研究テーマ(研究室紹介)

消化器疾患・生活習慣病学イメージ

当分野では、肝再生の分子機構の解明や劇症肝炎に対する肝細胞増殖因子(hepatocyte growth factor:HGF)の臨床応用(トランスレーショナルリサーチ)を目指しております。さらに omics 研究による消化器および腎疾患の病態解明と新規分子マーカーを探索を行なっております。最近では、消化器疾患における自然免疫と障害組織の再生・修復および炎症性発癌に関する研究、生活習慣病と肝疾患の研究、腸内細菌の腸管炎症における影響の研究を行っています。

研究室概要

部局 大学院医歯学総合研究科 Graduate School of Medical and Dental Sciences
専攻 健康科学専攻 Health Research Course
大講座 人間環境学 Human and Environmental Sciences
分野 消化器疾患・生活習慣病学 Digestive and Lifestyle Diseases
分野サイト http://www.kufm.kagoshima-u.ac.jp/~intmed2/

分野サイト

連絡先

TEL.099-275-5326 / FAX.099-264-3504

主要研究テーマ

内科学 Internal Medicine
肝臓病学 Hepatology
消化器病学 Gastroenterology
腎臓病学 Nephrology

スタッフ

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教授
氏名 井戸章雄 Akio IDO
専門分野 消化器病学、肝臓病学
研究テーマ 肝再生、肝発癌、消化管粘膜の再生・修復

研究者総覧 リポジトリ


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講師
氏名 森内昭博 Akihiro MORIUCHI
専門分野  
研究テーマ  

研究者総覧 リポジトリ


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助教
氏名 橋元慎一 Shinichi HASHIMOTO
専門分野 消化器病学、胆膵疾患
研究テーマ 超音波内視鏡診断、治療

研究者総覧 リポジトリ


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助教
氏名 馬渡誠一 Seiichi MAWATARI
専門分野 消化器病学、肝臓病学
研究テーマ 非アルコール性脂肪性肝疾患の病態解明

研究者総覧 リポジトリ

主な研究実績

井戸章雄
  1. Mera K, Uto H, Mawatari S, Ido A, Yoshimine Y, Nosaki T, Oda K, Tabu K, Kumagai K, Tamai T, Moriuchi A, Oketani M, Shimada Y, Hidaka M, Eguchi S, Tsubouchi H. Serum levels of apoptosis inhibitor of macrophage are associated with hepatic fibrosis in patients with chronic hepatitis C. BMC Gastroenterol 14: 27 2014.2
  2. Imamura Y, Uto H, Hiramine Y, Hosoyamada K, Ijuin S, Yoshifuku S, Miyahara H, Maenohara S, Oketani M, Ido A, Tsubouchi H. Increasing prevalence of diabetes mellitus in association with fatty liver in a Japanese population. J Gastroenterol 49(10):1406-1413; 2014.
  3. Oda K, Uto H, Kumagai K, Ido A, Kusumoto K, Shimoda K, Hayashi K, Stuver SO, Tanaka Y, Nishida N, Tokunaga K, Tsubouchi H. Impact of a single nucleotide polymorphism upstream of the IL28B gene in patients positive for anti-HCV antibody in an HCV hyperendemic area in Japan. J Med Virol. 86(11): 1877-85; 2014.
  4. Tokunaga M, Uto H, Oda K, Tokunaga M, Mawatari S, Kumagai K, Haraguchi K, Oketani M, Ido A, Ohnou N, Utsunomiya A, Tsubouchi H. Influence of human T-lymphotropic virus type 1 coinfection on the development of hepatocellular carcinoma in patients with hepatitis C virus infection. J Gastroenterol 49(12): 1567-1577; 2014.
  5. Funakawa K, Uto H, Sasaki F, Nasu Y, Mawatari S, Arima S, Nakazawa J, Taguchi H, Hashimoto S, Kanmura S, Setoyama H, Numata M, Tsubouchi H, Ido A. Effect of endoscopic submucosal dissection for superficial esophageal neoplasms and risk factors for postoperative stricture. Medicine (Baltimore) 94(1): e373; 2015
  6. Oda K, Uto H, Mawatari S, Ido A. Clinical features of hepatocellular carcinoma associated with nonalcoholic fatty liver disease: a review of human studies. Clin J Gastroenterol. 8(1): 1-9; 2015.
  7. Makino T, Kanmura S, Sasaki F, Nasu Y, Funakawa K, Tanaka A, Arima S, Nakazawa J, Taguchi H, Hashimoto S, Numata M, Uto H, Tsubouchi H, Ido A. Preoperative classification of submucosal fibrosis in colorectal laterally spreading tumors by endoscopic ultrasonography Endoscopy Inernational Open. 03: E1-E5; 2015.
  8. Sasaki F, Kumagai K, Uto H, Takami Y, Kure T, Tabu K, Nasu Y, Hashimoto S, Kanmura S, Numata M, Moriuchi A, Sakiyama T, Tsubouchi H, Ido A Expression of glycoprotein nonmetastatic melanoma protein B in macrophages infiltrating injured mucosa is associated with severity of experimental colitis in mice. Molecular Medicine Reports in press

