FIELD

Research outline

免疫学分野イメージ

Graduate School Graduate School of Medical and Dental Sciences
Course Health Research Course
Field Infection and Immunity
Department Immunology
Homepage https://www2.kufm.kagoshima-u.ac.jp/~mdio/preparing/

Homepage

Contact

TEL.+81-99-275-5305 / FAX.+81-99-275-5305

Research interests

  • Immunoregulation of mycobacterial infection
  • Macrophage differentiation and activation through ITAM-coupled receptors
  • Regulation of lymphocyte activation and malignancy through antigen receptors
  • Immunoregulation of itch
  • Allergy

Staff

教授:原博満

Professor
Name Hiromitsu HARA
Specialized field Immunology
Research interests
  • リンパ球の活性化と増殖・発癌機構
  • 自然免疫の活性化と各種疾患発症の関連

Researche Repository


Assistant Professor:飯笹英一

Assistant Professor
Name Ei-ichi IZASA
Specialized field Immunology
Research interests
  • Immunoregulation of mycobacterial infection
  • II型免疫応答の誘導メカニズム

Researche Repository

Research results

Hiromitsu HARA
  1. Iizasa E, Chuma Y, Uematsu T, Kubota M, Kawaguchi H, Umemura M, Toyonaga K, Kiyohara H, Yano I, Colonna M, Sugita M, Matsuzaki G, Yamasaki S, Yoshida H and Hara H: TREM2 is a receptor for non-glycosylated mycolic acids of mycobacteria that limits anti-mycobacterial macrophage activation. Nat Commun. 2021, 12:2299.
  2. Uematsu T, Iizasa E-I, Kobayashi N, Yoshida H and Hara H: Loss of CARD9-mediated innate activation attenuates severe influenza pneumonia without compromising host viral immunity.
    Sci Rep. 2015, 5:1757. doi: 10.1038/srep17577.
  3. Hara H, Yokosuka T, Hirakawa H, Ishihara C, Yasukawa S, Yamazaki M, Koseki H, Yoshida H and Saito T: Clustering of CARMA1 through SH3-GUK domain interactions is required for its activation of NF-κB signaling.
    Nat Commun. 2015, 6:5555. doi: 10.1038/ncomms6555.
  4. Yasukawa S, Miyazaki Y, Yoshii C, Nakaya M, Ozaki N, Toda S, Kuroda E, Ishibashi K-I, Yasuda T, Natsuaki Y, Mi-ichi F, Iizasa EI, Nakahara T, Yamazaki M, Kabashima K, Iwakura Y, Takai T, Saito T, Kurosaki T, Malissen B, Ohno N, Furue M, Yoshida H, and Hara H: An ITAM-Syk-CARD9 signaling axis triggers contact hypersensitivity by stimulating IL-1 production in dendritic cells.
    Nat Commun. 2014, 5:3755. doi:10.1038/ncomms4755.
  5. Hara H and Saito T: CARD9 vs. CARMA1 in innate and adaptive immunity.
    Trends in immunol. 2009, 30(5): 234-242.
  6. Hara H, Ishihara C, Takeuchi A, Xue L, Morris SW, Penninger JM, Yoshida H, Saito T: Cell-type-specific regulation of ITAM-mediated NF-κB activation by adaptors CARMA1 and CARD9.
    J Immunol. 2008, 181(2):918-30.
  7. Hara H, Ishihara C, Takeuchi A, Imanishi1 T, Xue L, Morris SW, Inui M, Takai T, Shibuya A, Saijo S, Iwakura Y, Ohno N, Koseki H, Yoshida H, Penninger JM & Saito T: The adaptor protein CARD9 is essential for the activation of myeloid cells through ITAM-associated and Toll-like receptors.
    Nat Immunol. 2007, 8(6):619-29.
  8. Suzuki N, Suzuki S, Millar DG, Unno M, Hara H, Calzascia T, Yamasaki S, Yokosuka T, Chen NJ, Elford AR, Suzuki J, Takeuchi A, Mirtsos C, Bouchard D, Ohashi PS, Yeh WC, Saito T: A critical role for the innate immune signaling molecule IRAK-4 in T cell activation.
    Science. 2006 Mar 31;311(5769):1927-32
  9. Hara H, Bakal C, Wada T, Bouchard D, Rottapel R, Saito T, Penninger JM: The molecular adapter Carma1 controls entry of IκB kinase into the central immune synapse.
    J Exp Med. 2004, 200(9):1167-77.
  10. Hara H, Wada T, Bakal C, Kozieradzki I, Suzuki S, Suzuki N, Nghiem M, Griffiths EK, Krawczyk C, Bauer B, D'Acquisto F, Ghosh S, Yeh WC, Baier G, Rottapel R, Penninger JM: The MAGUK family protein CARD11 is essential for lymphocyte activation.
    Immunity. 2003, 18(6):763-75.
  11. Hara H, Takeda A, Takeuchi M, Wakeham AC, Itie A, Sasaki M, Mak TW, Yoshimura A, Nomoto K, Yoshida H: The apoptotic protease-activating factor 1-mediated pathway of apoptosis is dispensable for negative selection of thymocytes.
    J Immunol. 2002, 168(5):2288-95.
  12. Hara H, Kishihara K, Matsuzaki G, Takimoto H, Tsukiyama T, Tigelaar RE and Nomoto K: Development of dendritic epidermal T cells with a skewed diversity of gamma delta TCRs in Vd1-deficient mice.
    J Immunol. 2000, 165(7):3695-705.

