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Research outline

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Research interests

• Diabetic complication
• Regulation of mitochondrial function
• Diabetes and peridontal disease
• Energy metabolism in the patients with diabetes/obesity
• perioperative blood glucose management

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Research results

Assistant Professor

Researche Repository

主な研究実績

Yoshihiko NISHIO

1. Arimura H, Askoro R, Fujio S, Ummah FC, Takajo T, Nagano Y, Nishio Y, Arita K.
   A Thyroid-stimulating Hormone (TSH) Producing Adenoma in a Patient with Severe Hypothyroidism: Thyroxine Replacement Reduced the TSH Level and Tumor Size.
   NMC Case Rep J. 2019 Dec 18;7(1):17-21
2. Yamamoto K, Ito T, Nagasato T, Shinnakasu A, Kurano M, Arimura A, Arimura H, Hashiguchi H, Deguchi T, Maruyama I, Nishio Y.
   Effects of glycemic control and hypoglycemia on Thrombus formation assessed using automated microchip flow chamber system: an exploratory observational study.
   Thromb J. 2019 Sep 2;17:17
3. Kume S, Araki SI, Ugi S, Morino K, Koya D, Nishio Y, Haneda M, Kashiwagi A, Maegawa H.
   Secular changes in clinical manifestations of kidney disease among Japanese adults with type 2 diabetes from 1996 to 2014. J Diabetes Investig. 2019 Jul;10(4):1032-1040
4. Ghavidel Darestani S, Kurano M, Shinnakasu A, Yamamoto K, Dochi Y, Uemura K, Ikeda Y, Arimura A, Arimura H, Kikuchi A, Hashiguchi H, Deguchi T, Nishio Y. Association between changes in the mRNA expression of platelet-activating factor receptor in peripheral blood mononuclear cells and progression of diabetic nephropathy. Diabetol Int. 11(1):11-18,2019
5. Shayo SC, Kawade S, Ogiso K, Yoshihiko N.
   Strategies to ameliorate endothelial dysfunction associated with metabolic syndrome, where are we?
   Diabetes Metab Syndr. 2019 May-Jun;13(3):2164-2169.
6. Ogiso K, Koriyama N, Obo T, Tokito A, Ueno T, Nishio Y.
   Performance of a 2-step insulin infusion protocol with adjustment of insulin doses for Asians in the medical intensive care unit following cardiothoracic surgery. Diabetol Int. 2018 Jun 15;10(1):12-23
7. Kurano M, Darestani SG, Shinnakasu A, Yamamoto K, Dochi Y, Uemura K, Ikeda Y, Kikuchi A, Hashiguchi H, Deguchi T, Nishio Y. mRNA expression of platelet activating factor receptor (PAFR) in peripheral blood mononuclear cells is associated with albuminuria and vascular dysfunction in patients with type 2 diabetes. Diabetes Res Clin Pract. 136:124-133,2018
8. Shinnakasu A, Yamamoto K, Kurano M, Arimura H, Arimura A, Kikuti A, Hashiguchi H, Deguchi T, Nishio Y. The Combination Therapy of Fenofibrate and Ezetimibe Improved Lipid Profile and Vascular Function Compared with Statins in Patients with Type 2 Diabetes.
   J Atheroscler Thromb. 2017 Jul 1;24(7):735-748
9. Kondo K, Morino K, Nishio Y, Ishikado A, Arima H, Nakao K, Nakagawa F, Nikami F, Sekine O, Nemoto KI, Suwa M, Matsumoto M, Miura K, Makino T, Ugi S, Maegawa H.
   Fiber-rich diet with brown rice improves endothelial function in type 2 diabetes mellitus: A randomized controlled trial.
   PLoS One. 2017 Jun 29;12(6):e0179869.
10. Masuda T, Ueda M, Suenaga G, Misumi Y, Tasaki M, Izaki A, Yanagisawa Y, Inoue Y, Motokawa H, Matsumoto S, Mizukami M, Arimura A, Deguchi T, Nishio Y, Yamashita T, Inomata Y, Obayashi K, Ando Y.
    Early skin denervation in hereditary and iatrogenic transthyretin amyloid neuropathy.
    Neurology. 2017 Jun 6;88(23):2192-2197.
11. Kume S, Kondo M, Maeda S, Nishio Y, Yanagimachi T, Fujita Y, Haneda M, Kondo K, Sekine A, Araki SI, Araki H, Chin-Kanasaki M, Ugi S, Koya D, Kitahara S, Maeda K, Kashiwagi A, Uzu T, Maegawa H.
    Hypothalamic AMP-Activated Protein Kinase Regulates Biphasic Insulin Secretion from Pancreatic β Cells during Fasting and in Type 2 Diabetes.
    EBioMedicine. 2016 Nov;13:168-180
12. Ugi S, Maegawa H, Morino K, Nishio Y, Sato T, Okada S, Kikkawa Y, Watanabe T, Nakajima H, Kashiwagi A. Evaluation of a Novel Glucose Area Under the Curve (AUC) Monitoring System: Comparison with the AUC by Continuous Glucose Monitoring.
    Diabetes Metab J. 2016 Aug;40(4):326-33
13. Fujio S, Takano K, Arimura H, Habu M, Bohara M, Hirano H, Hanaya R, Nishio Y, Koriyama C, Kinoshita Y, Arita K.
    Treatable glomerular hyperfiltration in patients with active acromegaly. Eur J Endocrinol. 2016 Oct;175(4):325-33
14. Tanaka A, Murohara T, Taguchi I, Eguchi K, Suzuki M, Kitakaze M, Sato Y, Ishizu T, Higashi Y, Yamada H, Nanasato M, Shimabukuro M, Teragawa H, Ueda S, Kodera S, Matsuhisa M, Kadokami T, Kario K, Nishio Y, Inoue T, Maemura K, Oyama J, Ohishi M, Sata M, Tomiyama H, Node K; PROTECT Study Investigators.
    Rationale and design of a multicenter randomized controlled study to evaluate the preventive effect of ipragliflozin on carotid atherosclerosis: the PROTECT study.
    Cardiovasc Diabetol. 2016 Sep 13;15(1):133
15. Arimura H, Hashiguchi H, Yamamoto K, Shinnakasu A, Arimura A, Kikuchi A, Deguchi T, Habu M, Fujio S, Arita K, Nishio Y.
    Investigation of the clinical significance of the growth hormone-releasing peptide-2 test for the diagnosis of secondary adrenal failure.
    Endocr J. 2016 Jun 30;63(6):533-44

