研究テーマ(研究室紹介)

回診2

「一つ一つの症例にベストを尽くす」「全人医療で患者と地域を救う」「症例の「なぜ」を解決して患者と地域に貢献」を三本柱としています。24時間365日救急受け入れをするなど最後の砦としての大学病院の使命を全うしながら、海外学会発表や論文投稿、症例報告など「鹿児島から全世界への情報発信」をするべく日夜頑張っている躍動感と笑いのあふれる講座です。

研究室概要

部局 大学院医歯学総合研究科 Graduate School of Medical and Dental Sciences
専攻 先進治療科学専攻 Advanced Therapeutics Course
大講座 循環器・呼吸器病学 Cardiovascular and Respiratory Disorders
分野 心臓血管・高血圧内科学 Cardiovascular Medicine and Hypertension
分野サイト http://www.kufm.kagoshima-u.ac.jp/~intmed1/

分野サイト

連絡先

TEL.099-275-5318 / FAX.099-265-8447

主要研究テーマ

高血圧 Hypertension
虚血性心疾患 Ischemic heart disease
動脈硬化 Atherosclerosis
心臓超音波 Cardiac echocardiography
成人先天性心疾患 Adult congenital heart disease
心不全 Heart failure
肺高血圧 Pulmonary hypertension
不整脈 Arrhythmia
心筋症 Cardiomyopathy

スタッフ

大石充 Mitsuru OHISHI

教授
氏名 大石充 Mitsuru OHISHI
専門分野 循環器学、虚血性心疾患、動脈硬化、高血圧
研究テーマ ・循環器レジストリを駆使した病態把握と心血管疾患治療seeds探索(KIDSレジストリなど)
・AI・deep learning・LAMP法を用いたBig Data(健診データやDPCデータ)解析
・垂水研究(多職種によるチーム医療コホート研究)
・高血圧ゼロの街 枕崎(高血圧治療が予後及び社会経済に与える影響を見るコホート研究)
・健康アイランド 種子島(既存の健診(学校健診や特定健診)を120%生かすことに島民全員の健康を維持することができるかを見るコホート研究
・高血圧・心不全をターゲットとした新しい創薬・治療法の開発
・受容体連関を基軸としたtranslational research

研究者総覧


池田義之 Yoshiyuki IKEDA

准教授
氏名 池田義之 Yoshiyuki IKEDA
専門分野 循環器学、動脈硬化、高血圧、抗加齢医学
研究テーマ ・オートファジーやミトコンドリアダイナミクスと心臓血管系の老化・心不全・動脈硬化・高血圧に関する研究
・閉経に伴う心臓血管系の老化・動脈硬化進展の機序の解明および治療法の確立
・レニン・アンギオテンシン・アルドステロン系と心臓血管系の老化・動脈硬化に関する研究
・高齢者高血圧患者に対する降圧治療に関する臨床研究
・フレイル・サルコペニアに関する基礎および臨床研究

研究者総覧


安田久代先生拡大

特任講師
氏名 安田久代 Hisayo YASUDA
専門分野 循環器学、超音波学
研究テーマ ・弁膜症の成因や予後に関する心臓超音波を用いた臨床研究

研究者総覧


湯淺敏典 Toshinori YUASA

講師
氏名 湯淺敏典 Toshinori YUASA
専門分野 循環器学、超音波学
研究テーマ 心臓超音波学(ドプラ法を用いた心機能評価, 運動負荷エコー、3Dエコー)
・軽運動負荷心エコーを用いた心臓弁膜症における心予備能の研究
・軽運動負荷心エコーを用いた心不全例における運動耐容能の研究
・心エコードプラ法による心時相解析を用いた各種心疾患の評価

研究者総覧 


窪薗琢郎 Takuro KUBOZONO

講師
氏名 窪薗琢郎 Takuro KUBOZONO
専門分野 循環器学、心不全、心臓リハビリテーション
研究テーマ ・心疾患患者における運動耐容能に関する研究
・心不全患者における血管機能に関する研究
・心不全患者における予後に関する研究
・心臓リハビリテーションに関する新たな治療法・介入の開発
・健診データベースをもとにした動脈硬化に関する研究
・家庭血圧測定の臨床的意義に関する研究
・地域住民の生活状況と循環器疾患に関する研究

研究者総覧


窪田佳代子 Kayoko KUBOTA

講師
氏名 窪田佳代子 Kayoko KUBOTA
専門分野 循環器学、肺循環、超音波学
研究テーマ ・肺高血圧症に対する早期診断や予後に関する臨床研究

研究者総覧


市來仁志 Hitoshi ICHIKI

助教
氏名 市來仁志 Hitoshi ICHIKI
専門分野 循環器学、不整脈
研究テーマ ・心房細動に対するカテーテルアブレーションについて
・心房細動に対するカテーテルアブレーション周術期の抗凝固療法について

研究者総覧


樋口公嗣 Koji HIGUCHI

助教
氏名 樋口公嗣 Koji HIGUCHI
専門分野 循環器学、心筋症
研究テーマ ・ファブリー病 

研究者総覧


赤﨑雄一 Yuichi AKASAKI

助教
氏名 赤﨑雄一 Yuichi AKASAKI
専門分野 循環器学、高血圧、動脈硬化
研究テーマ ・難治性高血圧の実態調査および予後に関する観察研究
・大動脈瘤および大動脈解離への寄与因子に関する臨床・基礎研究
・睡眠時無呼吸症候群と高血圧に関する臨床・基礎研究
・老化による筋肉減弱症(サルコペニア)が心血管疾患に及ぼす影響に関する基礎研究

