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Research outline

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Research interests

• Hypertension
• Ischemic heart disease
• Atherosclerosis
• Cardiac echocardiography
• Adult congenital heart disease
• Heart failure
• Pulmonary hypertension
• Arrhythmia
• Cardiomyopathy

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Research results

Mitsuru OHISHI

• Kubozono T, Akasaki Y, Kawasoe S, Ojima S, Kawabata T, Makizako H, Kuwahata S, Takenaka T, Maeda M, Ohno M, Kijimuta M, Fujiwara S, Miyagawa K, Ohishi M.
  The relationship between home blood pressure measurement and room temperature in a Japanese general population.
  Hypertens Res 2021; 44: 454-463.
• Kuwahata S, Takenaka T, Motoya T, Masuda K, Yonezawa H, Shinchi S, Kawashima Y, Mohri S, Ohishi M.
  Effect of QT prolongation in patients taking cholinesterase inhibitors (Donepezil) for alzheimer's disease. Circ Rep 2021; 3: 115-121.
• Ninomiya Y, Kawasoe S, Kubozono T, Tokushige A, Ichiki H, Miyahara H, Tokushige K, Ohishi M.
  Sex-specific relationship between abdominal obesity and new-onset atrial fibrillation in the general Japanese population.
  Heart Vessels 2021; 36: 1879-1884.
• Ninomiya Y, Inoue K, Tanaka N, Okada M, Tanaka K, Onishi T, Hirao Y, Oka T, Inoue H, Takayasu K, Nakamaru R, Kitagaki R, Koyama Y, Okamura A, Iwakura K, Ohishi M, Fujii K.
  Absence of first-pass isolation is associated with poor pulmonary vein isolation durability and atrial fibrillation ablation outcomes.
  J Arrhythm 2021; 37: 1468-1476.
• Kawasoe S, Kubozono T, Ojima S, Kawabata T, Miyahara H, Tokushige K, Ohishi M.
  J-shaped curve for the association between serum uric acid levels and the prevalence of blood pressure abnormalities.
  Hypertens Res 2021; 44: 1186-1193.
• Arikawa R, Kanda D, Ikeda Y, Tokushige A, Sonoda T, Anzaki K, Ohishi M.
  Prognostic impact of malnutrition on cardiovascular events in coronary artery disease patients with myocardial damage.
  BMC Cardiovasc Disord 2021; 21: 479.
• Ojima S, Kubozono T, Kawasoe S, Kawabata T, Miyahara H, Tokushige K, Ohishi M.
  Gender differences in the risk factors associated with atherosclerosis by carotid intima-media thickness, plaque score, and pulse wave velocity.
  Heart Vessels 2021; 36: 934-944.
• Sasaki Y, Ikeda Y, Uchikado Y, Akasaki Y, Sadoshima J, Ohishi M.
  Estrogen plays a crucial role in Rab9-dependent mitochondrial autophagy, delaying arterial senescence.
  J Am Heart Assoc 2021; 10: e019310.
• Iwatani N, Kubota K, Ikeda Y, Tokushige A, Miyanaga S, Higo K, Ohishi M.
  Different characteristics of mitochondrial dynamics-related miRNAs on the hemodynamics of pulmonary artery hypertension and chronic thromboembolic pulmonary hypertension.
  J Cardiol 2021; 78: 24-30.
• Shimono H, Kajiya T, Takaoka J, Miyamura A, Inoue T, Kitazono K, Ninomiya T, Atsuchi Y, Atsuchi N, Ohishi M.
  Characteristics of recurrent in-stent restenosis (ISR) after second and third generation drug-eluting stent (DES) implantation.
  Cor Art Dis 2021; 32: 36-41.
• Yoshimoto I, Iriki Y, Oketani N, Okui H, Ichiki H, Maenosono R, Namino F, Miyata M, Ohishi M.
  A randomized comparison of two direct oral anticoagulants for patients undergoing cardiac ablation with a contemporary warfarin control arm.
  J Interv Card Electrophysiol 2021; 60: 375-385.
• Uchikado Y, Ikeda Y, Sasaki Y, Iwabayashi M, Akasaki Y, Ohishi M.
  Association of lectin-like oxidized low-density lipoprotein receptor-1 with angiotensin II type 1 receptor impacts mitochondrial quality control, offering promise for the treatment of vascular senescence.
  Front Cardiovasc Med 2021; 8: 788655.
• Nakamura M, Hamada T, Tanaka A, Nishi K, Kume K, Goto Y, Beppu M, Hijioka H, Higashi Y, Tabata H, Mori K, Mishima Y, Uchino Y, Yamashiro K, Matsumura Y, Makizako H, Kubozono T, Tabira T, Takenaka T, Ohishi M, Sugiura T.
  Association of oral hypofunction with frailty, sarcopenia, and mild cognitive impairment: A cross-sectional study of community-dwelling Japanese older adults.
  J Clin Med 2021; 10: 1626. J Clin Med 2021; 10 (8): 1626.
• Nakajo M, Ojima S, Kawakami H, Tani A, Hirayama A, Jinguji M, Kubozono T, Ohishi M, Yoshiura T.
  Value of patlak ki images from 18F-FDG-PET/CT for evaluation of the relationships between disease activity and clinical events in cardiac sarcoidosis.
  Sci Rep 2021; 11: 2729.
• Kiuchi Y, Makizako H, Nakai Y, Tomioka K, Taniguchi Y, Kimura M, Kanouchi H, Takenaka T, Kubozono T, Ohishi M.
  The association between dietary variety and physical frailty in community-dwelling older adults.
  Healthcare 2021; 9: 32.
• Kaimoto K, Yamashita M, Suzuki T, Makizako H, Koriyama C, Kubozono T, Takenaka T, Ohishi M, Kanouchi H, Tarumizu Study Diet Group.
  Association of protein and magnesium intake with prevalence of prefrailty and frailty in community-dwelling older Japanese women.
  J Nutr Sci Vitaminol 2021; 67: 39-47.
• Maruta M, Makizako H, Ikeda Y, Miyata H, Nakamura A, Han G, Shimokihara S, Tokuda K, Kubozono T, Ohishi M, Tabira T.
  Association between apathy and satisfaction with meaningful activities in older adults with mild cognitive impairment: A population-based cross-sectional study.
  Int J Geriatr Psychiatry 2021; 36: 1065-1074.
• Maenosono R, Mizukami N, Ichiki H, Oketani N, Namino F, Masamoto I, Yuasa T, Yamakuchi M, Ohishi M, Hashiguchi T.
  Total atrial conduction time as a possible predictor of atrial fibrillation recurrence after catheter ablation for paroxysmal atrial fibrillation: relationship between electrical atrial remodeling and structural atrial remodeling time courses.
  J Med Ultrason 2021; 48: 295-306.
• Sugimoto T, Araki A, Fujita H, Honda K, Inagaki N, Ishida T, Kato J, Kishi M, Kobayashi K, Kouyama K, Noma H,Ohishi M, Satoh-Asahara N, Shimada H, Sugimoto K, Suzuki S, Takeya Y, Tamura Y, Tokuda H, Umegaki H, Watada H, Yamada Y, Sakurai T.
  The multi-domain intervention trial in older adults with diabetes mellitus for prevention of dementia in Japan: study protocol for a multi-center, randomized, 18-month controlled trial.
  Front Aging Neurosci 2021; 13: 680341.
• Inoue K, Hirao K, Kumagai K, Kimura M, Miyauchi Y, Tsushima E, Ohishi M, Kimura K, Yasaka M, Yamaji H, Okawa K, Fujimoto M.
  Long-term efficacy and safety of anticoagulation after atrial fibrillation ablation: data from the JACRE registry.
  J Cardiol 2021; 77: 263-270.
• Salim Anwar A, Kawasoe S, Kubozono T, Ojima S, Kawabata T, Ikeda Y, Miyahara H, Tokushige K, Ohishi M.
  Assessment of future hypertension risk by sex using combined body mass index and waist-to-height ratio.
  Circ Rep 2021 Nov 20;4: 9-16.

