Biochemistry and Genetics
Research outline
Graduate School | Graduate School of Medical and Dental Sciences |
---|---|
Course | Health Research Course |
Field | Developmental Medicine |
Department | Biochemistry and Genetics |
Homepage | http://www.kufm.kagoshima-u.ac.jp/~biochem1/ |
Contact
TEL.+81-99-275-5242 / FAX.+81-99-264-6274
Research interests
- The effects of Wnt signal on the invasiveness of glioma
- Reciprocal cell-to-cell interactions between ameloblastoma derived cells and stromal fibroblasts via cytokines
- Signal transduction
Staff
Professor
Name | Shosei KISHIDA |
---|---|
Specialized field | Biochemistry、Cell Biology、Signal transduction |
Research interests |
|
Lecturer
Name | Hirofumi KOYAMA |
---|---|
Specialized field | Molecular biology、Biochemistry |
Research interests | Wnt siganling |
Assistant Professor
Name | Mikio IIJIMA |
---|---|
Specialized field | Cell Biology、Pathological biochemistry、Molecular biology |
Research interests | Wnt siganling |
Assistant Professor
Name | Michiko KISHIDA |
---|---|
Specialized field | Cell Biology |
Research interests | Regulation of signal transduction by phosphorylation |
Research results
Shosei KISHIDA
- A conserved function in phosphatidylinositol metabolism for mammalian Vps13 family proteins.
Park JS, Halegoua S, Kishida S, Neiman AM.
PLoS One., (2015) Vol. 10, e0124836. - Regulation of IL-6 and IL-8 production by reciprocal cell-to-cell interactions between tumor cells and stromal fibroblasts through IL-1α in ameloblastoma.
Fuchigami T, Kibe T, Koyama H, Kishida S, Iijima M, Nishizawa Y, Hijioka H, Fujii T, Ueda M, Nakamura N, Kiyono T, Kishida M.
Biochem. Biophys. Res. Commun., (2014) Vol. 451, 491-496. - Ryk is essential for Wnt-5a-dependent invasiveness in human glioma.
Habu M, Koyama H, Kishida M, Kamino M, Iijima M, Fuchigami T, Tokimura H, Ueda M, Tokudome M, Koriyama C, Hirano H, Arita K, Kishida S.
J. Biochem., (2014) Vol. 156, 29-38. - Immunoreactivity of Wnt5a, Fzd2, Fzd6, and Ryk in glioblastoma: evaluative methodology for DAB chromogenic immunostaining.
Hirano H, Yonezawa H, Yunoue S, Habu M, Uchida H, Yoshioka T, Kishida S, Kishida M, Oyoshi T, Fujio S, Sugata S, Yamahata H, Hanaya R, Arita K.
Brain Tumor Pathol., (2014) Vol. 31, 85-93. - A novel ameloblastoma cell line (AM-3) secretes MMP-9 in response to Wnt-3a and induces osteoclastogenesis.
Kibe T, Fuchigami T, Kishida M, Iijima M, Ishihata K, Hijioka H, Miyawaki A, Semba I, Nakamura N, Kiyono T, Kishida S.
Oral Surg. Oral Med. Oral Pathol. Oral Radiol., (2013) Vol. 115, 780-788.
Hirofumi KOYAMA
- The Wnt5a-Ror2 axis promotes the signaling circuit between interleukin-12 and interferon-γ in colitis.
Sato A, Kayama H, Shojima K, Matsumoto S, Koyama H, Minami Y, Nojima S, Morii E, Honda H, Takeda K, Kikuchi A.
Sci. Rep., (2015) Vol. 5, 10536. - Reprogramming suppresses premature senescence phenotypes of Werner syndrome cells and maintains chromosomal stability over long-term culture.
Shimamoto A, Kagawa H, Zensho K, Sera Y, Kazuki Y, Osaki M, Oshimura M, Ishigaki Y, Hamasaki K, Kodama Y, Yuasa S, Fukuda K, Hirashima K, Seimiya H, Koyama H, Shimizu T, Takemoto M, Yokote K, Goto M, Tahara H.
