研究テーマ(研究室紹介)

心臓血管・高血圧内科学

Generalist with specialtyを合い言葉に心臓だけでなく全人的に内科全般を診られる医師の育成と、現場の“何故”を解決する臨床・基礎研究の充実をモットーとしています。
24時間365日救急受け入れをするなど最後の砦としての大学病院の使命を全うしながら、海外学会発表や論文投稿、症例報告など「鹿児島から全世界への情報発信」をするべく日夜頑張っている若い講座です。

研究室概要

部局 大学院医歯学総合研究科 Graduate School of Medical and Dental Sciences
専攻 先進治療科学専攻 Advanced Therapeutics Course
大講座 循環器・呼吸器病学 Cardiovascular and Respiratory Disorders
分野 心臓血管・高血圧内科学 Cardiovascular Medicine and Hypertension
分野サイト http://www.kufm.kagoshima-u.ac.jp/~intmed1/

分野サイト

連絡先

TEL.099-275-5318 / FAX.099-265-8447

主要研究テーマ

高血圧 Hypertension
虚血性心疾患 Ischemic heart disease
動脈硬化 Atherosclerosis
心臓超音波 Cardiac echocardiography
成人先天性心疾患 Adult congenital heart disease
心不全 Heart failure
肺高血圧 Pulmonary hypertension
不整脈 Arrhythmia
心筋症 Cardiomyopathy

スタッフ

大石充 Mitsuru OHISHI

教授
氏名 大石充 Mitsuru OHISHI
専門分野 循環器学、虚血性心疾患、動脈硬化、高血圧
研究テーマ ・循環器レジストリを駆使した病態把握と心血管疾患治療seeds探索
・心疾患予防に対するストラテジー構築
・安定した血圧を保つ降圧療法の開発
・レニン・アンジオテンシン系の新規作用機序の探索
・酸化ストレス・炎症を介した新規動脈硬化治療法の開発

研究者総覧 リポジトリ


宮田昌明 Masaaki MIYATA

准教授
氏名 宮田昌明 Masaaki MIYATA
専門分野 循環器学、高血圧、動脈硬化、心不全
研究テーマ ・活性化マクロファージを標的とした不安定プラークの分子イメージングと治療法の開発
・動脈硬化と血管傷害におけるアポ蛋白J(クラステリン)の作用解明
・循環器疾患における生化学マーカーの臨床応用
・脈波伝播速度による動脈硬化の臨床研究
・閉塞性動脈硬化症や心不全に対する和温療法の臨床・基礎研究

研究者総覧 リポジトリ


桶谷直也 Naoya OKETANI

講師
氏名 桶谷直也 Naoya OKETANI
専門分野 循環器学、不整脈
研究テーマ ・心房細動のカテーテルアブレーション(ストラテジーや合併症の予防)
・心室頻拍/細動のカテーテルアブレーション(基礎心疾患を伴うものやBrugada症候群、J波症候群)
・心筋イオンチャネル(学位論文)

研究者総覧 リポジトリ


湯淺敏典 Toshinori YUASA

講師
氏名 湯淺敏典 Toshinori YUASA
専門分野 循環器学、超音波学
研究テーマ 心臓超音波学(ドプラ法を用いた心機能評価, 運動負荷エコー、3Dエコー)
・軽運動負荷心エコーを用いた心臓弁膜症における心予備能の研究
・軽運動負荷心エコーを用いた心不全例における運動耐容能の研究
・心エコードプラ法による心時相解析を用いた各種心疾患の評価

研究者総覧 リポジトリ


髙﨑州亜 Kunitugu TAKASAKI

講師
氏名 髙﨑州亜 Kunitugu TAKASAKI
専門分野 循環器学、超音波学
研究テーマ ・心エコーによる心時相解析を用いた各種心疾患の心機能評価
・高血圧症例における左室形態と心機能との関連
・各種心疾患と左室・大動脈連関
・成人先天性心疾患の包括的診療体制の確立

研究者総覧 リポジトリ


池田義之 Yoshiyuki IKEDA

特任講師
氏名 池田義之 Yoshiyuki IKEDA
専門分野 循環器学、動脈硬化、高血圧、抗加齢医学
研究テーマ ・オートファジーやミトコンドリアダイナミクスと心臓血管系の老化・心不全・動脈硬化・高血圧に関する研究
・閉経に伴う心臓血管系の老化・動脈硬化進展の機序の解明および治療法の確立
・レニン・アンギオテンシン・アルドステロン系と心臓血管系の老化・動脈硬化に関する研究
・高齢者高血圧患者に対する降圧治療に関する臨床研究
・その他、高血圧・動脈硬化(脂質異常症)・老化(抗加齢)に関する基礎・臨床研究

研究者総覧


Takuro KUBOZONO

助教
氏名 窪薗琢郎 Takuro KUBOZONO
専門分野 循環器学、心不全、心臓リハビリテーション
研究テーマ ・心疾患患者における運動耐容能に関する研究
・心不全患者における血管機能に関する研究
・心不全患者における予後に関する研究
・心臓リハビリテーションに関する新たな治療法・介入の開発

研究者総覧 リポジトリ


saisin tanaka kubota dr

助教
氏名 田中(窪田)佳代子 Kayoko TANAKA(KUBOTA)
専門分野 循環器学、肺循環、超音波学
研究テーマ ・肺高血圧症

研究者総覧 リポジトリ


赤﨑雄一 Yuichi AKASAKI

助教
氏名 赤﨑雄一 Yuichi AKASAKI
専門分野 循環器学、高血圧、動脈硬化
研究テーマ ・難治性高血圧の実態調査および予後に関する観察研究
・大動脈瘤および大動脈解離への寄与因子に関する臨床・基礎研究
・睡眠時無呼吸症候群と高血圧に関する臨床・基礎研究
・老化による筋肉減弱症(サルコペニア)が心血管疾患に及ぼす影響に関する基礎研究

