FIELD

Drug Discovery of Next-generation GcMAF (Saisei Mirai)

Research outline

部局 大学院医歯学総合研究科 Graduate School of Medical and Dental Sciences
  寄附講座 Endowed Courses
講座 次世代GcMAF創薬学講座 Drug discovery of next-generation GcMAF (Saisei Mirai)

Contact

TEL.+81-99-275-6387 / FAX.

Research interests

GcMAF様活性物質の探索 Discovery of GcMAF-like factors
GcMAFの病態生理学的作用の解析 Analysis of pathophysiological actions of GcMAF
神経細胞とマイクログリアの相互作用による中枢神経系の機能調節の解析 Regulation of actions of central nervous system by interaction of neurons and microglia

Staff

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Specially Appointed Associate Professor
氏名 勝浦　五郎 Goro Katsuura
専門分野 神経薬理学、内分泌学
研究テーマ ・GcMAF様活性物質の探索と病態生理学的作用の解析
・脳内炎症と神経精神疾患について

Researche Repository

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Specially Appointed Assistant Professor
氏名 河村　菜実子 Namiko KAWAMURA
専門分野 神経薬理学
研究テーマ ・脳内炎症反応に及ぼすGcMAF様活性物質の作用
・中枢神経系Fractalkine-CX3CR1 シグナルの作用

Researche Repository

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Specialists
氏名 中間　里穂　Riho Nakama
専門分野 生化学
研究テーマ ・GcMAF活性物質の探索
・GcMAFの病態生理学的作用の解析

Researche Repository

Research results

Goro Katsuura
  • Fujikawa, A., Noda, Y., Yamamoto, H., Tanga, N., Sakaguchi, G., Hattori, S., Song, W.J., Sora, I., Nabeshima, T., Katsuura, G., Noda, M.
    Mice deficient in protein tyrosine phosphatase receptor type Z (PTPRZ) show reduced responsivity to methamphetamine despite an enhanced response to novelty.
    PLoS One, 14: e0221205. (2019)
  • Ishii, A., Katsuura, G., Imamaki, H., Kimura, H., Mori, K.P., Kuwabara, T., Kasahara, M.,Yokoi, H., Ohinata, K., Kawanishi, T., Tsuchida, J., Nakamoto, Y., Nakao, K., Yanagita, M., Mukoyama, M., Mori, K.
    Obesity-promoting and anti-thermogenic effects of neutrophil gelatinase-associated lipocalin in mice. Sci Rep., 7:15501 (2017)
  • Yamada-Goto, N., Ochi, Y., Katsuura, G., Yamashita, Y., Ebihara, K., Noguchi, M., Fujikura, J., Taura, D., Sone, M., Hosoda, K., Gottschall, P.E., Nakao, K.
    Neuronal cells derived from human induced pluripotent stem cells as a functional tool of melanocortin system.
    Neuropeptides, 65: 10-20 (2017)
  • Fujitsuka, N., Asakawa, A., Morinaga, A., Amitani, M.S., Amitani, H., Katsuura, G., Sawada, Y., Sudo, Y., Uezono, Y., Mochiki, E., Sakata, I., Sakai, T., Hanazaki, K., Yada, T., Yakabi, K., Sakuma, E., Ueki, T., Niijima, A., Nakagawa, K., Okubo, N., Takeda, H., Asaka, M., Inui, A.
    Increased ghrelin signaling prolongs survival in mouse models of human aging through　activation of sirtuin1.
    Mol. Psychiatry, 21: 1613-1623 (2016)
  • Moe, Y., Kyi-Tha-Thu, C., Tanaka, T., Ito, H., Yahashi, S., Matsuda, K.I., Kawata, M., Katsuura, G., Iwashige, F., Sakata, I., Akune, A., Inui, A., Sakai, T., Ogawa, S., Tsukahara, S. (2016)
    A Sexually Dimorphic Area of the Dorsal Hypothalamus in Mice and Common Marmosets.
    Endocrinology, 157: 4817-4828
  • Takemi, S., Sakata, I., Apu, A.S., Tsukahara, S., Yahashi, S., Katsuura, G., Iwashige,
    F., Akune, A., Inui, A., Sakai, T.
    Molecular Cloning of Ghrelin and Characteristics of Ghrelin-Producing Cells in the Gastrointestinal Tract of the Common Marmoset (Callithrix jacchus).
    Zoolog Sci., 33: 497-504 (2016)
  • Yamada-Goto, N., Katsuura, G., Ebihara, K., Inuzuka, M., Ochi, Y., Yamashita, Y., Kusakabe, T., Yasoda, A., Satoh-Asahara, N., Ariyasu, H., Hosoda, K., Nakao, K.
    Intracerebroventricular Administration of C-Type Natriuretic Peptide Suppresses Food Intake via Activation of the Melanocortin System in Mice.
    Diabetes, 62: 1500-1504 (2013)
  • Yamada-Goto, N., Katsuura, G., Ochi, Y., Ebihara, K., Kusakabe, T., Hosoda, K., Nakao, K.
    Impairment of fear-conditioning responses and changes of brain neurotrophic factors in diet-induced obese mice.
    J. Neuroendocrinol., 24: 1120-1125 (2012)
  • Himeno, A., Satoh-Asahara, N., Usui, T., Wada, H., Tochiya, M., Kono, S., Yamada-Goto, N., Katsuura, G., Hasegawa, K., Nakao, K., Shimatsu, A.
    Salivary cortisol levels are associated with outcomes of weight reduction therapy in obese Japanese patients.
    Metabolism, 61: 255-261 (2012)
  • Yamada, N., Katsuura, G., Ochi, Y., Ebihara, K., Kusakabe, T., Hosoda, K., Nakao, K. Impaired CNS leptin action is implicated in depression associated with obesity.
    Endocrinology, 152: 2634-2643 (2011)
  • Inuzuka, M., Tamura, N., Yamada, N., Katsuura, G., Oyamada, N., Taura, D., Sonoyama, T., Fukunaga, Y., Ohinata, K., Sone, M., Nakao, K.
    C-type natriuretic peptide as a new regulator of food intake and energy expenditure. Endocrinology, 151: 3633-3642 (2010)
  • Niisato, K., Fujikawa, A., Komai, S., Shintani, T., Watanabe, E., Sakaguchi, G., Katsuura, G., Manabe, T., Noda, M.
    Age-dependent enhancement of hippocampal long-term potentiation and impairment of spatial learning through the Rho-associated kinase pathway in protein tyrosine phosphatase receptor type-Z-deficient mice.
    J. Neurosci., 25: 1081-1088 (2005)
  • Yagami, T., Takahara, Y., Ishibashi, C., Sakaguchi, G., Itoh, N., Ueda, K., Nakazato, H., Okamura, N., Hiramatsu, Y., Honma, T., Arimura, A., Sakaeda, T., Katsuura, G. Amyloid β protein impairs motor function via thromboxane A2 in the rat striatum.
    Neurobiol. Dis., 16: 481-489 (2004)

