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連携大学院である臨床情報医工学分野は、国立病院機構鹿児島医療センターで活動しています。

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鹿児島医療センター臨床研究部長

主な研究実績

城ヶ崎倫久

1. Jougasaki M, Yasue H, Okumura K, Mukoyama M, Saito Y, Nakao K, Takahashi K: Atrial natriuretic peptide in the ventricles in patients with dilated cardiomyopathy and human foetuses. Histochem J 21: 715-720, 1989
2. Jougasaki M, Yasue H, Takahashi K: Perivascular nerve lesion of the coronary artery involved in spasm in a patient with variant angina. Pathology 21: 304-307, 1989
3. Yasue H, Obata K, Okumura K, Kurose M, Ogawa H, Matsuyama K, Jougasaki M, Saito Y, Nakao K, Imura H: Increased secretion of atrial natriuretic polypeptide from the left ventricle in patients with dilated cardiomyopathy. J Clin Invest 83: 46-51, 1989
4. Kimura T, Yasue H, Sakaino M, Rokutanda M, Jougasaki M, Araki H: Effects of magnesium on the tone of isolated human coronary arteries. Circulation 79: 1118-1124, 1989
5. Naito M, Jougasaki M, Takahashi K, Matsumi S, Hattori T, Takatsuki K: Ultrastructural behavior of human immuno-deficiency virus (HIV) in multi nucleated giant cells in thebrain of a Japanese hemophiliac presenting AIDS encephalopathy. Ultrastructural Pathology 13: 433-441, 1989
6. Saito Y, Nakao K, Itoh H, Yamada T, Mukoyama M, Arai H, Hosoda K, Shirakami G, Suga S, Jougasaki M, Morichika S, Imura H: Endothelin in human plasma and culture medium of aortic endothelial cells - Detection and characterization with radioimmunoassay using monoclonal antibody. Biochem Biophys Res Commun 161: 320-326, 1989
7. Kambayashi Y, Nakao K, Itoh H, Hosoda K, Saito Y, Yamada T, Mukoyama M, Arai H, Shirakami G, Suga S, Ogawa Y, Jougasaki M, Minamino N, Kangawa K, Matsuo H, Inouye K, Imura H: Isolation and sequence determination of rat cardiac natriuretic peptide. Biochem Biophys Res Commun 163: 233-240,1989
8. Saito Y, Nakao K, Shirakami G, Jougasaki M, Yamada T, Itoh H, Mukoyama M, Arai H, Hosoda K, Suga S, Ogawa Y, Imura H: Detection and characterization of endothelin-1-like immunoreactivity in rat plasma. Biochem Biophys Res Commun 163: 1512-1516, 1989
9. Saito Y, Nakao K, Yamada T, Itoh H, Mukoyama M, Arai H, Hosoda K, Shirakami G, Suga S, Jougasaki M, Ogawa Y, Imura H: Plasma endothelin-1-like immunoreactivity level (ET-1-LI) in healthy subjects and patients with hypertension. Hypertension 14: 335-336, 1989
10. Jougasaki M, Yasue H, Mukoyama M, Nakao K, Takahashi K: Appearance of atrial natriuretic peptide in the ventricles in patients with myocardial infarction. Am Heart J 119: 92-96, 1990
11. Araki H, Nishi K, Jougasaki M: Effects of thrombus on vascular tone in rat mesenteric arteries with endothelium in vivo. Circ Res 67: 312-318, 1990
12. Mukoyama M, Nakao K, Saito Y, Ogawa Y, Hosoda K, Suga S, Shrakami G, Jougasaki M, Imura H: Increased human brain natriuretic peptide in congestive heart failure. N Engl J Med 323: 757-758, 1990
13. Mukoyama M, Nakao K, Saito Y, Ogawa Y, Hosoda K, Suga S, Shirakami G, Jougasaki M, Imura H: Human brain natriuretic peptide, a novel cardiac hormone. Lancet 335: 801-802, 1990
14. Shirakami G, Nakao K, Saito Y Magaribuchi T, Nagata H, Jougasaki M, Mukoyama M, Arai H, Hosoda K, Suga S, Ogawa Y, Mori K, Imura H: Endothelin in human cerebrospinal fluid. Ther Res 11: 85-90, 1990
