FIELD

Research outline

消化器疾患・生活習慣病学イメージ

Graduate School Graduate School of Medical and Dental Sciences
Course Health Research Course
Field Human and Environmental Sciences
Department Digestive and Lifestyle Diseases
Homepage http://www.kufm.kagoshima-u.ac.jp/~intmed2/

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Contact

TEL.+81-99-275-5326 / FAX.+81-99-264-3504

Research interests

  • Internal Medicine
  • Hepatology
  • Gastroenterology
  • Nephrology

Staff

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Professor
Name Akio IDO
Specialized field Gastroenterology、Hepatology
Research interests 肝再生、肝発癌、消化管粘膜の再生・修復

Researcher Repository


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Lecturer
Name Akihiro MORIUCHI
Specialized field  
Research interests  

Researcher Repository


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Assistant Professor
Name Shinichi HASHIMOTO
Specialized field Gastroenterology、胆膵疾患
Research interests 超音波内視鏡診断、治療

Researcher Repository


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Assistant Professor
Name Seiichi MAWATARI
Specialized field Gastroenterology、Hepatology
Research interests 非アルコール性脂肪性肝疾患の病態解明

Researcher Repository

Research results

Akio IDO
  1. Mera K, Uto H, Mawatari S, Ido A, Yoshimine Y, Nosaki T, Oda K, Tabu K, Kumagai K, Tamai T, Moriuchi A, Oketani M, Shimada Y, Hidaka M, Eguchi S, Tsubouchi H. Serum levels of apoptosis inhibitor of macrophage are associated with hepatic fibrosis in patients with chronic hepatitis C. BMC Gastroenterol 14: 27 2014.2
  2. Imamura Y, Uto H, Hiramine Y, Hosoyamada K, Ijuin S, Yoshifuku S, Miyahara H, Maenohara S, Oketani M, Ido A, Tsubouchi H. Increasing prevalence of diabetes mellitus in association with fatty liver in a Japanese population. J Gastroenterol 49(10):1406-1413; 2014.
  3. Oda K, Uto H, Kumagai K, Ido A, Kusumoto K, Shimoda K, Hayashi K, Stuver SO, Tanaka Y, Nishida N, Tokunaga K, Tsubouchi H. Impact of a single nucleotide polymorphism upstream of the IL28B gene in patients positive for anti-HCV antibody in an HCV hyperendemic area in Japan. J Med Virol. 86(11): 1877-85; 2014.
  4. Tokunaga M, Uto H, Oda K, Tokunaga M, Mawatari S, Kumagai K, Haraguchi K, Oketani M, Ido A, Ohnou N, Utsunomiya A, Tsubouchi H. Influence of human T-lymphotropic virus type 1 coinfection on the development of hepatocellular carcinoma in patients with hepatitis C virus infection. J Gastroenterol 49(12): 1567-1577; 2014.
  5. Funakawa K, Uto H, Sasaki F, Nasu Y, Mawatari S, Arima S, Nakazawa J, Taguchi H, Hashimoto S, Kanmura S, Setoyama H, Numata M, Tsubouchi H, Ido A. Effect of endoscopic submucosal dissection for superficial esophageal neoplasms and risk factors for postoperative stricture. Medicine (Baltimore) 94(1): e373; 2015
  6. Oda K, Uto H, Mawatari S, Ido A. Clinical features of hepatocellular carcinoma associated with nonalcoholic fatty liver disease: a review of human studies. Clin J Gastroenterol. 8(1): 1-9; 2015.
  7. Makino T, Kanmura S, Sasaki F, Nasu Y, Funakawa K, Tanaka A, Arima S, Nakazawa J, Taguchi H, Hashimoto S, Numata M, Uto H, Tsubouchi H, Ido A. Preoperative classification of submucosal fibrosis in colorectal laterally spreading tumors by endoscopic ultrasonography Endoscopy Inernational Open. 03: E1-E5; 2015.
  8. Sasaki F, Kumagai K, Uto H, Takami Y, Kure T, Tabu K, Nasu Y, Hashimoto S, Kanmura S, Numata M, Moriuchi A, Sakiyama T, Tsubouchi H, Ido A Expression of glycoprotein nonmetastatic melanoma protein B in macrophages infiltrating injured mucosa is associated with severity of experimental colitis in mice. Molecular Medicine Reports in press

