• Research outline
• Research interests
• Staff
• Research results
• Collaborations
• Research Grant List

Research outline

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Research interests

• Experimental studies on the relationship between oral bacteria and systemic diseases
• Interaction between oral bacteria and salivary proteins
• Relationship between general and oral health condition in community-dwelling populations
• Behavioral science on oral health
• Impact of stressful condition on oral health
• Basic study on halitosis prevention
• Pathogenicity of root caries-inducing bacteria

Staff

Professor

Researche Repository

Associate Professor

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Lecturer

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Assistant Professor

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Assistant Professor

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Assistant Professor

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Research results

Takahiko OHO

1. Oho, T., Bikker, F. J., Nieuw Amerongen A. V., and Groenink, J.: A peptide domain on bovine milk lactoferrin inhibits the interaction between streptococcal surface protein antigen and a salivary agglutinin peptide domain. Infect. Immun., 72: 6181-6184, 2004.
2. Oho, T., Mitoma, M., and Koga, T.: Functional domain of bovine milk lactoferrin which inhibits the adherence of Streptococcus mutans cells to a salivary film. Infect. Immun., 70: 5279-5282, 2002.
3. Oho, T., Yoshida, Y., Shimazaki, Y., Yamashita, Y., and Koga, T.: Characteristics of patients complaining of halitosis and the usefulness of gas chromatography for diagnosing halitosis. Oral Surg. Oral Med. Oral Pathol. Oral Radiol. Endod., 91: 531-534, 2001.
4. Oho, T., Shimazaki, Y., Mitoma, M., Yoshimura, M., Yamashita, Y., Okano, K., Nakano, Y., Kawagoe, H., Fukuyama, M., Fujihara, N., and Koga, T.: Bovine milk antibodies against cell surface protein antigen PAc-glucosyltransferase fusion protein suppress cell adhesion and alter glucan synthesis of Streptococcus mutans. J. Nutr., 129: 1836-1841, 1999.
5. Oho, T., Yu, H., Yamashita, Y., and Koga, T.: Binding of salivary glycoprotein-secretory immunoglobulin A complex to the surface protein antigen of Streptococcus mutans. Infect. Immun., 66: 115-121, 1998.

Taihei YAMAGUCHI

1. Yamaguchi, T., Soutome, S., and Oho, T.: Purification of a novel fibronectin binding protein from 'Granulicatella para-adiacens'. Pathog. Dis., 71:73-80, 2014.
2. Zulfiqar, M., Yamaguchi, T., Sato, S., and Oho, T.: Oral Fusobacterium nucleatum subsp. polymorphum binds to human salivary α-amylase. Mol. Oral Microbiol., 28: 425-434, 2013.
3. Yamaguchi, T., Soutome, S., and Oho, T.: Identification and characterization of a fibronectin-binding protein from Granulicatella adiacens. Mol. Oral Microbiol., 26: 353-364, 2011.
4. Yamaguchi T., Matsumoto, M., Sugimoto, Y., Soutome, S., and Oho, T.: Gene cloning and characterization of Streptococcus intermedius fimbriae involved in saliva-mediated aggregation and adherence. Res. Microbiol., 160: 809-816, 2009.
5. Yamaguchi, T., Sharma, P., Athanasiou, M., Kumar, A., Yamada, S., and Kuehn, M.: Mutation of SENP1/SuPr-2 reveals an essential role for desumoylation in mouse development. Mol. Cell. Biol., 25: 5171-5182, 2005.

