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Research outline

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Graduate School Graduate School of Medical and Dental Sciences
Course Advanced Therapeutics Course
Field Oral and Maxillofacial Rehabilitation
Department Dental Anesthesiology
Homepage http://w3.hal.kagoshima-u.ac.jp/dental/masui/

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Contact

TEL.+81-99-275-6288 / FAX.+81-99-275-6288

Research interests

  • Airway management of pediatric patients with cleft lip and palate
  • Function of the autonomic nervous system during dental treatment
  • Prediction of blood pressure responses to acute stress using the finger photoplethysmogram indices
  • Effect of general anesthetics on vascular endothelial function during perioperative period
  • Efficacy of intraoperative glycemic control using glucose-insulin infusion on postoperative outcomes in major oral and maxillofacial surgery
  • Morphological analysis of thalamocortical axon fibers of rat posterior thalamic nuclei using a single neuron tracing study with viral vectors

Staff

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Professor
Name Mitsutaka SUGIMURA
Specialized field Dental Anesthesiology
Research interests
  • Cry1、Cry2KOマウスを用いた三叉神経領域の痛覚日内変動機構の解明
  • 卵巣摘出動物における口腔顔面領域の神経障害性疼痛の制御機構の解明
  • 低酸素症が自律神経機能に及ぼす影響

Researche Repository


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Associate Professor
Name  
Specialized field  
Research interests

Researche Repository


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Lecturer
Name Sachi OHNO
Specialized field Dental Anesthesiology
Research interests
  • Morphological analysis of thalamocortical axon fibers of rat posterior thalamic nuclei using a single neuron tracing study with viral vectors
  • Effect of general anesthetics on vascular endothelial function during perioperative period

Researche Repository



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Assistant Professor
Name Kaoru YAMASHITA
Specialized field Dental Anesthesiology
Research interests
  •  口腔外科手術が自律神経系に与える影響
  • 下顎埋伏智歯抜歯中の音楽聴取が自律神経系に与える影響
  • 局所麻酔薬が自律神経系に与える影響
  • 静脈内鎮静法が自律神経系に与える影響
  • 口唇口蓋裂患者の周術期管理に関する研究

Researche Repository 


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Assistant Professor
Name Yurina HIGA
Specialized field Dental Anesthesiology
Research interests  

Researche Repository


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Assistant Professor
Name Minako UCHINO
Specialized field Dental Anesthesiology
Research interests  

Researche Repository


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Assistant Professor
Name Rumi SIDO
Specialized field Dental Anesthesiology
Research interests  

Researche Repository


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Assistant Professor
Name Kohei HASHIGUCHI
Specialized field Dental Anesthesiology
Research interests  