研究者総覧


二宮雄一先生拡大2

特任助教
氏名 二宮雄一 Yuichi NINOMIYA
専門分野 循環器学、不整脈
研究テーマ ・心房細動に対するカテーテルアブレーションに関する臨床研究

研究者総覧


神田大輔 Daisuke KANDA

助教
氏名 神田大輔 Daisuke KANDA
専門分野 循環器学、虚血性心疾患
研究テーマ ・カテーテル治療と腎障害の影響

研究者総覧


堀添拡大

特任助教
氏名 堀添善尚 Yoshihisa HORIZOE
専門分野 循環器学、超音波学
研究テーマ ・心エコー関連

研究者総覧

主な研究実績

大石 充
  1. Ohishi M, Yoshida T, Oh A, Hiroi S, Takeshima T, Otsuka Y, Iwasaki K, Shimasaki Y.
    Analysis of antihypertensive treatment using real-world Japanese data-the retrospective study of antihypertensives for lowering blood pressure (REAL) study.
    Hypertens Res 2019; 42: 1057-1067.
  2. Ohishi M, Yoshida T, Nishigaki N, Oh A, Shimasaki Y.
    Antihypertensive treatment for hypertensive patients with heart failure using real-world Japanese data: Subanalysis of the REtrospective study of antihypertensives for lowering blood pressure (REAL) study.
    Clin Exp Hypertens 2019 Mar: 1-7.
  3. Ikeda Y, Sasaki T, Kuwahata S, Imamura M, Tanoue K, Komaki S, Hashiguchi M, Kuroda A, Akasaki Y, Ohishi M.
    Management instructions for elderly patients with hypertension.
    Clin Exp Hypertens. 2020 May 18;42(4):295-301.
  4. Ikeda Y, Ohishi M.
    Years of life lost analysis may promote governmental policy to prevent atherosclerotic cardiovascular disease.
    Circ J. 2019; 83: 965-966.
  5. Uchiyama N, Yuasa T, Miyata M, Horizoe Y, Chaen H, Kubota K, Takasaki K, Mizukami N, Kisanuki A, Ohishi M.
    Correlation of right ventricular wall stress with plasma B-type natriuretic peptide levels in patients with pulmonary hypertension.
    Circ J 2019; 83: 1278-1285.
  6. Kawasoe S, Ide K, Usui T, Kubozono T, Yoshifuku S, Miyahara H, Maenohara S, Ohishi M, Kawakami K.
    Distribution and characteristics of hypouricemia within the japanese general population: a cross-sectional study.
    Medicina (Kaunas) 2019; 55: E61.
  7. Horizoe Y, Takasaki K, Miyata M, Chaen H, Kubota K, Mizukami N, Yuasa T, Kisanuki A, Ohishi M.
    Analysis of biphasic right ventricular outflow doppler waveform in patients with pulmonary hypertension.
    International Heart Journal 2019; 60: 108-114.
  8. Higo K, Tezuka A, Ohishi M.
    The noninvasive electrocardiographic diagnosis of Takotsubo cardiomyopathy.
    Internal Medicine 2019; 58: 315.
  9. Higo K, Tokushige A, Tezuka A, Ojima S, Miyauchi T, Saihara K, Sunahara N, Taketomi E, Ohishi M.
    Isolated distal deep vein thrombus detected before orthopedic surgery: Is preoperative anticoagulation preferable?
    Ann Vasc Dis 2019; 12: 354-361.
  10. Miyanaga S, Kubota K, Iwatani N, Higo K, Miyata M, Horizoe Y, Ojima S, Kawasoe S, Kubozono T, Ohishi M.
    Predictors of exercise-induced pulmonary hypertension in patients with connective tissue disease.
    Heart Vessels 2019; 34: 1509-1518.
  11. Ojima S, Kubozono T, Saihara K, Miyauchi T, Kawasoe S, Kubota K, Shigemizu S, Ohtsubo H, Miyata M, Ohishi M.
    Significant clinical indexes of exercise-induced pulmonary hypertension in patients with connective tissue disease.
    Circulation Reports 2019; 1: 610-616.
  12. Shimono H, Kajiya T, Saku K, Ueno M, Takaoka J, Atsuchi Y, Atsuchi N, Ohishi M.
    Obstructive shock with mediastinal hematoma caused by chest compressions after successful primary percutaneous coronary intervention.
    J Cardiol Cases 2019; 20: 92-94.
  13. Shimono H, Kajiya T, Inoue H, Ueno M, Takaoka J, Atsuchi Y, Atsuchi N, Ohishi M.
    Left ventricular pseudo-aneurysm with ventricular septal rupture due to anterior st-segment elevation myocardial infarction.
    Intern Med 2019; 58: 1901-1905.
  14. Tezuka A, Higo K, Nakamukae Y, Nishihara S, Kamikawa M, Shimofuku C, Kawazoe K, Ohishi M.
    Bisoprolol successfully improved the intraventricular pressure gradient in a patient with midventricular obstructive hypertrophic cardiomyopathy with an apex aneurysm due to apical myocardial damage.
    Internal Medicine 2019; 58: 535-539.
  15. Makizako H, Kubozono T, Kiyama R, Takenaka T, Kuwahata S, Tabira T, Kanoya T, Horinouchi K, Shimada H, Ohishi M.
    Associations of social frailty with loss of muscle mass and weakness among community-dwelling older adults.
    Geriatr Gerontol Int 2019; 19: 76-80.
  16. Nakai Y, Makizako H, Kiyama R, Tomioka K, Taniguchi Y, Kubozono T, Takenaka T, Ohishi M.
    Association between chronic pain and physical frailty in community-dwelling older adults.
    Int J Environ Res Public Health. 2019; 16: 1330.
  17. Taniguchi Y, Makizako H, Kiyama R, Tomioka K, Nakai Y, Kubozono T, Takenaka T, Ohishi M.
    The association between osteoporosis and grip strength and skeletal muscle mass in community-dwelling older women.
    Int J Environ Res Public Health. 2019; 16: 1228.
  18. Namino F, Yamakuchi M, Iriki Y, Okui H, Ichiki H, Maenosono R, Oketani N, Masamoto I, Miyata M, Horiuchi M, Hashiguchi T, Ohishi M, Maruyama I.
    Dynamics of soluble thrombomodulin and circulating miRNAs in patients with atrial fibrillation undergoing radiofrequency catheter ablation.
    Clin Appl Thromb Hemost 2019; 25: 1076029619851570.
  19. Nakamura S, Hasebe N, Yatabe M, Kishi T, Ishida M, Ichihara A, Node K, Ishimitsu T, Itoh H, Ito M, Ohishi M, Ohkubo T, Kai H, Kashihara N, Kario K, Saitoh S, Tsuchihashi T, Nishiyama A, Higaki J, Miura K, Rakugi H, Kawano Y, Tamura K, Yatabe T, Ohya Y, Ito S.
