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Research outline

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Research interests

• Analysis and development of novel therapy for Refractory lung disorders
• Development of novel biomarker for interstitial lung disease and lung cancer
• Prospective cohort study for lung disease

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Research results

Hiromasa INOUE

書籍

1. Reddel HK, Barnes N, Barnes PJ, Bateman ED, Becker A, Bel E, Drazen JM, FitzGerald JM, Inoue H, Lemanske RF Jr, O'Byrne PM, Ohta K, Pedersen SE, Pizzichini E, Szefler SJ, Wenzel SE, Rowe B:
   Global Initiative for Asthma. Global Strategy for Asthma Management and Prevention. Revised 2014. Vancouver, GINA, 2014. Available from: www.ginasthma.org

総説

1. Sakuda S, Inoue H, Nagasawa H:
   Novel Biological Activities of Allosamidins.
   Molecules 2013, 18(6), 6952-6968; doi:10.3390/molecules18066952.
2. Matsumoto K, Inoue H:
   Viral infection in asthma and COPD .
   Respir Invest 2014, 52(2):92-100; http://dx.doi.org/10.1016/j.resinv.2013.08.005
3. Watanabe M, Machida K, Inoue H:
   A turn on and a turn off: BLT1 and BLT2 mechanisms in the lung.
   Expert Rev. Respir. Med. 8(4), 381–383 (2014).
4. Reddel HK, Bateman ED, Becker A, Boulet LP, Cruz AA, Drazen JM, Haahtela T, Hurd SS, Inoue H, de Jongste JC, Lemanske RF Jr, Levy ML, O'Byrne PM, Paggiaro P, Pedersen SE, Pizzichini E, Soto-Quiroz M, Szefler SJ, Wong GW, FitzGerald JM:
   A summary of the new GINA strategy: a roadmap to asthma control.
   Eur Respir J. 2015 Sep;46(3):622-39.  (2015).