15. Saito Y Nakao K, Mukoyama M, Shirakami G, Itoh H, Yamada T, Arai H, Hosoda K, Suga S, Jougasaki M, Ogawa Y, Nakajima S, Ueda M, Imura H: Application of monoclonal antibodies for endothelin to hypertensive research. Hypertension 15: 734-748, 1990
16. Ogawa Y, Nakao K, Mukoyama M, Shirakami G, Itoh H, Hosoda K, Saito Y, Arai H, Suga S, Jougasaki M, Yamada T, Kambayashi Y, Inouye K, Imura H: Rat brain natriuretic peptide - tissue distribution and molecular form - Endocrinology 126: 2225-2227, 1990
17. Shirakami G, Nakao K, Saito Y Magaribuchi T, Jougasaki M, Mukoyama M, Arai H, Hosoda K, Suga S, Ogawa Y, Yamada T, Mori K, Imura H: Acute pulmonary alveolar hypoxia increases lung and plasma endothelin-1 levels in conscious rats. Life Science 48: 969-976, 1991
18. Ogawa Y, Nakao K, Mukoyama M, Hosoda K, Shirakami G, Arai H, Saito Y, Suga S, Jougasaki M, Imura H: Natriuretic peptides as cardiac hormones in normotensive and spontaneously hypertensive rats -the ventricle is a major site of synthesis  and secretion of brain natriuretic peptide-. Circ Res 69: 491-500, 1991
19. Hosoda K, Nakao K, Mukoyama M, Saito Y, Jougasaki M, Shirakami G, Suga S, Ogawa Y, Yasue H, Imura H: Expression of brain natriuretic peptide gene in human heart -production in the ventricle-. Hypertension 17: 1152-1156, 1991
20. Mukoyama M, Nakao K, Hosoda K, Suga S, Saito Y Ogawa Y, Shirakami G, Jougasaki M, Obata K, Yasue H, Kambayashi Y, Inouye K, Imura H: Brain natriuretic peptide as a novel cardiac hormone in humans - evidence for an exquisite dual natriuretic peptide system, atrial natriuretic peptide and brain natriuretic peptide. J Clin Invest 87: 1402-1412, 1991
21. Yoshimura M, Yasue H, Morita E, Sakaino N, Jougasaki M, Kurose M, Mukoyama M, Saito Y, Nakao K, Imura H: Hemodynamic, renal, and hormonal responses to brain natriuretic peptide infusion in patients with congestive heart failure. Circulation 84: 1581-1588, 1991
22. Mukoyama M, Nakao K, Obata K, Jougasaki M, Yoshimura M, Morita E, Hosoda K, Suga S, Ogawa Y, Yasue H, Imura H: Augmented secretion of brain natriuretic peptide in acute myocardial infarction. Biochem Biophys Res Commun 180: 431-436, 1991
23. Nakao K, Mukoyama M, Hosoda K, Suga S, Ogawa Y, Saito Y, Shirakami G, Arai H, Jougasaki M, Imura H: Biosynthesis, secretion, and receptor selectivity of human brain natriuretic peptide. Can J Physiol Pharmacol 69: 1500-1506, 1991
24. Murohara T, Yasue H, Ohgushi M, Sakaino N, Jougasaki M: Age related attenuation of the endothelium dependent relaxation to noradrenaline in isolated pig coronary arteries. Cardiovasc Res 25: 1002-1009, 1991
25. Nakagawa O, Nakao K, Saito Y, Shirakami G, Jougasaki M, Mukoyama M, Hosoda K, Suga S, Ogawa Y, Kishimoto, Imura H. Isolation and characterization of porcine endothelin-like peptide. J Cardiovasc Pharmacol 7: S13-S16, 1991
26. Jougasaki M, Kugiyama K, Saito Y, Nakao K, Imura H, Yasue H: Suppression of endothelin-1 secretion by lysophosphatidylcholine in oxidized low density lipoprotein in cultured vascular endothelial cells. Circ Res 71: 614-619, 1992
27. Araki H, Muramoto J, Nishi K, Jougasaki M, Inoue M: Heparin adheres to the damaged arterial wall and inhibits its throbogenicity. Circ Res 71: 577-584, 1992
28. Nakao K, Yasue H, Fujimoto K, Jougasaki M, Yamamoto H, Hitoshi Y, Takatsu K, Miyamoto E: Increased expression and regional differences of atrial myosin light chain 1 in human ventricles with old myocardial infarction. Analysis using two monoclonal antibodies. Circulation 86: 1727-1737, 1992