橋元慎一
  1. Nasu Y, Ido A, Tanoue S, Hashimoto S, Sasaki F, Kanmura S, Setoyama H, Numata M, Funakawa K, Moriuchi A, Fujita H, Sakiyama T, Uto H, Oketani M, Tsubouchi H. Hepatocyte growth factor stimulates the migration of gastric epithelial cells by altering the subcellular localization of the tight junction protein ZO-1. J Gastroenterol.48(2):193-202,2013;Feb
  2. Kanno Y, Ito K, Fujita N, Noda Y, Kobayashi G, Horaguchi J, Koshita S, Ogawa T, Masu K, Hirasawa D, Sugawara T, Koike Y, Hashimoto S, Ishii S. Efficacy and safety of a WallFlex enteral stent for malignant gastric obstruction. Dig Endosc. 25(4):386-91, 2013; Jul
  3. Noda Y, Fujita N, Kobayashi G, Ito K, Horaguchi J, Hashimoto S, Koshita S, Ishii S, Kanno Y, Ogawa T, Masu K, Tsuchiya T, Oikawa M, Honda H, Sawai T, Uzuki M, Fujishima F. Prospective randomized controlled study comparing cell block method and conventional smear method for bile cytology. Dig Endosc. 25(4): 444-452, 2013
  4. Ito K, Horaguchi J, Fujita N, Noda Y, Kobayashi G, Koshita S, Kanno Y, Ogawa T, Masu K, Hashimoto S.Clinical usefulness of double-guidewire technique for difficult biliary cannulation in endoscopic retrograde cholangiopancreatography. Dig Endosc. 26(3): 442-449, 2014
  5. Funakawa K, Uto H, Sasaki F, Nasu Y, Mawatari S, Arima S, Nakazawa J, Taguchi H, Hashimoto S, Kanmura S, Setoyama H, Numata M, Tsubouchi H, Ido A. Effect of endoscopic submucosal dissection for superficial esophageal neoplasms and risk factors for postoperative stricture. Medicine. 94(1): e373, 2015
  6. Ibusuki K, Sakiyama T, Kanmura S, Maeda T, Iwashita Y, Nasu Y, Sasaki F, Taguchi H, Hashimoto S, Numata M, Uto H, Tsubouchi H, Ido A. Human neutrophil peptides induce interleukin-8 in intestinal epithelial cells through the P2 receptor and ERK1/2 signaling pathways. Int J Mol Med. 35(6):1603-1609. 2015.
  7. Higashi M, Yokoyama S, Yamamoto T, Goto Y, Kitazono I, Hiraki T, Taguchi H, Hashimoto S, Fukukura Y, Koriyama C, Mataki Y, Maemura K, Shinchi H, Jain M, Batra SK, Yonezawa S. Mucin Expression in Endoscopic Ultrasound-Guided Fine-Needle Aspiration Specimens Is a Useful Prognostic Factor in Pancreatic Ductal Adenocarcinoma. Pancreas. 44(5):728-34. 2015
  8. Makino T, Kanmura S, Sasaki F, Nasu Y, Funakawa K, Tanaka A, Arima S, Nakazawa J, Taguchi H, Hashimoto S, Numata M, Uto H, Tsubouchi H, Ido A. Preoperative classification of submucosal fibrosis in colorectal laterally spreading tumors by endoscopic ultrasonography. Endosc Int Open. 2015 Aug;3(4):E363-7.