研究者総覧 リポジトリ


内匠拓朗 Takuro TAKUMI

助教
氏名 内匠拓朗 Takuro TAKUMI
専門分野 循環器学、虚血性心疾患
研究テーマ ・冠微小循環障害と血小板機能の関連について
・スタチンの造影剤腎症抑制効果について

研究者総覧 リポジトリ


樋口公嗣 Koji HIGUCHI

特任助教
氏名 樋口公嗣 Koji HIGUCHI
専門分野 循環器学、心筋症
研究テーマ  

研究者総覧 リポジトリ

主な研究実績

大石充
  1. Tissue inhibitor of metalloproteinase-3 knockout mice exhibit enhanced energy expenditure through thermogenesis.
    Hanaoka Y, Yasuda O, Soejima H, Miyata K, Yamamoto E, Izumiya Y, Maeda N, Ohishi M, Rakugi H, Oike Y, Kim-Mitsuyama S, Ogawa H.
    PLoS One 2014; 9: e94930.
  2. Aortic pulse wave velocity improves cardiovascular event prediction: an individual participant meta-analysis of prospective observational data from 17,635 subjects.
    Ben-Shlomo Y, Spears M, Boustred C, May M, Simon GA, Benjamin EJ, Boutouyrie P, Cameron J, Chen CH, Cruickshank JK, Hwang SJ, Lakatta EG, Laurent S, Maldonado J, Mitchell GF, Najjar SS, Newman AB, Ohishi M, Pannier B, Pereira T, Ramachandran VS, Shokawa T, Sutton-Tyrell K, Verbeke F, Wang KL, Webb DJ, Hansen TW, Zoungas S, McEniery CM, Cockcroft JR, Wilkinson IB.
    J Am Coll Cardiol 2014; 63: 636–646.
  3. Novel effect of ezetimibe to inhibit the development of non-alcoholic fatty liver disease in Fatty Liver Shionogi mouse.
    Wang X, Sugimoto K, Fujisawa T, Shindo N, Minato S, Kamada Y, Hamano M, Ohishi M, Ikegami H, Rakugi H.
    Hepatol Res 2014; 44: 102-113.
  4. Loss of Angiotensin-converting enzyme 2 exaggerates high-calorie diet-induced insulin resistance by reduction of GLUT4 in mice.
    Takeda M, Yamamoto K, Takemura Y, Takeshita H, Hongyo K, Kawai T, Hanasaki-Yamamoto H, Oguro R, Takami Y, Tatara Y, Takeya Y, Sugimoto K, Kamide K, Ohishi M, Rakugi H.
    Diabetes 2013; 62: 223-233.
  5. Adioponectin single nucleotide polymorphism is a genetic risk factor for stroke through high pulse wave pressure: a cohort study.
    Kawai T, Ohishi M, Takeya Y, Onishi M, Ito N, Yamamoto K, Oguro R, Kamide K, Rakugi H.
    J Atheroscler Thromb 2013; 20: 152-160.
  6. -374 T/A polymorphism in receptor of advanced glycation end product (RAGE) gene is associated with onset of diabetes mellitus, atherosclerosis, and renal dysfunction in patients with hypertension.
    Kawai T, Kamide K, Ito N, Onishi M, Oguro R, Takeya Y, Tatara Y, Maekawa Y, Katsuya T, Ohishi M, Rakugi H.
    Clin Exp Hypertens 2013; 35: 236-241.
  7. Differences between daytime and night-time blood pressure variability regarding systemic atherosclerotic change and renal function.
    Kawai T, Ohishi M, Kamide K, Nakama C, Onishi M, Ito N, Takami Y, Takeya Y, Rakugi H.
    Hypertens Res 2013; 36: 232-239.
  8. Telmisartan modulates mitochondrial function in vascular smooth muscle cells.
    Takeuchi K, Yamamoto K, Ohishi M, Takeshita K, Hongyo K, Kawai T, Takeda M, Kamide K, Kurtz TW, Rakugi H.
    Hypertension Research 2013; 36: 433-439.
  9. Cut-off Value of Brachial-ankle Pulse Wave Velocity to Predict Cardiovascular Disease in Hypertensive Patients: A Cohort Study.
    Kawai T, Ohishi M, Onishi M, Ito N, Takeya Y, Maekawa Y, Rakugi H.
    J Atheroscler Thromb 2013; 20: 391-400.
  10. Effect of tablets with a combination of telmisartan and amlodipine on patients with hypertension: The Cotalo study.
    Ohishi M, Kawai T, Hayashi N, Kitano S, Katsuya T, Nagano M, Hirotani A, Yamamoto K, Kamide K, Rakugi H.
    J Atheroscler Thromb 2013; 20: 391-400.
宮田昌明
  1. Effects of Waon Therapy on Chronic Fatigue Syndrome: A Pilot Study.
    Soejima Y, Munemoto T, Masuda A, Uwatoko Y, Miyata M, MD, Tei C.
    Internal Medicine 2015; 54:333-338.
  2. Associations between the autonomic nervous system and the second derivative of the finger photoplethysmogram indices.
    Kohjitani A, Miyata M, Iwase Y, Ohno S, Tohya A, Manabe Y, Hashiguchi T, Sugiyama K.
    J Atheroscler Thromb 2014; 21: 501-8.
  3. The incidence of asymptomatic cerebral microthromboembolism after atrial fibrillation ablation: comparison of warfarin and dabigatran.
    Ichiki H, Oketani N, Ishida S, Iriki Y, Okui H, Maenosono R, Namino F, Ninomiya Y, Miyata M,  Hamasaki S, Tei C.
    Pacing Clin Electrophysiol 2013; 36: 1328-1335.
  4. Atrial fibrillation-induced endothelial dysfunction improves after restoration of sinus rhythm.
    Yoshino S, Yoshikawa A, Hamasaki S, Ishida S, Oketani N, Saihara K, Okui H, Kuwahata S, Fujita S, Ichiki H, Ueya N, Iriki Y, Maenosono R, Miyata M, Tei C.
    Int J Cardiol 2013; 168: 1280-1285.
  5. Influence of gefitinib and erlotinib on apoptosis and c-MYC expression in H23 lung cancer cells.
    Suenaga M, Yamamoto M, Tabata S, Itakura S, Miyata M, Hamasaki S, Furukawa T.