Yoshiyuki IKEDA

• Arikawa R, Kanda D, Ikeda Y, Tokushige A, Sonoda T, Anzaki K, Ohishi M.
  Prognostic impact of malnutrition on cardiovascular events in coronary artery disease patients with myocardial damage.
  BMC Cardiovasc Disord 2021; 21: 479.
• Sasaki Y, Ikeda Y, Uchikado Y, Akasaki Y, Sadoshima J, Ohishi M.
  Estrogen plays a crucial role in Rab9-dependent mitochondrial autophagy, delaying arterial senescence.
  J Am Heart Assoc 2021; 10: e019310.
• Iwatani N, Kubota K, Ikeda Y, Tokushige A, Miyanaga S, Higo K, Ohishi M.
  Different characteristics of mitochondrial dynamics-related miRNAs on the hemodynamics of pulmonary artery hypertension and chronic thromboembolic pulmonary hypertension.
  J Cardiol 2021; 78: 24-30.
• Uchikado Y, Ikeda Y, Sasaki Y, Iwabayashi M, Akasaki Y, Ohishi M.
  Association of lectin-like oxidized low-density lipoprotein receptor-1 with angiotensin II type 1 receptor impacts mitochondrial quality control, offering promise for the treatment of vascular senescence.
  Front Cardiovasc Med 2021; 8: 788655.
• Chen Y, Maejima Y, Shirakabe A, Yamamoto T, Ikeda Y, Sadoshima J, Zhai P.
  Ser9 phosphorylation of GSK-3β promotes aging in the heart through suppression of autophagy.
  J Cardiovasc Aging 2021; 1: 9.
• Oka SI, Byun J, Huang CY, Imai N, Ralda G, Zhai P, Xu X, Kashyap S, Warren JS, Alan Maschek J, Tippetts TS, Tong M, Venkatesh S, Ikeda Y, Mizushima W, Kashihara T, Sadoshima J.
  Nampt potentiates antioxidant defense in diabetic cardiomyopathy.
  Circ Res 2021; 129: 114-130.
• Salim Anwar A, Kawasoe S, Kubozono T, Ojima S, Kawabata T, Ikeda Y, Miyahara H, Tokushige K, Ohishi M.
  Assessment of future hypertension risk by sex using combined body mass index and waist-to-height ratio.
  Circ Rep 2021 Nov 20;4: 9-16.
• Ikeda Y, Sasaki T, Kuwahata S, Imamura M, Tanoue K, Komaki S, Hashiguchi M, Kuroda A, Akasaki Y, Ohishi M.
  Management instructions for elderly patients with hypertension.
  Clin Exp Hypertens. 2020 May 18;42(4):295-301.
• Kubota K, Miyanaga S, Iwatani N, Higo K, Tokushige A, Ikeda Y, Ohishi M.
  Geriatric Nutritional Risk Index is associated with prognosis in patients with pulmonary arterial hypertension and chronic thromboembolic pulmonary hypertension.
  Circ Rep 2020; 2: 372-377.
• Kanda D, Ikeda Y, Sonoda T, Tokushige A, Kosedo I, Yoshino S, Takumi T, Ohishi M.
  Malnutrition and non-use clopidogrel additively aggravate prognosis of critical limb ischemia patients who underwent revascularization.
  Circ Rep 2020; 2: 121-127.
• Sasaki Y, Ikeda Y, Miyauchi T, Uchikado Y, Akasaki Y, Ohishi M.
  Estrogen-SIRT1 axis plays a pivotal role in protecting arteries against menopause-induced senescence and atherosclerosis.
  J Atheroscler Thromb 2020 Jan 1; 27: 47-59.