    JSH Statement: Asahikawa declaration in promotion of diversity by the Japanese society of hypertension-the JSH Asahikawa declaration.
    Hypertens Res 2019; 42: 1483-1484.
  20. Tomiyama H, Ohkuma T, Ninomiya T, Mastumoto C, Kario K, Hoshide S, Kita Y, Inoguchi T, Maeda Y, Kohara K, Tabara Y, Nakamura M, Ohkubo T, Watada H, Munakata M, Ohishi M, Ito N, Nakamura M, Shoji T, Vlachopoulos C, Aboyans V, Yamashina A; Collaborative Group for J-BAVELs (Japan Brachial-Ankle Pulse Wave Velocity Individual Participant Data Meta-Analysis of Prospective Studies).
    Steno-stiffness approach for cardiovascular disease risk assessment in primary prevention.
    Hypertension 2019; 73: 508-513.
  21. Ito M, Ishimitsu T, Ichihara A, Itoh H, Ohishi M, Ohkubo T, Kai H, Kashihara N, Kario K, Saitoh S, Tsuchihashi T, Nakamura S, Nishiyama A, Node K, Hasebe N, Higaki J, Miura K, Rakugi H, Tamura K, Kawano Y, Yatabe T, Ohya Y, Ito S.
    JSH Statement: Kyoto declaration on hypertension research in Asia.
    Hypertens Res 2019; 42: 759-760.
池田義之
  1. Ikeda Y, Sasaki T, Kuwahata S, Imamura M, Tanoue K, Komaki S, Hashiguchi M, Kuroda A, Akasaki Y, Ohishi M.
    Management instructions for elderly patients with hypertension.
    Clin Exp Hypertens. 2020 May 18;42(4):295-301.
  2. Ikeda Y, Ohishi M.
    Years of life lost analysis may promote governmental policy to prevent atherosclerotic cardiovascular disease.
    Circ J. 2019; 83: 965-966.
  3. Saito T, Nah J, Oka SI, Mukai R, Monden Y, Maejima Y, Ikeda Y, Sciarretta S, Liu T, Li H, Baljinnyam E, Fraidenraich D, Fritzky L, Zhai P, Ichinose S, Isobe M, Hsu CP, Kundu M, Sadoshima J.
    An alternative mitophagy pathway mediated by Rab9 protects the heart against ischemia.
    Journal of Clinical Investigation 2019; 129: 802-819.
  4. Byun J, Oka SI, Imai N, Huang CY, Ralda G, Zhai P, Ikeda Y, Ikeda S, Sadoshima J.
    Both gain and loss of Nampt function promote pressure-overload-induced heart failure.
    Am J Physiol Heart Circ Physiol 2019; 317: H711-H725.
  5. Bhat S, Chin A, Shirakabe A, Ikeda Y, Ikeda S, Zhai P, Hsu CP, Sayed D, Abdellatif M, Byun J, Schesing K, Tang F, Tian Y, Babu G, Ralda G, Warren JS, Cho J, Sadoshima J, Oka SI.
    Recruitment of RNA polymerase II to metabolic gene promoters is inhibited in the failing heart possibly through PGC-1α (peroxisome proliferator-activated receptor-γ coactivator-1α) dysregulation.
    Circ Heart Fail 2019; 12: e005529.
  6. Ikeda Y, Sasaki T, Kuwahata S, Imamura M, Tanoue K, Komaki S, Hashiguchi M, Kuroda A, Akasaki Y, Hamada C, Ohishi M.
    Questionnaire survey from the viewpoint of concordance in patient and physician satisfaction concerning hypertensive treatment in elderly patients - patients voice study.
    Circ J 2018; 82: 1051-1061.
  7. Shirakabe A, Ikeda Y, Sciarretta S, Zablocki DK, Sadoshima J.
    Aging and autophagy in the heart.
    Circ Res 2016; 118(10): 1563-1576.
  8. Shirakabe A, Zhai P, Ikeda Y, Saito T, Maejima Y, Hsu CP, Nomura M, Egashira K, Levine B, Sadoshima J.
    Drp1-dependent mitochondrial autophagy plays a protective role against pressure overload-induced mitochondrial dysfunction and heart failure.
    Circulation 2016; 133(13): 1249-1263.
  9. Kyrychenko S, Kyrychenko V, Badr MA, Ikeda Y, Sadoshima J, Shirokova N.
    Pivotal role of miR-448 in the development of ROS-induced cardiomyopathy.
    Cardiovasc Res 2015; 108(3): 324-334.
  10. Oka SI, Zhai P, Yamamoto T, Ikeda Y, Byun J, Hsu CP, Sadoshima J.
    PPARα association with sirt1 suppresses cardiac fatty acid metabolism in the failing heart.
    Circ Heart Fail 2015; 8(6): 1123-1132.
安田久代
  1. Yasuda O, Fujii Y, Komaki R, Yasuda H, Moriyama T, Soejima Y.
    orrelation between renal function and muscle mass
    Campus Health 2018; 55(2): 52-56.
  2. Yamamura S, Izumiya Y, Ishida T, Onoue Y, Kimura Y, Hanatani S, Araki S, Fujisue K, Sueta D, Kanazawa H, Takashio S, Usuku H, Sugamura K, Sakamoto K, Yamamoto E, Yamamuro M, Yasuda H, Kojima S, Kaikita K, Hokimoto S, Ogawa H, Tsujita K.
    Reduced trans-mitral A-wave velocity predicts the presence of wild-type transthyretin amyloidosis in elderly patients with left ventricular hypertrophy
    Heart Vessels 2017; 32(6): 708-713.
  3. Sueta D, Hokimoto S, Okamoto K, Yasuda H, Usuku H, Tazume H, Yamamoto E, Sakamoto K, Izumiya Y, Tsujita K, Kaikita K, Sakaguchi H, Fukui T, Ogawa H .
    More Haste, Less Speed: Cardiac Perforation by a Thoracentesis Cathter
    International Journal of Cardiology Heart & Vasculature 2016; 11: 17-29
  4. Yamamoto M, Yamamoto E, Yasuda O, Yasuda H, Sakamoto K, Tsujita K, Izumiya Y, Kaikita K, Hokimoto O, Ogawa H.
    A case of Werner’s syndrome with cardiac syncrome X and heart failure with presereved ejection fraction.
    Journal of Cardiology Cases 2015; 12(6): 195-198.
  5. Misumi I, Honda T, Kurokawa H, Kubota Y, Ishii M, Sato R, Yamabe H, Yasuda H, Kaikita K, Hokimoto S, Ogawa H.
    Systolic Flow Reversal in a Case of Mid-Ventricular Obstructive Hypertrophic Cardiomyopathy.
    Intern Med 2015; 54(14): 1765-1769.
  6. Kurokawa H, Misumi I, Honda T, Usuku H, Yasuda H, Kaikita K, Hokimoto S, Ogawa H, Nakatsuka D, Tabata M .
    Resonant cardiac chamber with diastolic thrill.
    J Echocardiogr 2015; 13(12): 69-71
  7. Misumi I, Nishida Y, Honda T, Kurokawa H, Yasuda H, Kaikita K, Hokimoto S, Ogawa H.
