FIELD

Research outline

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Graduate School Graduate School of Medical and Dental Sciences
Course Health Research Course
Field Social and Behavioral Medicine
Department Psychiatry
Homepage http://www.kufm.kagoshima-u.ac.jp/~np/

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Contact

TEL.+81-99-275-5346 / FAX.+81-99-265-7089

Research interests

  • Molecular genetical study of neuropsychiatryic disorders
  • Molecular biological study of neuropsychiatryic disorders
  • Clinical study of neuropsychiatryic disorders
  • Surveillance study of chorea-acanthocytosis

Staff

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Associate Professor
Name Masayuki NAKAMURA
Specialized field biological psychiatry、臨床精神神経医学、老年精神医学
Research interests
  • Molecular genetical and biological study of neuropsychiatric diseases
  • 有棘赤血球舞踏病の調査研究
  • Clinical study of neuropsychiatryic disorders

Researche Repository


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Lecturer
Name Motofumi KASUGAI
Specialized field 臨床精神医学
Research interests
  • 司法精神医学
  • Clinical study of neuropsychiatryic disorders

Researche Repository


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Assistant Professor
Name Hiroshi KIMOTSUKI
Specialized field 臨床精神医学
Research interests リエゾン精神医学

Researche Repository


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Assistant Professor
Name Nari SHIOKAWA
Specialized field 臨床精神神経医学、Biological psychiatry
Research interests  

Researche Repository


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Assistant Professor
Name Takanori ISHIZUKA
Specialized field Biological psychiatry、臨床精神神経医学、老年精神医学
Research interests
  • 精神神経疾患の分子遺伝学・生物学的研究
  • Clinical study of neuropsychiatryic disorders

Researche Repository


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Assistant Professor
Name Natsuki SASAKI
Specialized field Biological psychiatry、臨床精神神経医学
Research interests
  • 精神神経疾患の分子遺伝学・生物学的研究
  • Clinical study of neuropsychiatryic disorders

Researche Repository


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Assistant Professor
Name Takehiro HAYASHI
Specialized field Biological psychiatry、臨床精神神経医学、臨床精神薬理学
Research interests
  • 精神神経疾患の分子遺伝学・生物学的研究
  • Clinical study of neuropsychiatryic disorders

Researche Repository


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Assistant Professor
Name Hitoshi SAKIMOTO
Specialized field  Biological psychiatry、臨床精神神経医学
Research interests
  • 精神神経疾患の分子遺伝学・生物学的研究
  • Clinical study of neuropsychiatryic disorders

Researche Repository


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Assistant Professor
Name Kayo KAMIMURA
Specialized field  臨床心理学、心理査定
Research interests  

Researche Repository


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Assistant Professor
Name Kaoru ARAI
Specialized field  
Research interests  

Researche Repository


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Assistant Professor
Name Aiko YASUNIWA
Specialized field  
Research interests

 

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特任研究員
Name Hanae HIWATASHI
Specialized field  
Research interests  

Researche Repository


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特任研究員
Name Izumi YOKOYAMA
Specialized field  
Research interests  

Researche Repository

Research results

Masayuki NAKAMURA
  1. The human serotonin transporter gene linked polymorphism (5-HTTLPR) shows ten novel allelic variants, Mol Psychiatry 5: 32-38, 2000
  2. The silencer activity of the novel human serotonin transporter linked polymorphic regions, Neurosci Lett 327: 13-16, 2002
  3. N-terminal proteolysis of full-length mutant huntingtin in an inducible PC12 cell model of Huntington's disease. Cell Cycle 6: 2970-2981, 2007
  4. Familial Semantic Dementia with P301L Mutation in the Tau Gene. Dement Geriatr Cogn Disord 31: 334-340, 2011
  5. Chorein, the protein responsible for chorea-acanthocytosis, interacts with β-adducin and β-actin. Biochem Biophys Res Commun 441: 96-101, 2013

Hiroshi KIMOTSUKI
  1. Dexmedetomidine aggravates cerebral ischemia in rats. Circulation Control 25: 50-55,2004.
  2. Migration of neutrophils elicited by leukotriene B4 is inhibited by fasudil, a Rho-kinase inhibitor, in the microvasculature of hamster cheek pouch. Circulation Control 25: 267-271, 2004.
  3. 脳器質性変化を伴う高齢者のうつ病の診断と治療に関する実態調査―アルツハイマー病と脳血管障害. 老年精神医学雑誌 20: 445-452, 2009.
  4. 難治性気分障害の治療―エビデンスレビューアルツハイマー病または脳血管障害を伴ううつ病の治療ガイドライン. 臨床精神医学 38: 1083-1092, 2009.

