研究テーマ(研究室紹介)

心臓血管・高血圧内科学

Generalist with specialtyを合い言葉に心臓だけでなく全人的に内科全般を診られる医師の育成と、現場の“何故”を解決する臨床・基礎研究の充実をモットーとしています。
24時間365日救急受け入れをするなど最後の砦としての大学病院の使命を全うしながら、海外学会発表や論文投稿、症例報告など「鹿児島から全世界への情報発信」をするべく日夜頑張っている若い講座です。

研究室概要

部局 大学院医歯学総合研究科 Graduate School of Medical and Dental Sciences
専攻 先進治療科学専攻 Advanced Therapeutics Course
大講座 循環器・呼吸器病学 Cardiovascular and Respiratory Disorders
分野 心臓血管・高血圧内科学 Cardiovascular Medicine and Hypertension
分野サイト http://www.kufm.kagoshima-u.ac.jp/~intmed1/

分野サイト

連絡先

TEL.099-275-5318 / FAX.099-265-8447

主要研究テーマ

高血圧 Hypertension
虚血性心疾患 Ischemic heart disease
動脈硬化 Atherosclerosis
心臓超音波 Cardiac echocardiography
成人先天性心疾患 Adult congenital heart disease
心不全 Heart failure
肺高血圧 Pulmonary hypertension
不整脈 Arrhythmia
心筋症 Cardiomyopathy

スタッフ

大石充 Mitsuru OHISHI

教授
氏名 大石充 Mitsuru OHISHI
専門分野 循環器学、虚血性心疾患、動脈硬化、高血圧
研究テーマ ・循環器レジストリを駆使した病態把握と心血管疾患治療seeds探索(KIDSレジストリなど) 
・垂水研究(多職種によるチーム医療コホート研究) 
・枕崎研究(高血圧治療が予後及び社会経済に与える影響を見るコホート研究) 
・受容体連関を基軸としたtranslational research

研究者総覧


湯淺敏典 Toshinori YUASA

講師
氏名 湯淺敏典 Toshinori YUASA
専門分野 循環器学、超音波学
研究テーマ ・心臓超音波学(ドプラ法を用いた心機能評価, 運動負荷エコー、3Dエコー)
・軽運動負荷心エコーを用いた心臓弁膜症における心予備能の研究
・軽運動負荷心エコーを用いた心不全例における運動耐容能の研究
・心エコードプラ法による心時相解析を用いた各種心疾患の評価

研究者総覧 


池田義之 Yoshiyuki IKEDA

講師
氏名 池田義之 Yoshiyuki IKEDA
専門分野 循環器学、動脈硬化、高血圧、抗加齢医学
研究テーマ ・オートファジーやミトコンドリアダイナミクスと心臓血管系の老化・心不全・動脈硬化・高血圧に関する研究
・閉経に伴う心臓血管系の老化・動脈硬化進展の機序の解明および治療法の確立
・レニン・アンギオテンシン・アルドステロン系と心臓血管系の老化・動脈硬化に関する研究
・高齢者高血圧患者に対する降圧治療に関する臨床研究
・フレイル・サルコペニアに関する基礎および臨床研究

研究者総覧


窪薗琢郎 Takuro KUBOZONO

講師
氏名 窪薗琢郎 Takuro KUBOZONO
専門分野 循環器学、心不全、心臓リハビリテーション
研究テーマ ・心疾患患者における運動耐容能に関する研究
・心不全患者における血管機能に関する研究
・心不全患者における予後に関する研究
・心臓リハビリテーションに関する新たな治療法・介入の開発

研究者総覧


田中(窪田)佳代子 Kayoko TANAKA(KUBOTA)

講師
氏名 田中(窪田)佳代子 Kayoko TANAKA(KUBOTA)
専門分野 循環器学、肺循環、超音波学
研究テーマ ・肺高血圧症

研究者総覧


赤﨑雄一 Yuichi AKASAKI

助教
氏名 赤﨑雄一 Yuichi AKASAKI
専門分野 循環器学、高血圧、動脈硬化
研究テーマ ・難治性高血圧の実態調査および予後に関する観察研究
・大動脈瘤および大動脈解離への寄与因子に関する臨床・基礎研究
・睡眠時無呼吸症候群と高血圧に関する臨床・基礎研究
・老化による筋肉減弱症(サルコペニア)が心血管疾患に及ぼす影響に関する基礎研究

研究者総覧


内匠拓朗 Takuro TAKUMI

助教
氏名 内匠拓朗 Takuro TAKUMI
専門分野 循環器学、虚血性心疾患
研究テーマ ・冠微小循環障害と血小板機能の関連について
・スタチンの造影剤腎症抑制効果について

研究者総覧


樋口公嗣 Koji HIGUCHI

助教
氏名 樋口公嗣 Koji HIGUCHI
専門分野 循環器学、心筋症
研究テーマ ・ファブリー病 

研究者総覧


奥井英樹 Hideki OKUI

特任助教
氏名 奥井英樹 Hideki OKUI
専門分野 循環器学、不整脈
研究テーマ 不整脈、冠循環 

研究者総覧


市來仁志 Hitoshi ICHIKI

助教
氏名 市來仁志 Hitoshi ICHIKI
専門分野 循環器学、不整脈
研究テーマ ・心房細動に対するカテーテルアブレーションについて
・心房細動に対するカテーテルアブレーション周術期の抗凝固療法について

