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当分野では、肝再生の分子機構の解明や肝障害に対する肝細胞増殖因子（hepatocyte growth factor：HGF）の有効性の検証など，障害肝組織の再生・修復および炎症性発癌に関する研究を行ってまいりました。近年では、消化管，胆膵疾患や腎疾患の腫瘍や慢性炎症に対する基礎、臨床研究を積極的に行っています。

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主な研究実績

井戸章雄

1. Tamai T, Oshige A, Tabu K, Tabu E, Ijyuin S, Sakae H, Onishi H, Muromachi K, Saisyoji A, Oda K, Kumagai K, Mawatari S, Moriuchi A, Sakurai K, Hori T, Ido A.Utility of percutaneous radiofrequency ablation alone or combined with transarterial chemoembolization for early hepatocellular carcinoma. Oncol Lett. 14(3): 3199-3206,2017
2. Tamai T, Kumagai　K, Sakae　H, Onishi H, Tabu K, Tabu E, Muromachi K, Saishoji A, Oda K, Mawatari S, Moriuchi A, Sakurai K, Ido A. Early sorafenib induction after transarterial chemoembolization for unresectable hepatocellular carcinoma: Can sorafenib after TACE improve loco-regional control? Mol Clin Oncol. 7(6): 1135-1141 2017
3. Tamai T,　Taniyama O, Oda K, Kasai A, Ijyuin S, Sakae H, Onishi H, Tabu K, Kumagai K, Mawatari S, Moriuchi A, Uto H, Ido A. Reduction effect of the quantity of radiation exposure and contrast media by image support system in transarterial chemoembolization for the treatment of hepatocellular carcinoma. J Gastroenterol Hepatol. 33（5）：1115-1122 2018
4. Mukaino A, Minami H, Isomoto H, Hamamoto H, Ihara E, Maeda Y, Higuchi O, Okanishi T, Kokudo Y, Deguchi K, Sasaki F, Ueki T, Murata KY, Yoshida T, Kinjyo M, Ogawa Y, Ido A, Matsuo H, Nakao K, Nakane S. Anti-ganglionic AChR antibodies in Japanese patients with motility disorders. J Gastroenterol. 53(12): 1227-1240 2018
5. Motoi S, Toyoda H, Obara T, Ohta E, Arita Y, Negishi K, Moriya K, Kuboi Y, Soejima M, Imai T, Ido A, TsubouchiH, Kawano T. Anti-Apoptotic Effects of Recombinant Human Hepatocyte Growth Factor on Hepatocytes Were Associated with Intrahepatic Hemorrhage Suppression Indicated by the Preservation of Prothrombin Time. Int J Mol Sci. 20(8): E1821 2019
6. Nishiguchi A, Sasaki F, Maeda H, Kabayama M, Ido A, Taguchi T. Multifunctional Hydrophobized Microparticles for Accelerated Wound Healing after Endoscopic Submucosal Dissection. Small 15: e1901566 2019
7. Maeda H, Sasaki F, Morinaga Y, Kabayama M, Iwaya H, Komaki Y, Arima S, Nasu Y, Tanoue S, Hashimoto S, Kanmura S, Nishiguchi A, Taguchi T, Ido A. Covering post-endoscopic submucosal dissection ulcers in miniature swine with hexanoyl (Hx:C6) group–modified alkaline-treated gelatin porous film (HAG) induces proper healing by decreasing inflammation and fibrosis. Digestion 22:(1-13) 2020
8. Nishikoba N, Kumagai K, Kanmura S, Nakamura Y, Ono M, Eguchi H, Kamibayashiyama T, Oda K, Mawatari S, Tanoue S, Hashimoto S, Tsubouchi H, Ido A. HGF-MET signaling shifts M1 macrophages towards an M2-like phenotype through PI3K-mediated induction of Arginase-1 expression. Frontiers in immunology IN PRESS 2020