PLoS One., (2014) Vol. 9, e112900. - Regulation of IL-6 and IL-8 production by reciprocal cell-to-cell interactions between tumor cells and stromal fibroblasts through IL-1α in ameloblastoma.
Fuchigami T, Kibe T, Koyama H, Kishida S, Iijima M, Nishizawa Y, Hijioka H, Fujii T, Ueda M, Nakamura N, Kiyono T, Kishida M.
Biochem. Biophys. Res. Commun., (2014) Vol. 451, 491-496. - Ryk is essential for Wnt-5a-dependent invasiveness in human glioma.
Habu M, Koyama H, Kishida M, Kamino M, Iijima M, Fuchigami T, Tokimura H, Ueda M, Tokudome M, Koriyama C, Hirano H, Arita K, Kishida S.
J. Biochem., (2014) Vol. 156, 29-38. - Antioxidants improve the phenotypes of dilated cardiomyopathy and muscle fatigue in mitochondrial superoxide dismutase-deficient mice.
Koyama H, Nojiri H, Kawakami S, Sunagawa T, Shirasawa T, Shimizu T.
Molecules. (2013) Vol. 18, 1383-1393.
Mikio IIJIMA
- Regulation of IL-6 and IL-8 production by reciprocal cell-to-cell interactions between tumor cells and stromal fibroblasts through IL-1α in ameloblastoma.
Fuchigami T, Kibe T, Koyama H, Kishida S, Iijima M, Nishizawa Y, Hijioka H, Fujii T, Ueda M, Nakamura N, Kiyono T, Kishida M.
Biochem. Biophys. Res. Commun., (2014) Vol. 451, 491-496. - Ryk is essential for Wnt-5a-dependent invasiveness in human glioma.
Habu M, Koyama H, Kishida M, Kamino M, Iijima M, Fuchigami T, Tokimura H, Ueda M, Tokudome M, Koriyama C, Hirano H, Arita K, Kishida S.
J. Biochem., (2014) Vol. 156, 29-38. - A novel ameloblastoma cell line (AM-3) secretes MMP-9 in response to Wnt-3a and induces osteoclastogenesis.
Kibe T, Fuchigami T, Kishida M, Iijima M, Ishihata K, Hijioka H, Miyawaki A, Semba I, Nakamura N, Kiyono T, Kishida S.
Oral Surg. Oral Med. Oral Pathol. Oral Radiol., (2013) Vol. 115, 780-788. - Subcellular localization and putative role of VPS13A/chorein in dopaminergic neuronal cells.
Hayashi T, Kishida M, Nishizawa Y, Iijima M, Koriyama C, Nakamura M, Sano A, Kishida S.
Biochem. Biophys. Res. Commun., (2012) Vol. 419, 511-516. - Wnt-5a signaling is correlated with infiltrative activity in human glioma by inducing cellular migration and MMP-2.
Kamino M, Kishida M, Kibe T, Ikoma K, Iijima M, Hirano H, Tokudome M, Chen L, Koriyama C, Yamada K, Arita K, Kishida S.
Cancer Sci., (2011) Vol. 102, 540-548.
Michiko KISHIDA
- Regulation of IL-6 and IL-8 production by reciprocal cell-to-cell interactions between tumor cells and stromal fibroblasts through IL-1α in ameloblastoma.
Fuchigami T, Kibe T, Koyama H, Kishida S, Iijima M, Nishizawa Y, Hijioka H, Fujii T, Ueda M, Nakamura N, Kiyono T, Kishida M.
Biochem. Biophys. Res. Commun., (2014) Vol. 451, 491-496. - Ryk is essential for Wnt-5a-dependent invasiveness in human glioma.
Habu M, Koyama H, Kishida M, Kamino M, Iijima M, Fuchigami T, Tokimura H, Ueda M, Tokudome M, Koriyama C, Hirano H, Arita K, Kishida S.