Takahisa DEGUCHI

1. Sugimoto K, Murakami H, Deguchi T, Arimura A, Daimon M, Suzuki S, Shimbo T, Yagihashi S.
   Cutaneous microangiopathy in patients with type 2 diabetes: Impaired vascular endothelial growth factor expression and its correlation with neuropathy, retinopathy and nephropathy.
   J Diabetes Investig 10:1318-1331,2019
2. Masuda T, Ueda M, Suenaga G, Misumi Y, Tasaki M, Izaki A, Yanagisawa Y, Inoue Y, Motokawa H, Matsumoto S, Mizukami M, Arimura A, Deguchi T, Nishio Y, Yamashita T, Inomata Y, Obayashi K, Ando Y.
   Early skin denervation in hereditary and iatrogenic transthyretin amyloid neuropathy.　Neurology　88（23）：2192-2197,2017
3. Horinouchi S, Deguchi T, Arimura K, Arimura A, Dochi Y, Uto T, Nakamura T, Arimura Y, Nishio Y, Takashima H. Median neuropathy at the wrist as an early manifestation of diabetic neuropathy. J Diabetes Invest 5: 709-713, 2014
4. Deguchi T, Nishio Y, Takashima H. Diabetes mellitus and autoimmune neuropathy. Brain Nerve 66(2):135-47, 2014
5. Deguchi T, Rosales R, Hashiguchi T, Arimura K. Antiplatelet Therapy, Diabetic Neuropathy and Peripheral Vascular Disease: A Unitary Approach. J Diabetes Metab S5: 005, 2012
6. Deguchi T, Hashiguchi T, Horinouchi S, Uto T, Oku H, Kimura K, Makisumi K, Arimura K. Serum VEGF increases in diabetic polyneuropathy, particularly in the neurologically active symptomatic stage. Diabetic Med 26(3): 247-252, 2009
7. Kimura K, Hashiguchi T, Deguchi T, Horinouchi S, Uto T, Oku H, Setoyama S, Maruyama I, Osame M, Arimura K.　Serum VEGF－As a prognostic factor of atherosclerosis. Atherosclerosis 194(1): 182-188, 2007