    Anticancer Res 2013; 33: 1547-1554.
  6. Novel therapy for atherosclerosis using recombinant immunotoxin against folate receptor β-expressing macrophages.
    Furusho Y, Miyata M, Matsuyama T, Nagai T, Li H, Akasaki Y, Hamada N, Miyauchi T, Ikeda Y, Shirasawa T, Ide K, Tei C.
    J Am Heart Assoc 2012; 1: e003079.
  7. Effects of valsartan on fibrinolysis in hypertensive patients with metabolic syndrome: the KACT-MetS Study.
    Miyata M, Ikeda Y, Nakamura S, Sasaki T, Abe S, Minagoe S, Torii H, Lee S, Tateishi S, Kihara K, Ohba I, Kajiya S, Furusho Y, Hamasaki S, Tei C, Kagoshima Collaborate Trial in Metabolic Syndrome (KACT-MetS) Investigators.
    Circ J. 2012; 76: 843-51.
  8. Highly sensitive cardiac troponin T in heart failure: comparison with echocardiographic parameters and natriuretic peptides.
    Kusumoto A, Miyata M, Kubozono T, Ikeda Y, Shinsato T, Kuwahata S, Fujita S, Takasaki K, Yuasa T, Hamasaki S, Tei C.
    J Cardiol.2012; 59: 202-208.
  9. Values of cardio-ankle vascular index (CAVI) between Amami islands and Kagoshima mainland among health checkup examinees.
    Hirasada K, Niimura H, Kubozono T, Nakamura A, Tatebo M, Ogawa S, Tsunematsu N, Chiba S, Matsushita T, Kusano K, Miyata M, Takezaki T.
    J Atheroscler Thromb.2012; 19: 69-80.
  10. Responses of the second derivative of the finger photoplethysmogram indices and hemodynamic parameters to anesthesia induction.
    Kohjitani A, Miyata M, Iwase Y, Sugiyama K.
    Hypertens Res.2012; 35: 166- 172.
桶谷直也
  1. The Optimal Setting of Complex Fractionated Atrial Electrograms Software in Substrate Ablation for Atrial Fibrillation.
    Namino F, Iriki Y, Maenosono R, Ichiki H, Okui H, Yoshimura A, Oketani N, Matsushita M, Ohishi M, Hashiguchi T.
    J Arrhythm. 2015; 31: 6-11.
  2. Atrial fibrillation-induced endothelial dysfunction improves after restoration of sinus rhythm.
    Yoshino S, Yoshikawa A, Hamasaki S, Ishida S, Oketani N, Saihara K, Okui H, Kuwahata S, Fujita S, Ichiki H, Ueya N, Iriki Y, Maenosono R, Miyata M, Tei C.
    Int J Cardiol. 2013; 168: 1280-1285.
  3. The Incidence of Asymptomatic Cerebral Microthromboembolism after Atrial Fibrillation Ablation: Comparison of Warfarin and Dabigatran.
    Ichiki H, Oketani N*, Ishida S, Iriki Y, Okui H, Maenosono R, Namino F, Ninomiya Y, Miyata M, Hamasaki S, Tei C.
    Pacing Clin Electrophysiol. 2013; 36: 1328-1335.
  4. Atrial fibrillation-induced endothelial dysfunction improves after restoration of sinus rhythm.
    Yoshino S, Yoshikawa A, Hamasaki S, Ishida S, Oketani N, Saihara K, Okui H, Kuwahata S, Fujita S, Ichiki H, Ueya N, Iriki Y, Maenosono R, Miyata M, Tei C.
    Int J Cardiol.2013; 168: 1280-1285.
  5. Characterization of the effect of serum bilirubin concentrations on coronary endothelial function via measurement of high-sensitivity C-reactive protein and high-density lipoprotein cholesterol.
    Yoshino S, Hamasaki S, Ishida S, Kataoka T, Yoshikawa A, Oketani N, Saihara K, Ichiki H, Kuwahata S, Fujita S, Takumi T, Yoshimoto I, Nakazaki M, Tei C.
    Heart Vessels. 2013; 28: 157-165.
  6. Effectiveness of esophagus detection by three-dimensional electroanatomical mapping to avoid esophageal injury during ablation of atrial fibrillation.
    Maenosono R, Oketani N*, Ishida S, Iriki Y, Ichiki H, Okui H, Ninomiya Y, Hamasaki S, Namino F, Matsushita M, Tei C, Hashiguchi T.
    J Cardiol. 2012; 60: 119-125.
  7. Incidence of Asymptomatic Cerebral Microthromboembolism After Atrial Fibrillation Ablation Guided by Complex Fractionated Atrial Electrogram.
    Ichiki H, Oketani N, Ishida S, Iriki Y, Okui H, Maenosono R, Ninomiya Y, Matsushita T, Miyata M, Hamasaki S, Tei C.
    J Cardiovasc Electrophysiol. 2012 Jun; 23: 567-573.
  8. Relationship between clinical outcomes and unintentional pulmonary vein isolation during substrate ablation of atrial fibrillation guided solely by complex fractionated atrial electrogram mapping.
    Iriki Y, Ishida S, Oketani N*, Ichiki H, Okui H, Ninomiya Y, Maenosono R, Matsushita T, Miyata M, Hamasaki S, Tei C.
    J Cardiol. 2011; 58: 278- 286.
  9. Relationship between bilirubin concentration, coronary endothelial function, and inflammatory stress in overweight patients.
    Yoshino S, Hamasaki S, Ishida S, Kataoka T, Yoshikawa A, Oketani N, Saihara K, Okui H, Shinsato T, Ichiki H, Kubozono T, Kuwahata S, Fujita S, Kanda D, Nakazaki M, Miyata M, Tei C.
    J Atheroscler Thromb. 2011; 18: 403-412.
  10. High expression level of Toll-like receptor 2 on monocytes is an important risk factor for arteriosclerotic disease.
