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整形外科分野の基礎研究・臨床研究を行っています。

研究室概要

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主要研究テーマ

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客員教授

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特任准教授

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主な研究実績

小宮節郎

• Risk of low bone mineral density in patients with rheumatoid arthritis treated with biologics.
  Takahashi K, Setoguchi T, Tawaratsumida H, Arishima Y, Tominaga H, Ishidou Y, Nagano S, Shigemizu S, Aoki N, Akimoto M, Otsubo H, Matsuda T, Kakoi H, Izumi T, Nakamura S, Yokouchi M, Sunahara N, Komiya S.
  BMC Musculoskelet Disord. 2015 Sep 30;16:269. doi: 10.1186/s12891-015-0732-x.
• Enrichment of bacteria samples by centrifugation improves the diagnosis of orthopaedics-related infections via real-time PCR amplification of the bacterial methicillin-resistance gene.
  Tsuru A, Setoguchi T, Kawabata N, Hirotsu M, Yamamoto T, Nagano S, Yokouchi M, Kakoi H, Kawamura H, Ishidou Y, Tanimoto A, Komiya S.BMC Res Notes. 2015 Jul 3;8:288. doi: 10.1186/s13104-015-1180-2.
• Hairy/enhancer-of-split related with YRPW motif protein 1 promotes osteosarcoma metastasis via matrix metallopeptidase 9 expression.
  Tsuru A, Setoguchi T, Matsunoshita Y, Nagao-Kitamoto H, Nagano S, Yokouchi M, Maeda S, Ishidou Y, Yamamoto T, Komiya S.
  Br J Cancer. 2015 Mar 31;112(7):1232-40. doi: 10.1038/bjc.2015.84.
• Risk factors for venous thromboembolism after spine surgery.Tominaga H, Setoguchi T, Tanabe F, Kawamura I, Tsuneyoshi Y, Kawabata N, Nagano S, Abematsu M, Yamamoto T, Yone K, Komiya S.
  Medicine (Baltimore). 2015 Feb;94(5):e466. doi: 10.1097/MD.0000000000000466.
• Ribosomal protein S3 regulates GLI2-mediated osteosarcoma invasion.
  Nagao-Kitamoto H, Setoguchi T, Kitamoto S, Nakamura S, Tsuru A, Nagata M, Nagano S, Ishidou Y, Yokouchi M, Kitajima S, Yoshioka T, Maeda S, Yonezawa S, Komiya S.
  Cancer Lett. 2015 Jan 28;356(2 Pt B):855-61. doi: 10.1016/j.canlet.2014.10.042.
• GLI2 is a novel therapeutic target for metastasis of osteosarcoma.
  Nagao-Kitamoto H, Nagata M, Nagano S, Kitamoto S, Ishidou Y, Yamamoto T, Nakamura S, Tsuru A, Abematsu M, Fujimoto Y, Yokouchi M, Kitajima S, Yoshioka T, Maeda S, Yonezawa S, Komiya S, Setoguchi T.
  Int J Cancer. 2015 Mar 15;136(6):1276-84. doi: 10.1002/ijc.29107. Epub 2014 Aug 8.
• Metastatic bone tumors: Analysis of factors affecting prognosis and efficacy of CT and 18F-FDG PET-CT in identifying primary lesions.
  Shimada H, Setoguchi T, Yokouchi M, Sasaki H, Ishidou Y, Kawamura I, Abematsu M, Nagano S, Komiya S.
  Mol Clin Oncol. 2014 Sep;2(5):875-881. Epub 2014 Jun 23.
• Arsenic trioxide prevents osteosarcoma growth by inhibition of GLI transcription via DNA damage accumulation.
  Nakamura S, Nagano S, Nagao H, Ishidou Y, Yokouchi M, Abematsu M, Yamamoto T, Komiya S, Setoguchi T.
  PLoS One. 2013 Jul 8;8(7):e69466. doi: 10.1371/journal.pone.0069466. Print 2013.
• Pathological femoral fractures due to osteomalacia associated with adefovir dipivoxil treatment for hepatitis B: a case report.
  Tanaka M, Setoguchi T, Ishidou Y, Arishima Y, Hirotsu M, Saitoh Y, Nakamura S, Kakoi H, Nagano S, Yokouchi M, Kamizono J, Komiya S.
  Diagn Pathol. 2012 Aug 20;7:108. doi: 10.1186/1746-1596-7-108.
• RBPJ is a novel target for rhabdomyosarcoma therapy.
