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Research outline

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Research interests

• Molecular basis for drug resistance and the reversal of the drug resistance
• Membrane transporter
• Cancer microenviroment
• Nucleolar stress and development of nucleolar-stress-targeting anticancer drug

Staff

Professor

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Assistant Professor

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Research results

Tatsuhiko FURUKAWA

• Yamamoto M, Arimura H, Fukushige T, Minami K, Nishizawa Y, Tanimoto A, Kanekura T, Nakagawa M, Akiyama S, Furukawa T.Abcb10 role in heme biosynthesis in vivo: Abcb10 knockout in mice causes anemia with protoporphyrin IX and iron accumulation. Mol Cell Biol. 2014 Mar;34(6):1077-84
• Zhao HY, Ooyama A, Yamamoto M, Ikeda R, Haraguchi M, Tabata S, Furukawa T, Che XF, Zhang S, Oka T, Fukushima M, Nakagawa M, Ono M, Kuwano M, Akiyama S　Molecular basis for the induction of an angiogenesis inhibitor, thrombospondin-1, by 5-fluorouracil. Cancer Res. 2008, 68 (17):7035-41 
• Owatari S, Akune S, Komatsu M, Ikeda R, Firth SD, Che XF., Yamamoto M, Tsujikawa K, Kitazono M, Ishizawa T, Takeuchi T, Aikou T, Mercer FBJ, Akiyama S, Furukawa T., Copper-transporting P-type ATPase, ATP7A, Confers Multidrug Resistance and its Expression is Related to Resistance to SN-38 in Clinical Colon Cancer, Cancer Res., 67(10): 4860-4868, 2007
• Ren X-Q., Furukawa T.., Nakajima Y., Takahashi H., Aoki S., Sumizawa, T., Haraguchi M., Kobayashi M., Chijiwa K., Akiyama S. ：GSH inhibits trypsinization of the C-terminal half of human MRP1. J. Biol. Chem., 280 (7):, 6231-6237. 2005
• Yabe T., Suzuki N., Furukawa T., Ishihara T., Katsura I. ：Multidrug resistance-associated protein MRP-1 regulates dauer diapause by its export activity in Caenorhabditis elegans. Development, 132 (14) : 3197-207, 2005
• Nakajima, Y.; Gotanda, T.; Uchimiya, H.; Furukawa T..; Haraguchi, M.; Ikeda, R.; Sumizawa, T.; Yoshida, H.; Akiyama, S., Inhibition of metastasis of tumor cells overexpressing thymidine phosphorylase by 2-deoxy-L-ribose. Cancer Res, 64, (5), 1794-801,2004
• Uchimiya H., Furukawa T.., Okamoto M., Nakajima Y., Matsushita S., Ikeda R., Gotanda T., Haraguchi M., Sumizawa T., Ono M., Kuwano M., Kanzaki T., Akiyama S. ：Suppression of thymidin e phosphorylase-mediated angiogenesis tumor growth by 2-deoxy-L-ribose. Cancer Res., 62(10), 2834-2939, 2002
• Qiao S., Iwashita T., Furukawa T., Yamamoto M., Sobue G., Takahashi M. ：Differential effects of leukocyte common antigen-related protein on biochemical and biological activi2007ties of RET-MEN2A and RET-MEN2B mutant proteins. J. Biol. Chem., 276 (12), 9460-9467, 2001
• Ren X.Q., Furukawa T.., Aoki S., Nakajima T., Sumizawa T., Haraguchi M., Chen Z.S., Kobayashi M., Akiyama S. ：Glutathione-dependent binding of a photoaffinity analog of agosterol A to the C-terminal half of human multidrug resistance protein. J. Biol. Chem., 276(25), 23197-23206, 2001
• Ohno N., Tani A., Uozumi K., Hanada S., Furukawa T., Akiba S., Sumizawa T., Utsunomiya A., Arima T., Akiyama S. ：Expression of functional lung resistance-related protein predicts poor outcome in adult T-cell leukemia. Blood, 98, (4), 1160-1165, 2001
• Komatsu M., Sumizawa T., Mutoh M., Chen Z.S., Terada K., Furukawa T., Yang X.L., Gao H., Miura N., Sugiyama T., Akiyama S. ：Copper-transporting P-type adenosine triphosphatase (ATP7B) is associated with cisplatin resistance. Cancer Res., 60, 1312-1316, 2000
• Matsushita S., Nitanda T., Furukawa T., Sumizawa T., Tani A., Nishimoto K., Akiba S., Miyadera K., Fukushima M., Yamada Y., Yoshida H., Kanzaki T.  , Akiyama S. ：The effect of a thymidine phosphorylase inhibitor on angiogenesis and apoptosis in tumors. Cancer Res., 59, 1911-1916, 1999
• Haraguchi M., Miyadera K., Uemura K., Sumizawa T., Furukawa T., Yamada K., Akiyama S. Yamada Y. ：Angiogenic activity of enzymes. Nature, 368, 198, 1994
• Furukawa T.., Itoh M., Krueger N.X., Streuli M. Saito H.：Specific interaction of the CD45 protein-tyrosine phosphatase with tyrosine-phosphorylated CD3 zeta chain. Proc. Natl. Acad. Sci. U S A, 91, 10928-10932, 1994
• Furukawa T.., Yoshimura A., Sumizawa T., Haraguchi M., Akiyama S., Fukui K., Ishizawa M. Yamada Y. ：Angiogenic factor. Nature, 356, 668, 1992