    Kuwahata S, Fujita S, Orihara K, Hamasaki S, Oba R, Hirai H, Nagata K, Ishida S, Kataoka T, Oketani N, Ichiki H, Iriki Y, Saihara K, Okui H, Ninomiya Y, Tei C.
    Atherosclerosis. 2010; 209: 248-254.
湯淺敏典
  1. Prosthetic tricuspid valve dysfunction assessed by three-dimensional transthracic and transesophageal echocardiography.
    Yuasa T, Takasaki K, Mizukami N, Ueya N, Kubota K, Horizoe Y, Chaen H, Kuwahara E, Kisanuki A, Hamasaki S.
    J Echocardiogr.2013; 11: 97-99.
  2. Clinical spectrum, frequency, and significance of myocardial dysfunction in severe sepsis and septic shock.
    Pulido JN, Afessa B, Masaki M, Yuasa T, Gillespie S, Herasevich V, Brown DR, Oh JK.
    Mayo Clin Proc.2012; 87: 620-628.
  3. Highly sensitive cardiac troponin T in heart failure: comparison with echocardiographic parameters and natriuretic peptides.
    Kusumoto A, Miyata M, Kubozono T, Ikeda Y, Shinsato T, Kuwahata S, Fujita S, Takasaki K, Yuasa T, Hamasaki S, Tei C.
    J Cardiol.2012; 59: 202-208.
  4. Different flow patterns between left and right internal thoracic artery grafts influence the evaluation of severe graft stenosis by transthoracic Doppler echocardiography.
    Mizukami N, Kisanuki A, Hamasaki S, Takasaki K, Yuasa T, Kuwahara E, Ueya N, Horizoe Y, Chaen H, Maruyama I, Imoto Y, Tei C.
    J Am Soc Echocardiogr. 2011; 24: 768-774
  5. Left ventricular global systolic dysfunction has a significant role in the development of diastolic heart failure in patients with systemic hypertension.
    Kono M, Kisanuki A, Ueya N, Kubota K, Kuwahara E, Takasaki K, Yuasa T, Mizukami N, Miyata M, Tei C.
    Hypertension Research.2010; 33: 1167-1173.
  6. Left atrium volume index and pathological features of left atrial appendage as a predictor of failure in postoperative sinus conversion.
    Kataoka T, Hamasaki S, Inoue K, Yuasa T, Tomita K, Ishida S, Ogawa M, Saihara K, Koriyama C, Nobuyoshi M, Sakata R, Tei C.
    J Cardiol.2010; 55: 274-282.
  7. Left ventricular systolic function is abnormal in diastolic heart failure: re-assessment of systolic function using cardiac time interval analysis.
    Kono M, Kisanuki A, Takasaki K, Nakashiki K, Yuasa T, Kuwahara E, Mizukami N, Uemura T, Kubota K, Ueya N, Miyata M, Tei C.
    J Cardiol.2009; 53: 437-446.
  8. Effects of cardiac resynchronization therapy on the Doppler Tei index.
    Yuasa T, Miyazaki C, Oh JK, Espinosa RE, Bruce CJ.
    J Am Soc Echocardiogr.2009; 22: 253-260.
  9. No reflow-like pattern in intramyocardial coronary artery suggests myocardial ischemia in patients with hypertrophic cardiomyopathy.
    Kim WS, Minagoe S, Mizukami N, Zhou X, Yoshinaga K, Takasaki K, Yuasa T, Kihara K, Hamasaki S, Otsuji Y, Kisanuki A, Tei C.
    J Cardiol.2008; 52: 7-16.
  10. Significance of asymmetric basal posterior wall thinning in patients with cardiac Fabry's disease.
    Kawano M, Takenaka T, Otsuji Y, Teraguchi H, Yoshifuku S, Yuasa T, Yu B, Miyata M, Hamasaki S, Minagoe S, Kanmura Y, Tei C.
    Am J Cardiol.2007; 99: 261-263.
髙﨑州亜
  1. Left ventricular dysfunction assessed by cardiac time interval analysis among different geometric patterns in untreated hypertension. Takasaki K, Miyata M, Imamura M, Yuasa T, Kuwahara E, Kubota K, Kono M, Ueya N, Horizoe Y, Chaen H, Mizukami N, Kisanuki A, Hamasaki S, Tei C
    Circ J.2012; 76: 1409-1414.
  2. Highly sensitive cardiac troponin T in heart failure: comparison with echocardiographic parameters and natriuretic peptides.
    Kusumoto A, Miyata M, Kubozono T, Ikeda Y, Shinsato T, Kuwahata S, Fujita S, Takasaki K, Yuasa T, Hamasaki S, Tei C.
    J Cardiol.2012; 59: 202-208.
  3. Left ventricular dysfunction assessed by cardiac time interval analysis among different geometric patterns in untreated hypertension. Takasaki K, Miyata M, Imamura M, Yuasa T, Kuwahara E, Kubota K, Kono M, Ueya N, Horizoe Y, Chaen H, Mizukami N, Kisanuki A, Hamasaki S, Tei C.
    Circ J.2012; 76: 1409-1414.
  4. Different flow patterns between left and right internal thoracic artery grafts influence the evaluation of severe graft stenosis by transthoracic Doppler echocardiography.
    Mizukami N, Kisanuki A, Hamasaki S, Takasaki K, Yuasa T, Kuwahara E, Ueya N, Horizoe Y, Chaen H, Maruyama I, Imoto Y, Tei C.
    J Am Soc Echocardiogr.2011; 24: 768-774.
  5. Recurrent mitral regurgitation late after annuloplasty for ischemic mitral regurgitation.
    Shiota M, Gillinov AM, Takasaki K, Fukuda S, Shiota T.
    Echocardiography. 2011; 28: 161-166.
  6. Recurrent mitral regurgitation late after annuloplasty for ischemic mitral regurgitation. Shiota M, Gillinov AM, Takasaki K, Fukuda S, Shiota T.