[総説]

  • Katsuura G, Kawamura N, Nishida M, Amitani H, Asakawa A, Inui A. Obesity study: animal models. Molecular mechanisms underpinning the development of obesity. P153-166. Edited by Clevio Nobrega PhD and Raquel Rodriguez-Lopez PhD. Springer (2014)
  • Yamada-Goto, N., Katsuura, G., Nakao, K. Mental function and Obesity. Functional Brain Mapping and the Endeavor to Understand the Working Brain. p301-341 (Edited by Francesco Signorelli and Domenico Chirchiglia). ISBN 980-953-307-973-3. InTech, Croatia. (2013)
  • Yamada-Goto, N., Katsuura, G., Nakao, K. A novel approach to obesity from mental function. J. Obes. Wt. Loss Ther., 3: 167. doi:10.4172/2165-7904.1000168 (2013) (Editorial) (2013)
  • "後藤(山田)伸子、勝浦五郎、越智ゆかり、中尾一和. メタボリックシンドロームの高次脳機能障害へのアプローチ；肥満の key 分子であるレプチンの肥満に合併するうつ病態における意義. 日本神経精神薬理学雑誌、32: 245-250 (2012)
  • "山田伸子、勝浦五郎、越智ゆかり、中尾一和 . うつ（メタボリックシンドローム：第2版、基礎・臨床の最新知見）. 日本臨床. 69 (Supple. 1): 421-425 (2011)
  • 山田伸子、勝浦五郎、海老原 健、越智ゆかり、細田公則、中尾一和. レプチンの抗うつ作用と肥満に合併するうつ病態における意義.肥満研究. 16: 188-191 (2010)
  • 勝浦五郎、中尾一和.　摂食調節. 日本医師会雑誌. 136: S88-S89 (2007)
Namiko KAWAMURA
  • Kawamura, N., Katsuura, G., Yamada-Goto, N., Novianti, E., Inui, A., Asakawa, A. Reduced brain fractalkine-CX3CR1 signaling is involved in the impaired cognition of streptozotocin-treated mice.
    IBRO Rep., 9: 233-240 (2020)
  • Li, YX., Cheng, K.C., Asakawa, A., Kato, I., Sato, Y., Amitani, H., Kawamura, N., Cheng, J.T., Iui, A.
    Role of musclin in the pathogenesis of hypertension in rat. PLoS One, 8 (8): e72004 (2013)

[総説]

  • 河村菜実子、勝浦五郎、浅川明弘.
    肥満の基礎. 食欲調節機序.
    臨牀消化器内科. 34: 365-370 (2019)
  • 河村菜実子、勝浦五郎、乾　明夫.
    分子から迫る神経薬理学. ニューロペプチドY受容体をターゲットとした臨床応用.
    Clinical Neuroscience、37: 16-17 (2019)
  • 河村菜実子、勝浦五郎、乾　明夫.
    分子から迫る神経薬理学. ニューロペプチドY受容体の生理的および薬理的作用.
    Clinical Neuroscience、36: 1388-1389 (2018)
  • 河村菜実子、勝浦五郎、乾　明夫.
    分子から迫る神経薬理学. ニューロペプチドY受容体の種類.
    Clinical Neuroscience、36: 1258-1259 (2018)
  • 河村菜実子、勝浦五郎、乾　明夫.
    ストレス関連疾患のメカニズム‐最近の知見から. 脳腸ペプチドの立場から.
    日本医事新報、4895: 24 (2018)
  • 河村菜実子、勝浦五郎、浅川明弘、乾　明夫.
    モチベーションと消化管ペプチド.
    最新精神医学、22: 399-405 (2017)
  • 河村菜実子、乾　明夫.
    摂食調節ペプチド受容体.
    医学のあゆみ、256: 603-607 (2016)
  • 河村菜実子、勝浦五郎、乾　明夫.
    食欲の神経内分泌性調節.
    消化と吸収、37: 161-163 (2015)