馬渡誠一
  1. Ibusuki R, Uto H*, Arima S, Mawatari S, Setoguchi Y, Iwashita Y, Hashimoto S, Maeda T, Tanoue S, Kanmura S, Oketani M, Ido A, Tsubouchi H. Transgenic expression of human neutrophil peptide-1 enhances hepatic fibrosis in mice fed a choline-deficient, L-amino acid-defined diet. Liver Int.;33(10):1549-56. 2013.
  2. Kumamoto R, Uto H*, Oda K, Ibusuki R, Tanoue S, Arima S, Mawatari S, Kumagai K, Numata M, Tamai T, Moriuchi A, Fujita H, Oketani M, Ido A, Tsubouchi H. Dietary fructose enhances the incidence of precancerous hepatocytes induced by administration of diethylnitrosamine in rat. Eur J Med Res. 18:54. 2013.
  3. Mawatari S, Uto H*, Ido A, Nakashima K, Suzuki T, Kanmura S, Kumagai K, Oda K, Tabu K, Tamai T, Moriuchi A, Oketani M, Shimada Y, Sudoh M, Shoji I, Tsubouchi H. Hepatitis C Virus NS3/4A Protease Inhibits Complement Activation by Cleaving Complement Component 4. PLoS One. 8(12):e82094. 2013.
  4. Arima S, Uto H*, Ibusuki R, Kumamoto R, Tanoue S, Mawatari S, Oda K, Numata M, Fujita H, Oketani M, Ido A, Tsubouchi H. Hypertension exacerbates liver injury and hepatic fibrosis induced by a choline-deficient L-amino acid-defined diet in rats. Int J Mol Med. 33(1):68-76. 2014.
  5. Mera K, Uto H*, Mawatari S, Ido A, Yoshimine Y, Nosaki T, Oda K, Tabu K, Kumagai K, Tamai T, Moriuchi A, Oketani M, Shimada Y, Hidaka M, Eguchi S, Tsubouchi H. Serum levels of apoptosis inhibitor of macrophage are associated with hepatic fibrosis in patients with chronic hepatitis C BMC Gastroenterol.;14(1):27.2014.
  6. Tokunaga M, Uto H*, Oda K, Tokunaga M, Mawatari S, Kumagai K, Haraguchi K, Oketani M, Ido A, Ohnou N, Utsunomiya A, Tsubouchi H. Influence of human T-lymphotropic virus type 1 coinfection on the development of hepatocellular carcinoma in patients with hepatitis C virus infection. J Gastroenterol. 49(12):1567-77.2014
  7. Funakawa K, Uto H*, Sasaki F, Nasu Y, Mawatari S, Arima S, Nakazawa J, Taguchi H, Hashimoto S, Kanmura S, Setoyama H, Numata M, Tsubouchi H, Ido A. Effect of Endoscopic Submucosal Dissection for Superficial Esophageal Neoplasms and Risk Factors for Postoperative Stricture. Medicine (Baltimore). 94(1):e373.2015.
  8. Yoshimine Y, Uto H*, Kumagai K, Mawatari S, Arima S, Ibusuki R, Mera K, Nosaki T, Kanmura S, Numata M, Tamai T, Moriuchi A, Tsubouchi H, Ido A. Hepatic expression of the Sptlc3 subunit of serine palmitoyltransferase is associated with the development of hepatocellular carcinoma in a mouse model of nonalcoholic steatohepatitis. Oncol Rep. 2015;33(4):1657-66.

分野サイト

新ニーズに対応する九州がんプロ養成プラン
GPなど(医歯学)
鹿児島大学
鹿児島大学病院
附属施設等
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