Shinichi HASHIMOTO
  1. Nasu Y, Ido A, Tanoue S, Hashimoto S, Sasaki F, Kanmura S, Setoyama H, Numata M, Funakawa K, Moriuchi A, Fujita H, Sakiyama T, Uto H, Oketani M, Tsubouchi H. Hepatocyte growth factor stimulates the migration of gastric epithelial cells by altering the subcellular localization of the tight junction protein ZO-1. J Gastroenterol.48(2):193-202,2013;Feb
  2. Kanno Y, Ito K, Fujita N, Noda Y, Kobayashi G, Horaguchi J, Koshita S, Ogawa T, Masu K, Hirasawa D, Sugawara T, Koike Y, Hashimoto S, Ishii S. Efficacy and safety of a WallFlex enteral stent for malignant gastric obstruction. Dig Endosc. 25(4):386-91, 2013; Jul
  3. Noda Y, Fujita N, Kobayashi G, Ito K, Horaguchi J, Hashimoto S, Koshita S, Ishii S, Kanno Y, Ogawa T, Masu K, Tsuchiya T, Oikawa M, Honda H, Sawai T, Uzuki M, Fujishima F. Prospective randomized controlled study comparing cell block method and conventional smear method for bile cytology. Dig Endosc. 25(4): 444-452, 2013
  4. Ito K, Horaguchi J, Fujita N, Noda Y, Kobayashi G, Koshita S, Kanno Y, Ogawa T, Masu K, Hashimoto S.Clinical usefulness of double-guidewire technique for difficult biliary cannulation in endoscopic retrograde cholangiopancreatography. Dig Endosc. 26(3): 442-449, 2014
  5. Funakawa K, Uto H, Sasaki F, Nasu Y, Mawatari S, Arima S, Nakazawa J, Taguchi H, Hashimoto S, Kanmura S, Setoyama H, Numata M, Tsubouchi H, Ido A. Effect of endoscopic submucosal dissection for superficial esophageal neoplasms and risk factors for postoperative stricture. Medicine. 94(1): e373, 2015
  6. Ibusuki K, Sakiyama T, Kanmura S, Maeda T, Iwashita Y, Nasu Y, Sasaki F, Taguchi H, Hashimoto S, Numata M, Uto H, Tsubouchi H, Ido A. Human neutrophil peptides induce interleukin-8 in intestinal epithelial cells through the P2 receptor and ERK1/2 signaling pathways. Int J Mol Med. 35(6):1603-1609. 2015.
  7. Higashi M, Yokoyama S, Yamamoto T, Goto Y, Kitazono I, Hiraki T, Taguchi H, Hashimoto S, Fukukura Y, Koriyama C, Mataki Y, Maemura K, Shinchi H, Jain M, Batra SK, Yonezawa S. Mucin Expression in Endoscopic Ultrasound-Guided Fine-Needle Aspiration Specimens Is a Useful Prognostic Factor in Pancreatic Ductal Adenocarcinoma. Pancreas. 44(5):728-34. 2015
  8. Makino T, Kanmura S, Sasaki F, Nasu Y, Funakawa K, Tanaka A, Arima S, Nakazawa J, Taguchi H, Hashimoto S, Numata M, Uto H, Tsubouchi H, Ido A. Preoperative classification of submucosal fibrosis in colorectal laterally spreading tumors by endoscopic ultrasonography. Endosc Int Open. 2015 Aug;3(4):E363-7.

Seiichi MAWATARI
  1. Ibusuki R, Uto H*, Arima S, Mawatari S, Setoguchi Y, Iwashita Y, Hashimoto S, Maeda T, Tanoue S, Kanmura S, Oketani M, Ido A, Tsubouchi H. Transgenic expression of human neutrophil peptide-1 enhances hepatic fibrosis in mice fed a choline-deficient, L-amino acid-defined diet. Liver Int.;33(10):1549-56. 2013.
  2. Kumamoto R, Uto H*, Oda K, Ibusuki R, Tanoue S, Arima S, Mawatari S, Kumagai K, Numata M, Tamai T, Moriuchi A, Fujita H, Oketani M, Ido A, Tsubouchi H. Dietary fructose enhances the incidence of precancerous hepatocytes induced by administration of diethylnitrosamine in rat. Eur J Med Res. 18:54. 2013.
  3. Mawatari S, Uto H*, Ido A, Nakashima K, Suzuki T, Kanmura S, Kumagai K, Oda K, Tabu K, Tamai T, Moriuchi A, Oketani M, Shimada Y, Sudoh M, Shoji I, Tsubouchi H. Hepatitis C Virus NS3/4A Protease Inhibits Complement Activation by Cleaving Complement Component 4. PLoS One. 8(12):e82094. 2013.
  4. Arima S, Uto H*, Ibusuki R, Kumamoto R, Tanoue S, Mawatari S, Oda K, Numata M, Fujita H, Oketani M, Ido A, Tsubouchi H. Hypertension exacerbates liver injury and hepatic fibrosis induced by a choline-deficient L-amino acid-defined diet in rats. Int J Mol Med. 33(1):68-76. 2014.
  5. Mera K, Uto H*, Mawatari S, Ido A, Yoshimine Y, Nosaki T, Oda K, Tabu K, Kumagai K, Tamai T, Moriuchi A, Oketani M, Shimada Y, Hidaka M, Eguchi S, Tsubouchi H. Serum levels of apoptosis inhibitor of macrophage are associated with hepatic fibrosis in patients with chronic hepatitis C BMC Gastroenterol.;14(1):27.2014.
  6. Tokunaga M, Uto H*, Oda K, Tokunaga M, Mawatari S, Kumagai K, Haraguchi K, Oketani M, Ido A, Ohnou N, Utsunomiya A, Tsubouchi H. Influence of human T-lymphotropic virus type 1 coinfection on the development of hepatocellular carcinoma in patients with hepatitis C virus infection. J Gastroenterol. 49(12):1567-77.2014
  7. Funakawa K, Uto H*, Sasaki F, Nasu Y, Mawatari S, Arima S, Nakazawa J, Taguchi H, Hashimoto S, Kanmura S, Setoyama H, Numata M, Tsubouchi H, Ido A. Effect of Endoscopic Submucosal Dissection for Superficial Esophageal Neoplasms and Risk Factors for Postoperative Stricture. Medicine (Baltimore). 94(1):e373.2015.
  8. Yoshimine Y, Uto H*, Kumagai K, Mawatari S, Arima S, Ibusuki R, Mera K, Nosaki T, Kanmura S, Numata M, Tamai T, Moriuchi A, Tsubouchi H, Ido A. Hepatic expression of the Sptlc3 subunit of serine palmitoyltransferase is associated with the development of hepatocellular carcinoma in a mouse model of nonalcoholic steatohepatitis. Oncol Rep. 2015;33(4):1657-66.

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