Researche Repository


Research results
Mitsutaka SUGIMURA
  • Yamagata K, Sugimura M, Yoshida M, Sekine S, Kawano A, Oyamaguchi A, Maegawa H, Niwa H. Estrogens Exacerbate Nociceptive Pain via Up-Regulation of TRPV1 and ANO1 in Trigeminal Primary Neurons of Female Rats. Endocrinology (2016) 157:4309-4317.
  • Sugimura M, Kudo C, Hanamoto H, Oyamaguchi A, Morimoto Y, Boku A, Niwa H. Considerations during intravenous sedation in geriatric dental patients with dementia. Clin Oral Investig. (2015) 19:1107-14.
  • Hanamoto H, Sugimura M, Morimoto Y, Kudo C, Boku A, Niwa H. Cough reflex under intravenous sedation during dental implant surgery is more frequent during procedures in the maxillary anterior region. J Oral Maxillofac Surg. (2013) 71(4):e158-63.
  • Hanamoto H, Sugimura M, Morimoto Y, Kudo C, Boku A, Niwa H. Small bolus of esmolol effectively prevents sodium nitroprusside-induced reflex tachycardia without adversely affecting blood pressure. J Oral Maxillofac Surg. (2012) 70:1045-51.
  • Morimoto Y., Sugimura M., Hanamoto H., Niwa H., Risk Factors for Hyperketonemia in Cleft Lip and Palate Infants During General Anesthesia, Journal of Maxillofacial Surgery, (2012) 70:1449-55.
  • Morimoto Y., Sugimura M., Hanamoto H., Niwa H., Limited mouth opening following induction of anesthesia in two patients with masticatory muscle tendon-aponeurosis hyperplasia, Journal of Clinical Anesthesia, (2011) 23; 598-600.
  • Sugimura M, Hanamoto H, Boku A, Morimoto Y, Taki K, Kudo C, Niwa H. Influence of Acute Hypoxia Combinedwith Nitrous Oxide on Cardiovascular Variability in Conscious Hypertensive Rats. Autonomic Neuroscience: Basic and Clinical. (2010) 156:73-81.
  • Boku A, Sugimura M, Morimoto Y, Hanamoto H and Niwa H, Hemodynamic and autonomic response to acute hemorrhage in streptozotocin-induced diabetic rats, Cardiovascular Diabetology, (2010) 9:78doi:10.1186/1475-2840-9-78.
  • Sugimura M, Hirose Y, Hanamoto H, Okada K, Boku A, Morimoto Y, Taki K, Niwa H. Influence of Acute    Progressive Hypoxia on Cardiovascular Variability in Conscious Spontaneously Hypertensive Rats. Autonomic Neuroscience: Basic and Clinical. (2008) 141: 94-103.
  • Morimoto Y, Sugimura M, Hirose Y, Taki K, Niwa H. Nasotracheal intubation under curve-tipped suction catheter guidance reducesepistaxis, Can J Anaesth,  (2006) 53: 295-8.
  • Sugimura M, Kitayama S, Morita K, Imai Y, Irifune M, Takarada T, Kawahara M, Dohi T, Effects of GABAergic agents on anesthesia induced by halothane, isoflurane, and thiamylal in mice, Pharmacol. Biochem. Behav, (2002) 72: 111-116.
  • Niwa H, Sugimura M, Satoh Y, Tanimoto A, Cardiovascular response to epinephrine-containing local anesthesia in patients with cardiovascular disease, Oral Surgery Oral Medicine Oral Pathology, (2001) 92, 610-616.
  • Sugimura M, Kitayama S, Morita K, Irifune M, Takarada T, Kawahara M, Dohi T, Effects of volatile and intravenous anesthetics on the uptake of GABA, glutamate and dopamine by their trnsporters heterologously expressed in COS cells and in rat brain synaptosomes, Toxicology Letters, (2001) 123: 69-76.
  • Irifune M, Sugimura M, Takarada T, Maeoka K, Shimizu Y, Dohi T, Nishikawa T and Kawahara M, Propofol anaesthesia in mice is potentiated by muscimol and reversed by bicuculline, Br. J. Anaesth. (1999) 83,: 665-667.
  • Sugimura M, Hirota Y, Shibutani T, Niwa H, Hori T, Kim Y and Matsuura H, An echocardiographic study of interactions between     pindolol and epinephrine contained in a local anesthetic solution, Anesth Prog. (1995) 42, 29-35.
  • Yamagata K, Hirose Y, Tanaka K, Yoshida M, Ohnuki T, Sendo R, Niwa H, Sugimura M.,Anesthetic Management of a Patient With a Vagal Nerve Stimulator. Anesth Prog. (2020) ;67:16-22.
  • Yamashita K, Kibe T, Aoyama K, Ohno S, Kohjitani A, Sugimura M. The State-Trait Anxiety Inventory Is Useful for Predicting the Autonomic Nervous System State of Patients Before the Extraction of an Impacted Mandibular Third Molar. Journal of Oral and Maxillofacial Surgery (2019) in press.
  • Yamashita K, Kibe T, Shidou Rumi, Kohjitani A, Nakamura N,Sugimura M. Difference in the effects of lidocaine with adrenaline and prilocaine with felypressin on the autonomic nervous system during extraction of the impacted mandibular third molar: A randomized control trial. Journal of oral and maxillofacial surgery: official journal of the American Association of Oral and Maxillofacial Surgeons, (2020);78(2):215.e1-215.e8.
  • Yamashita K, Kibe T, Ohno S, Kohjitani A, Sugimura M. The Effects of Music Listening During Extraction of the Impacted Mandibular Third Molar on the Autonomic Nervous System and Psychological State. Journal of oral and maxillofacial surgery: official journal of the American Association of Oral and Maxillofacial Surgeons, (2019) 77(6):1153.e1-1153.e8.
  • Yamashita K, Kibe T, Ohno S, Uchino M, Higa Y, Niiro A, Nakamura N, Sugimura M. Time to Recovery of Feeding After Alveolar Bone Graft Is Associated With Postoperative Nausea and Vomiting Within 2 Hours in Children. Clinical Medicine Insights : Pediatrics (2019) 13:1179556519855387
  • Tohya A, Kohjitani A, Ohno S, Yamashita K, Manabe Y, Sugimura M. Effects of glucose-insulin infusion during major oral and maxillofacial surgery on postoperative complications and outcomes. JA Clin Rep. Epub (2018) 4(1): 9.
  • Ohno S, Kohjitani A, Miyata M, Tohya A, Yamashita K, Hashiguchi T, Ohishi M, Sugimura M. Recovery of Endothelial Function after Minor-to-Moderate Surgery Is Impaired by Diabetes Mellitus, Obesity, Hyperuricemia and Sevoflurane-Based Anesthesia. Int. Heart Journal, (2018) 59(3): 559-565
  • Yamashita K, Kohjitani A, Miyata M, Ohno S, Tohya A, Ohishi M Sugimura M. Predictive factors of postoperative blood pressure abnormalities following a minor-to moderate surgery. Int. Heart Journal, (2018) 59(6):1359-1367

