Immunology
Research outline
Graduate School | Graduate School of Medical and Dental Sciences |
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Course | Health Research Course |
Field | Infection and Immunity |
Department | Immunology |
Homepage | https://www2.kufm.kagoshima-u.ac.jp/~mdio/preparing/ |
Contact
TEL.+81-99-275-5305 / FAX.+81-99-275-5305
Research interests
- Immunoregulation of mycobacterial infection
- Macrophage differentiation and activation through ITAM-coupled receptors
- Regulation of lymphocyte activation and malignancy through antigen receptors
- Immunoregulation of itch
- Allergy
Staff
Professor
Name | Hiromitsu HARA |
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Specialized field | Immunology |
Research interests |
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Assistant Professor
Name | Ei-ichi IZASA |
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Specialized field | Immunology |
Research interests |
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Research results
Hiromitsu HARA
- Iizasa E, Chuma Y, Uematsu T, Kubota M, Kawaguchi H, Umemura M, Toyonaga K, Kiyohara H, Yano I, Colonna M, Sugita M, Matsuzaki G, Yamasaki S, Yoshida H and Hara H: TREM2 is a receptor for non-glycosylated mycolic acids of mycobacteria that limits anti-mycobacterial macrophage activation. Nat Commun. 2021, 12:2299.
- Uematsu T, Iizasa E-I, Kobayashi N, Yoshida H and Hara H: Loss of CARD9-mediated innate activation attenuates severe influenza pneumonia without compromising host viral immunity.
Sci Rep. 2015, 5:1757. doi: 10.1038/srep17577. - Hara H, Yokosuka T, Hirakawa H, Ishihara C, Yasukawa S, Yamazaki M, Koseki H, Yoshida H and Saito T: Clustering of CARMA1 through SH3-GUK domain interactions is required for its activation of NF-κB signaling.
Nat Commun. 2015, 6:5555. doi: 10.1038/ncomms6555. - Yasukawa S, Miyazaki Y, Yoshii C, Nakaya M, Ozaki N, Toda S, Kuroda E, Ishibashi K-I, Yasuda T, Natsuaki Y, Mi-ichi F, Iizasa EI, Nakahara T, Yamazaki M, Kabashima K, Iwakura Y, Takai T, Saito T, Kurosaki T, Malissen B, Ohno N, Furue M, Yoshida H, and Hara H: An ITAM-Syk-CARD9 signaling axis triggers contact hypersensitivity by stimulating IL-1 production in dendritic cells.
Nat Commun. 2014, 5:3755. doi:10.1038/ncomms4755. - Hara H and Saito T: CARD9 vs. CARMA1 in innate and adaptive immunity.
Trends in immunol. 2009, 30(5): 234-242. - Hara H, Ishihara C, Takeuchi A, Xue L, Morris SW, Penninger JM, Yoshida H, Saito T: Cell-type-specific regulation of ITAM-mediated NF-κB activation by adaptors CARMA1 and CARD9.
J Immunol. 2008, 181(2):918-30. - Hara H, Ishihara C, Takeuchi A, Imanishi1 T, Xue L, Morris SW, Inui M, Takai T, Shibuya A, Saijo S, Iwakura Y, Ohno N, Koseki H, Yoshida H, Penninger JM & Saito T: The adaptor protein CARD9 is essential for the activation of myeloid cells through ITAM-associated and Toll-like receptors.
Nat Immunol. 2007, 8(6):619-29. - Suzuki N, Suzuki S, Millar DG, Unno M, Hara H, Calzascia T, Yamasaki S, Yokosuka T, Chen NJ, Elford AR, Suzuki J, Takeuchi A, Mirtsos C, Bouchard D, Ohashi PS, Yeh WC, Saito T: A critical role for the innate immune signaling molecule IRAK-4 in T cell activation.
Science. 2006 Mar 31;311(5769):1927-32 - Hara H, Bakal C, Wada T, Bouchard D, Rottapel R, Saito T, Penninger JM: The molecular adapter Carma1 controls entry of IκB kinase into the central immune synapse.
J Exp Med. 2004, 200(9):1167-77. - Hara H, Wada T, Bakal C, Kozieradzki I, Suzuki S, Suzuki N, Nghiem M, Griffiths EK, Krawczyk C, Bauer B, D'Acquisto F, Ghosh S, Yeh WC, Baier G, Rottapel R, Penninger JM: The MAGUK family protein CARD11 is essential for lymphocyte activation.
Immunity. 2003, 18(6):763-75. - Hara H, Takeda A, Takeuchi M, Wakeham AC, Itie A, Sasaki M, Mak TW, Yoshimura A, Nomoto K, Yoshida H: The apoptotic protease-activating factor 1-mediated pathway of apoptosis is dispensable for negative selection of thymocytes.
J Immunol. 2002, 168(5):2288-95. - Hara H, Kishihara K, Matsuzaki G, Takimoto H, Tsukiyama T, Tigelaar RE and Nomoto K: Development of dendritic epidermal T cells with a skewed diversity of gamma delta TCRs in Vd1-deficient mice.
J Immunol. 2000, 165(7):3695-705.
Ei-ichi IZASA
- Uematsu T, Iizasa E-I, Kobayashi N, Yoshida H and Hara H: Loss of CARD9-mediated innate activation attenuates severe influenza pneumonia without compromising host viral immunity.
