FIELD

Division of HTLV-1/ATL Carcinogenesis and Therapeutics

Research outline

Graduate School Graduate School of Medical and Dental Sciences
Endowed Courses Division of HTLV-1/ATL Carcinogenesis and Therapeutics

Contact

TEL.099-275-6656 / FAX.299-275-6656

Research interests

  • Basic research that contributes to prevention, diagnosis, and treatment for adult T-cell leukemia/lymphoma (ATL)

Staff

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Professor（additional post）
Name Shingo NAKAHATA
Specialized field Biochemistry, Molecular Biology
Research interests  ・Molecular pathology and mechanisms of adult T-cell leukemia/lymphoma (ATL)
・Development of new therapeutic drugs for ATL

Researche Repository

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学外研究員
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Research results

Singo NAKAHATA
  1. Nakahata S#, Syahrul C#(co-first author), Nakatake A, Sakamoto K, Yoshihama M, Nishikata I, Ukai Y, Matsuura T, Kameda T, Shide K, Kubuki Y, Hidaka T, Kitanaka A, Ito A, Takemoto S, Nakano N, Saito M, Iwanaga M, Sagara Y, Mochida K, Amano M, Maeda K, Sueoka E, Okayama A, Utsunomiya A, Shimoda K, Watanabe T, Morishita K. Clinical significance of soluble CADM1 as a novel marker for adult T-cell leukemia/lymphoma. Haematologica. 2021;106:532-542.
  2. Nakahata S#, Ichikawa T#(co-first author), Maneesaay P, Saito Y, Nagai K, Tamura T, Manachai N, Yamakawa N, Hamasaki M, Kitabayashi I, Arai Y, Kanai Y, Taki T, Abe T, Kiyonari H, Shimoda K, Ohshima K, Horii A, Shima H, Taniwaki M, Yamaguchi R, Morishita K. Loss of NDRG2 expression activates PI3K-AKT signalling via PTEN phosphorylation in ATLL and other cancers. Nat Commun. 2014;5:3393.
  3. Nakahata S, Saito Y, Marutsuka K, Hidaka T, Maeda K, Hatakeyama K, Shiraga T, Goto A, Takamatsu N, Asada Y, Utsunomiya A, Okayama A, Kubuki Y, Shimoda K, Ukai Y, Kurosawa G, Morishita K. Clinical significance of CADM1/TSLC1/IgSF4 expression in adult T-cell leukemia/lymphoma. Leukemia. 2012;26:1238-1246.
  4. Hidaka T#, Nakahata S#(co-first author), Hatakeyama K#, Hamasaki M, Yamashita K, Kohno T, Arai Y, Taki T, Nishida K, Okayama A, Asada Y, Yamaguchi R, Tsubouchi H, Yokota J, Taniwaki M, Higashi Y, Morishita K. Down-regulation of TCF8 is involved in the leukemogenesis of adult T-cell leukemia/lymphoma. Blood. 2008;112:383-393.
Singo NAKAHATA
Project・Event / SpanResearch
 Grant-in-Aid for Scientific Research (C),  "Research on immune escape strategies of HTLV-1 infected cells and mechanisms for promoting carcinogenesis", 2022-2024
Grant-in-Aid for Scientific Research (C),    "Elucidation of the pathogenesis mechanism of adult T cell leukemia (ATL) based on intestinal flora analysis", 2019-2021
 Grant-in-Aid for Scientific Research (C),   "Analysis of hypoxic stress response mechanism in adult T cell leukemia (ATL)", 2016-2018
 Takeda Science Foundation,   "Elucidation of the molecular mechanism and physiological significance of abnormal expression of BCL11B gene in ATL", 2015
 Japan Leukemia Research Fund,  "Elucidation of the molecular mechanism of PTEN phosphorylation abnormalities in adult T cell leukemia (ATL) and development of its inhibitors", 2014
 Mochida memorial foundation for medical and pharmaceutical research,   "Elucidation of the molecular mechanism of PTEN phosphorylation abnormalities in adult T cell leukemia (ATL) and development of inhibitors", 2014
   
   
   
   
   　 
   
   
   
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