Hisayo YASUDA

1. Yasuda O, Fujii Y, Komaki R, Yasuda H, Moriyama T, Soejima Y.
   orrelation between renal function and muscle mass
   Campus Health 2018; 55(2): 52-56.
2. Yamamura S, Izumiya Y, Ishida T, Onoue Y, Kimura Y, Hanatani S, Araki S, Fujisue K, Sueta D, Kanazawa H, Takashio S, Usuku H, Sugamura K, Sakamoto K, Yamamoto E, Yamamuro M, Yasuda H, Kojima S, Kaikita K, Hokimoto S, Ogawa H, Tsujita K.
   Reduced trans-mitral A-wave velocity predicts the presence of wild-type transthyretin amyloidosis in elderly patients with left ventricular hypertrophy
   Heart Vessels 2017; 32(6): 708-713.
3. Sueta D, Hokimoto S, Okamoto K, Yasuda H, Usuku H, Tazume H, Yamamoto E, Sakamoto K, Izumiya Y, Tsujita K, Kaikita K, Sakaguchi H, Fukui T, Ogawa H .
   More Haste, Less Speed: Cardiac Perforation by a Thoracentesis Cathter
   International Journal of Cardiology Heart & Vasculature 2016; 11: 17-29
4. Yamamoto M, Yamamoto E, Yasuda O, Yasuda H, Sakamoto K, Tsujita K, Izumiya Y, Kaikita K, Hokimoto O, Ogawa H.
   A case of Werner’s syndrome with cardiac syncrome X and heart failure with presereved ejection fraction.
   Journal of Cardiology Cases 2015; 12(6): 195-198.
5. Misumi I, Honda T, Kurokawa H, Kubota Y, Ishii M, Sato R, Yamabe H, Yasuda H, Kaikita K, Hokimoto S, Ogawa H.
   Systolic Flow Reversal in a Case of Mid-Ventricular Obstructive Hypertrophic Cardiomyopathy.
   Intern Med 2015; 54(14): 1765-1769.
6. Kurokawa H, Misumi I, Honda T, Usuku H, Yasuda H, Kaikita K, Hokimoto S, Ogawa H, Nakatsuka D, Tabata M .
   Resonant cardiac chamber with diastolic thrill.
   J Echocardiogr 2015; 13(12): 69-71
7. Misumi I, Nishida Y, Honda T, Kurokawa H, Yasuda H, Kaikita K, Hokimoto S, Ogawa H.
   Markedly High B-type Natriuretic Peptide Level in a Patient with Duchenne Muscular Dystrophy and Left Ventricular Non-Compaction.
   Internal Medicine 2015; 54(17): 2197-2200.
8. Misumi I, Honda T, Kusuhara K, Yasuda H, Kaikita K, Hokimoto S, Ogawa H.
   Paradoxical increase in E/e’ratio after treatment of heart failure intwo patients with preserved ejection fraction.
   Journal of Medical Ultrasonocs 2014; 42: 239-241.
9. Usuku H, Obayashi K, Shono M, Oshima T, Tasaki M, Yasuda H, Ogawa H, Ando Y.
   Usefulness of plasma B-type natriuretic peptide as a prognostic marker of cardiac function in senile systemic amyloidosis and in familial amyloidotic polyneuropathy
   Amyloidosis 2014; 20(4): 251-255.
10. Misumi I, Ito M, Rokutanda T, Kusuhara K, Akahoshi R, Matsumoto M, Tanaka H, Yasuda H, Kaikita K, Hokimoto S, Ogawa H.
    Hemodynamic influence of triphasic mitral inflow velocity: a case report.
    Journal of Echocardiography 2014; 12: 43-45.