  Nagao H, Setoguchi T, Kitamoto S, Ishidou Y, Nagano S, Yokouchi M, Abematsu M, Kawabata N, Maeda S, Yonezawa S, Komiya S.
  PLoS One. 2012;7(7):e39268. doi: 10.1371/journal.pone.0039268. Epub 2012 Jul 9.
• Accumulation of p62 in degenerated spinal cord under chronic mechanical compression: functional analysis of p62 and autophagy in hypoxic neuronal cells.
  Tanabe F, Yone K, Kawabata N, Sakakima H, Matsuda F, Ishidou Y, Maeda S, Abematsu M, Komiya S, Setoguchi T.
  Autophagy. 2011 Dec;7(12):1462-71.
• Role of GOLPH3 and GOLPH3L in the proliferation of human rhabdomyosarcoma.
  Kunigou O, Nagao H, Kawabata N, Ishidou Y, Nagano S, Maeda S, Komiya S, Setoguchi T.
  Oncol Rep. 2011 Nov;26(5):1337-42. doi: 10.3892/or.2011.1413.
• Pharmacological inhibition of the Hedgehog pathway prevents human rhabdomyosarcoma cell growth.
  Kawabata N, Ijiri K, Ishidou Y, Yamamoto T, Nagao H, Nagano S, Maeda S, Komiya S, Setoguchi T.
  Int J Oncol. 2011 Oct;39(4):899-906. doi: 10.3892/ijo.2011.1076. Epub 2011 Jun 14.
• Role of GLI2 in the growth of human osteosarcoma.
  Nagao H, Ijiri K, Hirotsu M, Ishidou Y, Yamamoto T, Nagano S, Takizawa T, Nakashima K, Komiya S, Setoguchi T.
  J Pathol. 2011 Jun;224(2):169-79. doi: 10.1002/path.2880. Epub 2011 Apr 19.
• Suppression of osteosarcoma cell invasion by chemotherapy is mediated by urokinase plasminogen activator activity via up-regulation of EGR1.
  Matsunoshita Y, Ijiri K, Ishidou Y, Nagano S, Yamamoto T, Nagao H, Komiya S, Setoguchi T.
  PLoS One. 2011 Jan 20;6(1):e16234. doi: 10.1371/journal.pone.0016234.
• Upregulation of Notch pathway molecules in oral squamous cell carcinoma.
  Hijioka H, Setoguchi T, Miyawaki A, Gao H, Ishida T, Komiya S, Nakamura N.
  Int J Oncol. 2010 Apr;36(4):817-22.
• High mobility group box 1 is upregulated after spinal cord injury and is associated with neuronal cell apoptosis.
  Kawabata H, Setoguchi T, Yone K, Souda M, Yoshida H, Kawahara K, Maruyama I, Komiya S.
  Spine (Phila Pa 1976). 2010 May 15;35(11):1109-15.
• Mazabraud's syndrome with solitary myxoma and monostotic fibrous dysplasia.
  Arishima Y, Setoguchi T, Abematsu M, Tominaga H, Fukunaga E, Komiya S.
  J Orthop Sci. 2010 Jan;15(1):144-7. doi: 10.1007/s00776-009-1408-x.
• The knock-down of overexpressed EZH2 and BMI-1 does not prevent osteosarcoma growth.
  Sasaki H, Setoguchi T, Matsunoshita Y, Gao H, Hirotsu M, Komiya S.
  Oncol Rep. 2010 Mar;23(3):677-84.
• Smoothened as a new therapeutic target for human osteosarcoma.
  Hirotsu M, Setoguchi T, Sasaki H, Matsunoshita Y, Gao H, Nagao H, Kunigou O, Komiya S.
  Mol Cancer. 2010 Jan 12;9:5. doi: 10.1186/1476-4598-9-5.
• Tumour formation by single fibroblast growth factor receptor 3-positive rhabdomyosarcoma-initiating cells.
  Hirotsu M, Setoguchi T, Matsunoshita Y, Sasaki H, Nagao H, Gao H, Sugimura K, Komiya S.
  Br J Cancer. 2009 Dec 15;101(12):2030-7. doi: 10.1038/sj.bjc.6605407. Epub 2009 Nov 3.
• Retinal astrocyte differentiation mediated by leukemia inhibitory factor in cooperation with bone morphogenetic protein 2.
  Fukushima M, Setoguchi T, Komiya S, Tanihara H, Taga T.
  Int J Dev Neurosci. 2009 Nov;27(7):685-90. doi: 10.1016/j.ijdevneu.2009.07.006.
• Inhibition of Notch pathway prevents osteosarcoma growth by cell cycle regulation.
  Tanaka M, Setoguchi T, Hirotsu M, Gao H, Sasaki H, Matsunoshita Y, Komiya S.
  Br J Cancer. 2009 Jun 16;100(12):1957-65. doi: 10.1038/sj.bjc.6605060.

主な研究費取得状況

小宮節郎