研究者総覧


神田大輔 Daisuke KANDA

特任助教
氏名 神田大輔 Daisuke KANDA
専門分野 循環器学、虚血性心疾患
研究テーマ ・カテーテル治療と腎障害の影響

研究者総覧

主な研究実績

大石充
  1. Impairment of iodine-123-metaiodobenzylguanidine (123I-MIBG) uptake in patients with pulmonary artery hypertension
    . Higo K, Kubota K, Miyanaga S, Miyata M, Nakajo M, Jinguji M, Ohishi M.
    Internal Heart J 2018; 59(1): 112-119.
  2. Association between waist-to-height ratio and endothelial dysfunction in patients with morbidity: a report from the FMD-J Study.
    Tokushige A, Ueda S, Tomiyama H, Ohishi M, Kohro T, Higashi Y, Takase B, Suzuki T, Ishizu T, Yamazaki T, Furumoto T, Kario K, Inoue T, Koba S, Takemoto Y, Hano T, Sata M, Ishibashi Y, Node K, Maemura K, Ohya Y, Furukawa T, Ito H, Yamashina A.
    Circ J 2017; 81(12): 1911-1918.
  3. Proposed cut-off value of brachial-ankle pulse wave velocity for the management of hypertension.
    Ohkuma T, Tomiyama H, Ninomiya T, Kario K, Hoshide S, Kita Y, Inoguchi T, Maeda Y, Kohara K, Tabara Y, Nakamura M, Ohkubo T, Watada H, Munakata M, Ohishi M, Itoh N, Nakamura M, Shoji T, Vlachopoulos C, Yamashina A.
    Circ J 2017; 81(10): 1540-1542.
  4. In-Stent Catheter-Induced Neointimal Dissection Assessed by Optical Coherence Tomography.
    Ohmure K, Yoshino S, Fukumoto D, Shimono H, Tabata H, Uchikado Y, Tateishi S, Ohishi M.
    JACC Cardiovasc Interv 2017; 10 (14): 1462-1463.
  5. Brachial-ankle pulse wave velocity and the risk prediction of cardiovascular disease: an individual participant data meta-analysis.
    Ohkuma T, Ninomiya T, Tomiyama H, Kario K, Hoshide S, Kita Y, Inoguchi T, Maeda Y, Kohara K, Tabara Y, Nakamura M, Ohkubo T, Watada H, Munakata M, Ohishi M, Ito N, Nakamura M, Shoji T, Vlachopoulos C, Yamashina A, on the behalf of the collaborative group for Japan Brachial-Ankle pulse wave VELocity individual participant data meta-analysis of prospective studies (J-BAVEL).
    Hypertension 2017; 69(6): 1045-1052.
  6. Mechanism of the blood pressure-lowering effect of sodium-glucose cotransporter 2 inhibitors in obese patients with type 2 diabetes.
    Kawasoe S, Maruguchi Y, Kajiya S, Uenomachi H, Miyata M, Kawasoe M, Kubozono T, Ohishi M.
    BMC Pharmacol Toxicol 2017; 18(1): 23.
  7. Unroofed coronary sinus with cardiac veins.
    Kajiya T, Takaoka J, Atsuchi N, Atsuchi Y, Ohishi M.
    Acta Cardiol 2017; 72(2): 223.
  8. High pulse wave velocity has a strong impact on early carotid atherosclerosis in a Japanese general male population.
    Kubozono T, Miyata M, Kawasoe S, Ojima S, Yoshifuku S, Miyahara H, Maenohara, S, Ohishi M.
    Circ J 2017; 81: 310-315.
  9. Evaluation of safety and efficacy of periprocedural use of rivaroxaban and apixaban in catheter ablation for atrial fibrillation.
    Yoshimura A, Iriki Y, Ichiki H, Oketani N, Okui H, Maenosono R, Namino F, Miyata M, Ohishi M.
    J Cardiol 2017; 69 (1): 228-235.
  10. A case of anticoagulant treatment-resistant Trousseau syndrome controlled by treatment of the underlying lung adenocarcinoma: utility of monitoring D-dimer levels .
    Kuwahata S, Takenaka T, Yasuda S, Sakoda T, Taniyama H, Nagata Y, Iwakawa J, Matsumoto S, Seto T, Takenoyama M, Abe S, Ohishi M.
    J Cardiol Cases 2017; 15: 65-69.
湯淺敏典
  1. Validity of a novel method for estimating low-density lipoprotein cholesterol levels in diabetic patients.
    Chaen H, Kinchiku S, Miyata M, Kajiya S, Uenomachi H, Yuasa T, Takasaki K, Ohishi M.
    J Atheroscler Thromb 2016; 23: 1355-1364.
  2. Angle between the common and internal carotid arteries detected by ultrasound is related to intima-media thickness among those with atherosclerotic disease.
    Daitoku S, Yuasa T, Tsunenari H, Maenohara S, Mine K, Tamatsu Y, Shimada K, Koriyama
    C, Ohishi M, Horiuchi M.
    Environ Health Prev Med 2015; 20: 216-223.
  3. Attenuated early diastolic interventricular septum bulging by pulmonary hypertension due to later developed aortic regurgitation.
    Nomoto Y, Tsurugida M, Kihara K, Miyauchi E, Kosedo I, Yuasa T, Otsuji Y, Ohishi M.
    J Echocardiogr 2015; 13: 110-112.
  4. Prosthetic tricuspid valve dysfunction assessed by three-dimensional transthracic and transesophageal echocardiography.
    Yuasa T, Takasaki K, Mizukami N, Ueya N, Kubota K, Horizoe Y, Chaen H, Kuwahara E, Kisanuki A, Hamasaki S.
    J Echocardiogr.2013; 11: 97-99.