原著

1. Moriwaki A, Inoue H, Nakano T, Matsunaga Y, Matsuno Y, Matsumoto T, Fukuyama S, Kan-o K, Matsumoto K, Tsuda-Eguchi M, Nagakubo D, Yoshie O, Yoshimura A, Kuno M, Nakanishi Y:
   T cell treatment with small-interfering RNA for SOCS3 modulates allergic airway responses in a murine model of asthma.
   Am J Respir Cell Mol Biol 44(4):448-55, 2011.
2. Matsumoto K, Kan-o K, Tsuda-Eguchi M, Fukuyama S, Matsumoto T, Moriwaki A, Matsunaga Y, Tsutsui H, Kawai T, Takeuchi O, Akira S, Yagita H, Azuma M, Nakanishi Y, Inoue H:
      Essential role of B7-H1 in double-stranded RNA-induced augmentation of an asthma phenotype in mice.
   Am J Respir Cell Mol Biol 45(1):31-9, 2011 Jul.
3. Fukuyama S, Matsunaga Y, Zhanghui W, Noda N, Asai Y, Moriwaki A, Matsumoto T, Nakano T, Matsumoto K, Nakanishi Y, Inoue H:
   A zinc chelator TPEN attenuates airway hyperresponsiveness and airway inflammation in mice in vivo.
   Allergol Int 60(3):259-66, 2011.
4.  Matsunaga Y, Inoue H, Fukuyama S, Yoshida H, Moriwaki A, Matsumoto T, Matsumoto K, Asai Y, Kubo M, Yoshimura A, Nakanishi Y:
   Effects of a Janus kinase inhibitor, pyridone 6, on airway responses in a murine model of asthma.
   Biochem Biophys Res Commun 404(1):261-67, 2011.
5. Tanaka S, Motomura Y, Suzuki Y, Yagi R, Inoue H, Miyatake S, Kubo M:
   The enhancer HS2 critically regulates GATA-3-mediated Il4 transcription in T(H)2 cells.
   Nat Immunol 12(1):77-85, 2011.
6. Moriwaki A, Matsumoto K, Matsunaga Y, Fukuyama S, Matsumoto T, Kan-o K, Noda N, Asai Y, Nakanishi Y, Inoue H:
   IL-13 suppresses double-stranded RNA-induced IFN-lambda production in lung cells.
   Biochem Biophys Res Commun 404(4):922-7, 2011.
7. Motomura Y, Kitamura H, Hijikata A, Matsunaga Y, Matsumoto K, Inoue H, Atarashi K, Hori S, Watarai H, Zhu J, Taniguchi M, Kubo M:
   The transcription factor E4BP4 regulates the production of IL-10 and IL-13 in CD4+ T cells.
   Nat Immunol 2011 May;12(5):450-9.
8. Sato Y, Suzuki S, Muraoka S, Kikuchi N, Noda N, Matsumoto T, Inoue H, Nagasawa H, Sakuda S:
   Preparation of allosamidin and demethylallosamidin photoaffinity probes and analysis of allosamidin-binding proteins in asthmatic mice.
   Bioorg Med Chem. 2011 May 15;19(10):3054-9.
9. Hisasue J, Fukuyama S, Nakagaki N, Moriwaki A, Inoue S, Sakurada N, Kaneko H, Takayama K, Inoue H, Nakanishi Y:
   Inhalative administration of insulin using a new bubble jet atomization device.
   Fukuoka Acta Medica 102(6):215-222, 2011.
10. Nakagawa R, Yoshida H, Asakawa M, Tamiya T, Inoue N, Morita R, Inoue H, Nakao A, Yoshimura A:
    Pyridone 6, a pan-JAK inhibitor, ameliorates allergic skin inflammation of NC/Nga mice via suppression of Th2 and enhancement of Th17.
    J Immunol. 2011 Nov 1;187(9):4611-20. Epub 2011 Sep 28. DOI: 10.4049/jimmunol.1100649.
11. Sawaguchi M, Tanaka S, Nakatani Y, Harada Y, Mukai K, Matsunaga Y, Ishiwata K, Oboki K, Kambayashi T, Watanabe N, Karasuyama H, Nakae S, Inoue H, Kubo M:
    Role of Mast Cells and Basophils in IgE Responses and in Allergic Airway Hyperresponsiveness.
    J Immunol. 2012 Feb 15;188(4):1809-18. Epub 2012 Jan 16.  DOI: 10.4049/jimmunol.1101746
12. Yoshida H, Kimura A, Fukaya T, Sekiya T, Morita R, Shichita T, Inoue H, Yoshimura A:
    Low dose CP-690,550 (tofacitinib), a pan-JAK inhibitor, accelerates the onset of experimental autoimmune encephalomyelitis by potentiating Th17 differentiation.
    Biochem Biophys Res Commun. 2012 Feb 10;418(2):234-40. Epub 2012 Jan 9. DOI: 10.1016/j.bbrc.2011.12.156.
13. Harada Y, Tanaka S, Motomura Y, Harada Y, Ohno S, Ohno S, Yanagi Y, Inoue H, Kubo M:
    The 3' Enhancer CNS2 Is a Critical Regulator of Interleukin-4-Mediated Humoral Immunity in Follicular Helper T Cells.
    Immunity. 2012 Feb 24;36(2):188-200 DOI: 10.1016/j.immuni.2012.02.002.
14. Matsumoto K, Asai Y, Fukuyama S, Kan-o K, Matsunaga Y, Noda N, Kitajima H, Inoue H:
    IL-6 induced by double-stranded RNA augments allergic inflammation via suppression of Foxp3+T cell/IL-10 axis.
    Am J Respir Cell Mol Biol 2012 Jun;46(6):740-7 DOI: 10.1165/rcmb.2010-0479OC.
15. Kan-O K, Matsumoto K, Inoue H, Fukuyama S, Asai Y, Watanabe W, Kurokawa M, Araya J, Kuwano K, Nakanishi Y:
    Corticosteroids plus long-acting beta2-agonists prevent double-stranded RNA-induced upregulation of B7-H1 on airway epithelium .
    Int Arch Allergy Immunol 2012 Aug 31;160(1):27-36  DOI: 10.1159/000338430.
16. Taira T, Ishii G, Nagai K, Yoh K, Takahashi Y, Matsumura Y, Kojima M, Ohmatsu H, Goto K, Niho S, Takashima H, Inoue H, Ohe Y, Ochiai A:
    Characterization of the immunophenotype of the tumor budding and its prognostic implications in squamous cell carcinoma of the lung.
    Lung Cancer. 2012 Jun;76(3):423-30. Epub 2011 Dec 6.
17. Kato T, Koriyama C, Khan N, Samukawa T, Yanagi M, Hamada T, Yokomakura N, Otsuka T, Inoue H, Sato M, Natsugoe S, Akiba S:
    EGFR mutations and human papillomavirus in lung cancer.
    Lung Cancer. 2012 Nov;78(2):144-7. doi: 10.1016/j.lungcan.2012.08.011. Epub 2012 Sep 10.
18. Samukawa T, Hamada T, Uto H, Yanagi M, Tsukuya G, Nosaki T, Maeda M, Hirano T, Tsubouchi H, Inoue H:
    The elevation of serum napsin A in idiopathic pulmonary fibrosis, compared with KL-6, surfactant protein-A and surfactant protein-D.
    BMC Pulm Med. 2012 Sep 11;12(1):55. doi: 10.1186/1471-2466-12-55
19. Yoshida M, Nakano T, Fukuyama S, Matsumoto T, Eguchi M, Moriwaki A, Takata S, Machida K, Kanaya A, Matsumoto K, Nakanishi Y, Inoue H:
    Effects of tiotropium on lung function in severe asthmatics with or without emphysematous changes.
    Pulm Pharmacol Ther. 2013 Apr;26(2):159-66. doi: 10.1016/j.pupt.2012.09.007. Epub 2012 Oct 13.
20. Matsui S, Hebisawa A, Sakai F, Yamamoto H, Terasaki Y, Kurihara Y, Waseda Y, Kawamura T, Miyashita T, Inoue H, Hata N, Masubuchi H, Sugino K, Kishi J, Kobayashi H, Usui Y, Komazaki Y, Kawabata Y, Ogura T:
    Immunoglobulin G4-related lung disease: clinicoradiological and pathological features.
    Respirology. 2013 Apr;18(3):480-7. doi: 10.1111/resp.12016.
21. Kan-o K, Matsunaga Y, Fukuyama S, Moriwaki A, Hirai-Kitajima H, Yokomizo T, Aritake K, Urade Y, Nakanishi Y, Inoue H, Matsumoto K:
    Mast cells contribute to double-stranded RNA-induced augmentation of airway eosinophilia in a murine model of asthma.
    Respir Res. 2013 Mar 4;14:28. doi: 10.1186/1465-9921-14-28
22. Matsunaga Y, Fukuyama S, Okuno T, Sasaki F, Matsunobu T, Asai Y, Matsumoto K, Saeki K, Oike M, Sadamura Y, Machida K, Nakanishi Y, Kubo M, Yokomizo T, Inoue H:
    Leukotriene B4 receptor BLT2 negatively regulates allergic airway eosinophilia.
    FASEB J 2013 Aug;27(8):3306-14. doi: 10.1096/fj.12-217000. Epub 2013 Apr 19.
23. Kan-o K, Matsumoto K, Asai-Tajiri Y, Fukuyama S, Hamano S, Seki N, Nakanishi Y, Inoue H:
    PI3K-delta mediates double-stranded RNA-induced upregulation of B7-H1 in BEAS-2B airway epithelial cells.
    Biochem Biophys Res Commun. 2013 May 31;435(2):195-201. doi: 10.1016/j.bbrc.2013.04.082. Epub 2013 May 6.　
24. Noda N, Matsumoto K, Fukuyama S, Asai Y, Kitajima H, Seki N, Matsunaga Y, Kan-O K, Moriwaki A, Morimoto K, Inoue H, Nakanishi Y:
    Cigarette smoke impairs phagocytosis of apoptotic neutrophils by alveolar macrophages via inhibition of the histone deacetylase/Rac/CD9 pathways.
    Int Immunol. 2013 Nov;25(11):643-50. doi: 10.1093/intimm/dxt033. Epub 2013 Aug 29.
25. Tamiya T, Ichiyama K, Kotani H, Fukaya T, Sekiya T, Shichita T, Honma K, Yui K, Matsuyama T, Nakao T, Fukuyama S, Inoue H, Nomura M, Yoshimura A:
    Smad2/3 and IRF4 play a cooperative role in IL-9-producing T cell induction.
    J Immunol. 2013 Sep 1;191(5):2360-71. doi: 10.4049/jimmunol.1301276. Epub 2013 Aug 2.
26. Matsumoto K, Aizawa H, Fukuyama S, Yoshida M, Komori M, Takata S, Koto H, Inoue H:
    Low-dose salbutamol suppresses airway responsiveness to histamine but not methacholine in subjects with asthma.