Nari SHIOKAWA
  1. Chorein, the protein responsible for chorea-acanthocytosis, interacts with β-adducin and β-actin. Biochem Biophys Res Commun 441: 96-101, 2013

Takanori ISHIZUKA
  1. Familial semantic dementia with P301L mutation in the Tau gene. Dement Geriatr Cogn Disord 31: 334-40, 2011
  2. Different clinical phenotypes in siblings with a presenilin-1 P264L mutation. Dement Geriatr Cogn Disord 33: 132-40, 2012
  3. 認知症症状を呈した高齢初発てんかん4例. 精神科 25: 555-560, 2014.

Natsuki SASAKI
  1. Chorein interacts with α-tubulin and histone deacetylase 6, and overexpression preserves cell viability during nutrient deprivation in human embryonic kidney 293 cells. FASEB J. 30: 3726-3732, 2016

Takehiro HAYASHI
  1. Adult-type metachromatic leukodystrophy with compound heterozygous ARSA mutations: A case report and phenotypic comparison with a previously reported case. Psychiatry Clin Neurosci 65: 105-8, 2011
  2. Quetiapine-induced frequent ventricular contraction. Gen Hosp Psychiatry 34: 211.e1-3, 2012
  3. Subcellular localization and putative role of VPS13A/chorein in dopaminergic cells. Biochem Biophys Res Commun 419: 511-6, 2012

Hitoshi SAKIMOTO
  1. 認知症症状を呈した高齢初発てんかん4例. 精神科 25: 555-560, 2014.
  2. A new phenotype of mitochondrial disease characterized by familial late-onset predominant axial myopathy and encephalopathy. Biochem Biophys Res Commun 472: 118-24, 2016

Hanae HIWATASHI
  1. 2-Methyl-5-pyridyl 2-(Substituted-phenoxy)-ethyl Esters with Precocious Metamorphosis-Inducing Activity. J Psticide Sci 26: 390-2, 2001

Izumi YOKOYAMA
  1. Sakimoto H, Nakamura M, Nagata O, Yokoyama I, Sano A. Phenotypic abnormalities in a chorea-acanthocytosis mouse model are modulated by strain background. Biochem Biophys Res Commun. 2016 Mar 25;472(1):118-24.
  2. Tomomi Kiyota, PhD; Yaman Lu, BSN; Bhagyalazmi Dyavashetty, BS, MS; Maryam Nemati, MD; Izumi Yokoyama, BS; R. Lee Mosley, PhD; Howard E. Gendelman, MD Granulocyte-macrophage colony-stimulating factor neuroprotective activities in Alzheimer’s disease mice Journal of Neuroimmunology. 15 June 2018

Patents and copy Rights

title ヘムオキシゲナーゼの誘導または誘導促進剤としてのフラバノン誘導体
出願人・特許権者:杏林製薬株式会社 
inventor /
application number
発明者:宮地弘幸、永楽智彦、石黒英恵
特願2004-170090
application date 2004年06月08日

Research Grant List

Masayuki NAKAMURA
Project・Event / Span 基盤研究(C)平成30-32年度
Research 神経有棘赤血球症の共通分子病態の解析
Project・Event / Span 基盤研究(C)平成27-29年度
Research 特異な中間表現型を有した統合失調症多発家系から同定した責任遺伝子の解析
Project・Event / Span 基盤研究(C)平成24-26年度
Research choreinとミトコンドリア関連細胞死の関連について
Project・Event / Span 基盤研究(C)平成21-23年度
Research 精神疾患と有棘赤血球舞踏病病因遺伝子のコピー数多型解析
Project・Event / Span 基盤研究(C)平成19-20年度
Research 精神神経疾患におけるミトコンドリア遺伝子異常の解析
Takanori ISHIZUKA
Project・Event / Span 若手研究(B)平成27-28年度
Research 若年認知症関連遺伝子群の包括的変異解析と高齢初発てんかんの特異的臨床症状の抽出
Natsuki SASAKI
Project・Event / Span 若手研究 平成30-32年度
Research Choreinの細胞死調整機構への関わりに関する研究
Takehiro HAYASHI
 Project・Event / Span  若手研究 平成30-33年度
 Research  22q11.2欠失症候群患者における薬剤性パーキンソニズムの発症機序解明
 Project・Event / Span  若手研究(B)平成28-29年度
 Research  薬剤性パーキンソニズムにおけるシナプトタグミンファミリーの関与についての研究

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