Sachi OHNO
  • Ohno S, Kuramoto E, Furuta T, Hioki H, Tanaka YR, Fujiyama F, Sonomura T, Uemura M, Sugiyama K, Kaneko T. A morphological analysis of thalamocortical axon fibers of rat posterior thalamic nuclei: a single neuron tracing study with vial vectors. Cereb Cortex (2012) 2840-57.
  • Ohno S, Miyata M, Kohjitani A, Tohya A, Ohishi M, Sugiyama K. Associations between blood pressure responses to acute stress and impaired renal function and serum uric acid level. Clin Exp Hypertens (2015) (in press).
  • Yamashita K, Kibe T, Aoyama K, Ohno S, Kohjitani A, Sugimura M. The State-Trait Anxiety Inventory Is Useful for Predicting the Autonomic Nervous System State of Patients Before the Extraction of an Impacted Mandibular Third Molar. Journal of Oral and Maxillofacial Surgery (2019) in press.
  • Yamashita K, Kibe T, Ohno S, Kohjitani A, Sugimura M. The Effects of Music Listening During Extraction of the Impacted Mandibular Third Molar on the Autonomic Nervous System and Psychological State. Journal of oral and maxillofacial surgery: official journal of the American Association of Oral and Maxillofacial Surgeons, (2019) 77(6):1153.e1-1153.e8.
  • Yamashita K, Kibe T, Ohno S, Uchino M, Higa Y, Niiro A, Nakamura N, Sugimura M. Time to Recovery of Feeding After Alveolar Bone Graft Is Associated With Postoperative Nausea and Vomiting Within 2 Hours in Children. Clinical Medicine Insights : Pediatrics (2019) 13:1179556519855387
  • Tohya A, Kohjitani A, Ohno S, Yamashita K, Manabe Y, Sugimura M. Effects of glucose-insulin infusion during major oral and maxillofacial surgery on postoperative complications and outcomes. JA Clin Rep. Epub (2018) 4(1): 9.
  • Ohno S, Kohjitani A, Miyata M, Tohya A, Yamashita K, Hashiguchi T, Ohishi M, Sugimura M. Recovery of Endothelial Function after Minor-to-Moderate Surgery Is Impaired by Diabetes Mellitus, Obesity, Hyperuricemia and Sevoflurane-Based Anesthesia. Int. Heart Journal, (2018) 59(3): 559-565
  • Yamashita K, Kohjitani A, Miyata M, Ohno S, Tohya A, Ohishi M Sugimura M. Predictive factors of postoperative blood pressure abnormalities following a minor-to moderate surgery. Int. Heart Journal, (2018) 59(6):1359-1367
  • Matsuda W, Sonomura T, Honma S, Ohno S, Goto T, Hirai S, Itoh M, Honda Y, Fujieda H, Udagawa J, Takano S, Fujiyama F, Ueda S. Anatomical variations of the torcular Herophili: macroscopic study and clinical aspects. Anat Sci Int. (2018);93 (4): 464-468.
  • Matsuda W, Sonomura T, Honma S, Ohno S, Goto T, Hirai S, Itoh M, Honda Y, Fujieda H, Udagawa J, Ueda S.Anatomical variations of the recurrent artery of Heubner: number, origin, and course. Anat Sci Int. (2018);93(3):317-322.
  • Kuramoto E, Iwai H, amanaka A, Ohno S, Seki H, Tanaka YR, Furuta T, Hioki H, Goto T. Dorsal and ventral parts of thalamic nucleus submedius project to different areas of rat orbitofrontal cortex: A single neuron-tracing study using virus vectors. J Comp Neurol. 2017 Dec 15;525(18):3821-3839
  • Kuramoto E, Iwai H, Yamanaka A, Ohno S, Goto T, Hioki H. Individual mediodorsal thalamic neurons project to multiple areas of the rat prefrontal cortex: A single neuron-tracing study using virus vectors. J Comp Neurol. (2017) Jan 1;525(1):166-185.