Setsuko SATO

1. 佐藤節子, 水枝谷幸恵, 日野陽一, 於保孝彦:　市販飲料のう蝕誘発性リスク. 口腔衛生会誌, 57:117-125, 2007.
2. 日野陽一, 佐藤節子, 山口泰平, 北田勝浩, 長田恵美, 鉛山ゆかり, 伊藤博夫, 於保孝彦:　「資料」鹿児島大学新入生の歯科健診結果. 口腔衛生会誌, 57:42-47, 2007.
3. Kanamoto, T., Sato, S., Nakashima, H., and Inoue, M.: Proliferation of mitogen-stimulated human peripheral blood mononuclear cells is inhibited by extracellular arginine deiminase of Granulicatella elegans isolated from the human mouth. J. Infect. Chemother., 13: 353-355, 2007.
4. Kanamoto, T., Sato, S., and Inoue, M.: Genetic heterogeneities and phenotypic characteristics of strains of the genus Abiotrophia and proposal of Abiotrophia para-adiacens sp. nov. J. Clin. Microbiol., 38: 492-498, 2000.
5. Sato, S., Kanamoto, T., and Inoue, M.: Abiotrophia elegans strains comprise 8% of the nutritionally variant streptococci isolated from the human mouth. J. Clin. Microbiol., 37: 2553-2556, 1999.

Emi NAGATA

1. de Toledo, A., Nagata, E., Yoshida, Y., and Oho, T.: Streptococcus oralis coaggregation receptor polysaccharides induce inflammatory responses in human aortic endothelial cells. Mol. Oral Microbiol., 27: 295-307, 2012.
2. Nagata, E., de Toledo, A., and Oho, T.: Invasion of human aortic endothelial cells by oral viridans group streptococci and induction of inflammatory cytokine production. Mol. Oral Microbiol., 26: 78-88, 2011.
3. Nagata, E., Okayama, H., Ito, H.-O., Yamashita, Y., Inoue, M., and Oho, T.: Serotype-specific polysaccharide of Streptococcus mutans contributes to infectivity in endocarditis. Oral Microbiol. Immunol., 21: 420-423, 2006.
4. Nagata, E., Okayama, H., Ito, H.-O., Semba, I, Inoue, M., and Oho, T.: Experimental infective endocarditis induced by human supragingival dental plaque in rats. Eur. J. Oral Sci., 113: 499-504, 2005.
5. Okayama, H., Nagata, E., Ito, H.-O., Oho, T., and Inoue, M.: Experimental abscess formation caused by human dental plaque. Microbiol. Immunol., 49: 399-405, 2005.

Takeshi NISHIYAMA

1. 北田 勝浩，西山 毅，日野 陽一，長田 恵美，五月女さき子，佐藤 節子，山口 泰平，Toledo Andréia，於保 孝彦:　地域住民の特定健康診査と歯周疾患検診における診査項目の関連性．口腔衛生会誌, 61: 245-253, 2011.
2. 田中千穂子，西山 毅，五月女さき子，長田恵美，三重幸恵，北田勝浩，佐藤節子，日野陽一，山口泰平，於保孝彦:　唇顎口蓋裂児の咀嚼能力および食事や口腔に対する保護者の意識に関する研究. 口腔衛生会誌, 60:88-95, 2010.
3. 西山　毅, 飯島洋一, 於保孝彦:　牛乳より精製されるMicellar Calcium Phosphate-Phosphopeptideのエナメル質再石灰化作用の検討. 口腔衛生会誌, 59:2-6, 2009.

Jyunko OBATA

1. Obata, J., Takeshita, T., Shibata, Y., Yamanaka, W., Unemori, M., Akamine, A., and Yamashita, Y.: Identification of the microbiota in carious dentin legions using 16S rRNA gene sequencing. PLoS ONE, 9: e103712, 2014.

Collaborations

1. 土壌細菌の持つ硫化物分解酵素に関する研究、鹿児島大学大学院医歯学総合研究科口腔微生物学分野
2. Strteptococcus mutans のバイオフィルム形成に及ぼす環境因子の作用、鹿児島大学大学院医歯学総合研究科口腔微生物学分野
3. 硫化水素産生能の違いによる Streptococcus anginosus の膿瘍形成能の解析、松本歯科大学細菌学講座
4. 食道がん術後肺炎予防に対する周術期口腔機能管理の有効性に関する多施設共同後ろ向き研究、長崎大学病院他

Research Grant List

Takahiko OHO

Taihei YAMAGUCHI

Setsuko SATO

Emi NAGATA

Takeshi NISHIYAMA

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