    Markedly High B-type Natriuretic Peptide Level in a Patient with Duchenne Muscular Dystrophy and Left Ventricular Non-Compaction.
    Internal Medicine 2015; 54(17): 2197-2200.
  8. Misumi I, Honda T, Kusuhara K, Yasuda H, Kaikita K, Hokimoto S, Ogawa H.
    Paradoxical increase in E/e’ratio after treatment of heart failure intwo patients with preserved ejection fraction.
    Journal of Medical Ultrasonocs 2014; 42: 239-241.
  9. Usuku H, Obayashi K, Shono M, Oshima T, Tasaki M, Yasuda H, Ogawa H, Ando Y.
    Usefulness of plasma B-type natriuretic peptide as a prognostic marker of cardiac function in senile systemic amyloidosis and in familial amyloidotic polyneuropathy
    Amyloidosis 2014; 20(4): 251-255.
  10. Misumi I, Ito M, Rokutanda T, Kusuhara K, Akahoshi R, Matsumoto M, Tanaka H, Yasuda H, Kaikita K, Hokimoto S, Ogawa H.
    Hemodynamic influence of triphasic mitral inflow velocity: a case report.
    Journal of Echocardiography 2014; 12: 43-45.
湯淺敏典
  1. Uchiyama N, Yuasa T, Miyata M, Horizoe Y, Chaen H, Kubota K, Takasaki K, Mizukami N, Kisanuki A, Ohishi M.
    Correlation of right ventricular wall stress with plasma B-type natriuretic peptide levels in patients with pulmonary hypertension.
    Circ J 2019; 83: 1278-1285.
  2. Horizoe Y, Takasaki K, Miyata M, Chaen H, Kubota K, Mizukami N, Yuasa T, Kisanuki A, Ohishi M.
    Analysis of biphasic right ventricular outflow doppler waveform in patients with pulmonary hypertension.
    International Heart Journal 2019; 60: 108-114.
  3. Chaen H, Kinchiku S, Miyata M, Kajiya S, Uenomachi H, Yuasa T, Takasaki K, Ohishi M.
    Validity of a novel method for estimating low-density lipoprotein cholesterol levels in diabetic patients.
    J Atheroscler Thromb 2016; 23: 1355-1364.
  4. Daitoku S, Yuasa T, Tsunenari H, Maenohara S, Mine K, Tamatsu Y, Shimada K, Koriyama C, Ohishi M, Horiuchi M.
    Angle between the common and internal carotid arteries detected by ultrasound is related to intima-media thickness among those with atherosclerotic disease.
    Environ Health Prev Med 2015; 20: 216-223.
  5. Nomoto Y, Tsurugida M, Kihara K, Miyauchi E, Kosedo I, Yuasa T, Otsuji Y, Ohishi M.
    Attenuated early diastolic interventricular septum bulging by pulmonary hypertension due to later developed aortic regurgitation.
    J Echocardiogr 2015; 13: 110-112.
  6. Yuasa T, Takasaki K, Mizukami N, Ueya N, Kubota K, Horizoe Y, Chaen H, Kuwahara E, Kisanuki A, Hamasaki S.
    Prosthetic tricuspid valve dysfunction assessed by three-dimensional transthracic and transesophageal echocardiography.
    J Echocardiogr.2013; 11: 97-99.
  7. Pulido JN, Afessa B, Masaki M, Yuasa T, Gillespie S, Herasevich V, Brown DR, Oh JK.
    Clinical spectrum, frequency, and significance of myocardial dysfunction in severe sepsis and septic shock.
    Mayo Clin Proc.2012; 87: 620-628.
  8. Kusumoto A, Miyata M, Kubozono T, Ikeda Y, Shinsato T, Kuwahata S, Fujita S, Takasaki K, Yuasa T, Hamasaki S, Tei C.
    Highly sensitive cardiac troponin T in heart failure: comparison with echocardiographic parameters and natriuretic peptides.
    J Cardiol.2012; 59: 202-208.
  9. Mizukami N, Kisanuki A, Hamasaki S, Takasaki K, Yuasa T, Kuwahara E, Ueya N, Horizoe Y, Chaen H, Maruyama I, Imoto Y, Tei C.
    Different flow patterns between left and right internal thoracic artery grafts influence the evaluation of severe graft stenosis by transthoracic Doppler echocardiography.
    J Am Soc Echocardiogr. 2011; 24: 768-774.
  10. Kono M, Kisanuki A, Ueya N, Kubota K, Kuwahara E, Takasaki K, Yuasa T, Mizukami N, Miyata M, Tei C.
    Left ventricular global systolic dysfunction has a significant role in the development of diastolic heart failure in patients with systemic hypertension.
    Hypertension Research.2010; 33: 1167-1173.
窪薗琢郎
  1. Kawasoe S, Ide K, Usui T, Kubozono T, Yoshifuku S, Miyahara H, Maenohara S, Ohishi M, Kawakami K.
    Distribution and characteristics of hypouricemia within the japanese general population: a cross-sectional study.
    Medicina (Kaunas) 2019; 55: E61.
  2. Miyanaga S, Kubota K, Iwatani N, Higo K, Miyata M, Horizoe Y, Ojima S, Kawasoe S, Kubozono T, Ohishi M.
    Predictors of exercise-induced pulmonary hypertension in patients with connective tissue disease.
    Heart Vessels 2019; 34: 1509-1518.
  3. Ojima S, Kubozono T, Saihara K, Miyauchi T, Kawasoe S, Kubota K, Shigemizu S, Ohtsubo H, Miyata M, Ohishi M.
    Significant clinical indexes of exercise-induced pulmonary hypertension in patients with connective tissue disease.
    Circulation Reports 2019; 1: 610-616.
  4. Makizako H, Kubozono T, Kiyama R, Takenaka T, Kuwahata S, Tabira T, Kanoya T, Horinouchi K, Shimada H, Ohishi M.
    Associations of social frailty with loss of muscle mass and weakness among community-dwelling older adults.
    Geriatr Gerontol Int 2019; 19: 76-80.
  5. Nakai Y, Makizako H, Kiyama R, Tomioka K, Taniguchi Y, Kubozono T, Takenaka T, Ohishi M.
    Association between chronic pain and physical frailty in community-dwelling older adults.
    Int J Environ Res Public Health. 2019; 16: 1330.
  6. Taniguchi Y, Makizako H, Kiyama R, Tomioka K, Nakai Y, Kubozono T, Takenaka T, Ohishi M.
    The association between osteoporosis and grip strength and skeletal muscle mass in community-dwelling older women.
    Int J Environ Res Public Health. 2019; 16: 1228.