    Echocardiography. 2011; 28: 161-166.
  7. Different flow patterns between left and right internal thoracic artery grafts influence the evaluation of severe graft stenosis by transthoracic Doppler echocardiography.
    Mizukami N, Kisanuki A, Hamasaki S, Takasaki K, Yuasa T, Kuwahara E, Ueya N, Horizoe Y, Chaen H, Maruyama I, Imoto Y, Tei C.
    J Am Soc Echocardiogr. 2011; 24: 768-774.
  8. Echocardiographic predictors for persistent functional mitral regurgitation after aortic valve replacement in patients with aortic valve stenosis.
    Matsumura Y, Gillinov AM, Toyono M, Oe H, Yamano T, Takasaki K, Saraiva RM, Shiota T.
    Am J Cardiol. 2010; 106: 701-706.
  9. Left ventricular global systolic dysfunction has a significant role in the development of diastolic heart failure in patients with systemic hypertension.
    Kono M, Kisanuki A, Ueya N, Kubota K, Kuwahara E, Takasaki K, Yuasa T, Mizukami N, Miyata M, Tei C.
    Hypertens Res. 2010; 33: 1167-1173.
  10. Noninvasive quantitative evaluation of the patency of internal mammary artery grafts to the left anterior descending coronary artery by transthoracic Doppler echocardiography. Mizukami N, Minagoe S, Otsuji Y, Neishi Y, Akasaka T, Hamasaki S, Yuasa T, Miyata M, Maruyama S, Yoshida K, Sakata R, Tei C.
    J Cardiol.2006; 48: 305-314.
池田義之
  1. Endogenous drp1 mediates mitochondrial autophagy and protects the heart against energy stress.
    Ikeda Y, Shirakabe A, Maejima Y, Zhai P, Sciarretta S, Toli J, Nomura M, Mihara K, Egashira K, Ohishi M, Abdellatif M, Sadoshima J.
    Circ Res.2015; 16: 264-278.
  2. Molecular Mechanisms Mediating Mitochondrial Dynamics and Mitophagy and their Functional Roles in the Cardiovascular System.
    Ikeda Y, Shirakabe A, Brady C, Zablocki D, Ohishi M, and Sadoshima J.
    J Mol Cell Cardiol. 2015; 78C: 116-122.
  3. Endogenous Drp1 mediates mitochondrial autophagy and protects the heart against energy stress.
    Ikeda Y, Shirakabe A, Maejima Y, Zhai P, Sciarretta S, Toli J, Nomura M, Mihara K, Egashira K, Ohishi M, Jessica T, Abdellatif M, Sadoshima J.
    Circ Res. 2015; 116: 264-278.
  4. Nicotinamide mononucleotide, an intermediate of NAD+ synthesis, protects the heart from ischemia and reperfusion.
    Yamamoto T, Byun J, Zhai P, Ikeda Y, Oka S, Sadoshima J.
    PLoS One.2014; 9: e98972.
  5. The Role of SUMO-1 in Cardiac Oxidative Stress and Hypertrophy.
    Lee A, Jeong D, Mitsuyama S, Oh JG, Liang L, Ikeda Y, Sadoshima J, Hajjar R, Kho C.
    Antioxid Redox Signal. 2014; 21: 1986-2001.
  6. New Insights into the Role of Mitochondrial Dynamics and Autophagy during Oxidative Stress and Aging in the Heart.
    Ikeda Y, Sciarretta S, Nagarajan N, Rubattu S, Volpe M, Frati G, Sadoshima J.
    Oxid Med Cell Longev. 2014; 2014: 210934.
  7. Broad suppression of NADPH oxidase activity exacerbates ischemia/reperfusion injury through inadvertent downregulation of hypoxia-inducible factor-1α and upregulation of peroxisome proliferator-activated receptor-α.
    Matsushima S, Kuroda J, Ago T, Zhai P, Ikeda Y, Oka S, Fong GH, Tian R, Sadoshima J.
    Circ Res. 2013; 112: 1135-1149.
  8. Autophagy plays an essential role in mediating regression of hypertrophy during unloading of the heart.
    Hariharan N, Ikeda Y, Hong C, Alcendor RR, Usui S, Gao S, Maejima Y, Sadoshima J.
    PLoS One.2013; 8: e51632.
  9. Novel Therapy for Atherosclerosis Using Recombinant Immunotoxin Against Folate Receptor β-Expressing Macrophages.
    Furusho Y, Miyata M, Matsuyama T, Nagai T, Li H, Akasaki Y, Hamada N, Miyauchi T, Ikeda Y, Shirasawa T, Ide K, Tei C.
    J Am Heart Assoc. 2012; 1: e003079.
  10. Waon therapy upregulates Hsp90 and leads to angiogenesis through the Akt-endothelial nitric oxide synthase pathway in mouse hindlimb ischemia.
    Miyauchi T, Miyata M, Ikeda Y, Akasaki Y, Hamada N, Shirasawa T, Furusho Y, Tei C.
    Circ J. 2012; 76: 1712-1721.
窪薗琢郎
  1. Comparative study of therapeutic effects of short- and long-acting loop diuretics in outpatients with chronic heart failure (COLD-CHF).
    Miyata M, Sasaki T, Ikeda Y, Shinsato T, Kubozono T, Furusho Y, Kusumoto A, Hamasaki S, Tei C; COLD-CHF Investigators.
    J Cardiol. 2012; 59: 352-358.
  2. Highly sensitive cardiac troponin T in heart failure: comparison with echocardiographic parameters and natriuretic peptides.
    Kusumoto A, Miyata M, Kubozono T, Ikeda Y, Shinsato T, Kuwahata S, Fujita S, Takasaki K, Yuasa T, Hamasaki S, Tei C.
    J Cardiol. 2012; 59: 202-208.
  3. Values of cardio-ankle vascular index (CAVI) between Amami islands and Kagoshima mainland among health checkup examinees.