Takuro KUBOZONO

1. Kubozono T, Akasaki Y, Kawasoe S, Ojima S, Kawabata T, Makizako H, Kuwahata S, Takenaka T, Maeda M, Ohno M, Kijimuta M, Fujiwara S, Miyagawa K, Ohishi M.
   The relationship between home blood pressure measurement and room temperature in a Japanese general population.
   Hypertens Res 2021; 44: 454-463.
2. Ninomiya Y, Kawasoe S, Kubozono T, Tokushige A, Ichiki H, Miyahara H, Tokushige K, Ohishi M.
   Sex-specific relationship between abdominal obesity and new-onset atrial fibrillation in the general Japanese population.
   Heart Vessels 2021; 36: 1879-1884.
3. Kawasoe S, Kubozono T, Ojima S, Kawabata T, Miyahara H, Tokushige K, Ohishi M.
   J-shaped curve for the association between serum uric acid levels and the prevalence of blood pressure abnormalities.
   Hypertens Res 2021; 44: 1186-1193.
4. Ojima S, Kubozono T, Kawasoe S, Kawabata T, Miyahara H, Tokushige K, Ohishi M.
   Gender differences in the risk factors associated with atherosclerosis by carotid intima-media thickness, plaque score, and pulse wave velocity.
   Heart Vessels 2021; 36: 934-944.
5. Nakamura M, Hamada T, Tanaka A, Nishi K, Kume K, Goto Y, Beppu M, Hijioka H, Higashi Y, Tabata H, Mori K, Mishima Y, Uchino Y, Yamashiro K, Matsumura Y, Makizako H, Kubozono T, Tabira T, Takenaka T, Ohishi M, Sugiura T.
   Association of oral hypofunction with frailty, sarcopenia, and mild cognitive impairment: A cross-sectional study of community-dwelling Japanese older adults.
   J Clin Med 2021; 10: 1626.
6. Nakajo M, Ojima S, Kawakami H, Tani A, Hirayama A, Jinguji M, Kubozono T, Ohishi M, Yoshiura T.
   Value of patlak ki images from 18F-FDG-PET/CT for evaluation of the relationships between disease activity and clinical events in cardiac sarcoidosis.
   Sci Rep 2021; 11: 2729.
7. Kiuchi Y, Makizako H, Nakai Y, Tomioka K, Taniguchi Y, Kimura M, Kanouchi H, Takenaka T, Kubozono T, Ohishi M.
   The association between dietary variety and physical frailty in community-dwelling older adults.
   Healthcare 2021; 9: 32.
8. Kaimoto K, Yamashita M, Suzuki T, Makizako H, Koriyama C, Kubozono T, Takenaka T, Ohishi M, Kanouchi H, Tarumizu Study Diet Group.
   Association of protein and magnesium intake with prevalence of prefrailty and frailty in community-dwelling older Japanese women.
   J Nutr Sci Vitaminol 2021; 67: 39-47.
9. Maruta M, Makizako H, Ikeda Y, Miyata H, Nakamura A, Han G, Shimokihara S, Tokuda K, Kubozono T, Ohishi M, Tabira T.
   Association between apathy and satisfaction with meaningful activities in older adults with mild cognitive impairment: A population-based cross-sectional study.
   Int J Geriatr Psychiatry 2021; 36: 1065-1074.
10. Miyoshi T, Ito H, Shirai K, Horinaka S, Higaki J, Yamamura S, Saiki A, Takahashi M, Masaki M, Okura T, Kotani K, Kubozono T, Yoshioka R, Kihara H, Hasegawa K, Satoh-Asahara N, Orimo H; CAVI‐J (Prospective Multicenter Study to Evaluate Usefulness of Cardio‐Ankle Vascular Index in Japan) investigators.
    Predictive value of the cardio-ankle vascular index for cardiovascular events in patients at cardiovascular risk.
    J Am Heart Assoc 2021; 10: e020103.

Kayoko KUBOTA

1. Iwatani N, Kubota K, Ikeda Y, Tokushige A, Miyanaga S, Higo K, Ohishi M.
   Different characteristics of mitochondrial dynamics-related miRNAs on the hemodynamics of pulmonary artery hypertension and chronic thromboembolic pulmonary hypertension.
   J Cardiol 2021; 78: 24-30.
2. Kubota K, Miyanaga S, Iwatani N, Higo K, Tokushige A, Ikeda Y, Ohishi M.
   Geriatric Nutritional Risk Index is associated with prognosis in patients with pulmonary arterial hypertension and chronic thromboembolic pulmonary hypertension.
   Circ Rep 2020; 2: 372-377.
3. Uchiyama N, Yuasa T, Miyata M, Horizoe Y, Chaen H, Kubota K, Takasaki K, Mizukami N, Kisanuki A, Ohishi M.
   Correlation of right ventricular wall stress with plasma B-type natriuretic peptide levels in patients with pulmonary hypertension.
   Circ J 2019; 83: 1278-1285.
4. Horizoe Y, Takasaki K, Miyata M, Chaen H, Kubota K, Mizukami N, Yuasa T, Kisanuki A, Ohishi M.
   Analysis of biphasic right ventricular outflow doppler waveform in patients with pulmonary hypertension.
   International Heart Journal 2019; 60: 108-114.
5. Miyanaga S, Kubota K, Iwatani N, Higo K, Miyata M, Horizoe Y, Ojima S, Kawasoe S, Kubozono T, Ohishi M.
   Predictors of exercise-induced pulmonary hypertension in patients with connective tissue disease.
   Heart Vessels 2019; 34: 1509-1518.
6. Ojima S, Kubozono T, Saihara K, Miyauchi T, Kawasoe S, Kubota K, Shigemizu S, Ohtsubo H, Miyata M, Ohishi M.
   Significant clinical indexes of exercise-induced pulmonary hypertension in patients with connective tissue disease.
   Circulation Reports 2019; 1: 610-616.
7. Higo K, Kubota K, Miyanaga S, Miyata M, Nakajo M, Jinguji M, Ohishi M.
   Impairment of iodine-123-metaiodobenzylguanidine (123I-MIBG) uptake in patients with pulmonary artery hypertension.
   Internal Heart J 2018; 59 (1): 112-119.
8. Higo K, Kubota K, Takeda A, Higashi M, Ohishi M.
   Successful antemortem diagnosis and treatment of pulmonary tumor thrombotic microangiopathy.
   Intern Med. 2014; 53: 2595-2599.