29. Fujimoto K, Yasue H, Nakao K, Yamamoto H, Hitoshi Y, Jougasaki M, Okumura K, Ogawa H, Takatsu K, Miyamoto E: Novel monoclonal antibodies specific for human cardiac myosin light-chain 1: useful tools for analysis of normal and pathological hearts. J Histochem Cytochem 41: 35-42, 1993
30. Yoshimura M, Yasue H, Okumura K, Ogawa H, Jougasaki M, Mukoyama M, Nakao K, Imura H: Different secretion patterns of atrial natriuretic peptide and brain natriuretic peptide in patients with congestive heart failure. Circulation 87: 464-469, 1993
31. Morita E, Yasue H, Yoshimura M, Ogawa H, Jougasaki M, Matsumura T, Mukoyama M, Nakao K: Increased plasma levels of brain natriuretic peptide in patients with acute myocardial infarction. Circulation 87: 82-91, 1993
32. Tanaka H, Yasue H, Yoshimura M, Morita E, Jougasaki M, Kato H, Miyao Y, Nakao K: Suppression of hyperventilation-induced attacks with infusion of atrial natriuretic peptide in patients with variant angina. Am J Cardiol 72: 128-133, 1993
33. Yasue H, Yoshimura M, Sumida H, Kikuta K, Kugiyama K, Jougasaki M, Ogawa H, Okumura K, Mukoyama M, Nakao K: Localization and mechanism of secretion of B-type natriuretic peptide in comparison with those of A-type natriuretic peptide in normal subjects and patients with heart failure. Circulation 90: 195-203, 1994
34. Yoshimura M, Yasue H, Tanaka H, Kikuta K, Sumida H, Kato H, Jougasaki M, Nakao K: Responses of plasma concentrations of A type natriuretic peptide and B type natriuretic peptide to alacepril, an angiotensin-converting enzyme inhibitor, in patients with congestive heart failure. Br Heart J 72: 528-533, 1994
35. Okumura K, Yasue H, Fujii H, Kugiyama K, Matsuyama K, Yoshimura M, Jougasaki M, Kikuta K, Kato H, Tanaka H, Sumida H, Nakao K: Effects of brain (B-type) natriuretic peptide on coronary artery diameter and coronary hemodynamic variables in humans: comparison with effects on systemic hemodynamic variables. J Am Coll Cardiol 25: 342-348, 1995
36. Tabuchi T, Okumura K, Matsunaga T, Tsunoda R, Jougasaki M, Yasue H: Linear ablation of the isthmus between the inferior vena cava and tricuspid annulus for the treatment of atrial flutter. A study in the canine atrial flutter model. Circulation 92: 1312-1319, 1995
37. Jougasaki M, Wei C-M, Aarhus LL, Heublein DM, Sandberg SM, Burnett JC Jr.: Renal Localization and actions of adrenomedullin: a natriuretic peptide. Am J Physiol 268: F657-F633, 1995
38. Jougasaki M, Wei C-M, Heublein DM, Sandberg SM, Burnett JC Jr.: Immunohistochemical localization of adrenomedullin in canine heart and aorta. Peptides 16: 773-775, 1995
39. Jougasaki M, Wei C-M, McKinley LJ, Burnett JC Jr.: Elevation of circulating and ventricular adrenomedullin in human congestive heart failure. Circulation 92: 286-289, 1995
40. Jougasaki M, Rodeheffer RJ, Redfield MM, Yamamoto K, Wei C-M, McKinley LJ, Burnett JC Jr.: Cardiac secretion of adrenomedullin in human heart failure. J Clin Invest 97: 2370-2376, 1996
41. Yamamoto K, Burnett JC Jr., Jougasaki M, Nishimura RA, Bailey KR, Saito Y, Nakao K, Redfield MM: Superiority of brain natriuretic peptide as a hormonal marker of ventricular systolic and diastolic dysfunction and ventricular hypertrophy. Hypertension 28: 988-994,1996
42. Jougasaki M, Aarhus LL, Heublein DM, Sandberg SM, Burnett JC Jr. Role of prostaglandins and renal nerves in the renal actions of adrenomedullin. Am J Physiol 272: F260-F266, 1997