  7. Kawasoe S, Kubozono T, Yoshifuku S, Ojima S, Miyata M, Miyahara H, Maenohara S, Ohishi M.
    Uric acid level and new-onset atrial fibrillation in the japanese general population - longitudinal study.
    Circ J 2018; 83: 156-163.
  8. Kawasoe S, Kubozono T, Ojima S, Miyata M, Ohishi M.
    Combined assessment of the red cell distribution width and B-type natriuretic peptide: a more useful prognostic marker of cardiovascular mortality in heart failure patients.
    Intern Med 2018; 57: 1681-1688.
  9. Kawasoe S, Ide K, Usui T, Kubozono T, Yoshifuku S, Miyahara H, Maenohara S, Ohishi M, Kawakami K.
    Association of serum triglycerides with arterial stiffness in subjects with low levels of low-density lipoprotein cholesterol.
    Cir J 2018; 82: 3052-3057.
  10. Kubozono T, Miyata M, Kawasoe S, Ojima S, Yoshifuku S, Miyahara H, Maenohara, S, Ohishi M.
    High pulse wave velocity has a strong impact on early carotid atherosclerosis in a Japanese general male population.
    Circ J 2017; 81: 310-315.
窪田佳代子
  1. Uchiyama N, Yuasa T, Miyata M, Horizoe Y, Chaen H, Kubota K, Takasaki K, Mizukami N, Kisanuki A, Ohishi M.
    Correlation of right ventricular wall stress with plasma B-type natriuretic peptide levels in patients with pulmonary hypertension.
    Circ J 2019; 83: 1278-1285.
  2. Horizoe Y, Takasaki K, Miyata M, Chaen H, Kubota K, Mizukami N, Yuasa T, Kisanuki A, Ohishi M.
    Analysis of biphasic right ventricular outflow doppler waveform in patients with pulmonary hypertension.
    International Heart Journal 2019; 60: 108-114.
  3. Miyanaga S, Kubota K, Iwatani N, Higo K, Miyata M, Horizoe Y, Ojima S, Kawasoe S, Kubozono T, Ohishi M.
    Predictors of exercise-induced pulmonary hypertension in patients with connective tissue disease.
    Heart Vessels 2019; 34: 1509-1518.
  4. Ojima S, Kubozono T, Saihara K, Miyauchi T, Kawasoe S, Kubota K, Shigemizu S, Ohtsubo H, Miyata M, Ohishi M.
    Significant clinical indexes of exercise-induced pulmonary hypertension in patients with connective tissue disease.
    Circulation Reports 2019; 1: 610-616.
  5. Higo K, Kubota K, Miyanaga S, Miyata M, Nakajo M, Jinguji M, Ohishi M.
    Impairment of iodine-123-metaiodobenzylguanidine (123I-MIBG) uptake in patients with pulmonary artery hypertension.
    Internal Heart J 2018; 59 (1): 112-119.
  6. Higo K, Kubota K, Takeda A, Higashi M, Ohishi M.
    Successful antemortem diagnosis and treatment of pulmonary tumor thrombotic microangiopathy.
    Intern Med. 2014; 53: 2595-2599.
  7. Kubota K, Otsuji Y, Ueno T, Koriyama C, Levine RA, Sakata R, Tei C.
    Functional mitral stenosis after surgical annuloplasty for ischemic mitral regurgitation: importance of subvalvular tethering in the mechanism and dynamic deterioration during exertion.
    J Thorac Cardiovasc Surg. 2010; 140: 617-623.
市來仁志
  1. Yoshimura A, Iriki Y, Ichiki H, Oketani N, Okui H, Maenosono R, Namino F, Miyata M, Ohishi M.
    Evaluation of safety and efficacy of periprocedural use of rivaroxaban and apixaban in catheter ablation for atrial fibrillation.
    J Cardiol 2017; 69(1): 228-235.
  2. Ichiki H, Oketani N, Ishida S, Iriki Y, Okui H, Maenosono R, Namino F, Ninomiya Y, Miyata M, Hamasaki S, Tei C.
    The incidence of asymptomatic cerebral microthromboembolism after atrial fibrillation ablation: comparison of warfarin and dabigatran.
    Pacing Clin Electrophysiol 2013; 36(11): 1328-1335.
  3. Yoshino S, Yoshikawa A, Hamasaki S, Ishida S, Oketani N, Saihara K, Okui H, Kuwahata S, Fujita S, Ichiki H, Ueya N, Iriki Y, Maenosono R, Miyata M, Tei C.
    Atrial fibrillation-induced endothelial dysfunction improves after restoration of sinus rhythm.
    Int J Cardiol 2013; 168(2): 1280-1285.
  4. Yoshino S, Hamasaki S, Ishida S, Kataoka T, Yoshikawa A, Oketani N, Saihara K, Ichiki H, Kuwahata S, Fujita S, Takumi T, Yoshimoto I, Nakazaki M, Tei C.
    Characterization of the effect of serum bilirubin concentrations on coronary endothelial function via measurement of high-sensitivity C-reactive protein and high-density lipoprotein cholesterol.
    Heart Vessels 2013; 28(2): 157-165.
  5. Maenosono R, Oketani N, Ishida S, Iriki Y, Ichiki H, Okui H, Ninomiya Y, Hamasaki S, Namino F, Matsushita M, Tei C, Hashiguchi T.
    Effectiveness of esophagus detection by three-dimensional electroanatomical mapping to avoid esophageal injury during ablation of atrial fibrillation.
    J Cardiol 2012; 60(2): 119-125.
  6. Ichiki H, Oketani N, Ishida S, Iriki Y, Okui H, Maenosono R, Ninomiya Y, Matsushita T, Miyata M, Hamasaki S, Tei C.
    Incidence of asymptomatic cerebral microthromboembolism after atrial fibrillation ablation guided by complex fractionated atrial electrogram.
    J Cardiovasc Electrophysiol 2012; 23(6): 567-573.
  7. Iriki Y, Ishida S, Oketani N, Ichiki H, Okui H, Ninomiya Y, Maenosono R, Matsushita T, Miyata M, Hamasaki S, Tei C.
    Relationship between clinical outcomes and unintentional pulmonary vein isolation during substrate ablation of atrial fibrillation guided solely by complex fractionated atrial electrogram mapping.
    J Cardiol 2011; 58(3): 278-286.
  8. Yoshino S, Hamasaki S, Ishida S, Kataoka T, Yoshikawa A, Oketani N, Saihara K, Okui H, Shinsato T, Ichiki H, Kubozono T, Kuwahata S, Fujita S, Kanda D, Nakazaki M, Miyata M, Tei C.