Koji HIGUCHI

1. Kubo T, Ochi Y, Baba Y, Hirota T, Tanioka K, Yamasaki N, Yoshimitsu M, Higuchi K, Takenaka T, Nakajima K, Togawa T, Tsukimura T, Sano S, Tei C, Sakuraba H, Kitaoka H.
   Prevalence and clinical features of Fabry disease in Japanese male patients with diagnosis of hypertrophic cardiomyopathy.
   J Cardiol 2017; 69: 302-307.
2. Sun Z, Lee CJ, Mejia-Guerrero S, Zhang Y, Higuchi K, Li RK, Medin JA.
   Neonatal transfer of membrane-bound stem cell factor improves survival and heart function in aged mice after myocardial ischemia.
   Hum Gene Ther. 2012; 23: 1280-1289.
3. Yoshimitsu M, Higuchi K, Miyata M, Devine S, Mattman A, Sirrs S, Medin JA, Tei C, Takenaka T.
   Identification of novel mutations in the α-galactosidase A gene in patients with Fabry disease: Pitfalls of mutation analyses in patients with low α-galactosidase A activity.
   J cardiol. 2011; 57: 345-353.
4. Yoshimitsu M, Higuchi K, Fan X, Takao S, Medin JA, Tei C, Takenaka T.
   Sequencing and characterization of the porcine alpha-galactosidase A gene: towards the generation of a porcine model for Fabry disease.
   Mol Biol Rep. 2011; 38: 3145-3152.
5. Higuchi K, Yoshimitsu M, Fan X, Guo X, Rasaiah VI, Yen J, Tei C, Takenak T, Medin JA.
   Alpha-galactosidase A-Tat fusion enhances storage reduction in hearts and kidneys of Fabry mice.
   Mol Med. 2010; 16: 216-221.
6. Sato T, Ramsubir S, Higuchi K, Yanagisawa T, Medin JA.
   Vascular endothelial growth factor broadens lentivector distribution in the heart after neonatal injection.
   J Cardiol. 2009; 54: 245-254.
7. Higuchi K, Ayach B, Sato T, Chen M, Devine SP, Rasaiah VI, Dawood F, Yanagisawa T, Tei C, Takenaka T, Liu PP, Medin JA.
   Direct injection of kit ligand-2 lentivirus improves cardiac repair and rescues mice post-myocardial infarction.
   Mol Ther. 2009; 17: 262-268.
8. Takenaka T, Teraguchi H, Yoshida A, Taguchi S, Ninomiya K, Umekita Y, Yoshida H, Horinouchi M, Tabata K, Yonezawa S, Yoshimitsu M, Higuchi K, Nakao S, Anan R, Minagoe S, Tei C.
   Terminal stage cardiac findings in patients with cardiac Fabry disease: an electrocardiographic, echocardiographic, and autopsy study.
   J Cardiol. 2008; 51: 50-59.
9. Yoshimitsu M, Higuchi K, Ramsubir S, Nonaka t, Rasaiah VI, Siatskas C, Liang SB, Murray GJ, Brady RO, Medin JA.
   Efficient correction of Fabry mice and patient cells mediated by lentiviral transduction of hematopoietic stem/progenitor cells.
   Gene Ther. 2007; 14: 256-265.
10. Yoshimitsu M, Higuchi K, Dawood F, Rasaiah VI, Ayach B, Chen M, Liu P, Medin JA.
    Correction of cardiac abnormalities in fabry mice by direct intraventricular injection of a recombinant lentiviral vector that engineers expression of alpha-galactosidase A.
    Circ J. 2006; 70: 1503-1508.

Hitoshi ICHIKI

1. Ninomiya Y, Kawasoe S, Kubozono T, Tokushige A, Ichiki H, Miyahara H, Tokushige K, Ohishi M.
   Sex-specific relationship between abdominal obesity and new-onset atrial fibrillation in the general Japanese population.
   Heart Vessels 2021; 36: 1879-1884.
2. Yoshimoto I, Iriki Y, Oketani N, Okui H, Ichiki H, Maenosono R, Namino F, Miyata M, Ohishi M.
   A randomized comparison of two direct oral anticoagulants for patients undergoing cardiac ablation with a contemporary warfarin control arm.
   J Interv Card Electrophysiol 2021; 60: 375-385.
3. Maenosono R, Mizukami N, Ichiki H, Oketani N, Namino F, Masamoto I, Yuasa T, Yamakuchi M, Ohishi M, Hashiguchi T.
   Total atrial conduction time as a possible predictor of atrial fibrillation recurrence after catheter ablation for paroxysmal atrial fibrillation: relationship between electrical atrial remodeling and structural atrial remodeling time courses.
   J Med Ultrason 2021; 48: 295-306.
4. Sato T, Yoshimoto I, Oketani N, Okui H, Iriki Y, Ichiki H, Maenosono R, Namino F, Miyata M, Ohishi M.
   Predictors of heart failure caused by volume overload using an irrigation catheter during catheter ablation for atrial fibrillation
   Int J Clin Cardiol 2019; 6: 155 (1-5).
5. Yoshimura A, Iriki Y, Ichiki H, Oketani N, Okui H, Maenosono R, Namino F, Miyata M, Ohishi M.
   Evaluation of safety and efficacy of periprocedural use of rivaroxaban and apixaban in catheter ablation for atrial fibrillation.
   J Cardiol 2017; 69(1): 228-235.
6. Ichiki H, Oketani N, Ishida S, Iriki Y, Okui H, Maenosono R, Namino F, Ninomiya Y, Miyata M, Hamasaki S, Tei C.
   The incidence of asymptomatic cerebral microthromboembolism after atrial fibrillation ablation: comparison of warfarin and dabigatran.
   Pacing Clin Electrophysiol 2013; 36(11): 1328-1335.
7. Yoshino S, Yoshikawa A, Hamasaki S, Ishida S, Oketani N, Saihara K, Okui H, Kuwahata S, Fujita S, Ichiki H, Ueya N, Iriki Y, Maenosono R, Miyata M, Tei C.
   Atrial fibrillation-induced endothelial dysfunction improves after restoration of sinus rhythm.
   Int J Cardiol 2013; 168(2): 1280-1285.
8. Yoshino S, Hamasaki S, Ishida S, Kataoka T, Yoshikawa A, Oketani N, Saihara K, Ichiki H, Kuwahata S, Fujita S, Takumi T, Yoshimoto I, Nakazaki M, Tei C.
   Characterization of the effect of serum bilirubin concentrations on coronary endothelial function via measurement of high-sensitivity C-reactive protein and high-density lipoprotein cholesterol.
   Heart Vessels 2013; 28(2): 157-165.
9. Maenosono R, Oketani N, Ishida S, Iriki Y, Ichiki H, Okui H, Ninomiya Y, Hamasaki S, Namino F, Matsushita M, Tei C, Hashiguchi T.
   Effectiveness of esophagus detection by three-dimensional electroanatomical mapping to avoid esophageal injury during ablation of atrial fibrillation.
   J Cardiol 2012; 60(2): 119-125.
10. Ichiki H, Oketani N, Ishida S, Iriki Y, Okui H, Maenosono R, Ninomiya Y, Matsushita T, Miyata M, Hamasaki S, Tei C.
    Incidence of asymptomatic cerebral microthromboembolism after atrial fibrillation ablation guided by complex fractionated atrial electrogram.
    J Cardiovasc Electrophysiol 2012; 23(6): 567-573.