Kouichi KAWAHARA

1. Murata Y, Kotania T, Supriatn Y, Kitamura Y, Imada S, Kawahara K, Nishio M, Daniwijay E.D, Sadakata H, Kusakari S, Mori M, Kanazawa Y, Saito Y, Okawa K, Takeda-Morishita M, Okazawa H, Ohnishi H, Azuma T, Suzuki A, and Matozaki T., The protein tyrosine phosphatase SAP-1 protects against colitis through regulation of CEACAM20 in the intestinal epithelium.
   Proc. Natl. Acad. Sci. USA. 112(31):E4264-71, 2015.
2. Maehama T, Kawahara K, Nishio M, Suzuki A, Hanada K., Nucleolar Stress Induces Ubiquitination-Independent Proteasomal Degradation of PICT1., J. Biol. Chem, 289(30):20802-20812, 2014.
3. Miyoshi K , Yanagi S , Kawahara K, Nishio M, Tsubouchi H, Imazu Y, Koshida R, Matsumoto N, Taguchi A, Yamashita S, Suzuki A, and Nakazato M., Epithelial Pten Controls Acute Lung Injury and Fibrosis by Regulating Alveolar Epithelial Cell Integrity., Am J Respir Crit Care Med, 187(3):262-75. 2013.
4. Nishio M, Hamada KO, Kawahara KO, Sasaki M, Noguchi F, Chiba S, Mizuno K, Suzuki SO, Dong Y, Tokuda M, Morikawa T, Hikasa H, Eggenschwiler J, Yabuta N, Nojima H, Nakagawa K, Hata Y, Nishina H, Mimori K, Mori M, Sasaki T, Mak TW, Nakano T, Itami S, Suzuki A., Cancer susceptibility and embryonic lethality in Mob1a/1b double-mutant mice., J Clin Invest, 122(12):4505-18, 2012 (O:These two authors are contributed equally to this work as a second author).
5. Sasaki M*, Kawahara K*, Nishio M, Mimori K, Kogo R, Hamada K , Itoh B, Wangjia J, Komatsu Y, Yang R.Y, Hikasa H, Horie Y, Yamashita T, Kamijo T, Zhang Y, Prives C, Nakano T, Mak W.T, Sasaki T, Maehama T, Mori M and Suzuki A., Regulation of the MDM2-p53 Pathway and Tumor Growth by PICT1/GLTSCR2 via Nucleolar RPL11., Nature Medicine, 17(8):944-51, 2011 (*:These two authors are contributed equally to this work as a first author).
6. Kawahara K, Hashimoto M, Bar-On P, Ho GJ, Crews L, Mizuno H, Rockenstein E, Imam SZ, Masliah E., alpha-Synuclein aggregates interfere with Parkin solubility and distribution: role in the pathogenesis of Parkinson disease., J. Biol. Chem,283(11):6979-87,2008.
7. Yanagi S, Kishimoto H, Kawahara K, Sasaki T, Sasaki M, Nishio M, Yajima N, Hamada K, Horie Y, Kubo H, Whitsett JA, Mak TW, Nakano T, Nakazato M, Suzuki A., Pten controls lung morphogenesis, bronchioalveolar stem cells, and onset of lung adenocarcinomas in mice., J Clin Invest,117(10):2929-40,2007.
8. Kishimoto H, Ohteki T, Yajima N, Kawahara K, Natsui M, Kawarasaki S, Hamada K, Horie Y, Kubo Y, Arase S, Taniguchi M, Vanhaesebroeck B, Mak TW, Nakano T, Koyasu S, Sasaki T, Suzuki A., The Pten/PI3K pathway governs the homeostasis of Valpha14iNKT cells., Blood,109(8):3316-24, 2007.
9. Kawahara K, Morishita T, Nakamura T, Hamada F, Toyoshima K, and Akiyama T., Downregulation of beta-catenin by The Colorectal Tumor Suppressor APC Requires Association with Axin and beta-catenin., J. Biol. Chem,275(12), 8369-8374.,2000.

Masatatsu YAMAMOTO

• Yamamoto M, Arimura H, Fukushige T, Minami K, Nishizawa Y, Tanimoto A, Kanekura T, Nakagawa M, Akiyama S, Furukawa T.
  Abcb10 role in heme biosynthesis in vivo: Abcb10 knockout in mice causes anemia with protoporphyrin IX and iron accumulation.
  Mol Cell Biol. 2014 Mar;34(6):1077-84
• Yamamoto M, Yaginuma K, Tsutsui H, Sagara J, Guan X, Seki E, Yasuda K, Yamamoto M, Akira S, Nakanishi K, Noda T, Taniguchi S.
  ASC is essential for LPS-induced activation of procaspase-1 independently of TLR-associated signal adaptor molecules.
  Genes Cells. 2004 Nov;9(11):1055-67

Patents and copy Rights

Research Grant List

Tatsuhiko FURUKAWA

Kouichi KAWAHARA

Masatatsu YAMAMOTO

Yoshinari SHINSATO

Kentaro MINAMI

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