  5. Clinical spectrum, frequency, and significance of myocardial dysfunction in severe sepsis and septic shock.
    Pulido JN, Afessa B, Masaki M, Yuasa T, Gillespie S, Herasevich V, Brown DR, Oh JK.
    Mayo Clin Proc.2012; 87: 620-628.
  6. Highly sensitive cardiac troponin T in heart failure: comparison with echocardiographic parameters and natriuretic peptides.
    Kusumoto A, Miyata M, Kubozono T, Ikeda Y, Shinsato T, Kuwahata S, Fujita S, Takasaki
    K, Yuasa T, Hamasaki S, Tei C.
    J Cardiol.2012; 59: 202-208.
  7. Different flow patterns between left and right internal thoracic artery grafts influence the evaluation of severe graft stenosis by transthoracic Doppler echocardiography.
    Mizukami N, Kisanuki A, Hamasaki S, Takasaki K, Yuasa T, Kuwahara E, Ueya N, Horizoe Y, Chaen H, Maruyama I, Imoto Y, Tei C.
    J Am Soc Echocardiogr. 2011; 24: 768-774
  8. Left ventricular global systolic dysfunction has a significant role in the development of diastolic heart failure in patients with systemic hypertension.
    Kono M, Kisanuki A, Ueya N, Kubota K, Kuwahara E, Takasaki K, Yuasa T, Mizukami N, Miyata M, Tei C.
    Hypertension Research.2010; 33: 1167-1173.
  9. Left atrium volume index and pathological features of left atrial appendage as a predictor of failure in postoperative sinus conversion.
    Kataoka T, Hamasaki S, Inoue K, Yuasa T, Tomita K, Ishida S, Ogawa M, Saihara K, Koriyama C, Nobuyoshi M, Sakata R, Tei C.
    J Cardiol.2010; 55: 274-282.
  10. Left ventricular systolic function is abnormal in diastolic heart failure: re-assessment of systolic function using cardiac time interval analysis.
    Kono M, Kisanuki A, Takasaki K, Nakashiki K, Yuasa T, Kuwahara E, Mizukami N, Uemura T, Kubota K, Ueya N, Miyata M, Tei C.
    J Cardiol.2009; 53: 437-446.
池田義之
  1. Aging and autophagy in the heart.
    Shirakabe A, Ikeda Y, Sciarretta S, Zablocki DK, Sadoshima J.
    Circ Res 2016; 118(10): 1563-1576.
  2. Drp1-Dependent Mitochondrial Autophagy Plays a Protective Role Against Pressure Overload-Induced Mitochondrial Dysfunction and Heart Failure.
    Shirakabe A, Zhai P, Ikeda Y, Saito T, Maejima Y, Hsu CP, Nomura M, Egashira K, Levine
    B, Sadoshima J.
    Circulation 2016; 133(13): 1249-1263.
  3. Pivotal role of miR-448 in the development of ROS-induced cardiomyopathy.
    Kyrychenko S, Kyrychenko V, Badr MA, Ikeda Y, Sadoshima J, Shirokova N.
    Cardiovasc Res 2015; 108(3): 324-334.
  4. PPARα association with sirt1 suppresses cardiac fatty acid metabolism in the failing heart. Oka SI, Zhai P, Yamamoto T, Ikeda Y, Byun J, Hsu CP, Sadoshima J.
    Circ Heart Fail 2015; 8(6): 1123-1132.
  5. Endogenous drp1 mediates mitochondrial autophagy and protects the heart against energy stress.
    Ikeda Y, Shirakabe A, Maejima Y, Zhai P, Sciarretta S, Toli J, Nomura M, Mihara K,
    Egashira K, Ohishi M, Abdellatif M, Sadoshima J.
    Circ Res 2015; 16(116): 264-278.
  6. Molecular Mechanisms Mediating Mitochondrial Dynamics and Mitophagy and their Functional Roles in the Cardiovascular System.
    Ikeda Y, Shirakabe A, Brady C, Zablocki D, Ohishi M, and Sadoshima J.
    J Mol Cell Cardiol 2015; 78C: 116-122.
  7. Endogenous Drp1 mediates mitochondrial autophagy and protects the heart against energy stress.
    Ikeda Y, Shirakabe A, Maejima Y, Zhai P, Sciarretta S, Toli J, Nomura M, Mihara K,
    Egashira K, Ohishi M, Jessica T, Abdellatif M, Sadoshima J.
    Circ Res 2015; 116(2): 264-278.
  8. New Insights into the Role of Mitochondrial Dynamics and Autophagy during Oxidative Stress and Aging in the Heart.
    Ikeda Y, Sciarretta S, Nagarajan N, Rubattu S, Volpe M, Frati G, Sadoshima J.
    Oxidative Medicine and Cellular Longevity 2014; 2014:210934.
  9. Nicotinamide mononucleotide, an intermediate of NAD+ synthesis, protects the heart from ischemia and reperfusion.
    Yamamoto T, Byun J, Zhai P, Ikeda Y, Oka S, Sadoshima J.
    PLoS One 2014; 9(6): e98972.
  10. The Role of SUMO-1 in Cardiac Oxidative Stress and Hypertrophy.
    Lee A, Jeong D, Mitsuyama S, Oh JG, Liang L, Ikeda Y, Sadoshima J, Hajjar R, Kho C.
    Antioxid Redox Signal 2014; 21(14): 1986-2001.
窪薗琢郎
  1. Mechanism of the blood pressure-lowering effect of sodium-glucose cotransporter 2 inhibitors in obese patients with type 2 diabetes.