    Relationship between bilirubin concentration, coronary endothelial function, and inflammatory stress in overweight patients.
    J Atheroscler Thromb 2011; 18(5): 403-412.
  9. Saihara K, Hamasaki S, Ishida S, Kataoka T, Yoshikawa A, Orihara K, Ogawa M, Oketani N, Fukudome T, Atsuchi N, Shinsato T, Okui H, Kubozono T, Ichiki H, Kuwahata S, Mizoguchi E, Fujita S, Takumi T, Ninomiya Y, Tomita K, Tei C.
    Enjoying hobbies is related to desirable cardiovascular effects.
    Heart Vessels 2010; 25(2): 113-120.
  10. Ichiki H, Hamasaki S, Nakasaki M, Ishida S, Yoshikawa A, Kataoka T, Ogawa M, Saihara K, Okui H, Orihara K, Shinsato T, Oketani N, Shirasawa T, Ninomiya Y, Kuwahata S, Fujita S, Takumi T, Iriki Y, Yoshino S, Matsushita T, Tei C.
    Relationship between hyperglycemia and coronary vascular resistance in non-diabetic patients.
    Int J Cardiol 2010; 141(1): 44-48.
樋口公嗣
  1. Kubo T, Ochi Y, Baba Y, Hirota T, Tanioka K, Yamasaki N, Yoshimitsu M, Higuchi K, Takenaka T, Nakajima K, Togawa T, Tsukimura T, Sano S, Tei C, Sakuraba H, Kitaoka H.
    Prevalence and clinical features of Fabry disease in Japanese male patients with diagnosis of hypertrophic cardiomyopathy.
    J Cardiol 2017; 69: 302-307.
  2. Sun Z, Lee CJ, Mejia-Guerrero S, Zhang Y, Higuchi K, Li RK, Medin JA.
    Neonatal transfer of membrane-bound stem cell factor improves survival and heart function in aged mice after myocardial ischemia.
    Hum Gene Ther. 2012; 23: 1280-1289.
  3. Yoshimitsu M, Higuchi K, Miyata M, Devine S, Mattman A, Sirrs S, Medin JA, Tei C, Takenaka T.
    Identification of novel mutations in the α-galactosidase A gene in patients with Fabry disease: Pitfalls of mutation analyses in patients with low α-galactosidase A activity.
    J cardiol. 2011; 57: 345-353.
  4. Yoshimitsu M, Higuchi K, Fan X, Takao S, Medin JA, Tei C, Takenaka T.
    Sequencing and characterization of the porcine alpha-galactosidase A gene: towards the generation of a porcine model for Fabry disease.
    Mol Biol Rep. 2011; 38: 3145-3152.
  5. Higuchi K, Yoshimitsu M, Fan X, Guo X, Rasaiah VI, Yen J, Tei C, Takenak T, Medin JA.
    Alpha-galactosidase A-Tat fusion enhances storage reduction in hearts and kidneys of Fabry mice.
    Mol Med. 2010; 16: 216-221.
  6. Sato T, Ramsubir S, Higuchi K, Yanagisawa T, Medin JA.
    Vascular endothelial growth factor broadens lentivector distribution in the heart after neonatal injection.
    J Cardiol. 2009; 54: 245-254.
  7. Higuchi K, Ayach B, Sato T, Chen M, Devine SP, Rasaiah VI, Dawood F, Yanagisawa T, Tei C, Takenaka T, Liu PP, Medin JA.
    Direct injection of kit ligand-2 lentivirus improves cardiac repair and rescues mice post-myocardial infarction.
    Mol Ther. 2009; 17: 262-268.
  8. Takenaka T, Teraguchi H, Yoshida A, Taguchi S, Ninomiya K, Umekita Y, Yoshida H, Horinouchi M, Tabata K, Yonezawa S, Yoshimitsu M, Higuchi K, Nakao S, Anan R, Minagoe S, Tei C.
    Terminal stage cardiac findings in patients with cardiac Fabry disease: an electrocardiographic, echocardiographic, and autopsy study.
    J Cardiol. 2008; 51: 50-59.
  9. Yoshimitsu M, Higuchi K, Ramsubir S, Nonaka t, Rasaiah VI, Siatskas C, Liang SB, Murray GJ, Brady RO, Medin JA.
    Efficient correction of Fabry mice and patient cells mediated by lentiviral transduction of hematopoietic stem/progenitor cells.
    Gene Ther. 2007; 14: 256-265.
  10. Yoshimitsu M, Higuchi K, Dawood F, Rasaiah VI, Ayach B, Chen M, Liu P, Medin JA.
    Correction of cardiac abnormalities in fabry mice by direct intraventricular injection of a recombinant lentiviral vector that engineers expression of alpha-galactosidase A.
    Circ J. 2006; 70: 1503-1508.
赤﨑雄一
  1. Cheng KK, Akasaki Y, Lecommandeur E, Lindsay RT, Murfitt S, Walsh K, Griffin JL.
    Metabolomic analysis of Akt1-mediated muscle hypertrophy in models of diet-induced obesity and age-related fat accumulation.
    J Proteome Res. 2015; 14: 342-352.
  2. Akasaki Y, Ouchi N, Izumiya Y, Bernardo BL, Lebrasseur NK, Walsh K.
    Glycolytic fast-twitch muscle fiber restoration counters adverse age-related changes in body composition and metabolism.
    Aging Cell. 2014; 13: 80-91.
  3. Miyauchi T, Miyata M, Ikeda Y, Akasaki Y, Hamada N, Shirasawa T, Furusho Y, Tei C.
    Waon therapy upregulates hsp90 and leads to angiogenesis through the Akt-endothelial nitric oxide synthase pathway in mouse hindlimb ischemia.
    Circ J. 2012; 76: 1712-1721.
  4. Furusho Y, Miyata M, Matsuyama T, Nagai T, Li H, Akasaki Y, Hamada N, Miyauchi T, Ikeda Y, Shirasawa T, Ide K, Tei C.
    Novel therapy for atherosclerosis using recombinant immunotoxin against folate receptor β-expressing macrophages.
    J Am Heart Assoc. 2012; 1: e003079.
  5. Araki S, Izumiya Y, Hanatani S, Rokutanda T, Usuku H, Akasaki Y, Takeo T, Nakagata N, Walsh K, Ogawa H.
    Akt1-mediated skeletal muscle growth attenuates cardiac dysfunction and remodeling after experimental myocardial infarction.
    Circ Heart Fail. 2012; 5: 116-125.
  6. Hamada N, Miyata M, Eto H, Ikeda Y, Shirasawa T, Akasaki Y, Miyauchi T, Furusho Y, Nagaki A, Aronow BJ, Tei C.
    Loss of clusterin limits atherosclerosis in apolipoprotein E-deficient mice via reduced expression of Egr-1 and TNF-α.
    J Atheroscler Thromb. 2011; 18: 209-216.
  7. Zeng L, Akasaki Y, Sato K, Ouchi N, Izumiya YY, Walsh K.
