Research outline


Graduate School Graduate School of Medical and Dental Sciences
Course Health Research Course
Field Developmental Medicine
Department Oral Microbiology



TEL.+81-99-275-6156 / FAX.+81-99-275-6158

Research interests

  • Research on oral commensal flora
  • Research on antimicrobial peptides
  • Resistance to antibacterial agents in S. aureus
  • Research on virulence factors in periodontal bacteria
  • Research on mechanism of S. mutans adaptation to oral cavity



Name 中田匡宣 Masanobu NAKATA
Specialized field 細菌学
Research interests ・細菌病原因子の機能と発現調節機構の解明

Researche Repository


Assistant Professor
Name 大貝悠一 Yuichi OOGAI
Specialized field 細菌学
Research interests ・細菌の生体内定着に関わる因子の研究
・細菌Small RNAの研究

Researche Repository

staff dummy

Assistant Professor
Name 神原賢治 Kenji KANBARA
Specialized field ウイルス学、免疫学
Research interests ・口腔感染症と全身疾患

Researche Repository

Research results

Masanobu NAKATA
  1. Nakata M, Sumitomo T, Patenge N, Kreikemeyer B, Kawabata S. Thermosensitive pilus production by FCT type 3 Streptococcus pyogenes controlled by Nra regulator translational efficiency. Mol. Microbiol. 2020. 113:173-189.
  2. Nakata M, Kawabata S. Detection of Fibronectin-Binding Proteins of Streptococcus pyogenes Using Ligand Blot Analysis. Methods Mol. Biol. 2020. 2136:181-190.
  3. Okahashi N, Nakata M, Hirose Y, Morisaki H, Kataoka H, Kuwata H, Kawabata S. Streptococcal H202 inhibits IgE-triggered degranulation of RBL-2H3 mast cell/basophil cell line by inducing cell death. PLoS One. 2020. 15:e0231101.
  4. Kriebel K, Hieke C, Müller-Hilke B, Nakata M, Bernd Kreikemeyer. Oral biofilms from symbiotic to pathogenic interactions and associated disease – Connection of Periodontitis and Rheumatic arthritis by peptidylarginine deiminase. Front. Microbiol. 2018. 9:53.
  5. Sumioka R, Nakata M, Okahashi N, Li Y, Wada S, Yamaguchi M, Sumitomo T, Hayashi M, Kawabata S. Streptococcus sanguinis induces neutrophil cell death by production of hydrogen peroxide. PLoS One. 2017. 12: e0172223.

Yuichi OOGAI
  1. Oogai Y, Gotoh Y, Ogura Y, Kawada-Matsuo M, Hayashi T, Komatsuzawa H. Small RNA repertoires and their intraspecies variation in Aggregatibacter actinomycetemcomitans. DNA Res. 2018. 25:207-215.
  2. Oogai Y, Yamaguchi M, Kawada-Matsuo M, Sumitomo T, Kawabata S, Komatsuzawa H. Lysine and Threonine Biosynthesis from Aspartate Contributes to Staphylococcus aureus Growth in Calf Serum. Appl. Environ. Microbiol. 2016. 82:6150-6157.
  3. Oogai Y, Kawada-Matsuo M, Komatsuzawa H. Staphylococcus aureus SrrAB Affects Susceptibility to Hydrogen Peroxide and Co-Existence with Streptococcus sanguinis. PLoS One. 2016. 11:e0159768.
  4. Oogai Y, Matsuo M, Hashimoto M, Kato F, Sugai M and Komatsuzawa H. Expressions of virulence factors by Staphylococcus aureus grown in serum. Appl. Environ. Microbiol. 2011 77:8097-105

Research Grant List

Masanobu NAKATA
Project・Event / SpanResearch
科学研究費 挑戦的研究 (萌芽)
科学研究費 基盤研究 (B)
科学研究費 国際共同研究加速基金 (国際共同研究強化)
Yuichi OOGAI
Project・Event / SpanResearch
科学研究費 基盤研究(C)
歯周病原因菌の病原性因子及び挿入配列を制御するsmall RNAの解析
科学研究費 基盤研究(C)
A. actinomycetemcomitansの産生する生理活性ペプチドの探索
科学研究費 若手研究(B)
A. actinomycetemcomitans表層タンパクの同定及び病原性解析