Yuichi AKASAKI

1. Kubozono T, Akasaki Y, Kawasoe S, Ojima S, Kawabata T, Makizako H, Kuwahata S, Takenaka T, Maeda M, Ohno M, Kijimuta M, Fujiwara S, Miyagawa K, Ohishi M.
   The relationship between home blood pressure measurement and room temperature in a Japanese general population.
   Hypertens Res 2021; 44: 454-463.
2. Sasaki Y, Ikeda Y, Uchikado Y, Akasaki Y, Sadoshima J, Ohishi M.
   Estrogen plays a crucial role in Rab9-dependent mitochondrial autophagy, delaying arterial senescence.
   J Am Heart Assoc 2021; 10: e019310.
3. Uchikado Y, Ikeda Y, Sasaki Y, Iwabayashi M, Akasaki Y, Ohishi M.
   Association of lectin-like oxidized low-density lipoprotein receptor-1 with angiotensin II type 1 receptor impacts mitochondrial quality control, offering promise for the treatment of vascular senescence.
   Front Cardiovasc Med 2021; 8: 788655.
4. Ikeda Y, Sasaki T, Kuwahata S, Imamura M, Tanoue K, Komaki S, Hashiguchi M, Kuroda A, Akasaki Y, Ohishi M.
   Management instructions for elderly patients with hypertension.
   Clin Exp Hypertens 2020; 42: 295-301.
5. Sasaki Y, Ikeda Y, Miyauchi T, Uchikado Y, Akasaki Y, Ohishi M.
   Estrogen-SIRT1 axis plays a pivotal role in protecting arteries against menopause-induced senescence and atherosclerosis.
   J Atheroscler Thromb 2020 Jan 1; 27: 47-59.
6. Cheng KK, Akasaki Y, Lecommandeur E, Lindsay RT, Murfitt S, Walsh K, Griffin JL.
   Metabolomic analysis of Akt1-mediated muscle hypertrophy in models of diet-induced obesity and age-related fat accumulation.
   J Proteome Res. 2015; 14: 342-352.
7. Akasaki Y, Ouchi N, Izumiya Y, Bernardo BL, Lebrasseur NK, Walsh K.
   Glycolytic fast-twitch muscle fiber restoration counters adverse age-related changes in body composition and metabolism.
   Aging Cell. 2014; 13: 80-91.
8. Miyauchi T, Miyata M, Ikeda Y, Akasaki Y, Hamada N, Shirasawa T, Furusho Y, Tei C.
   Waon therapy upregulates hsp90 and leads to angiogenesis through the Akt-endothelial nitric oxide synthase pathway in mouse hindlimb ischemia.
   Circ J. 2012; 76: 1712-1721.
9. Furusho Y, Miyata M, Matsuyama T, Nagai T, Li H, Akasaki Y, Hamada N, Miyauchi T, Ikeda Y, Shirasawa T, Ide K, Tei C.
   Novel therapy for atherosclerosis using recombinant immunotoxin against folate receptor β-expressing macrophages.
   J Am Heart Assoc. 2012; 1: e003079.
10. Araki S, Izumiya Y, Hanatani S, Rokutanda T, Usuku H, Akasaki Y, Takeo T, Nakagata N, Walsh K, Ogawa H.
    Akt1-mediated skeletal muscle growth attenuates cardiac dysfunction and remodeling after experimental myocardial infarction.
    Circ Heart Fail. 2012; 5: 116-125.
11. Hamada N, Miyata M, Eto H, Ikeda Y, Shirasawa T, Akasaki Y, Miyauchi T, Furusho Y, Nagaki A, Aronow BJ, Tei C.
    Loss of clusterin limits atherosclerosis in apolipoprotein E-deficient mice via reduced expression of Egr-1 and TNF-α.
    J Atheroscler Thromb. 2011; 18: 209-216.
12. Zeng L, Akasaki Y, Sato K, Ouchi N, Izumiya YY, Walsh K.
    Insulin-like 6 is induced by muscle injury and functions as a regenerative factor.
    J Biol Chem.2010; 285: 36060-36069.
13. Shinsato T, Miyata M, Kubozono T, Ikeda Y, Fujita S, Kuwahata S, Akasaki Y, Hamasaki S, Fujiwara H, Tei C.
    Waon therapy mobilizes CD34+ cells and improves peripheral arterial disease.
    J Cardiol. 2010; 56: 361-366.