    Kawasoe S, Maruguchi Y, Kajiya S, Uenomachi H, Miyata M, Kawasoe M, Kubozono T, Ohishi M.
    BMC Pharmacol Toxicol 2017; 18(1): 23.
  2. High pulse wave velocity has a strong impact on early carotid atherosclerosis in a Japanese general male population.
    Kubozono T, Miyata M, Kawasoe S, Ojima S, Yoshifuku S, Miyahara H, Maenohara, S,
    Ohishi M.
    Circ J 2017; 81: 310-315.
  3. Uric acid level and prevalence of atrial fibrillation in 285,882 Japanese general population.
    Kawasoe S, Kubozono T, Yoshifuku S, Ojima S, Oketani N, Miyata M, Miyahara H,
    Maenohara S, Ohishi M.
    Cir J 2016; 80: 2453-2459.
  4. Combined effects of repeated sauna therapy and exercise training on cardiac function and physical activity in patients with chronic heart failure.
    Haseba S, Sakakima H, Kubozono T, Nakao S, Ikeda S.
    Disabil Rehabil 2015; 20: 1-7.
  5. Values of cardio-ankle vascular index (CAVI) between Amami islands and Kagoshima mainland among health checkup examinees.
    Hirasada K, Niimura H, Kubozono T, Nakamura A, Tatebo M, Ogawa S, Tsunematsu N,
    Chiba S, Matsushita T, Kusano K, Miyata M, Takezaki T.
    J Atheroscler Thromb 2012; 19: 69-80.
  6. Comparative study of therapeutic effects of short- and long-acting loop diuretics in outpatients with chronic heart failure (COLD-CHF).
    Miyata M, Sasaki T, Ikeda Y, Shinsato T, Kubozono T, Furusho Y, Kusumoto A, Hamasaki
    S, Tei C; COLD-CHF Investigators.
    J Cardiol 2012; 59: 352-358.
  7. Highly sensitive cardiac troponin T in heart failure: comparison with echocardiographic parameters and natriuretic peptides.
    Kusumoto A, Miyata M, Kubozono T, Ikeda Y, Shinsato T, Kuwahata S, Fujita S, Takasaki
    K, Yuasa T, Hamasaki S, Tei C.
    J Cardiol 2012; 59: 202-208.
  8. Improvement of autonomic nervous activity by Waon therapy in patients with chronic heart failure.
    Kuwahata S, Miyata M, Fujita S, Kubozono T, Shinsato T, Ikeda Y, Hamasaki S, Kuwaki T,
    Tei C.
    J Cardiol 2011; 57: 100-106.
  9. Relationship between bilirubin concentration, coronary endothelial function, and inflammatory stress in overweight patients.
    Yoshino S, Hamasaki S, Ishida S, Kataoka T, Yoshikawa A, Oketani N, Saihara K, Okui H,
    Shinsato T, Ichiki H, Kubozono T, Kuwahata S, Fujita S, Kanda D, Nakazaki M, Miyata
    M, Tei C.
    J Atheroscler Thromb 2011; 18: 403-412.
  10. Acute and chronic effects of smoking on arterial stiffness.
    Kubozono T, Miyata M, Ueyama K, Hamasaki S, Kusano K, Kubozono O, Tei C.
    Circ J 2011; 75: 698-702.
田中(窪田)佳代子
  1. Impairment of iodine-123-metaiodobenzylguanidine (123I-MIBG) uptake in patients with pulmonary artery hypertension.
    Higo K, Kubota K, Miyanaga S, Miyata M, Nakajo M, Jinguji M, Ohishi M.
    Internal Heart J 2018; 59 (1): 112-119.
  2. Successful Antemortem Diagnosis and Treatment of Pulmonary Tumor Thrombotic Microangiopathy.
    Higo K, Kubota K, Takeda A, Higashi M, Ohishi M.
    Intern Med. 2014; 53: 2595-2599.
  3. Functional mitral stenosis after surgical annuloplasty for ischemic mitral regurgitation: importance of subvalvular tethering in the mechanism and dynamic deterioration during exertion.
    Kubota K, Otsuji Y, Ueno T, Koriyama C, Levine RA, Sakata R, Tei C.
    J Thorac Cardiovasc Surg. 2010; 140: 617-623.
赤﨑雄一
  1. Metabolomic analysis of Akt1-mediated muscle hypertrophy in models of diet-induced obesity and age-related fat accumulation.
    Cheng KK, Akasaki Y, Lecommandeur E, Lindsay RT, Murfitt S, Walsh K, Griffin JL.
    J Proteome Res. 2015; 14: 342-352.
  2. Glycolytic fast-twitch muscle fiber restoration counters adverse age-related changes in body composition and metabolism.
    Akasaki Y, Ouchi N, Izumiya Y, Bernardo BL, Lebrasseur NK, Walsh K.
    Aging Cell. 2014; 13: 80-91.
  3. Waon Therapy Upregulates Hsp90 and Leads to Angiogenesis Through the Akt-Endothelial Nitric Oxide Synthase Pathway in Mouse Hindlimb Ischemia.
    Miyauchi T, Miyata M, Ikeda Y, Akasaki Y, Hamada N, Shirasawa T, Furusho Y, Tei C.
    Circ J. 2012; 76: 1712-1721.
  4. Novel Therapy for Atherosclerosis Using Recombinant Immunotoxin Against Folate Receptor β-Expressing Macrophages.
    Furusho Y, Miyata M, Matsuyama T, Nagai T, Li H, Akasaki Y, Hamada N, Miyauchi T, Ikeda Y, Shirasawa T, Ide K, Tei C.
    J Am Heart Assoc. 2012; 1: e003079.
