Research outline


Graduate School Graduate School of Medical and Dental Sciences
Course Advanced Therapeutics Course
Field Cooperative Department of Innovative Medicine
Department Neurohumoral Biology



TEL.+81-99-223-1151 / FAX.+81-99-226-9246

Research interests

  • Pathophysiological Study of Cardiotrophin-1 in Cardiovascular Diseases
  • Pathophysiological Study of Interleukin-6 in Cardiac Myxoma
  • Pathophysiological Study of Interleukin-33 and ST2 in Cardiovascular Diseases
  • Study of Pleiotropic Effects of Statins


城ヶ崎倫久 Michihisa Jougasaki

Name Michihisa JOUGASAKI
Specialized field 循環器病学
Research interests
  • 心臓病における生理活性物質の研究
  • 心臓腫瘍における生理活性物質の研究
  • 動脈硬化における生理活性物質の研究

Research results

  1. Shimokawahara H, Jougasaki M, Setoguchi M, Ichiki T, Sonoda M, Nuruki N, Nakashima H, Murohara T, Tsubouchi H.:
    Relationship between vascular endothelial growth factor and left ventricular dimension in patients with acute myocardial infarction. J Cardiol; 64: 360-305, 2014.
  2. Tokito A, Jougasaki M, Ichiki T, Hamasaki S.:
    Cardiotrophin-1 induces matrix metalloproteinase-1 in human aortic endothelial cells. PLoS One. 2013 Jul 23; 8(7): 68801.
  3. Jougasaki M.:
    Cardiotrophin-1 in cardiovascular regulation. Adv Clin Chem 52: 41-76, 2010.
  4. Jougasaki M, Ichiki T, Takenoshita Y, Setoguchi M.:
    Statins suppress interleukin-6-induced monocyte chemo-attractant protein-1 by inhibiting Janus kinase/signal transducers and activators of transcription pathways in human vascular endothelial cells. Br J Pharmacol 159: 1294-1303, 2010.
  5. Ichiki T, Jougasaki M, Setoguchi M, Imamura J, Nakashima H, Matsuoka T, Sonoda M, Nakamura K, Minagoe S, Tei C.:
    Cardiotrophin-1 stimulates intercellular adhesion molecule-1 and monocyte chemoattractant protein-1 in human aortic endothelial cells. Am J Physiol Heart Circ Physiol 294(2): H750-H763, 2008.
  6. Jougasaki M, Leskinen H, Larsen AM, Luchner A, Cataliotti A, Tachibana I, Burnett JC Jr.:
    Ventricular cardiotrophin-1 activation precedes BNP in experimental heart failure. Peptides 24: 889-892, 2003.
  7. Jougasaki M, Leskinen H, Larsen AM, Cataliotti A, Chen HH, Burnett JC Jr.:
    Leukemia Inhibitory Factor Is Augmented in the Heart in Experimental Heart Failure. Eur J Heart fail 5: 137-145, 2003.
  8. Jougasaki M, Larsen AM, Cataliotti A, Christiansen DC, Burnett JC Jr.:
    Cardiotrophin-1 stimulates endothelin-1 via Gp130 in vascular endothelial cells. Peptides 23: 1441-1447, 2002.
  9. Jougasaki M, Grantham JA, Redfield MM, Burnett JC Jr.:
    Regulation of cardiac adrenomedullin in heart failure. Peptides 22: 1841-1850, 2001.
  10. Jougasaki M, Heublein DM, Sandberg SM, Burnett JC Jr.:
    Attenuated natriuretic actions of adrenomedullin in experimental heart failure. J Card Fail 7: 75-83, 2001.
  11. Jougasaki M, Burnett JC Jr.:
    Continuing insights into the heart as an endocrine organ: adrenomedullin and cardiac fibroblasts. Cardiovasc Res 49: 695-696, 2001.
  12. Jougasaki M, Burnett JC Jr.:
    Adrenomedullin as a renal regulator peptide. Nephrol Dial Transplant 15: 293-295, 2000.
  13. Jougasaki M, Tachibana I, Luchner A, Leskinen H, Redfield MM, Burnett JC Jr.:
    Augmented cardiac cardiotrophin-1 in experimental congestive heart failure. Circulation 101: 14-17, 2000.
  14. Jougasaki M, Burnett JC Jr.:
    Adrenomedullin: Potential in physiology and pathophysiology. Life Sci 66: 855-872, 2000.
  15. Jougasaki M, Schirger JA, Simari RD, Burnett JC Jr.:
    Autocrine Role for the Endothelin-B Receptor in the Secretion of Adrenomedullin. Hypertension 32: 917-922, 1998.
  16. Jougasaki M, Stevens TL, Borgeson DD, Luchner A, Redfield MM, Burnett JC Jr.:
    Adrenomedullin in experimental congestive heart failure: Cardiorenal activation. Am J Physiol 273: R1392-1399, 1997.
  17. Jougasaki M, Aarhus LL, Heublein DM, Sandberg SM, Burnett JC Jr.:
    Role of prostaglandins and renal nerves in the renal actions of adrenomedullin. Am J Physiol 272: F260-F266, 1997.
  18. Jougasaki M, Rodeheffer RJ, Redfield MM, Yamamoto K, Wei C-M, McKinley LJ, Burnett JC Jr.:
    Cardiac secretion of adrenomedullin in human heart failure. J Clin Invest 97: 2370-2376, 1996.
  19. Jougasaki M, Wei C-M, McKinley LJ, Burnett JC Jr.:
    Elevation of circulating and ventricular adrenomedullin in human congestive heart failure. Circulation 92: 286-289, 1995.
  20. Jougasaki M, Wei C-M, Heublein DM, Sandberg SM, Burnett JC Jr.:
    Immunohistochemical localization of adrenomedullin in canine heart and aorta. Peptides 16: 773-775, 1995.
  21. Jougasaki M, Wei C-M, Aarhus LL, Heublein DM, Sandberg SM, Burnett JC Jr.:
    Renal Localization and actions of adrenomedullin: a natriuretic peptide. Am J Physiol 268: F657-F633, 1995.
  22. Jougasaki M, Kugiyama K, Saito Y, Nakao K, Imura H, Yasue H:
    Suppression of endothelin-1 secretion by lysophosphatidylcholine in oxidized low density lipoprotein in cultured vascular endothelial cells. Circ Res 71:
  23. Jougasaki M, Yasue H, Mukoyama M, Nakao K, Takahashi K:
    Appearance of atrial natriuretic peptide in the ventricles in patients with myocardial infarction. Am Heart J 119: 92-96, 1990.
  24. Jougasaki M, Yasue H, Takahashi K:
    Perivascular nerve lesion of the coronary artery involved in spasm in a patient with variant angina. Pathology 21: 304-307, 1989.
  25. Jougasaki M, Yasue H, Okumura K, Mukoyama M, Saito Y, Nakao K, Takahashi K:
    Atrial natriuretic peptide in the ventricles in patients with dilated cardiomyopathy and human foetuses. Histochem J 21: 715-720, 1989.


  • 糖尿病患者におけるDPP-4阻害薬のスイッチングが生理活性物質に及ぼす影響の研究

Research Grant List

Project・Event / ResearchSpan
NHO指定研究 平成26年度指定研究
EBM研究 平成24年度課題
Oxygen Preconditioning prevents Contrast-Induced Nephropathy after cardiac catheterization (OPtion CIN)
EBM研究 平成24年度課題
EBM研究 平成22年度課題
観血的医療処置時の抗血栓薬の適切な管理に関する研究 Management of antithrombotic agents during surgery or other kinds of medical procedures with bleeding.