Yuichi NINOMIYA

1. Ninomiya Y, Kawasoe S, Kubozono T, Tokushige A, Ichiki H, Miyahara H, Tokushige K, Ohishi M.
   Sex-specific relationship between abdominal obesity and new-onset atrial fibrillation in the general Japanese population.
   Heart Vessels 2021; 36: 1879-1884.
2. Ninomiya Y, Inoue K, Tanaka N, Okada M, Tanaka K, Onishi T, Hirao Y, Oka T, Inoue H, Takayasu K, Nakamaru R, Kitagaki R, Koyama Y, Okamura A, Iwakura K, Ohishi M, Fujii K.
   Absence of first-pass isolation is associated with poor pulmonary vein isolation durability and atrial fibrillation ablation outcomes.
   J Arrhythm 2021; 37: 1468-1476.
3. Okada M, Tanaka N, Oka T, Tanaka K, Ninomiya Y, Hirao Y, Yoshimoto I, Inoue H, Kitagaki R, Onishi T, Koyama Y, Okamura A.
   Clinical significance of left ventricular reverse remodeling after catheter ablation of atrial fibrillation in patients with left ventricular systolic dysfunction.
   J Cardiol 2021; 77: 500-508.
4. Tanaka N, Tanaka K, Hirao Y, Okada M, Ninomiya Y, Yoshimoto I, Onishi T, Koyama Y, Okamura A, Iwakura K, Fujii K, Sakata Y, Inoue K.
   A home sleep apnea test to screen patients with atrial fibrillation for sleep apnea prior to catheter ablation.
   Circ J 2021; 85: 252-260.
5. Oka T, Tanaka K, Ninomiya Y, Hirao Y, Tanaka N, Okada M, Inoue H, Takayasu K, Kitagaki R, Koyama Y, Okamura A, Iwakura K, Sakata Y, Fujii K, Inoue K.
   Impact of baseline left atrial function on long-term outcome after catheter ablation for paroxysmal atrial fibrillation.
   J Cardiol 2020; 75: 352-359.
6. Inoue H, Tanaka N, Tanaka K, Ninomiya Y, Hirao Y, Oka T, Okada M, Kitagaki R, Takayasu K, Koyama Y, Okamura A, Iwakura K, Fujii K, Sakata Y, Inoue K.
   Burden and long firing of premature atrial contraction early after catheter ablation predict late recurrence of atrial fibrillation.
   Circ J 2020; 84: 894-901.
7. Nakamaru R, Okada M, Tanaka N, Tanaka K, Ninomiya Y, Hirao Y, Oka T, Inoue H, Takayasu K, Koyama Y, Okamura A, Iwakura K, Rakugi H, Sakata Y, Fujii K, Inoue K.
   Outcomes after atrial fibrillation ablation in patients with premature atrial contractions originating from non-pulmonary veins.
   JACC Clin Electrophysiol 2019; 5: 1319-1327.
8. Okada M, Tanaka K, Matsunaga-Lee Y, Ninomiya Y, Hirao Y, Oka T, Tanaka N, Inoue H, Iwakura K, Fujii K, Inoue K.
   Multiple shifts of the earliest retrograde atrial activation site along the tricuspid annulus during the fast-slow form of atrioventricular nodal reentrant tachycardia by radiofrequency modification.
   Int Heart J 2019; 60: 761-767.
9. Nakamaru R, Tanaka N, Okada M, Tanaka K, Ninomiya Y, Hirao Y, Oka T, Inoue H, Koyama Y, Okamura A, Iwakura K, Rakugi H, Sakata Y, Fujii K, Inoue K.
   Usefulness of failed electrical cardioversion for early recurrence after catheter ablation for atrial fibrillation as a predictor of future recurrence.
   Am J Cardiol 2019; 123: 794-800.

Daisuke KANDA

1. Arikawa R, Kanda D, Ikeda Y, Tokushige A, Sonoda T, Anzaki K, Ohishi M.
   Prognostic impact of malnutrition on cardiovascular events in coronary artery disease patients with myocardial damage.
   BMC Cardiovasc Disord 2021; 21: 479.
2. Kanda D, Ikeda Y, Sonoda T, Tokushige A, Kosedo I, Yoshino S, Takumi T, Ohishi M.
   Malnutrition and non-use clopidogrel additively aggravate prognosis of critical limb ischemia patients who underwent revascularization.
   Circ Rep 2020; 2: 121-127.
3. Kosedo I, Tokushige A, Takumi T, Yoshikawa A, Teraguchi K, Takenouchi K, Shiraishi K, Ikeda D, Imamura M, Sonoda T, Kanda D, Ikeda Y, Ido A, Ohishi M.
   Use of proton pump inhibitors is associated with an increase in adverse cardiovascular events in patients with hemodialysis: insight from the KIDS Registry.
   Eur J Intern Med 2020; 72: 79-87.
4. Sonoda T, Takumi T, Miyata M, Kanda D, Kosedo I, Yoshino S, Ohishi M.
   Validity of a novel method for estimating low-density lipoprotein cholesterol levels incardiovascular disease patients treated with statins.
   J Atheroscler Thromb 2018; 25: 643-652.
5. Tokushige A, Miyata M, Sonoda T, Kosedo I, Kanda D, Takumi T, Kumagae Y, Fukukura Y, Ohishi M.
   Prospective study on the incidence of cerebrovascular disease after coronary angiography.
   J Atheroscler Thromb 2018; 25(3): 224-232.
6. Kanda D, Takumi T, Miyata M, Tokushige A, Sonoda T, Yoshino S, Saihara K, Ohishi M.
   Angiotensin-converting enzyme inhibitor prevents the worsening of renal function in the late phase after percutaneous coronary intervention.
   J Atheroscler Thromb 2016; 23(2): 233-240.
7. Yoshino S, Hamasaki S, Ishida S, Kataoka T, Yoshikawa A, Oketani N, Saihara K, Okui H, Shinsato T, Ichiki H, Kubozono T, Kuwahata S, Fujita S, Kanda D, Nakazaki M, Miyata M, Tei C.
   Relationship between bilirubin concentration, coronary endothelial function, and inflammatory stress in overweight patients. J Atheroscler Thromb 2011; 18: 403-412.

