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Research outline

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Research interests

• Search for novel molecular markers involved in the development and progression of oral cancer
• Study of DNA methylation status in oral cancer
• Study on tumor immunity system using animal models of autoimmune diseases

Staff

Professor

Researche Repository

Associate Professor

Researche Repository

技術職員

Research results

2020年　原著論文

• Ikeda M, Shima K, Kondo T, Semba I. Atypical immunohistochemical patterns can complement the histopathological diagnosis of oral premalignant lesions. Journal of Oral Biosciences 62: 93-98, 2020

2019年　原著論文

• Kusuyama J, Amir MS, Albertson BG, Bandow K, Ohnishi T, Nakamura T, Noguchi K, Shima K, Semba I, Matsuguchi T. JNK inactivation suppresses osteogenic differentiation, but robustly induces osteopontin expression in osteoblasts through the induction of inhibitor of DNA binding 4 (Id4). FASEB J. 33(6):7331-7347, 2019
• Kusuyama J, Seong CH, Makarewicz NS, Ohnishi T, Shima K, Semba I, Bandow K, Matsuguchi T. Low intensity pulsed ultrasound (LIPUS) maintains osteogenic potency through the increased expression and stability of Nanog through spleen tyrosine kinase (Syk) activation. Cellular Signalling 62: 109345, 2019
• Kusuyama J, Seong CH, Nakamura T, Ohnishi T, Amir MS, Shima K, Semba I, Noguchi K, Matsuguchi T. BMP9 prevents induction of osteopontin in JNK-inactivated osteoblasts via Hey1-Id4 interaction. Int J Biochem Cell Biol 116, 105614, 2019

2018年　著書

• 仙波伊知郎、口腔外科ハンドマニュアル '18、（共著）クインテッセンス出版、2018

2018年　著総説

• 仙波伊知郎、嶋香織　頭頸部腫瘍II：歯原性腫瘍と顎顔面骨の病変、歯原性嚢胞、病理と臨床 36 (4): 335-339, 2018

2018年　原著論文

• Ma S, Ogino S, Parsana P, Nishihara R, Qian Z, Shen J, Mima K, Masugi Y, Cao Y, Nowak JA, Shima K, Hoshida Y, Giovannucci EL, Gala MK, ChanAT, Fuchs CS, Parmigiani G, Huttenhower C, Waldron L. Continuity of Transcriptomes Among Colorectal Cancer Subtypes Based on Meta-analysis. Genome Biology, 19: 142, 2018

2017年　原著論文

• Kusuyama J, Ohnishi T, Bandow K, Amir MS, Shima K, Semba I, Matsuguchi T. Constitutive activation of p46JNK2 is indispensable for C/EBPdelta induction in the initial stage of adipogenic differentiation. Biochem J 2017; 474(20): 3421-3437.
• Kusuyama J, Bandow K, Ohnishi T, Hisadome M, Shima K, Semba I, Matsuguchi T. Osteopontin inhibits osteoblast responsiveness through the downregulation of focal adhesion kinase mediated by the induction of low molecular weight-protein tyrosine phosphatase. Mol Biol Cell 2017; (10): 1326-1236.
• Kujiraoka S, Tsunematsu T, Sato Y, Yoshida M, Ishikawa A, Tohyama R, Tanaka M, Kobayashi Y, Kondo T, Ushio A, Otsuka K, Kurosawa M, Saito M, Yamada A, Arakaki R, Nagai H, Nikai H, Takeuchi K, Nagao T, Miyamoto Y, Ishimaru N, Kudo Y. Establishment and characterization of a clear cell odontogenic carcinoma cell line with EWSR1-ATF1 fusion gene. Oral Oncol. 2017; 69: 46-55.
• Honjo K, Hiraki T, Higashi M, Noguchi H, Nomoto M, Yoshimura T, Batra SK, Yonezawa S, Semba I, Nakamura N, Tanimoto A, Yamada S. Immunohistochemical expression profiles of mucin antigens in salivary gland mucoepidermoid carcinoma: MUC4- and MUC6-negative expression predicts a shortened survival in the early postoperative phase. Histol Histopathol 2017; 33(2): 201-213.
• Okubo A, Fujii K, Kondo T, Semba I, Higashi Y, Kanehara T. Kimura’s disease in the oral cavity: A rare manifestation of immunogloblin G4-related disease. J Dermatol. 2017; 19: e357-358.
• Kujiraoka S, Tsunematsu T, Sato Y, Yoshida M, Ishikawa A, Tohyama R, Tanaka M, Kobayashi Y, Kondo T, Ushio A, Otsuka K, Kurosawa M, Saito M, Yamada A, Arakaki R, Nagai H, Nikai H, Takeuchi K, Nagao T, Miyamoto Y, Ishimaru N, Kudo Y. Establishment and characterization of a clear cell odontogenic carcinoma cell line with EWSR1-ATF1 fusion gene. Oral Oncol. 2017;69:46-55.