Sci Rep. 2015, 5:1757. doi: 10.1038/srep17577. - 永野幸生、飯笹英一、相同組み換えで色々できちゃうDNAクローニング、生物工学会誌、印刷中、2015
- Phongsisay V, Iizasa E, Hara H, Yamasaki S: 3-O-sulfo-β-D-galactose moiety of endogenous sulfoglycolipids is a potential ligand for immunoglobulin-like receptor LMIR5.
Mol Immunol. 63: 595-9, 2015. - Phongsisay V, Iizasa E, Hara H, Yoshida H: Evidence for TLR4 and FcRγ-CARD9 activation by cholera toxin B subunit and its direct bindings to TREM2 and LMIR5 receptors.
Mol Immunol. 66:463-71, 2015. - Phongsisay V, Iizasa E, Hara H, Yamasaki S: LMIR5 extracellular domain activates myeloid cells through toll-like receptor 4.
Mol Immunol. 62:169-77, 2014. - Yasukawa S., Miyazaki Y., Yoshii C., Nakaya M., Ozaki N., Toda S., Kuroda E., Ishibashi K., Yasuda T., Natsuaki Y, Mi-ichi F, Iizasa E, Nakahara T, Yamazaki M., Kabashima K, Iwakura Y, Takai T, Saito T, Kurosaki T, Malissen B, Ohno N, Furue M, Yoshida H, Hara H: An ITAM-Syk-CARD9 signalling axis triggers contact hypersensitivity by stimulating IL-1 production in dendritic cells.
Nat Commun. 5:3755, 2014. - Iizasa E, Mitsutomi M, and Nagano Y: Direct binding of a plant LysM receptor-like kinase, LysM RLK1/CERK1, to chitin in vitro. J. Biol. Chem.
American Society for Biochemistry and Molecular biology. 285: 2996-3004 (2010) - Nagano, Y.2, Takao, S.3, Kudo, T.4, Iizasa, E.1, and Anai, T.5 Yeast-based recombineering of DNA fragments into plant transformation vectors by one-step transformation.
Plant Cell Rep. Springer Publishing. 26: 2111-2117 (2007) - Iizasa, E and Nagano Y: Highly efficient yeast-based in vivo DNA cloning of multiple DNA fragments and the simultaneous construction of yeast/ Escherichia coli shuttle vectors.
Biotechniques. Informa Life Science Publishing. 40: 75-83 (2006)
Patents and copy Rights
名称 / 出願番号 | 発明者等 |
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ノックアウト非ヒト化動物 特願2015-246551 |
野出孝一、吉田裕樹、Hiromitsu HARA 平瀬徹明、宮崎義之 平成27年7月24日 |
ノックアウト非ヒト化動物 特開2011-092026 |
野出孝一、吉田裕樹、Hiromitsu HARA 平瀬徹明、宮崎義之 平成21年10月27日 |
NK細胞の機能調節剤およびそのスクリーニング法 特開2008-118862 |
齋藤隆、Hiromitsu HARA 平成18年11月8日 |
組み換えDNA作成法 特許第49615635号 |
永野幸生、Ei-ichi IZASA 平成24年4月6日 |
Collaborations
- 新規多発血管性肉芽腫症モデルマウスの確立(佐賀大学・膠原病内科学)
- 総合硝子体学の研究:基盤病態の解明と治療の研究(鹿児島大学・眼科学)
- ダメージ関連分子パターン受容体の神経障害性疼痛における役割(佐賀大学・生理学)
- 原虫感染に対するCARD9を介した新規自然免疫活性化経路の解析(佐賀大学・免疫学)
- インフルエンザウイルスと内因性リガンドを認識する新規自然免疫受容体の解析(北里研究所)
Research Grant List
Hiromitsu HARA
Project・Event / Span | Research |
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基盤研究(B) 平成27~29年度 |
脂質センサー型ITAM受容体による抗酸菌特異的脂質の認識と結核病態の制御 |
挑戦的萌芽研究 平成27~28年度 |
アレルギー性化合物を認識する自然免疫受容体の探索 |
基盤研究(B) 平成24~26年度 |
肺感染症における新規自然免疫受容体の役割の解明 |
新学術領域研究 平成24~26年度 |
アレルギー性接触皮膚炎感作に必要な非感染性自然免疫活性化経路 |
基盤研究(B) 平成21~23年度 |
CARMA1シグナルの制御機構と免疫恒常性維持における役割 |
特定領域研究 平成22~23年度 |
ITAM受容体-CARD9経路による自己免疫病の発症・増悪機構の解明 |
基盤研究(C) 平成19~20年度 |
ITAM保有受容体のNF-κB活性化シグナル伝達機構と生理的意義の解明 |
特定領域研究 平成20~21年度 |
ITAM受容体-CARD9シグナルの自己免疫病における役割 |
内藤記念科学振興財団 研究助成金 平成27年度 |
結核菌表層の病原性脂質を認識する自然免疫受容体の機能解析 |
アステラス病態代謝研究会 研究助成金 平成27年度 |
結核菌表層の病原性脂質による自然免疫応答の制御機構 |
Ei-ichi IZASA
Project・Event / Span | Research |
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若手研究(B) 平成26~27年度 |
結核菌を認識する新規骨髄系ITAMRの同定 |
笹川科学研究助成 平成27年度 |
哺乳類におけるキチン受容体の同定 |