上村修司

1. Kanmura S, Hamamoto H, Morinaga Y, Oda K, Fujita T, Arima S, Nasu Y, Sasaki F, Hashimoto S, Taguchi H, Setoyama H, Ido AFecal Human Neutrophil Peptide Levels Correlate with Intestinal Inflammation in Ulcerative Colitis.　Digestion.　 93(4):300-308、2016
2. Kanmura S,　Hamamoto H, Tanaka A, Arima S, Sasaki F, Tanoue S, Nasu Y, Hashimoto S, Higashi M, Ido A. Diagnostic utility of linked color imaging in the evaluation of colonic mucosal inflammation in ulcerative colitis: a pilot study. Endosc Int Open. 7(8): E937-E943 2019
3. Ibusuki K, Sakiyama T, Kanmura S, Maeda T, Iwashita Y, Nasu Y, Sasaki F, Taguchi H, Hashimoto S, Numata M, Uto H, Tsubouchi H, Ido A. Human neutrophil peptides induce interleukin-8 in intestinal epithelial cells through the P2 receptor and ERK1/2 signaling pathways. Int J Mol Med 35(6): 1603-1609 2015
4. Maeda T, Sakiyama T, Kanmura S, Hashimoto S, Ibusuki K, Tanoue S, Komaki Y, Arima S, Nasu Y, Sasaki F, Taguchi H, Numata M, Uto H, Tsubouchi H, Ido A. Int J Mol Med. 1777-1785 2016
5. Ono Y, Kanmura S, Morinaga Y, Oda K, Kawabata K, Arima S, Sasaki F, Nasu Y, Tanoue S, Hashimoto S, Taguchi H, Uto H, Tsubouchi H, Ido A The utility of apoptosis inhibitor of macrophages as a possible diagnostic marker in patients with Crohn’s disease BMC Gastroenterol 17（1）： 40 2017
6. Kawabata K, Kanmura S, Morinaga Y, Tanaka A, Makino T, Fujita T, Arima S, Sasaki F, Nasu Y, Tanoue S, Hashimoto S, Ido A. A high‑fructose diet induces epithelial barrier dysfunction and exacerbates the severity of dextran sulfate sodium‑induced colitis. Int J Mol Med 43(3): 1487-1496 2018
7. Hiraishi N, Kanmura S, Oda K, Arima S, Kumagai K, Mawatari S, Tanoue S, Sasaki F, Hashimoto S, Ido A. Extract of Lactobacillus plantarum strain 06CC2 induces JNK/p38 MAPK pathway-mediated apoptosis through endoplasmic reticulum stress in Caco2 colorectal cancer cells. Biochem Biophys Rep. 100691 2019
8. Tanaka A, Kanmura S, Morinaga Y, Kawabata K, Arima S, Sasaki F, Nasu Y, Tanoue S, Hashimoto S, Takeshita M, Takeda S, Ido A. Oral administration of Lactobacillus plantarum arum 06CC2 prevents experimental colitis in mice via an anti‑inflammatory response. Mol Med Rep. 1181-1191 2019

田ノ上史郎

1. Kanmura S, Tanaka A, Yutsudou K, Kuwazuru K, Komaki F, Komaki Y, Iwaya H, Arima S, Sasaki F, Tanoue S, Hashimoto S, Ido A. Significance of Linked Color Imaging for Predicting the Risk of Clinical Relapse in Ulcerative Colitis. Gastroenterol Res Pract. 2020 Mar 6;2020:3108690. doi: 10.1155/2020/3108690.
2. Kamikihara Y, Tanoue S, Kawahira M, Iwaya H, Arima S, Sasaki F, Nasu Y, Hashimoto S, Kanmura S, Higashi M, Gejima K, Ido A. A case of gallbladder neuroendocrine carcinoma diagnosed preoperatively using somatostatin receptor scintigraphy. Oncol Lett. 2020 Jan;19(1):247-254. doi: 10.3892/ol.2019.11101. Epub 2019 Nov 14.
3. Hiraishi N, Kanmura S, Oda K, Arima S, Kumagai K, Mawatari S, Tanoue S, Sasaki F, Hashimoto S, Ido A. Extract of Lactobacillus plantarum strain 06CC2 induces JNK/p38 MAPK pathway-mediated apoptosis through endoplasmic reticulum stress in Caco2 colorectal cancer cells. Biochem Biophys Rep. 2019 Oct 3;20:100691.
4. Komaki Y, Kanmura S, Sasaki F, Maeda H, Oda K, Arima S, Tanoue S, Nasu Y, Hashimoto S, Mawatari S, Tsubouchi H, Ido A. Hepatocyte Growth Factor Facilitates Esophageal Mucosal Repair and Inhibits the Submucosal Fibrosis in a Rat Model of Esophageal Ulcer. Digestion. 2018 Sep 18:1-12.
5. Tanoue S, Kaplan DE. CD14(+) regulatory dendritic cells in patients with hepatocellular carcinoma and cirrhosis. Hepatology. 2016 Apr;63(4):1391-2.
6. Tanoue S, Chang LY, Li Y, Kaplan DE. Monocyte-derived dendritic cells from cirrhotic patients retain similar capacity for maturation/activation and antigen presentation as those from healthy subjects. Cell Immunol. 2015 May;295(1):36-45.
7. Doi H, Tanoue S, Kaplan DE. Peripheral CD27-CD21- B-cells represent an exhausted lymphocyte population in hepatitis C cirrhosis. Clin Immunol. 2014 Feb;150(2):184-91.
8. Tanoue S, Uto H, Kumamoto R, Arima S, Hashimoto S, Nasu Y, Takami Y, Moriuchi A, Sakiyama T, Oketani M, Ido A, Tsubouchi H. Liver regeneration after partial hepatectomy in rat is more impaired in a steatotic liver induced by dietary fructose compared to dietary fat. Biochem Biophys Res Commun. 2011 Apr 1;407(1):163-8.