    Respir Investig. 2013 Sep;51(3):158-65. doi: 10.1016/j.resinv.2013.03.001. Epub 2013 May 7.
27. Shirai T, Kawayama T, Nagase H, Inoue H, Sato S, Asano K, Kume H:
    Exhaled nitric oxide measurement may predict asthma exacerbation after stepping down formoterol/budesonide combination therapy in adult asthma.
    J Allergy Ther 2014; 5(3):173. doi:10.4172/2155-6121.1000173.
28. Sadamura-Takenaka Y, Ito T, Noma S, Oyama Y, Yamada S, Kawahara K, Inoue H, Maruyama I. HMGB1 promotes the development of pulmonary arterial hypertension in rats.
    PLoS One. 2014 Jul 17;9(7):e102482. doi: 10.1371/journal.pone.0102482. eCollection 2014.
29. Tsukuya G, Matsumoto K, Fukuyama S, Crawford B, Nakanishi Y, Ichinose M, Machida K, Samukawa1 T, Ninomiya T, Kiyohara Y, Inoue H:
    Validation of a COPD screening questionnaire and establishment of diagnostic cut-points in a Japanese general population: the Hisayama Study.
    Allergol Int 2015; 64(1):49-53  doi: 10.1016/j.alit.2014.06.002.
30. Yonekawa A, Saijo S, Hoshino Y, Miyake Y, Ishikawa E, Suzukawa M, Inoue H, Tanaka M, Yoneyama M,Oh-Hora M, Akashi K, Yamasaki S:
    Dectin-2 is a direct receptor for mannose-capped lipoarabinomannan of mycobacteria.
    Immunity. 2014 Sep 18;41(3):402-13. doi: 10.1016/j.immuni.2014.08.005. Epub 2014 Aug 28.
31. Matsumoto K, Seki N, Fukuyama S, Moriwaki A, Kan-O K, Matsunaga Y, Noda N, Yoshida M, Koto H, Takata S, Nakanishi Y, Kiyohara Y, Inoue H:
    Prevalence of asthma with airflow limitation, COPD, and COPD with variable airflow limitation in older subjects in a general Japanese population: The Hisayama Study.
    Respir Investig 2015 Jan;53(1):22-9  doi:10.1016/j.resinv.2014.08.002.
32. Mataki H, Enokida H, Chiyomaru T, Mizuno K, Matsushita R, Goto Y, Nishikawa R, Higashimoto I, Samukawa T, Nakagawa M, Inoue H, Seki N:
    Downregulation of the microRNA-1/133a cluster enhances cancer cell migration and invasion in lung-squamous cell carcinoma via regulation of Coronin1C.
    J Hum Genet 2015 Feb;60(2):53-61. doi: 10.1038/jhg.2014.111. [Epub ahead of print] doi: 10.1038/jhg.2014.111.
33. Mataki H, Seki N, Chiyomaru T, Enokida H, Goto Y, Kumamoto T, Machida K, Mizuno K, Nakagawa M, Inoue H:
    Tumor-suppressive microRNA-206 as a dual inhibitor of MET and EGFR oncogenic signaling in lung squamous cell carcinoma.
    Int J Oncol 2015 Mar;46(3): 1039-1050, 2015  doi: 10.3892/ijo.2014.2802.
34. Asai-Tajiri Y, Matsumoto K, Fukuyama S, Kan-o K, Nakano T, Ohno T, Azuma M, Inoue H, Nakanishi Y. Small interfering RNA against CD86 during allergen challenge blocks experimental allergic asthma.
    Respir Res. 2014 Oct 27;15(1):132. 　doi:10.1186/s12931-014-0132-z.
35. Hamada T, Samukawa T, Kumamoto T, Hatanaka K, Tsukuya G, Yamamoto M, Machida K, Watanabe M, Mizuno K, Higashimoto I, Inoue Y, Inoue H:
    Serum B cell-activating factor (BAFF) level in connective tissue disease associated interstitial lung disease.
    BMC Pulm Med. 2015 Sep 30;15(1):110. doi: 10.1186/s12890-015-0105-0.
36. Kubota S, Watanabe M, Shirato M, Okuno T, Higashimoto I, Machida K, Yokomizo T, Inoue H:
    An inhaled phosphodiesterase 4 inhibitor E6005 suppresses pulmonary inflammation in mice.
    Eur J Pharmacol. 2015 Oct 8. pii: S0014-2999(15)30293-4. doi: 10.1016/j.ejphar.2015.10.013. [Epub ahead of print] PMID: 26455478.
37. Mizuno K, Seki N, Mataki H, Matsushita R, Kamikawaji K, Kumamoto T, Takagi
    K, Goto Y, Nishikawa R, Kato M, Enokida H, Nakagawa M, Inoue H:
    Tumor-suppressive microRNA-29 family inhibits cancer cell migration and
    invasion directly targeting LOXL2 in lung squamous cell carcinoma.
    Int J Oncol 48(2):450, 2016
38. Onoue A, Omori H, Katoh T, Kubota K, Nonami Y, Ogata Y, Inoue H:
    Relationship of airflow limitation severity with work productivity reduction
    and sick leave in a Japanese working population.
    Int J Chron Obstruct Pulmon Dis 2016 in press