43. Chini EN, Chini CCS, Bolliger C, Jougasaki M, Grande JP, Burnett JC Jr, Dousa T. Cytoprotective effects of adrenomedullin in glomerular cell injury: central role of cAMP signaling pathway. Kidney International 52: 917-925, 1997
44. Jougasaki M, Stevens TL, Borgeson DD, Luchner A, Redfield MM, Burnett JC Jr. Adrenomedullin in experimental congestive heart failure: Cardiorenal activation. Am J Physiol 273: R1392-1399, 1997
45. Rasmussen TE, Jougasaki M, Supaporn T, Hallet JW Jr, Brooks DP, Burnett JC Jr. Cardiovascular actions of ET-B activation in vivo and modulation by receptor antagonism. Am J Physiol 273: R131-R138, 1997
46. Lisy O, Jougasaki M, Schirger JA, Chen HH, Barclay PT, Burnett JC Jr.: Neutral endopeptidase inhibition potentiates the natriuretic actions of adrenomedullin. Am J Physiol 275: F410-F414, 1998
47. Jougasaki M, Schirger JA, Simari RD, Burnett JC Jr.: Autocrine Role for the Endothelin-B Receptor in the Secretion of Adrenomedullin. Hypertension 32: 917-922, 1998
48. Luchner A, Burnett JC Jr., Jougasaki M, Hense H-W, Riegger G, Schunkert H: Augmentation of the cardiac natriuretic peptides by beta-receptor antagonism: Evidence from a population-based study. J Am Coll Cardiol 32: 1839-1844, 1998
49. Schirger JA, Heublein DM, Chen HH, Lisy O, Jougasaki M, Wennberg PW, Burnett JC Jr.: Presence of Dendroaspis natriuretic peptide-like immunoreactivity in human plasma and its increase during duman heart failure. Mayo Clin Proc 74: 126-130, 1999
50. Lisy O, Jougasaki M, Heublein DM, Schirger JA, Chen HH, Wennberg PW, Burnett JC Jr.: The renal actions of synthetic DNP. Kidney International 56: 502-508, 1999
51. Chen HH, Schirger JA, Chau WL, Jougasaki M, Lisy O, Redfield MM, Burnett JC Jr.: Renal response to acute neutral endopeptidase inhibition in mild and severe experimental heart failure. Circulation 100:2443-2448, 1999
52. Jougasaki M, Burnett JC Jr.: Adrenomedullin: Potential in physiology and pathophysiology. Life Science 66: 855-872, 2000
53. Schirger JA, Grantham JA, Kullo IJ, Jougasaki M, Wennberg PW, Chen HH, Lisy O, Miller V, Simari RD, Burnett JC Jr.: Vascular actions of brain natriuretic peptide: modulation by atherosclerosis and neutral endopeptidase inhibition. Journal of American College of Cardiology 35: 796-801, 2000
54. Jougasaki M, Tachibana I, Luchner A, Leskinen H, Redfield MM, Burnett JC Jr.: Augmented cardiac cardiotrophin-1 in experimental congestive heart failure. Circulation 101: 14-17, 2000
55. Jougasaki M, Burnett JC Jr.: Adrenomedullin as a renal regulator peptide. Kidney Dialysis Transplantation 15: 293-295, 2000
56. Luchner A, Burnett JC Jr., Jougasaki M, Hense H-W, Heid IM, Muders F, Riegger GAJ, Schunkert H: Evaluation of brain natriuretic peptide (BNP) as marker of left ventricular dysfunction and hypertrophy in the population. Journal of Hypertension 18: 1121-1128, 2000
57. Lisy O, Redfield MM, Jovanovic S, Jougasaki M, Jovanovic A, Leskinen h, Terzic A, Burnett JC Jr.: Mechanical unloading versus neurohumoral stimulation on myocardial structure and endocrine function in vivo. Circulation 102: 338-343, 2000
58. Yamamoto K, Burnett JC Jr., Bermudez EA, Jougasaki M, Bailey KR, Redfield MM: Clinical criteria and biochemical markers for the detection of systolic dysfunction. Journal of Cardiac Failure 6: 194-200, 2000
59. Lainchbury JG, Meyer D, Jougasaki M, Burnett JC Jr., Redfield MM: Effects of adrenomedullin on load and myocardial performance in normal and heart-failure dogs. Am J Physiol 279: H1000-H1006, 2000