  5. Akt1-Mediated Skeletal Muscle Growth Attenuates Cardiac Dysfunction and Remodeling after Experimental Myocardial Infarction.
    Araki S, Izumiya Y, Hanatani S, Rokutanda T, Usuku H, Akasaki Y, Takeo T, Nakagata N, Walsh K, Ogawa H.
    Circ Heart Fail. 2012; 5: 116-125.
  6. Loss of clusterin limits atherosclerosis in apolipoprotein E-deficient mice via reduced expression of Egr-1 and TNF-α.
    Hamada N, Miyata M, Eto H, Ikeda Y, Shirasawa T, Akasaki Y, Miyauchi T, Furusho Y, Nagaki A, Aronow BJ, Tei C.
    J Atheroscler Thromb. 2011; 18: 209-216.
  7. Insulin-like 6 is induced by muscle injury and functions as a regenerative factor.
    Zeng L, Akasaki Y, Sato K, Ouchi N, Izumiya YY, Walsh K.
    J Biol Chem.2010; 285: 36060-36069.
  8. Waon therapy mobilizes CD34+ cells and improves peripheral arterial disease.
    Shinsato T, Miyata M, Kubozono T, Ikeda Y, Fujita S, Kuwahata S, Akasaki Y, Hamasaki S, Fujiwara H, Tei C.
    J Cardiol. 2010; 56: 361-366.
  9. Tacrolimus-eluting stent inhibits neointimal hyperplasia via calcineurin/NFAT signaling in porcine coronary artery model.
    Hamada N, Miyata M, Eto H, Shirasawa T, Akasaki Y, Nagaki A, Tei C.
    Atherosclerosis. 2010; 208: 97-103.
  10. Sfrp5 Is an Anti-Inflammatory Adipokine That Modulates Metabolic Dysfunction in Obesity.
    Ouchi N, Higuchi A, Ohashi K, Oshima Y, Gokce N, Shibata R, Akasaki Y, Shimono A, Walsh K.
    Science. 2010; 329: 454-457.
内匠拓朗
  1. 1. Angiotensin-converting enzyme inhibitor prevents the worsening of renal function in the late phase after percutaneous coronary intervention.
    Kanda D, Takumi T, Miyata M, Tokushige A, Sonoda T, Yoshino S, Saihara K, Ohishi M.
    J Atheroscler Thromb 2016; 23(2): 233-240.
  2. 2. Plaque characteristics and arterial remodeling in coronary and peripheral arterial systems.
    Yoshiki Matsuo, Takuro Takumi, Verghese Mathew, Woo-Young Chung, Gregory W. Barsness, Charanjit S. Rihal, Rajiv Gulati, Eric T. McCue, David R. Holmes, Eric Eeckhout, Ryan J. Lennon,Lilach O.
    Lerman c, Amir Lerman a.
    Atherosclerosis. 2012; 223: 365-371.
  3. 3. The Association Between Renal Atherosclerotic Plaque Characteristics and Renal Function Before and After Renal Artery Intervention.
    Takuro Takumi, Verghese Mathew, Gregory W. Barsness, etsuro Kataoka, Ronen Rubinshtein, Charanjit S. Rihal, Rajiv Gulati, Eric Eeckhout, Ryan J. Lennon, Lilach O. Lerman, Amir Lerman.
    Mayo Clinic Proceedings. 2011; 86: 1165-1172.
  4. 4. Coronary endothelial dysfunction is associated with a reduction in coronary artery compliance and an increase in wall shear stress.
    Takuro Takumi, Eric H Yang, Verghese Mathew, Charanjit S Rihal, Rajiv Gulati, Lilach O Lerman, Amir Lerman.
    Heart. 2010; 96: 773-778.
  5. 5. Limitation of Angiography to Identify the Culprit Plaque in Acute Myocardial Infarction With Coronary Total Occlusion: Utility of Coronary Plaque Temperature Measurement to Identify the Culprit Plaque.
    Takuro Takumi, Souki Lee, Shuichi Hamasaki, Kouichi Toyonaga, Daisuke Kanda, Keisuke Kusumoto, Hitoshi Toda, oshihiro Takenaka, Masaaki Miyata, Ryuichiro Anan, Yutaka Otsuji, Chuwa Tei.
    Journal of the American College of Cardiology.2007; 50: 2197-2203.
樋口公嗣
  1. Prevalence and clinical features of Fabry disease in Japanese male patients with diagnosis of hypertrophic cardiomyopathy.
    Kubo T, Ochi Y, Baba Y, Hirota T, Tanioka K, Yamasaki N, Yoshimitsu M, Higuchi K, Takenaka T, Nakajima K, Togawa T, Tsukimura T, Sano S, Tei C, Sakuraba H, Kitaoka H.
    J Cardiol 2017; 69: 302-307.
  2. Neonatal transfer of membrane-bound stem cell factor improves survival and heart function in aged mice after myocardial ischemia.
    Sun Z, Lee CJ, Mejia-Guerrero S, Zhang Y, Higuchi K, Li RK, Medin JA.
    Hum Gene Ther. 2012; 23: 1280-1289.
  3. Identification of novel mutations in the α-galactosidase A gene in patients with Fabry disease: Pitfalls of mutation analyses in patients with low α-galactosidase A activity.
    Yoshimitsu M, Higuchi K, Miyata M, Devine S, Mattman A, Sirrs S, Medin JA, Tei C, Takenaka T.
    J cardiol. 2011; 57: 345-353.
  4. Sequencing and characterization of the porcine alpha-galactosidase A gene: towards the generation of a porcine model for Fabry disease.
    Yoshimitsu M, Higuchi K, Fan X, Takao S, Medin JA, Tei C, Takenaka T.