    Hirasada K, Niimura H, Kubozono T, Nakamura A, Tatebo M, Ogawa S, Tsunematsu N, Chiba S, Matsushita T, Kusano K, Miyata M, Takezaki T.
    J Atheroscler Thromb.2012; 19: 69-80.
  4. Relationship between bilirubin concentration, coronary endothelial function, and inflammatory stress in overweight patients.
    Yoshino S, Hamasaki S, Ishida S, Kataoka T, Yoshikawa A, Oketani N, Saihara K, Okui H, Shinsato T, Ichiki H, Kubozono T, Kuwahata S, Fujita S, Kanda D, Nakazaki M, Miyata M, Tei C.
    J Atheroscler Thromb. 2011; 18: 403-412.
  5. Acute and chronic effects of smoking on arterial stiffness.
    Kubozono T, Miyata M, Ueyama K, Hamasaki S, Kusano K, Kubozono O, Tei C.
    Circ J. 2011; 75: 698-702.
  6. Effect of Waon therapy on oxidative stress in chronic heart failure.
    Fujita S, Ikeda Y, Miyata M, Shinsato T, Kubozono T, Kuwahata S, Hamada N, Miyauchi T, Yamaguchi T, Torii H, Hamasaki S, Tei C.
    Circ J. 2011; 75: 348-356.
  7. Improvement of autonomic nervous activity by Waon therapy in patients with chronic heart failure.
    Kuwahata S, Miyata M, Fujita S, Kubozono T, Shinsato T, Ikeda Y, Hamasaki S, Kuwaki T, Tei C.
    J Cardiol. 2011; 57: 100-106.
  8. Acute and Chronic Effects of Smoking on Arterial Stiffness.
    Kubozono T, Miyata M, Ueyama K, Hamasaki S, Kusano K, Kubozono O, Tei C.
    Circ J. 2011; 75: 698-702.
  9. Waon therapy mobilizes CD34+ cells and improves peripheral arterial disease.
    Shinsato T, Miyata M, Kubozono T, Ikeda Y, Fujita S, Kuwahata S, Akasaki Y, Hamasaki S, Fujiwara H, Tei C.
    J Cardiol. 2010; 56: 361-366.
  10. Enjoying hobbies is related to desirable cardiovascular effects.
    Saihara K, Hamasaki S, Ishida S, Kataoka T, Yoshikawa A, Orihara K, Ogawa M, Oketani N, Fukudome T, Atsuchi N, Shinsato T, Okui H, Kubozono T, Ichiki H, Kuwahata S, Mizoguchi E, Fujita S, Takumi T, Ninomiya Y, Tomita K, Tei C.
    Heart Vessels. 2010; 25: 113-120.
田中(窪田)佳代子
  1. Successful Antemortem Diagnosis and Treatment of Pulmonary Tumor Thrombotic Microangiopathy.
    Higo K, Kubota K, Takeda A, Higashi M, Ohishi M.
    Intern Med. 2014; 53: 2595-2599.
  2. Functional mitral stenosis after surgical annuloplasty for ischemic mitral regurgitation: importance of subvalvular tethering in the mechanism and dynamic deterioration during exertion.
    Kubota K, Otsuji Y, Ueno T, Koriyama C, Levine RA, Sakata R, Tei C.
    J Thorac Cardiovasc Surg. 2010; 140: 617-623.
赤﨑雄一
  1. Metabolomic analysis of Akt1-mediated muscle hypertrophy in models of diet-induced obesity and age-related fat accumulation.
    Cheng KK, Akasaki Y, Lecommandeur E, Lindsay RT, Murfitt S, Walsh K, Griffin JL.
    J Proteome Res. 2015; 14: 342-352.
  2. Glycolytic fast-twitch muscle fiber restoration counters adverse age-related changes in body composition and metabolism.
    Akasaki Y, Ouchi N, Izumiya Y, Bernardo BL, Lebrasseur NK, Walsh K.
    Aging Cell. 2014; 13: 80-91.
  3. Waon Therapy Upregulates Hsp90 and Leads to Angiogenesis Through the Akt-Endothelial Nitric Oxide Synthase Pathway in Mouse Hindlimb Ischemia.
    Miyauchi T, Miyata M, Ikeda Y, Akasaki Y, Hamada N, Shirasawa T, Furusho Y, Tei C.
    Circ J. 2012; 76: 1712-1721.
  4. Novel Therapy for Atherosclerosis Using Recombinant Immunotoxin Against Folate Receptor β-Expressing Macrophages.
    Furusho Y, Miyata M, Matsuyama T, Nagai T, Li H, Akasaki Y, Hamada N, Miyauchi T, Ikeda Y, Shirasawa T, Ide K, Tei C.
    J Am Heart Assoc. 2012; 1: e003079.
  5. Akt1-Mediated Skeletal Muscle Growth Attenuates Cardiac Dysfunction and Remodeling after Experimental Myocardial Infarction.
    Araki S, Izumiya Y, Hanatani S, Rokutanda T, Usuku H, Akasaki Y, Takeo T, Nakagata N, Walsh K, Ogawa H.
    Circ Heart Fail. 2012; 5: 116-125.
  6. Loss of clusterin limits atherosclerosis in apolipoprotein E-deficient mice via reduced expression of Egr-1 and TNF-α.
    Hamada N, Miyata M, Eto H, Ikeda Y, Shirasawa T, Akasaki Y, Miyauchi T, Furusho Y, Nagaki A, Aronow BJ, Tei C.
    J Atheroscler Thromb. 2011; 18: 209-216.
  7. Insulin-like 6 is induced by muscle injury and functions as a regenerative factor.
    Zeng L, Akasaki Y, Sato K, Ouchi N, Izumiya YY, Walsh K.
    J Biol Chem.2010; 285: 36060-36069.
  8. Waon therapy mobilizes CD34+ cells and improves peripheral arterial disease.
    Shinsato T, Miyata M, Kubozono T, Ikeda Y, Fujita S, Kuwahata S, Akasaki Y, Hamasaki S, Fujiwara H, Tei C.
    J Cardiol. 2010; 56: 361-366.
  9. Tacrolimus-eluting stent inhibits neointimal hyperplasia via calcineurin/NFAT signaling in porcine coronary artery model.