馬渡誠一

1. Mawatari S,Uto H, Ido A, Nakashima K, Suzuki T, Kanmura S, Kumagai K, Oda K, Tabu K, Tamai T, Moriuchi A, Oketani M, Shimada Y, Sudoh M, Shoji I, Tsubouchi H. Hepatitis C virus NS3/4A Protease Inhibits Complement Activation by Cleaving Complement Component 4. PLoS One　8(12)　 e82094　2013
2. Mawatari S, Uto H, Moriuchi A, Tabu K, Muromachi K, Tabu E, Oda K, Imanaka D, Oshige A, Nakazawa J, Kumagai K, Tamai T, Okamoto H, Tsubouchi H, Ido A. Horizontal transmission of de novo hepatitis B between spouses: A case report. Hepatol Res 45(8): 933-938 2015
3. Mawatari S, Oda K, Tabu K, Ijuin S, Kumagai K, Inada Y, Uto H, Hiramine Y, Kure T, Fujisaki K, Hashiguchi M, Hori T, Oshige A, Imanaka D, Saishoji A, Taniyama O, Sakae H, Tamai T, Moriuchi A, Ido A. New resistance-associated substitutions and failure of dual oral therapy with daclatasvir and asunaprevir. J Gastroenterol. 52(7): 855-867 2017
4. Mawatari S, Moriuchi A, Ohba F, Kawano T, Oda K,Takikawa Y, Takikawa H, Ido A, Tsubouchi H. The recovery of the PT-INR to less than 1.3 predicts survival in patients with severe acute liver injury. J Gastroenterol. 53(7): 861-872 2018
5. Mawatari S, Oda K, Tabu K, Ijuin S, Kumagai K, Fujisaki K, Hashiguchi M, Inada Y, Uto H, Hiramine Y, Kure T, Hori T, Taniyama O, Kasai A, Tamai T, Moriuchi A, Ido A. The co-existence of NS5A and NS5B resistance-associated substitutions is associated with virologic failure in Hepatitis C Virus genotype 1 patients treated with sofosbuvir and ledipasvir. PLoS One. 13(6): e0198642 2018
6. Kure T, Mawatari S, Imamura Y, Oda K, Kumagai K, Hiramine Y, Miyahara H, Kanmura S, Moriuchi A, Uto H, Horiuchi M, Ido A. Nonalcoholic fatty liver disease is associated with both subcutaneous and visceral adiposity -A cross-sectional study-Medicine (Baltimore). 98(46): e17879. 2019
7. Tabu K, Mawatari S, Oda K, Kumagai K, Inada Y, Uto H, Saisyoji A, Hiramine Y, Hashiguchi M, Tamai T, Hori T, Fujisaki K, Imanaka D, Kure T, Taniyama O, Toyodome A, Ijuin S, Sakae H, Sakurai K, Moriuchi A, Kanmura S, Ido A. Hypovascular tumors developed into hepatocellular carcinoma at a high rate despite the elimination of hepatitis C virus by direct-acting antivirals. PLoS One. 15(8): e0237475 2020
8. Mawatari S, Oda K, Kumagai K, Tabu K, Ijuin S, Fujisaki K, Inada Y, Uto H, Saisyoji A, Hiramine Y, Hori T, Taniyama O, Toyodome A, Sakae H, Hashiguchi M, Kure T, Sakurai K, Tamai T, Moriuchi A, Ido A. Viral and host factors are associated with retreatment failure in hepatitis C patients receiving all-oral direct antiviral therapy Hepatol Res. 50(4) 453-465 2020

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