J. Biochem., (2014) Vol. 156, 29-38. - Immunoreactivity of Wnt5a, Fzd2, Fzd6, and Ryk in glioblastoma: evaluative methodology for DAB chromogenic immunostaining.
Hirano H, Yonezawa H, Yunoue S, Habu M, Uchida H, Yoshioka T, Kishida S, Kishida M, Oyoshi T, Fujio S, Sugata S, Yamahata H, Hanaya R, Arita K.
Brain Tumor Pathol., (2014) Vol. 31, 85-93. - A novel ameloblastoma cell line (AM-3) secretes MMP-9 in response to Wnt-3a and induces osteoclastogenesis.
Kibe T, Fuchigami T, Kishida M, Iijima M, Ishihata K, Hijioka H, Miyawaki A, Semba I, Nakamura N, Kiyono T, Kishida S.
Oral Surg. Oral Med. Oral Pathol. Oral Radiol., (2013) Vol. 115, 780-788. - Subcellular localization and putative role of VPS13A/chorein in dopaminergic neuronal cells.
Hayashi T, Kishida M, Nishizawa Y, Iijima M, Koriyama C, Nakamura M, Sano A, Kishida S.
Biochem. Biophys. Res. Commun., (2012) Vol. 419, 511-516.
Research Grant List
Shosei KISHIDA
Project・Event / Span | Research |
---|---|
文部科学省 基盤研究(C)分担 平成25-27年度 |
自己免疫性脳炎の病態解析および新規抗原の解明 |
文部科学省 基盤研究(C)分担 平成25-27年度 |
口蓋裂術後の瘢痕拘縮分子メカニズムの解明と新規創傷被覆材開発への展開 |
文部科学省 基盤研究(C)代表 平成21-23年度 |
腫瘍の病態におけるWntシグナルの役割 |
文部科学省 基盤研究(C)代表 平成19、20年度 |
シナプス形成におけるWntシグナル伝達経路の役割 |
文部科学省 基盤研究(C)代表 平成17、18年度 |
Wntシグナルによる細胞極性の制御機構の解析 |
Hirofumi KOYAMA
Project・Event / Span | Research |
---|---|
文部科学省 挑戦的萌芽研究 分担 平成26、27年度 |
デスアシルグレリン受容体を介した新しい食欲制御機構の解明 |
文部科学省 挑戦的萌芽研究 分担 平成26-28年度 |
食欲を調節するアドロピンやオーグリンのシグナル伝達の解明 |
Mikio IIJIMA
Project・Event / Span | Research |
---|---|
文部科学省 挑戦的萌芽研究 代表 平成26、27年度 |
デスアシルグレリン受容体を介した新しい食欲制御機構の解明 |
文部科学省 基盤研究(C)代表 平成23-25年度 |
イムノクロマト法によるシトリン欠損症迅速簡便診断法の開発と臨床応用 |
文部科学省 挑戦的萌芽研究 代表 平成19-21年度 |
骨異常と片眼性異常が認められたアスパラギン酸グルタミン酸輸送体欠損マウス |
文部科学省 基盤研究(C)代表 平成14、15年度 |
変異citrinタンパク質は肝細胞を細胞死させるか |
文部科学省 基盤研究(C)代表 平成12、13年度 |
新規遺伝子citrinとaralarの機能解析 |
Michiko KISHIDA
Project・Event / Span | Research |
---|---|
文部科学省 基盤研究(C)分担 平成23-25年度 |
エナメル上皮腫による骨破壊・浸潤に関わる細胞間シグナルの解明と治療戦略への展開 |
文部科学省 挑戦的萌芽研究 分担 平成23、24年度 |
神経ペプチドグレリンの新規受容体の同定と作用機構の解明 |
文部科学省 基盤研究(C)代表 平成21-23年度 |
腫瘍の病態におけるWntシグナルの役割 |
文部科学省 基盤研究(C)代表 平成20-22年度 |
悪性グリオーマにおけるWntシグナル活性化の検討と診断・治療への応用 |
文部科学省 若手研究(B)代表 平成19、20年度 |
Wnt-11蛋白質の精製とその生理機能の解析 |