    Mol Biol Rep. 2011; 38: 3145-3152.
  5. Alpha-galactosidase A-Tat fusion enhances storage reduction in hearts and kidneys of Fabry mice.
    Higuchi K, Yoshimitsu M, Fan X, Guo X, Rasaiah VI, Yen J, Tei C, Takenak T, Medin JA.
    Mol Med. 2010; 16: 216-221.
  6. Vascular endothelial growth factor broadens lentivector distribution in the heart after neonatal injection.
    Sato T, Ramsubir S, Higuchi K, Yanagisawa T, Medin JA.
    J Cardiol. 2009; 54: 245-254.
  7. Direct injection of kit ligand-2 lentivirus improves cardiac repair and rescues mice post-myocardial infarction.
    Higuchi K, Ayach B, Sato T, Chen M, Devine SP, Rasaiah VI, Dawood F, Yanagisawa T, Tei C, Takenaka T, Liu PP, Medin JA.
    Mol Ther. 2009; 17: 262-268.
  8. Terminal stage cardiac findings in patients with cardiac Fabry disease: an electrocardiographic, echocardiographic, and autopsy study.
    Takenaka T, Teraguchi H, Yoshida A, Taguchi S, Ninomiya K, Umekita Y, Yoshida H, Horinouchi M, Tabata K, Yonezawa S, Yoshimitsu M, Higuchi K, Nakao S, Anan R, Minagoe S, Tei C.
    J Cardiol. 2008; 51: 50-59.
  9. Efficient correction of Fabry mice and patient cells mediated by lentiviral transduction of hematopoietic stem/progenitor cells.
    Yoshimitsu M, Higuchi K, Ramsubir S, Nonaka t, Rasaiah VI, Siatskas C, Liang SB, Murray GJ, Brady RO, Medin JA.
    Gene Ther. 2007; 14: 256-265.
  10. Correction of cardiac abnormalities in fabry mice by direct intraventricular injection of a recombinant lentiviral vector that engineers expression of alpha-galactosidase A.
    Yoshimitsu M, Higuchi K, Dawood F, Rasaiah VI, Ayach B, Chen M, Liu P, Medin JA.
    Circ J. 2006; 70: 1503-1508.
奥井英樹
  1. Evaluation of safety and efficacy of periprocedural use of rivaroxaban and apixaban in catheter ablation for atrial fibrillation.
    Yoshimura A, Iriki Y, Ichiki H, Oketani N, Okui H, Maenosono R, Namino F, Miyata
    M, Ohishi M.
    J Cardiol 2017; 69(1): 228-235.
  2. The optimal setting of complex fractionated atrial electrograms software in substrate ablation for atrial fibrillation.
    Namino F, Iriki Y, Maenosono R, Ichiki H, Okui H, Yoshimura A, Oketani N, Matsushita M, Ohishi M, Hashiguchi T.
    J Arrhythm 2015; 31: 6-11.
  3. Relationship between apnoea-hypopnoea index and angiographic coronary disease phenotypes in patients presenting with acute myocardial infarction.
    Yoshino S, Yoshikawa A, Hamasaki S, Ishida S, Oketani N, Saihara K, Okui H, Kuwahata S, Fujita S, Ichiki H, Ueya N, Iriki Y, Maenosono R, Miyata M, Tei C.Acute Card Care 2013; 15(2): 26-33.
  4. The incidence of asymptomatic cerebral microthromboembolism after atrial fibrillation ablation: comparison of warfarin and dabigatran.
    Ichiki H, Oketani N, Ishida S, Iriki Y, Okui H, Maenosono R, Namino F, Ninomiya Y, Miyata M, Hamasaki S, Tei C.
    Pacing Clin Electrophysiol 2013; 36: 1328-1355.
  5. Atrial fibrillation-induced endothelial dysfunction improves after restoration of sinus rhythm. Yoshino S, Yoshikawa A, Hamasaki S, Ishida S, Oketani N, Saihara K, Okui H, Kuwahata S, Fujita S, Ichiki H, Ueya N, Iriki Y, Maenosono R, Miyata M, Tei C.
    Int J Cardiol 2013; 168: 1280-1285.
  6. Effectiveness of esophagus detection by three-dimensional electroanatomical mapping to avoid esophageal injury during ablation of atrial fibrillation.
    Maenosono R, Oketani N, Ishida S, Iriki Y, Ichiki H, Okui H, Ninomiya Y, Hamasaki S, Namino F, Matsushita M, Tei C, Hashiguchi T.
    J Cardiol 2012; 60: 119-125.
  7. Relationship between clinical outcomes and unintentional pulmonary vein isolation during substrate ablation of atrial fibrillation guided solely by complex fractionated atrial electrogram mapping.
    Iriki Y, Ishida S, Oketani N, Ichiki H, Okui H, Ninomiya Y, Maenosono R, Matsushita T, Miyata M, Hamasaki S, Tei C.
    J Cardiol; 58: 278-286.
  8. Relationship Between Bilirubin Concentration, Coronary Endothelial Function, and Inflammatory Stress in Overweight Patients.
    Yoshino S, Hamasaki S, Ishida S, Kataoka T, Yoshikawa A, Oketani N, Saihara K, Okui H, Shinsato T, Ichiki H, Kubozono T, Kuwahata S, Fujita S, Kanda D, Nakazaki M, Miyata M, Tei C.
    J Atheroscler Thromb 2011; 18(5): 403-412.
  9. Relationship between hyperglycemia and coronary vascular resistance in non-diabetic patients.