    Hamada N, Miyata M, Eto H, Shirasawa T, Akasaki Y, Nagaki A, Tei C.
    Atherosclerosis. 2010; 208: 97-103.
  10. Sfrp5 Is an Anti-Inflammatory Adipokine That Modulates Metabolic Dysfunction in Obesity.
    Ouchi N, Higuchi A, Ohashi K, Oshima Y, Gokce N, Shibata R, Akasaki Y, Shimono A, Walsh K.
    Science. 2010; 329: 454-457.
内匠拓朗
  1. Plaque characteristics and arterial remodeling in coronary and peripheral arterial systems.
    Yoshiki Matsuo, Takuro Takumi, Verghese Mathew, Woo-Young Chung, Gregory W. Barsness, Charanjit S. Rihal, Rajiv Gulati, Eric T. McCue, David R. Holmes, Eric Eeckhout, Ryan J. Lennon,Lilach O. Lerman c, Amir Lerman a.
    Atherosclerosis. 2012; 223: 365-371.
  2. The Association Between Renal Atherosclerotic Plaque Characteristics and Renal Function Before and After Renal Artery Intervention.
    Takuro Takumi, Verghese Mathew, Gregory W. Barsness, etsuro Kataoka, Ronen Rubinshtein, Charanjit S. Rihal, Rajiv Gulati, Eric Eeckhout, Ryan J. Lennon, Lilach O. Lerman, Amir Lerman.
    Mayo Clinic Proceedings. 2011; 86: 1165-1172.
  3. Coronary endothelial dysfunction is associated with a reduction in coronary artery compliance and an increase in wall shear stress.
    Takuro Takumi, Eric H Yang, Verghese Mathew, Charanjit S Rihal, Rajiv Gulati, Lilach O Lerman, Amir Lerman.
    Heart. 2010; 96: 773-778.
  4. Limitation of Angiography to Identify the Culprit Plaque in Acute Myocardial Infarction With Coronary Total Occlusion: Utility of Coronary Plaque Temperature Measurement to Identify the Culprit Plaque.
    Takuro Takumi, Souki Lee, Shuichi Hamasaki, Kouichi Toyonaga, Daisuke Kanda, Keisuke Kusumoto, Hitoshi Toda, oshihiro Takenaka, Masaaki Miyata, Ryuichiro Anan, Yutaka Otsuji, Chuwa Tei.
    Journal of the American College of Cardiology.2007; 50: 2197-2203.
樋口公嗣
  1. Neonatal transfer of membrane-bound stem cell factor improves survival and heart function in aged mice after myocardial ischemia.
    Sun Z, Lee CJ, Mejia-Guerrero S, Zhang Y, Higuchi K, Li RK, Medin JA.
    Hum Gene Ther. 2012; 23: 1280-1289.
  2. Identification of novel mutations in the α-galactosidase A gene in patients with Fabry disease: Pitfalls of mutation analyses in patients with low α-galactosidase A activity.
    Yoshimitsu M, Higuchi K, Miyata M, Devine S, Mattman A, Sirrs S, Medin JA, Tei C, Takenaka T.
    J cardiol. 2011; 57: 345-353.
  3. Sequencing and characterization of the porcine alpha-galactosidase A gene: towards the generation of a porcine model for Fabry disease.
    Yoshimitsu M, Higuchi K, Fan X, Takao S, Medin JA, Tei C, Takenaka T.
    Mol Biol Rep. 2011; 38: 3145-3152.
  4. Alpha-galactosidase A-Tat fusion enhances storage reduction in hearts and kidneys of Fabry mice.
    Higuchi K, Yoshimitsu M, Fan X, Guo X, Rasaiah VI, Yen J, Tei C, Takenak T, Medin JA.
    Mol Med. 2010; 16: 216-221.
  5. Vascular endothelial growth factor broadens lentivector distribution in the heart after neonatal injection.
    Sato T, Ramsubir S, Higuchi K, Yanagisawa T, Medin JA.
    J Cardiol. 2009; 54: 245-254.
  6. Direct injection of kit ligand-2 lentivirus improves cardiac repair and rescues mice post-myocardial infarction.
    Higuchi K, Ayach B, Sato T, Chen M, Devine SP, Rasaiah VI, Dawood F, Yanagisawa T, Tei C, Takenaka T, Liu PP, Medin JA.
    Mol Ther. 2009; 17: 262-268.
  7. Terminal stage cardiac findings in patients with cardiac Fabry disease: an electrocardiographic, echocardiographic, and autopsy study.
    Takenaka T, Teraguchi H, Yoshida A, Taguchi S, Ninomiya K, Umekita Y, Yoshida H, Horinouchi M, Tabata K, Yonezawa S, Yoshimitsu M, Higuchi K, Nakao S, Anan R, Minagoe S, Tei C.
    J Cardiol. 2008; 51: 50-59.
  8. Efficient correction of Fabry mice and patient cells mediated by lentiviral transduction of hematopoietic stem/progenitor cells.
    Yoshimitsu M, Higuchi K, Ramsubir S, Nonaka t, Rasaiah VI, Siatskas C, Liang SB, Murray GJ, Brady RO, Medin JA.
    Gene Ther. 2007; 14: 256-265.
  9. Correction of cardiac abnormalities in fabry mice by direct intraventricular injection of a recombinant lentiviral vector that engineers expression of alpha-galactosidase A.
    Yoshimitsu M, Higuchi K, Dawood F, Rasaiah VI, Ayach B, Chen M, Liu P, Medin JA.
    Circ J. 2006; 70: 1503-1508.
  10. Stem cell factor receptor induces progenitor and natural killer cell-mediated cardiac survival and repair after myocardial infarction.
    Ayach BB, Yoshimitsu M, Dawood F, Sun M, Arab S, Chen M, Higuchi K, Siatskas C, Lee P, Lim H, Zhang J, Cukerman E, Stanford WL, Medin JA, Liu PP.
    Proc Natl Acad Sci USA. 2006; 103: 2304-2309.