症例報告

1. A case of multiple squamous cell papillomas of the trachea.
   Ogata-Suetsugu S, Izumi M, Takayama K, Nakashima T, Inoue H, Nakanishi Y:
   Ann Thorac Cardiovasc Surg. 2011 Apr;17(2):212-4.
2. A case of diffuse large B-cell lymphoma of the lung demonstrating diffuse ground-glass shadows.
   Ogata-Suetsugu S, Maeyama T, Takeshita M, Hamada N, Takayama K, Inoue H, Nakanishi Y:
   Ann Thorac Cardiovasc Surg. 2011;17(6):591-4. Epub 2011 Aug 17.
3. Polyangiitis overlap syndrome of granulomatosis with polyangiitis (Wegener's granulomatosis) and eosinophilic granulomatosis with polyangiitis (Churg-Strauss syndrome).
   Uematsu H, Takata S, Sueishi K, Inoue H:
   BMJ Case Rep. 2014 Feb 27;2014. pii: bcr2013010195. doi: 10.1136/bcr-2013-010195. 

Masaki WATANABE

総説

• Watanabe M, Machida K, Inoue H:
  A turn on and a turn off: BLT1 and BLT2 mechanisms in the lung.
  Expert Rev. Respir. Med. 8(4), 381–383 (2014)

原著

• Kubota S, Watanabe M, Shirato M, Okuno T, Higashimoto I, Machida K, Yokomizo T, Inoue H:
  An inhaled phosphodiesterase 4 inhibitor E6005 suppresses pulmonary inflammation in mice.
  Eur J Pharmacol. 2015 Oct 8. pii: S0014-2999(15)30293-4. doi: 10.1016/j.ejphar.2015.10.013. [Epub ahead of print] PMID: 26455478.

Takuya SAMUKAWA

原著

• Samukawa T, Hamada T, Uto H, Yanagi M, Tsukuya G, Nosaki T, Maeda M, Hirano T, Tsubouchi H, Inoue H:
  The elevation of serum napsin A in idiopathic pulmonary fibrosis, compared with KL-6, surfactant protein-A and surfactant protein-D.
  BMC Pulm Med. 2012 Sep 11;12(1):55. doi: 10.1186/1471-2466-12-55.
• Hamada T, Samukawa T, Kumamoto T, Hatanaka K, Tsukuya G, Yamamoto M, Machida K, Watanabe M, Mizuno K, Higashimoto I, Inoue Y, Inoue H:
  Serum B cell-activating factor (BAFF) level in connective tissue disease associated interstitial lung disease.
  BMC Pulm Med. 2015 Sep 30;15(1):110. doi: 10.1186/s12890-015-0105-0.

Keiko MIZUNO

原著

• Keiko Mizuno, Naohiko Seki, Hiroko Mataki, Ryosuke Matsushita, Kazuto Kamikawaji, Tomohiro Kumamoto, Koichi Takagi, Yusuke Goto, Rika Nishikawa, Mayuko Kato, Hideki Enokida, Masayuki Nakagawa, Hiromasa Inoue:
  Tumor-suppressive microRNA-29 family inhibits cancer cell migration and invasion directly targeting LOXL2 in lung squamous cell carcinoma.
  International Journal of Oncology in press.

Research Grant List

Hiromasa INOUE

Keiko MIZUNO

Masaki WATANABE

Ikko HIGASHIMOTO

Takuya SAMUKAWA

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