Kaoru YAMASHITA
  • Yamashita K, Kibe T, Aoyama K, Ohno S, Kohjitani A, Sugimura M. The State-Trait Anxiety Inventory Is Useful for Predicting the Autonomic Nervous System State of Patients Before the Extraction of an Impacted Mandibular Third Molar. Journal of Oral and Maxillofacial Surgery (2019) in press.
  • Yamashita K, Kibe T, Shidou Rumi, Kohjitani A, Nakamura N,Sugimura M. Difference in the effects of lidocaine with adrenaline and prilocaine with felypressin on the autonomic nervous system during extraction of the impacted mandibular third molar: A randomized control trial. Journal of oral and maxillofacial surgery: official journal of the American Association of Oral and Maxillofacial Surgeons, (2020);78(2):215.e1-215.e8. (1.781)
  • Yamashita K, Kibe T, Ohno S, Kohjitani A, Sugimura M. The Effects of Music Listening During Extraction of the Impacted Mandibular Third Molar on the Autonomic Nervous System and Psychological State. Journal of oral and maxillofacial surgery: official journal of the American Association of Oral and Maxillofacial Surgeons, (2019) 77(6):1153.e1-1153.e8.
  • Yamashita K, Kibe T, Ohno S, Uchino M, Higa Y, Niiro A, Nakamura N, Sugimura M. Time to Recovery of Feeding After Alveolar Bone Graft Is Associated With Postoperative Nausea and Vomiting Within 2 Hours in Children. Clinical Medicine Insights : Pediatrics (2019) 13:1179556519855387
  • Tohya A, Kohjitani A, Ohno S, Yamashita K, Manabe Y, Sugimura M. Effects of glucose-insulin infusion during major oral and maxillofacial surgery on postoperative complications and outcomes. JA Clin Rep. Epub (2018) 4(1): 9.
  • Ohno S, Kohjitani A, Miyata M, Tohya A, Yamashita K, Hashiguchi T, Ohishi M, Sugimura M. Recovery of Endothelial Function after Minor-to-Moderate Surgery Is Impaired by Diabetes Mellitus, Obesity, Hyperuricemia and Sevoflurane-Based Anesthesia. Int. Heart Journal, (2018) 59(3): 559-565
  • Yamashita K, Kohjitani A, Miyata M, Ohno S, Tohya A, Ohishi M Sugimura M. Predictive factors of postoperative blood pressure abnormalities following a minor-to moderate surgery. Int. Heart Journal, (2018) 59(6):1359-1367
  • 山下 薫, 岐部俊郎, 糀谷 淳, 比嘉憂理奈, 新納彩子, 内野美菜子, 青山歌奈絵, 四道瑠美, 橋口浩平, 杉村光隆. グレン循環患児における口唇形成・口蓋形成術に対する全身麻酔経験, 日本歯科麻酔学会誌, 2019;47(2):65‒67
  • 山下 薫, 糀谷 淳, 岐部俊郎, 大野 幸, 佐古沙織, 杉村光隆. 精神遅滞と肺 高血圧症を有す18p-症候群患者の智歯抜歯術における全身麻酔経験.日本障害者歯科学会誌 (2018); 39(1):28-32

Research Grant List

Mitsutaka SUGIMURA
Project・Event / Span  
Research  
Project・Event / Span  
Research  
Project・Event / Span  
Research  

Sachi OHNO
Project・Event / Span  
Research  
Project・Event / Span  
Research  

Kaoru Yamashita
Project・Event / Span 科学研究費補助金 若手研究 / 2018年4月〜2021年3月
Research 聴覚を介する自律神経制御法の確立 -時計遺伝子欠損マウスでの検討と臨床応用-

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