHIRA |
新規MIA gene familyによる口腔癌の血管新生·リンパ管新生機構の解明 |
|
Grant-in-aid for Scientific research (C) PI: 藤井 澄 |
胃癌前癌病変であるテロメア短縮病変における遺伝子異常 Genetic alteration in the short telomere lesion as a precancerous lesion of gastric cancer |
|
Grant-in-aid for Scientific research (C) PI: 吉村 卓也 |
運動によるmyokineを介した口腔癌微小環境・免疫機能改善と癌細胞への直接作 |
|
Grant-in-aid for Early Career Research (B) PI: Tomonori SASAHIRA |
口腔癌の新規リンパ管新生マーカーMIAの機能解析 Functional analysis of MIA, which is the novel lymphangiogenic marker of oral cancer |
|
Grant-in-aid for Scientific research (C) PI: 國安 弘基 |
アンギオテンシン活性化機構を標的とする大腸癌肝転移治療戦略の確立 |
|
Grant-in-aid for Scientific research (C) PI: 大森 斉 |
温熱療法による癌幹細胞の抑制と治療への応用の検討 |
|
Grant-in-aid for Early Career Research (B) PI: Tomonori SASAHIRA |
口腔癌の診断・治療におけるヘッジホッグ変異の有用性に関する研究 |
Kaori SHIMA
| Project・Event / Span | Research |
|---|---|
| 科学研究費補助金 若手研究 代表 令和2〜4年度 |
腫瘍発生を促進させる自己免疫状態での新規腫瘍免疫システムの解明 |
| 科学研究費補助金 若手研究（B）代表 平成29〜31年度 |
自己免疫疾患モデルを用いた新規腫瘍発生制御免疫システムの解明 |
Phuong Thao Nguyen
| Project・Event / Span | Research |
|---|---|
|
Kagoshima University International Joint Research Promotion PI: Phuong Thao NGUYEN |
A deep learning for prediction of prognosis and therapy response in head and neck cancers though multi-staining. |
|
公益財団法人ヒロセ財団の研究助成 PI: Phuong Thao NGUYEN |
胆管癌の新規腫瘍マーカーであるEPS8L3によるYAPの核内移行に関する新展開 |
|
Grant-in-aid for Early Career Research PI: Phuong Thao NGUYEN |
EPS8L3 mediates YAP nuclear translocation and promotes liver tumorigenesis |
|
Grant-in-aid for Early Career Research PI: Phuong Thao NGUYEN |
Periodontitis induced alterations of gut microbial metabolite promotes liver cancer through senescence |
|
Hiroshima University grant PI: Phuong Thao NGUYEN |
Asssociation of periodontittis and liver diseases |
|
Research grant for JSPS postdoc PI: Phuong Thao NGUYEN |
Study on development of novel therapy targeting N-cadherin for oral cancer |