主な研究費取得状況

宮田昌明
事業・種目 / 期間研究
日本学術振興会 科学研究費
基盤研究(C)代表
2014~2016年度
葉酸レセプターβ抗体を用いた分子イメージングの前臨床試験と新規診断法の開発
桶谷直也
事業・種目 / 期間研究
日本学術振興会 科学研究費
基盤研究(C)代表
2014~2018年度
CFAEアブレーションを軸とした慢性心房細動の包括的新規治療法の開発
MSD / 2014年 心房細動症例において糖尿病、脂質異常、高血圧の左心耳血流速度に対する影響
湯淺敏典
事業・種目 / 期間研究
MSD / 2014年 軽運動負荷時の循環応答と運動耐容能の関係:軽運動負荷心エコーを用いた検討
池田義之
事業・種目 / 期間研究
日本学術振興会 科学研究費
研究活動スタート支援
2014~2015年度
ミトコンドリアダイナミクスを標的とした心臓老化に対する新しい治療法の開発
第9回高血圧と冠動脈疾患研究会 / 2014年 第9回高血圧と冠動脈疾患研究助成
田中(窪田)佳代子
事業・種目 / 期間研究
MSD / 2014年 肺高血圧症における肺血管内皮機能の評価
赤﨑雄一
事業・種目 / 期間研究
日本学術振興会 科学研究費
基盤研究(C)代表
2014~2016年度
サルコペニアにおけるレニン・アンジオテンシン系の作用およびメカニズムの解明
MSD / 2014~2015年度 長期的RAS系抑制が加齢性筋減少症および糖・脂質代謝に及ぼす影響
入來泰久、波野史典、前之園隆一、吉村あきの、桶谷直也
事業・種目 / 期間研究
福田記念医療技術振興財団
2013年度
心房細動に対する Complex Fractionated Atrial Electrogram (CFAE) を指標としたカテーテルアブレーションにおいてCFAEの領域を視覚化するためのCARTO®の至適設定について病院臨床検査部との共同研究

分野サイト

がんプロフェッショナル養成基盤推進プラン
GPなど(医歯学)
鹿児島大学
鹿児島大学病院
附属施設等
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