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Research interests

• Regulation of synaptic function by neuronal activity-dependent gene expression
• Molecular and cellular mechanisms underlying memory-related processes in the brain

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Research results

Hiroyuki Okuno

• Okuno H, Minatohara K, Bito H. Inverse synaptic tagging: An inactive synapse-specific mechanism to capture activity-induced Arc/arg3.1 and to locally regulate spatial distribution of synaptic weights. Semin Cell Dev Biol, 77: 43-50, 2017.
• Minatohara K, Akiyoshi M, Okuno H. Role of immediate-early genes in synaptic plasticity and neuronal ensembles underlying the memory trace. Front Mol Neurosci, 8: Article 78, 2016.
• Vousden DA, Epp J, Okuno H, Nieman BJ, van Eede M, Dazai J, Ragan T, Bito H, Frankland PW, Lerch JP, Henkelman RM: Whole-brain mapping of behaviourally induced neural activation in mice. Brain Struct Funct, 220:2043-2057, 2015.
• Nonaka M, Kim R, Fukushima H, Sasaki K, Suzuki K, Okamura M, Ishii Y, Kawashima T, Kamijo S, Takemoto-Kimura S, Okuno H, Kida S, Bito H: Region-specific activation of CRTC1-CREB signaling mediates long-term fear memory. Neuron, 84:92-106, 2014.
• Kawashima T, Kitamura K, Suzuki K, Nonaka M, Kamijyo S, Takemoto-Kimura S, Kano M, Okuno H, Ohki K, Bito H: Functional labeling of neurons and their projections using the synthetic activity?dependent promoter E-SARE. Nat Methods, 10:889?895, 2013.
• Okuno H, Akashi K, Ishii Y, Yagishita-Kyo N, Suzuki K, Nonaka M, Kawashima T, Fujii H, Takemoto-Kimura S, Abe M, Natsume R, Chowdhury S, Sakimura K, Worley PF, Bito H. Inverse synaptic tagging of inactive synapses via dynamic interaction of Arc/Arg3.1 with CaMKIIβ. Cell, 149:886-898, 2012.
• Kawashima T., Okuno H, Nonaka M, Adachi-Morishima A, Kyo N, Okamura M, Takemoto-Kimura S, Worley P, Bito H: A synaptic activity-responsive element in the Arc/Arg3.1 promoter essential for synapse-to-nucleus signaling in activated neurons. Proc Natl Acad Sci USA, 106:316-321, 2009.
• Tokuyama W, Okuno H, Hashimoto T, Li Y-X, Miyashita Y: BDNF upregulation during declarative memory formation in the monkey inferotemporal cortex. Nat Neurosci, 3:1134-1142, 2000. 
• Okuno H., Tokuyama W, Li Y-X, Hashimoto T, Miyashita Y: Quantitative evaluation of neurotrophin and trk mRNA expression in visual and limbic areas along the occipito-temporo-hippocampal pathway in adult macaque monkeys. J Comp Neurol, 408:378-398, 1999.

Misako HARAGUCHI

• Tabata S, Yamamoto M, Goto H, Hirayama A, Ohishi M, Kuramoto T, Mitsuhashi A, Ikeda R, Haraguchi M, Kawahara K, Shinsato Y, Minami K, Saijo A, Hanibuchi M, Nishioka Y, Sone S, Esumi H, Tomita M, Soga T, Furukawa T, Akiyama SI. Thymidine Catabolism as a Metabolic Strategy for Cancer Survival. Cell Rep. 19(7):1313-1321, 2017.
• Haraguchi M, Sato M, Ozawa M. CRISPR/Cas9n-Mediated Deletion of the Snail 1Gene (SNAI1) Reveals Its Role in Regulating Cell Morphology, Cell-Cell Interactions, and Gene Expression in Ovarian Cancer (RMG-1) Cells.PLoS One. 10:e0132260. 2015
• Haraguchi M, Indo HP, Iwasaki Y, Iwashita Y, Fukushige T, Majima HJ, Izumo K, Horiuchi M, Kanekura T, Furukawa T, Ozawa M. Snail modulates cell metabolism in MDCK cells. Biochem Biophys Res Commun. 432:618-625, 2013.
• Haraguchi M. The role of transcriptional regulator snail in cell detachment, reattachment and migration. Cell Adh Migr. 3:259-263, 2009.
• Haraguchi M, Okubo T, Miyashita Y, Miyamoto Y, Hayashi M, Crotti TN, McHugh KP, Ozawa M. Snail regulates cell-matrix adhesion by regulation of the expression of integrins and basement membrane proteins. J Biol Chem. 283(35):23514-23, 2008.
• Haraguchi M, Torii S, Matsuzawa Si, Xie Z, Kitada S, Krajewski S, Yoshida H, Mak TW, Reed JC. Apoptotic protease activating factor 1 (Apaf-1)-independent cell death suppression by Bcl-2. J Exp Med, 191:1709-1720, 2000.
• Haraguchi M, Miyadera K, Uemura K, Sumizawa T, Furukawa T, Yamada K, Akiyama S, Yamada Y. Angiogenic activity of enzymes. Nature, 368:198, 1994.

Yuji Kiyama

• Kiyama Y., Kikkawa Y.S., Kinoshita M., Matsumoto Y., Kondo K., Fujimoto C., Iwasaki S., Yamasoba T., Manabe T. The adhesion molecule cadherin 11 is essential for acquisition of normal hearing ability through middle ear development in the mouse. Laboratory Investigation, doi: 10.1038/s41374-018-0083-y. 2018.
• Nakazawa T., *Hashimoto R., Sakoori K., Sugaya Y., Tanimura A., Hashimotodani Y., Ohi K., Yamamori H., Yasuda Y., Umeda-Yano S., Kiyama Y., Konno K., Inoue T., Yokoyama K., Inoue T., Numata S., Ohnuma T., Iwata N., Ozaki N., Hashimoto H., Watanabe M., Manabe T., Yamamoto T., Takeda M. & Kano M. Emerging roles of ARHGAP33 in intracellular trafficking of TrkB and pathophysiology of neuropsychiatric disorders. Nature Communications, 7: 10594, 2016.
• Wakabayashi C., Kiyama Y., Kunugi H., *Manabe T. & Iwakura Y.: Age-dependent regulation of depression-like behaviors through modulation of adrenergic receptor alpha(1)A subtype expression revealed by the analysis of interleukin-1 receptor antagonist knockout mice. Neuroscience, 192: 475-484, 2011.
• Morikawa E., Mori H., Kiyama Y., Mishina M., Asano T., Kirino T. Attenuation of focal ischemic brain injury in mice deficient in the epsilon1 (NR2A) subunit of NMDA receptor, Journal of Neuroscience, 18: 9727-9732, 1998.
• Kiyama Y., Manabe T., Sakimura K., Kawakami F., Mori H., Mishina M. Increased thresholds for long-term potentiation and contextual learning in mice lacking the NMDA-type glutamate receptor epsilon1 subunit., Journal of Neuroscience, 18: 6704-6712, 1998.

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