60. Luchner A, Jougasaki M, Friedrich E, Borgeson DD, Stevens TL, Redfield MM, Riegger GAJ, Burnett JC Jr.: Activation of cardiorenal and pulmonary tissue endothelin-1 in experimental heart failure. American Journal of Physiology 279: R974-R979, 2000
61. Chen HH, Grantham JA, Schirger JA, Jougasaki M, Redfield MM, Burnett JC Jr.: Subcutaneous administration of brain natriuretic peptide in experimental heart failure. Journal of American College of Cardiology 36: 1706-1712, 2000
62. Jougasaki M, Burnett JC Jr.: Continuing insights into the heart as an endocrine organ: adrenomedullin and cardiac fibroblasts. Cardiovascular Research 49: 695-696, 2001
63. Jougasaki M, Heublein DM, Sandberg SM, Burnett JC Jr.: Attenuated natriuretic actions of adrenomedullin in experimental heart failure. Journal of Cardiac Failure 7: 75-83, 2001
64. Cataliotti A, Malatino L, Jougasaki M, Zoccali C, Castellino P, Giacone G, Bellanuova I, Tripepi R, Seminara G, Parlongo S, Stancanelli B, Bonanno G, Fatuzzo P, Rapisarda F, Belluardo P, Signorelli SS, Heublein DM, Lainchbury JG, Leskinen H, Bailey KR, Redfield MM  Burnett JC Jr.: Circulating natriuretic peptides in end-stage renal disease: Role for BNP as biomarker for  ventricular remodeling. Mayo Clinic Proceeding 76: 1111-1119, 2001
65. Jougasaki M, Grantham JA, Redfield MM, Burnett JC Jr.: Regulation of cardiac adrenomedullin in heart failure. Peptides  22: 1841-1850, 2001
66. Cataliotti A, Boerrigter G, Chen HH, Jougasaki M, Costello LC, Tsuruda T, Lee SC, Malatino LS, Burnett JC Jr.: Differential actions of vasopeptidase inhibition versus angiotensin-converting enzyme inhibition on diuretic therapy in experimental congestive heart failure. Circulation 105: 639-644, 2002
67. Tsuruda T, Jougasaki M, Boerrigter G, Huntley BK, Chen HH, D'Assoro AB, Lee SC, Larsen AM, Cataliotti A, Burnett JC Jr.: Cardiotrophin-1 stimulation of cardiac fibroblast growth: roles for glycoprotein 130/leukemia inhibitory factor receptor and the endothelin type A receptor. Circ Res 90: 128-134, 2002
68. Lee SC, Stevens TL, Sandberg SM, Heublein DM, Nelson SM, Jougasaki M, Redfield MM, Burnett JC Jr.: The potential of brain natriuretic peptide as a biomarker for New York Heart Association class during the outpatient treatment of heart failure. J Card Fail 8:149-54, 2002
69. Cataliotti A, Giordano M, De Pascale E, Giordano G, Castellino P, Jougasaki M, Costello LC, Boerrigter G, Tsuruda T, Belluardo P, Lee SC, Huntley B, Sandberg S, Malatino LS, Burnett JC Jr.: CNP production in the kidney and effects of protein intake restriction in nephrotic syndrome. Am J Physiol (Renal Physiol) 283:F464-72, 2002
70. Jougasaki M, Larsen AM, Cataliotti A, Christiansen DC, Burnett JC Jr.: Cardiotrophin-1 stimulates endothelin-1 via Gp130 in vascular endothelial cells. Peptides 23:1441, 2002
71. Jougasaki M, Leskinen H, Larsen AM, Cataliotti A, Chen HH, Burnett JC Jr.: Leukemia Inhibitory Factor Is Augmented in the Heart in Experimental Heart Failure. European Journal of Heart failure 5:137-145, 2003
72. Tsuruda T, Jougasaki M, Boerrigter G, Costello-Boerrigter LC, Cataliotti A, Lee SC, Salz-Gilman L, Nordstrom LJ, McGregor CG, Burnett JC Jr.: Ventricular adrenomedullin is associated with myocyte hypertrophy in human transplanted heart. Regul Pept 112:161-166, 2003