    Ichiki H, Hamasaki S, Nakasaki M, Ishida S, Yoshikawa A, Kataoka T, Ogawa M, Saihara K, Okui H, Orihara K, Shinsato T, Oketani N, Shirasawa T, Ninomiya Y, Kuwahata S, Fujita S, Takumi T, Iriki Y, Yoshino S, Matsushita T, Tei C.
    Int J Cardiol 2010; 141(1): 44-48.
  10. Effect of uric acid on coronary microvascular endothelial function in women: association with eGFR and ADMA.
    Kuwatata S, Hamasaki S, Ishida S, Kataoka T, Yoshikawa A, Orihara K, Ogawa M, Oketani N, Saihara K, Okui H, Shinsato T, Kubozono T, Ichiki H, Fujita S, Takumi T, Yoshino S, Nakazaki M, Miyata M, Tei C.
    J Atheroscler Thromb 2010; 17(3): 259-269.
市來仁志
  1. Evaluation of safety and efficacy of periprocedural use of rivaroxaban and apixaban in catheter ablation for atrial fibrillation.
    Yoshimura A, Iriki Y, Ichiki H, Oketani N, Okui H, Maenosono R, Namino F, Miyata M, Ohishi M.
    J Cardiol 2017; 69(1): 228-235.
  2. The incidence of asymptomatic cerebral microthromboembolism after atrial fibrillation ablation: comparison of warfarin and dabigatran.
    Ichiki H, Oketani N, Ishida S, Iriki Y, Okui H, Maenosono R, Namino F, Ninomiya Y, Miyata M, Hamasaki S, Tei C.
    Pacing Clin Electrophysiol 2013; 36(11): 1328-1335.
  3. Atrial fibrillation-induced endothelial dysfunction improves after restoration of sinus rhythm.
    Yoshino S, Yoshikawa A, Hamasaki S, Ishida S, Oketani N, Saihara K, Okui H, Kuwahata S, Fujita S, Ichiki H, Ueya N, Iriki Y, Maenosono R, Miyata M, Tei C.
    Int J Cardiol 2013; 168(2): 1280-1285.
  4. Characterization of the effect of serum bilirubin concentrations on coronary endothelial function via measurement of high-sensitivity C-reactive protein and high-density lipoprotein cholesterol.
    Yoshino S, Hamasaki S, Ishida S, Kataoka T, Yoshikawa A, Oketani N, Saihara K, Ichiki H, Kuwahata S, Fujita S, Takumi T, Yoshimoto I, Nakazaki M, Tei C.
    Heart Vessels 2013; 28(2): 157-165.
  5. Effectiveness of esophagus detection by three-dimensional electroanatomical mapping to avoid esophageal injury during ablation of atrial fibrillation.
    Maenosono R, Oketani N, Ishida S, Iriki Y, Ichiki H, Okui H, Ninomiya Y, Hamasaki S, Namino F, Matsushita M, Tei C, Hashiguchi T.
    J Cardiol 2012; 60(2): 119-125.
  6. Incidence of asymptomatic cerebral microthromboembolism after atrial fibrillation ablation guided by complex fractionated atrial electrogram.
    Ichiki H, Oketani N, Ishida S, Iriki Y, Okui H, Maenosono R, Ninomiya Y, Matsushita T, Miyata M, Hamasaki S, Tei C.
    J Cardiovasc Electrophysiol 2012; 23(6): 567-573.
  7. Relationship between clinical outcomes and unintentional pulmonary vein isolation during substrate ablation of atrial fibrillation guided solely by complex fractionated atrial electrogram mapping.
    Iriki Y, Ishida S, Oketani N, Ichiki H, Okui H, Ninomiya Y, Maenosono R, Matsushita T, Miyata M, Hamasaki S, Tei C.
    J Cardiol 2011; 58(3): 278-286.
  8. Relationship between bilirubin concentration, coronary endothelial function, and inflammatory stress in overweight patients.
    Yoshino S, Hamasaki S, Ishida S, Kataoka T, Yoshikawa A, Oketani N, Saihara K, Okui H, Shinsato T, Ichiki H, Kubozono T, Kuwahata S, Fujita S, Kanda D, Nakazaki M, Miyata M, Tei C.
    J Atheroscler Thromb 2011; 18(5): 403-412.
  9. Enjoying hobbies is related to desirable cardiovascular effects.
    Saihara K, Hamasaki S, Ishida S, Kataoka T, Yoshikawa A, Orihara K, Ogawa M, Oketani N, Fukudome T, Atsuchi N, Shinsato T, Okui H, Kubozono T, Ichiki H, Kuwahata S, Mizoguchi E, Fujita S, Takumi T, Ninomiya Y, Tomita K, Tei C.
    Heart Vessels 2010; 25(2): 113-120.
  10. Relationship between hyperglycemia and coronary vascular resistance in non-diabetic patients.
    Ichiki H, Hamasaki S, Nakasaki M, Ishida S, Yoshikawa A, Kataoka T, Ogawa M, Saihara K, Okui H, Orihara K, Shinsato T, Oketani N, Shirasawa T, Ninomiya Y, Kuwahata S, Fujita S, Takumi T, Iriki Y, Yoshino S, Matsushita T, Tei C.
    Int J Cardiol 2010; 141(1): 44-48.
神田大輔
  1. Angiotensin-converting enzyme inhibitor prevents the worsening of renal function in the late phase after percutaneous coronary intervention.
    Kanda D, Takumi T, Miyata M, Tokushige A, Sonoda T, Yoshino S, Saihara K, Ohishi M.
    J Atheroscler Thromb 2016; 23(2): 233-240.