    Insulin-like 6 is induced by muscle injury and functions as a regenerative factor.
    J Biol Chem.2010; 285: 36060-36069.
  8. Shinsato T, Miyata M, Kubozono T, Ikeda Y, Fujita S, Kuwahata S, Akasaki Y, Hamasaki S, Fujiwara H, Tei C.
    Waon therapy mobilizes CD34+ cells and improves peripheral arterial disease.
    J Cardiol. 2010; 56: 361-366.
  9. Hamada N, Miyata M, Eto H, Shirasawa T, Akasaki Y, Nagaki A, Tei C.
    Tacrolimus-eluting stent inhibits neointimal hyperplasia via calcineurin/NFAT signaling in porcine coronary artery model.
    Atherosclerosis. 2010; 208: 97-103.
  10. Ouchi N, Higuchi A, Ohashi K, Oshima Y, Gokce N, Shibata R, Akasaki Y, Shimono A, Walsh K.
    Sfrp5 is an anti-inflammatory adipokine that modulates metabolic dysfunction in obesity.
    Science. 2010; 329: 454-457.
二宮雄一
  1. Nakamaru R, Okada M, Tanaka N, Tanaka K, Ninomiya Y, Hirao Y, Oka T, Inoue H, Takayasu K, Koyama Y, Okamura A, Iwakura K, Rakugi H, Sakata Y, Fujii K, Inoue K.
    Outcomes after atrial fibrillation ablation in patients with premature atrial contractions originating from non-pulmonary veins.
    JACC Clin Electrophysiol 2019; 5: 1319-1327.
  2. Okada M, Tanaka K, Matsunaga-Lee Y, Ninomiya Y, Hirao Y, Oka T, Tanaka N, Inoue H, Iwakura K, Fujii K, Inoue K.
    Multiple shifts of the earliest retrograde atrial activation site along the tricuspid annulus during the fast-slow form of atrioventricular nodal reentrant tachycardia by radiofrequency modification.
    Int Heart J 2019; 60: 761-767.
  3. Nakamaru R, Tanaka N, Okada M, Tanaka K, Ninomiya Y, Hirao Y, Oka T, Inoue H, Koyama Y, Okamura A, Iwakura K, Rakugi H, Sakata Y, Fujii K, Inoue K.
    Usefulness of failed electrical cardioversion for early recurrence after catheter ablation for atrial fibrillation as a predictor of future recurrence.
    Am J Cardiol 2019; 123: 794-800.
  4. Tanaka N, Tanaka K, Ninomiya Y, Hirao Y, Oka T, Okada M, Inoue H, Nakamaru R, Takayasu K, Kitagaki R, Koyama Y, Okamura A, Iwakura K, Sakata Y, Fujii K, Inoue K.
    Comparison of the safety and efficacy of automated annotation-guided radiofrequency ablation and 2nd-generation cryoballoon ablation in paroxysmal atrial fibrillation.
    Circ J 2019; 83: 548-555.
  5. Oka T, Inoue K, Tanaka K, Ninomiya Y, Hirao Y, Tanaka N, Okada M, Inoue H, Nakamaru R, Koyama Y, Okamura A, Iwakura K, Sakata Y, Fujii K.
    Left atrial reverse remodeling after catheter ablation of nonparoxysmal atrial fibrillation in patients with heart failure with reduced ejection fraction.
    Am J Cardiol 2018; 122: 89-96.
  6. Okada M, Inoue K, Tanaka K, Ninomiya Y, Hirao Y, Oka T, Tanaka N, Inoue H, Nakamaru R, Koyama Y, Okamura A, Iwakura K, Sakata Y, Fujii K.
    Efficacy and safety of figure-of-eight suture for hemostasis after radiofrequency catheter ablation for atrial fibrillation.
    Circ J 2018; 82: 956-964.
  7. Ninomiya Y, Hamasaki S, Nomoto Y, Kawabata T, Fukumoto D, Yoshimura A, Imamura S, Ogawa M, Shiramomo Y, Kawaida K, Yotsumoto G, Suzuyama H, Nishigami K, Sakamoto T, Ohishi M.
    A case of acute coronary syndrome caused by delayed coronary ischemia after transcatheter aortic valve implantation.
    J Cardiol Cases 2017; 17: 107-110.
  8. Ichiki H, Oketani N, Ishida S, Iriki Y, Okui H, Maenosono R, Namino F, Ninomiya Y, Miyata M, Hamasaki S, Tei C.
    The incidence of asymptomatic cerebral microthromboembolism after atrial fibrillation ablation: comparison of warfarin and dabigatran.
    Pacing Clin Electrophysiol 2013; 36: 1328-1335.
  9. Ichiki H, Oketani N, Ishida S, Iriki Y, Okui H, Maenosono R, Ninomiya Y, Matsushita T, Miyata M, Hamasaki S, Tei C.
    Incidence of asymptomatic cerebral microthromboembolism after atrial fibrillation ablation guided by complex fractionated atrial electrogram.
    J Cardiovasc Electrophysiol 2012; 23: 567-573.
  10. Maenosono R, Oketani N, Ishida S, Iriki Y, Ichiki H, Okui H, Ninomiya Y, Hamasaki S, Namino F, Matsushita M, Tei C, Hashiguchi T.
    Effectiveness of esophagus detection by three-dimensional electroanatomical mapping to avoid esophageal injury during ablation of atrial fibrillation.
    J Cardiol 2012; 60: 119-125.
神田大輔
  1. Sonoda T, Takumi T, Miyata M, Kanda D, Kosedo I, Yoshino S, Ohishi M.
    Validity of a novel method for estimating low-density lipoprotein cholesterol levels incardiovascular disease patients treated with statins.
    J Atheroscler Thromb 2018; 25: 643-652.
  2. Tokushige A, Miyata M, Sonoda T, Kosedo I, Kanda D, Takumi T, Kumagae Y, Fukukura Y, Ohishi M.
    Prospective study on the incidence of cerebrovascular disease after coronary angiography.
    J Atheroscler Thromb 2018; 25(3): 224-232.
  3. Kanda D, Takumi T, Miyata M, Tokushige A, Sonoda T, Yoshino S, Saihara K, Ohishi M.
    Angiotensin-converting enzyme inhibitor prevents the worsening of renal function in the late phase after percutaneous coronary intervention.
    J Atheroscler Thromb 2016; 23(2): 233-240.
  4. Yoshino S, Hamasaki S, Ishida S, Kataoka T, Yoshikawa A, Oketani N, Saihara K, Okui H, Shinsato T, Ichiki H, Kubozono T, Kuwahata S, Fujita S, Kanda D, Nakazaki M, Miyata M, Tei C.
    Relationship between bilirubin concentration, coronary endothelial function, and inflammatory stress in overweight patients. J Atheroscler Thromb 2011; 18: 403-412.