2017年　症例報告

• 豊留宗一郎，野添悦郎，石畑清秀，大河内孝子，嶋香織，中村典史. 下顎骨に生じた骨芽細胞腫の1例. 日口腔外誌 2017; 63(8): 388-393.
• 村上寿理，石畑清秀，野添悦郎，松本幸三，嶋香織，中村典史. 口腔内病変から診断しえたメトトレキセート関連リンパ増殖性疾患の１例. 日口腔外誌 2017; 63 (11): 552-557.

2016年　総説

• 仙波伊知郎：口腔癌と口腔前癌病変　歯界展望 2016; 128 (1): 180-1

2016年　原著論文

• Tsunematsu T, Fujiwara N, Yoshida M, Takayama Y, Kujiraoka S, Qi G, Kitagawa M, Kondo T, Yamada A, Arakaki R, Miyauchi M, Ogawa I, Abiko Y, Nikawa H, Murakami S, Takata T, Ishimaru N, Kudo Y. Human odontogenic epithelial cells derived from epithelial rests of Malassez possess stem cell properties. Lab Invest 2016; 96 (10): 1063-75. (4.857)
• Nagata M, Kanie T, Shima K. Cemental tear in an autotransplanted tooth that had been functioning for 15 years. Clinical Advances in Periodontics 2016; 6 (3): 111-7.
• Nagata M, Nagata M, Kanie T, Shima K. Clinical and histologic aspect of cervical cemental tears as a risk for periodontal diseases. Clinical Advances in Periodontics 2016; 6 (4): 167-74
• Kondo T, Tsunematsu T, Yamada A, Arakaki R, Saito M, Otsuka K, Kujiraoka S, Ushio A, Kurosawa M, Kudo Y, Ishimaru N. Acceleration of tumor growth due to dysfunction in M1 macrophages and enhanced angiogenesis in an animal model of autoimmune disease. Lab Invest. 2016 ;96(4):468-80.

2016年　症例報告

• 中井大史、嶋香織、國芳秀晴、吉武義泰、竹部史朗、篠原正徳：舌に発生した軟骨脂肪腫の1例。日口腔外誌 2017; 63 (1): 21-4.
• Yoshimura T, Yamada S, Ishida T, Tanaka K, Kitazono I, Kume K, Hijioka H, Semba I, Nakamura N, Tanimoto A. Cystadenocarcinoma of the minor salivary gland arising in the upper lip: A surgical case of an inadequate cytology specimen hampering conclusive diagnosis. Human Path Case Reports 2016; 9: 64-8.
• Yoshimura T, Yamada S, Shima K, Nakamura N, Tanimoto A. An elastofibromatous lesion at the tip of the sublingual fold. J Dent & Oral Disord 2016; 2 (6): 1031.

Research Grant List

Ichiro SEMBA

Kaori SHIMA

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