Katutaro MORINO

1. Horibe K, Morino K, Miyazawa I, Tanaka-Mizuno S, Kondo K, Sato D, Ohashi N, Ida S, Yanagimachi     T, Yoshimura M, Itoh R, Murata K, Miura K, Arima H, Fujita Y, Ugi S, Maegawa H; SUMS-ADDIT-2 Research group. Metabolic changes induced by dapagliflozin, an SGLT2 inhibitor, in Japanese    patients with type 2 diabetes treated by oral anti-diabetic agents: A randomized, clinical trial  Diabetes Res Clin Pract. 186: 109781, 2022
2. Iwasaki H, Ichihara Y, Morino K, Lemecha M, Sugawara L, Sawano T, Miake J, Sakurai H, Nishi E, Maegawa H, Imamura T. Takeshi MicroRNA-494-3p inhibits formation of fast oxidative muscle fibres by targeting E1A-binding protein p300 in human-induced pluripotent stem cells. Sci Rep. 11: 1161, 2021
3. Harada K, Morino K (equally contributed), Ishikawa M, Miyazawa I, Yasuda T, Hayashi M, Ishikado A, Maegawa H. Glycemic control and number of natural teeth: analysis of cross-sectional Japanese employment-based dental insurance claims and medical check-up data Diabetol Int. 13: 244-252, 2021
4. Morino K, Kondo K, Tanaka S, Nishida Y, Nakae S, Yamada Y, Ugi S, Fuse K, Miyazawa I, Ohi A, Nishida K, Kurihara M, Sasaki M, Ebine N, Sasaki S, Katsukawa F, Maegawa H. Total energy expenditure is comparable between patients with and without diabetes mellitus: Clinical Evaluation of Energy Requirements in Patients with Diabetes Mellitus (CLEVER-DM) Study. BMJ Open Diabetes Research and Care, 7: e000648, 2019
5. Okamoto T, Morino K, Ugi S, Nakagawa F, Lemecha M, Ida S, Ohashi N, Sato D, Fujita Y, Maegawa H. Microbiome potentiates endurance exercise through intestinal acetate production. Am J Physiol Endocrinol Metab. 16: E956-E966, 2019
6. Inoue H, Morino K, Ugi S, Tanaka-Mizuno S, Fuse K, Miyazawa I, Kondo K, Sato D, Ohashi N, Ida S, Sekine O, Yoshimura M, Murata K, Miura K, Arima H, Maegawa H; SUMS-ADDIT-1 Research group. Ipragliflozin, a sodium-glucose cotransporter 2 inhibitor, reduces bodyweight and fat mass, but not muscle mass, in Japanese type 2 diabetes patients treated with insulin: A randomized clinical trial. J Diabetes Investig. 10: 1012-1021, 2019
7. Lemecha M, Morino K, Imamura T, Iwasaki H, Ohashi N, Ida S, Sato D, Sekine O, Ugi S, Maegawa H. MiR-494-3p regulates mitochondrial biogenesis and thermogenesis through PGC1-α signalling in beige adipocytes. Sci Rep. 8: 15096, 2018.
8. Kobayashi S,Morino K,Okamoto T,Tanaka M,Ida S,Ohashi N,Murata K,Yanagimachi T,Sakai J,Maegawa H,Fujita Y,Kume S. Acetate derived from the intestinal tract has a critical role in maintaining skeletal muscle mass and strength in mice. Physiol Rep.12:e16047,2024
9. Ohgaku S,Ida S,Ohashi N,Morino K,Ishikado A,Yanagimachi T,Murata K,Sato D,Ugi S,Nasiri A,Shulman Gl,Maegawa H,Kume S,Fujita Y. O-GlcNAc modification in endothelial cells modulates adiposity nia fat absorption from the intestine in mice. Heliyon. 10:e34490,2024 

Aiko ARIMURA

1. Arimura A, Deguchi T, Sugimoto K, Uto T, Nakamura T, Arimura Y, Arimura K, Yagihashi S, Nishio Y, Takashima H. Intraepidermal nerve fiber density and nerve conduction study parameters correlate with clinical staging of diabetic polyneuropathy.Diabetes Res Clin Pract 99(1): 24-29, 2013

Research Grant List

Yoshihiko NISHIO

Takahisa DEGUCHI

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