主な研究費取得状況

大石 充
事業・種目 / 期間研究
日本学術振興会
科学研究費 基盤研究(C) 代表 / 2016年度~2018年度
大規模検診から高浸透率家系を抽出する新しい高血圧遺伝子同定法の確立.
池田義之
事業・種目 / 期間研究
日本学術振興会
科学研究費 基盤研究(C) 代表 / 2016年度~2018年度
血管老化・動脈硬化に対するオルタナティブオートファジーを軸とした治療法の開発.
窪薗琢郎
事業・種目 / 期間研究
日本学術振興会
科学研究費 基盤研究(C) 代表 / 2016年度~2019年度
フレイルと心不全の相互関連因子探索と心臓リハビリテーションの有効性に関する研究.
田中(窪田)佳代子
事業・種目 / 期間研究
日本学術振興会
科学研究費 基盤研究(C) 代表 / 2017年度~2019年度
次世代シーケンサーによる家族性肺高血圧症の遺伝子解析:特発性肺高血圧症の機序解明.
樋口公嗣
事業・種目 / 期間研究
日本学術振興会
科学研究費 基盤研究(C) 代表 / 2017年度~2019年度
Fabry病の新規αガラクトシダーゼ遺伝子変異による酵素の生体内動態に関する研究.
赤﨑雄一
事業・種目 / 期間研究
日本学術振興会
科学研究費 基盤研究(C) 代表 / 2017年度~2019年度
ミトコンドリアダイナミクスとオートファージを標的としたサルコペニアの新規治療法.
神田大輔
事業・種目 / 期間研究
日本学術振興会
研究活動スタート支援 / 2016年度~2017年度
末梢動脈疾患における新規動脈硬化マーカーの確立.

分野サイト

新ニーズに対応する九州がんプロ養成プラン
GPなど(医歯学)
鹿児島大学
鹿児島大学病院
附属施設等
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