73. Jougasaki M, Leskinen H, Larsen AM, Luchner A, Cataliotti A, Tachibana I, Burnett JC Jr.: Ventricular cardiotrophin-1 activation precedes BNP in experimental heart failure. Peptides 24:889-892, 2003
74. Schirger JA, Chen HH, Jougasaki M, Lisy O, Boerrigter G, Cataliotti A, Burnett JC Jr.: Endothelin A receptor antagonism in experimental congestive heart failure results in augmentation of the renin-angiotensin system and sustained sodium retention. Circulation 109:249-254, 2004
75. Jougasaki M: Age-related cardiorenal changes and predisposition to congestive heart failure. Geriatrics & Aging 7:38-41, 2004
76. Yoshinaga M, Sameshima K, Jougasaki M, Yoshikawa H, Tanaka Y, Hashiguchi J, Tahara H, Ichiki T, Shimizu S, Nakamura K: Emergence of cardiovascular risk factors from mild obesity in Japanese elementary school children. Diabetes Care 29: 1408-1410, 2006
77. Jougasaki M: Adrenomedullin as a renal peptide. The Handbook of Biologically Active Peptides 1257-1261, 2006
78. Martin FL, Supaporn T, Chen HH, Sandberg SM, Matsuda Y, Jougasaki M, Burnett Jr JC.: Distinct roles for renal particulate and soluble guanylyl cyclases in preserving renal function in experimental acute heart failure. Am J Physiol Regul Integr Comp Physiol 293: R1580-1585, 2007
79. Buchner S, Muscholl M, Debl K, Hense HW, Doring A, Stritzke J, Schunkert H, Jougasaki M, Burnett JC Jr, Riegger GA, Luchner A: Left atrial size by planimetry is superior to M-mode diameter: biochemical calibration by atrial and brain natriuretic peptide. Am Soc Echocardiogr 21: 380-385, 2008
80. Ichiki T, Jougasaki M, Setoguchi M, Shimokawahara H, Nakashima H, Matsuoka T, Sonoda M, Nakamura K, Minagoe S, Tei C: Plasma levels of soluble glycoprotein 130 in acute myocardial infarction. J Cardiol 50: 101-109, 2007 
81. Ichiki T, Jougasaki M, Setoguchi M, Imamura J, Nakashima H, Matsuoka T, Sonoda M, Nakamura K, Minagoe S, Tei C: Cardiotrophin-1 stimulates intercellular adhesion molecule-1 and monocyte chemoattractant protein-1 in human aortic endothelial cells. Am J Physiol Heart Circ Physiol 294: H750-H763, 2008
82. Jougasaki M, Ichiki T, Takenoshita Y, Setoguchi M: Statin Suppresses Interleukin-6 – Induced Monocyte Chemoattractant Protein-1 by Inhibiting JAK/STAT Pathway in Human Vascular Endothelial Cells. Br J Pharmacol 159: 1294-1303, 2010
83. Jougasaki M: Cardiotrophin-1 in cardiovascular regulation. Adv Clin Chem 52: 41-76, 2010
84. Ichiki T, Huntley BK, Heublein DM, Sandberg SM, McKie PM, Martin FL, Jougasaki M, Burnett JC Jr: Corin is present in the normal human heart, kidney, and blood, with pro-B-type natriuretic peptide processing in the circulation. Clin Chem 57: 40-47, 2011
85. Tokito A, Jougasaki M, Ichiki T, Hamasaki S. Cardiotrophin-1 induces matrix metalloproteinase-1 in human aortic endothelial cells. PLoS One. 2013 Jul 23; 8(7): 68801
86. Shimokawahara H, Jougasaki M, Setoguchi M, Ichiki T, Sonoda M, Nuruki N, Nakashima H, Murohara T, Tsubouchi H. Relationship between vascular endothelial growth factor and left ventricular dimension in patients with acute myocardial infarction. J Cardiol 64: 360-305, 2014
87. Tokito A, Koriyama N, Ijuin A, Ogiso K, Nishio Y, Jougasaki M. Switching from sitagliptin to alogliptin under treatment with pioglitazone increases high-molecular weight adiponectin in type 2 diabetes: a prospective observational study. Journal of Diabetes Mellitus 2015 (in press)

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城ヶ崎倫久

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