Ei-ichi IZASA
  1. Uematsu T, Iizasa E-I, Kobayashi N, Yoshida H and Hara H: Loss of CARD9-mediated innate activation attenuates severe influenza pneumonia without compromising host viral immunity.
    Sci Rep. 2015, 5:1757. doi: 10.1038/srep17577.
  2. 永野幸生、飯笹英一、相同組み換えで色々できちゃうDNAクローニング、生物工学会誌、印刷中、2015
  3. Phongsisay V, Iizasa E, Hara H, Yamasaki S: 3-O-sulfo-β-D-galactose moiety of endogenous sulfoglycolipids is a potential ligand for immunoglobulin-like receptor LMIR5.
    Mol Immunol. 63: 595-9, 2015.
  4. Phongsisay V, Iizasa E, Hara H, Yoshida H: Evidence for TLR4 and FcRγ-CARD9 activation by cholera toxin B subunit and its direct bindings to TREM2 and LMIR5 receptors.
    Mol Immunol. 66:463-71, 2015.
  5. Phongsisay V, Iizasa E, Hara H, Yamasaki S: LMIR5 extracellular domain activates myeloid cells through toll-like receptor 4.
    Mol Immunol. 62:169-77, 2014.
  6. Yasukawa S., Miyazaki Y., Yoshii C., Nakaya M., Ozaki N., Toda S., Kuroda E., Ishibashi K., Yasuda T., Natsuaki Y, Mi-ichi F, Iizasa E, Nakahara T, Yamazaki M., Kabashima K, Iwakura Y, Takai T, Saito T, Kurosaki T, Malissen B, Ohno N, Furue M, Yoshida H, Hara H: An ITAM-Syk-CARD9 signalling axis triggers contact hypersensitivity by stimulating IL-1 production in dendritic cells.
    Nat Commun. 5:3755, 2014.
  7. Iizasa E, Mitsutomi M, and Nagano Y: Direct binding of a plant LysM receptor-like kinase, LysM RLK1/CERK1, to chitin in vitro. J. Biol. Chem.
    American Society for Biochemistry and Molecular biology. 285: 2996-3004 (2010)
  8. Nagano, Y.2, Takao, S.3, Kudo, T.4, Iizasa, E.1, and Anai, T.5 Yeast-based recombineering of DNA fragments into plant transformation vectors by one-step transformation.
    Plant Cell Rep. Springer Publishing. 26: 2111-2117 (2007)
  9. Iizasa, E and Nagano Y: Highly efficient yeast-based in vivo DNA cloning of multiple DNA fragments and the simultaneous construction of yeast/ Escherichia coli shuttle vectors.
    Biotechniques. Informa Life Science Publishing. 40: 75-83 (2006)

Patents and copy Rights

名称 / 出願番号発明者等
ノックアウト非ヒト化動物
特願2015-246551
野出孝一、吉田裕樹、Hiromitsu HARA
平瀬徹明、宮崎義之
平成27年7月24日
ノックアウト非ヒト化動物
特開2011-092026
野出孝一、吉田裕樹、Hiromitsu HARA
平瀬徹明、宮崎義之
平成21年10月27日
NK細胞の機能調節剤およびそのスクリーニング法
特開2008-118862
齋藤隆、Hiromitsu HARA
平成18年11月8日
組み換えDNA作成法
特許第49615635号
永野幸生、Ei-ichi IZASA
平成24年4月6日

Collaborations

  • 新規多発血管性肉芽腫症モデルマウスの確立(佐賀大学・膠原病内科学)
  • 総合硝子体学の研究:基盤病態の解明と治療の研究(鹿児島大学・眼科学)
  • ダメージ関連分子パターン受容体の神経障害性疼痛における役割(佐賀大学・生理学)
  • 原虫感染に対するCARD9を介した新規自然免疫活性化経路の解析(佐賀大学・免疫学)
  • インフルエンザウイルスと内因性リガンドを認識する新規自然免疫受容体の解析(北里研究所)

Research Grant List

Hiromitsu HARA
Project・Event / SpanResearch
基盤研究(B)
平成27~29年度
脂質センサー型ITAM受容体による抗酸菌特異的脂質の認識と結核病態の制御
挑戦的萌芽研究
平成27~28年度
アレルギー性化合物を認識する自然免疫受容体の探索
基盤研究(B)
平成24~26年度
肺感染症における新規自然免疫受容体の役割の解明
新学術領域研究
平成24~26年度
アレルギー性接触皮膚炎感作に必要な非感染性自然免疫活性化経路
基盤研究(B)
平成21~23年度
CARMA1シグナルの制御機構と免疫恒常性維持における役割
特定領域研究
平成22~23年度
ITAM受容体-CARD9経路による自己免疫病の発症・増悪機構の解明
基盤研究(C)
平成19~20年度
ITAM保有受容体のNF-κB活性化シグナル伝達機構と生理的意義の解明
特定領域研究
平成20~21年度
ITAM受容体-CARD9シグナルの自己免疫病における役割
内藤記念科学振興財団
研究助成金 平成27年度
結核菌表層の病原性脂質を認識する自然免疫受容体の機能解析
アステラス病態代謝研究会
研究助成金 平成27年度
結核菌表層の病原性脂質による自然免疫応答の制御機構
Ei-ichi IZASA
Project・Event / SpanResearch
若手研究(B)
平成26~27年度
結核菌を認識する新規骨髄系ITAMRの同定
笹川科学研究助成
平成27年度
哺乳類におけるキチン受容体の同定

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