Yoshihisa HORIZOE

1. Horizoe Y, Takasaki K, Miyata M, Chaen H, Kubota K, Mizukami N, Yuasa T, Kisanuki A, Ohishi M.
   Analysis of biphasic right ventricular outflow doppler waveform in patients with pulmonary hypertension.
   International Heart Journal 2019; 60: 108-114.
2. Uchiyama N, Yuasa T, Miyata M, Horizoe Y, Chaen H, Kubota K, Takasaki K, Mizukami N, Kisanuki A, Ohishi M.
   Correlation of right ventricular wall stress with plasma B-type natriuretic peptide levels in patients with pulmonary hypertension.
   Circ J 2019; 83: 1278-1285.
3. Miyanaga S, Kubota K, Iwatani N, Higo K, Miyata M, Horizoe Y, Ojima S, Kawasoe S, Kubozono T, Ohishi M.
   Predictors of exercise-induced pulmonary hypertension in patients with connective tissue disease.
   Heart Vessels 2019; 34: 1509-1518.
4. Horizoe Y, Takasaki K, Miyata M, Chaen H, Kubota K, Mizukami N, Yuasa T, Kisanuki A, Ohishi M.
   Analysis of biphasic right ventricular outflow doppler waveform in patients with pulmonary hypertension.
   International Heart Journal 2019; 60: 108-114.
5. Yuasa T, Takasaki K, Mizukami N, Ueya N, Kubota K, Horizoe Y, Chaen H, Kuwahara E, Kisanuki A, Hamasaki S.
   Prosthetic tricuspid valve dysfunction assessed by three-dimensional transthracic and transesophageal echocardiography.
   J Echocardiogr 2013; 11: 97-99.
6. Takasaki K, Miyata M, Imamura M, Yuasa T, Kuwahara E, Kubota K, Kono M, Ueya N, Horizoe Y, Chaen H, Mizukami N, Kisanuki A, Hamasaki S, Tei C.
   Left ventricular dysfunction assessed by cardiac time interval analysis among different geometric patterns in untreated hypertension.
   Circ J 2012; 76: 1409-1414.

Takeshi SONODA

1. Arikawa R, Kanda D, Ikeda Y, Tokushige A, Sonoda T, Anzaki K, Ohishi M.
   Prognostic impact of malnutrition on cardiovascular events in coronary artery disease patients with myocardial damage.
   BMC Cardiovasc Disord 2021; 21: 479.
2. Kanda D, Ikeda Y, Sonoda T, Tokushige A, Kosedo I, Yoshino S, Takumi T, Ohishi M
   Malnutrition and non-use clopidogrel additively aggravate prognosis of critical limb ischemia patients who underwent revascularization.
   Circ Rep 2020; 2: 121-127.
3. Kosedo I, Tokushige A, Takumi T, Yoshikawa A, Teraguchi K, Takenouchi K, Shiraishi K, Ikeda D, Imamura M, Sonoda T, Kanda D, Ikeda Y, Ido A, Ohishi M.
   Use of proton pump inhibitors is associated with an increase in adverse cardiovascular events in patients with hemodialysis: insight from the KIDS Registry.
   Eur J Intern Med 2020; 72: 79-87.
4. Sonoda T, Takumi T, Miyata M, Kanda D, Kosedo I, Yoshino S, Ohishi M.
   Validity of a novel method for estimating low-density lipoprotein cholesterol levels incardiovascular disease patients treated with statins.
   J Atheroscler Thromb 2018; 25: 643-652.
5. Tokushige A, Miyata M, Sonoda T, Kosedo I, Kanda D, Takumi T, Kumagae Y, Fukukura Y, Ohishi M.
   Prospective study on the incidence of cerebrovascular disease after coronary angiography.
   J Atheroscler Thromb. 2018; 25: 224-232.
6. Kanda D, Takumi T, Miyata M, Tokushige A, Sonoda T, Yoshino S, Saihara K, Ohishi M.
   Angiotensin-converting enzyme inhibitor prevents the worsening of renal function in the late phase after percutaneous coronary intervention.
   Angiotensin-converting enzyme inhibitor prevents the worsening of renal function in the late phase after percutaneous coronary intervention.

Sunao MIYANAGA

1. Iwatani N, Kubota K, Ikeda Y, Tokushige A, Miyanaga S, Higo K, Ohishi M.
   Different characteristics of mitochondrial dynamics-related miRNAs on the hemodynamics of pulmonary artery hypertension and chronic thromboembolic pulmonary hypertension.
   J Cardiol 2021; 78: 24-30.
2. Miyanaga S, Kubota K, Iwatani N, Higo K, Miyata M, Horizoe Y, Ojima S, Kawasoe S, Kubozono T, Ohishi M.
   Predictors of exercise-induced pulmonary hypertension in patients with connective tissue disease.
   Heart Vessels 2019; 34: 1509-1518.
3. Higo K, Kubota K, Miyanaga S, Miyata M, Nakajo M, Jinguji M, Ohishi M.
   Impairment of iodine-123-metaiodobenzylguanidine (123I-MIBG) uptake in patients with pulmonary artery hypertension.
   Internal Heart J 2018; 59: 112-119.
4. Higo K, Kubota K, Miyanaga S, Miyata M, Nakajo M, Jinguji M, Ohishi M.
   Impairment of iodine-123-metaiodobenzylguanidine (123I-MIBG) uptake in patients with pulmonary artery hypertension.
   Internal Heart J 2018; 59: 112-119.

Research Grant List

Mitsuru OHISHI

Yoshiyuki IKEDA

Takuro KUBOZONO

Kayoko KUBOTA

Koji HIGUCHI

Hitoshi ICHIKI

Yuichi AKASAKI

Daisuke KANDA