主な研究費取得状況

大石 充
事業・種目 / 期間研究
日本学術振興会
科学研究費 基盤研究(C) 代表 / 2016年度~2018年度
大規模検診から高浸透率家系を抽出する新しい高血圧遺伝子同定法の確立.
池田義之
事業・種目 / 期間研究
日本学術振興会
科学研究費 基盤研究(C) 代表(分担 窪薗琢郎, 赤﨑雄一, 大石 充) / 2019年度~2022年度
オルタナティブオートファジーとマクロファージを標的としたサルコペニア治療法の確立.
市來仁志
事業・種目 / 期間研究
日本学術振興会
科学研究費 基盤研究(C) 代表(分担 池田義之, 大石 充, 橋口照人) / 2019年度~2023年度
心房細動患者の認知症予防に関する研究-脳血管障害・血管内皮機能障害との関連-.
窪薗琢郎
事業・種目 / 期間研究
日本学術振興会
科学研究費 基盤研究(C) 代表 (分担 大石 充, 宮田昌明, 池田義之) / 2016年度~2019年度
フレイルと心不全の相互関連因子探索と心臓リハビリテーションの有効性に関する研究.
窪田佳代子
事業・種目 / 期間研究
日本学術振興会
科学研究費 基盤研究(C) 代表 (分担 大石 充, 池田義之, 吉満 誠, 朝野仁裕. 連携 大阪大学:高島成二) / 2017年度~2019年度
次世代シーケンサーによる家族性肺高血圧症の遺伝子解析:特発性肺高血圧症の機序解明.
樋口公嗣
事業・種目 / 期間研究
日本学術振興会
科学研究費 基盤研究(C) 代表 (分担 吉満 誠) / 2017年度~2019年度
Fabry病の新規αガラクトシダーゼ遺伝子変異による酵素の生体内動態に関する研究.
赤﨑雄一
事業・種目 / 期間研究
日本学術振興会
科学研究費 基盤研究(C) 代表 (分担 池田義之, 大石 充) / 2017年度~2019年度
ミトコンドリアダイナミクスとオートファージを標的としたサルコペニアの新規治療法.
神田大輔
事業・種目 / 期間研究
日本学術振興会
研究活動スタート支援 / 2016年度~2017年度
末梢動脈疾患における新規動脈硬化マーカーの確立.

分野サイト

新ニーズに対応する九州がんプロ養成プラン
GPなど(医歯学)
鹿児島大学
鹿児島大学病院
附属施設等
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