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Research outline

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Research interests

• Regulation of bone metabolism by nervous system
• Molecular mechanisms regulating tooth development
• Biological Analysis for Biomaterials
• Neural mechanism for pain control

Staff

Professor

Researche Repository

Associate Professor

Researche Repository

Assistant Professor

Researche Repository

Assistant Professor

Researche Repository

Research results

Tetsuya GOTO

1. Goto T, Kuramoto E, Dhar A, Wang RP, Seki H, Iwai H, Yamanaka A, Matsumoto SE, Hara H, Michikawa M, Ohyagi Y, Leung WK, Chang RC. Neurodegeneration of Trigeminal Mesencephalic Neurons by the Tooth Loss Triggers the Progression of Alzheimer's Disease in 3×Tg-AD Model Mice. J Alzheimers Dis 76(4):1443-1459, 2020.
2. Goto T and Leung WK. Tooth Loss and Alzheimer’s Disease. Curr Oral Health Rep, 6(2): pp82-88, 2019.
3. Goto T, Iwai H, Kuramoto E, Yamanaka A. Neuropeptides and ATP signaling in the trigeminal ganglion. Jpn Dent Sci Rev. 53(4):117-124, 2017.
4. Goto T, Oh SB, Takeda M, Shinoda M, Sato T, Gunjikake KK, Iwata K. Recent advances in basic research on the trigeminal ganglion. J Physiol Sci. 66(5): 381-386, 2016.
5. Ozeki K, Goto T, Aoki H, Matsuzawa. Influence of the crystallinity of a suputtered hydroxyapatite film on its osteocompatibility. Bio-Medical Materials and Engineering 26, 139-147, 2015.
6. Nagao S, Goto T, Kataoka S, Toyono T, Egusa H, Yatani H, Maki K.Expression of neuropeptide receptor mRNA during osteoblastic differentiation of mouse iPS cells. Neuropeptides 48, 399-406, 2014.
7. Kurata S, Goto T, K Gunjigake K, Kataoka S, N Kuroishi K, Ono K, Toyono T, Kobayashi S, Yamaguchi K. Nerve Growth Factor Involves Mutual Interaction between Neurons and Satellite Glial Cells in the Rat Trigeminal Ganglion. Acta Histochem Cytochem. ;46(2):65-73, 2013.
8. Fukuda A, Goto T, Kuroishi KN, Gunjigake KK, Kataoka S, Kobayashi S, Yamaguchi K. Hemokinin-1 competitively inhibits substance P-induced stimulation of osteoclast formation and function. Neuropeptides. 47(4):251-9, 2013.
9. Ichiki T, Kuroishi KN, Gunjigake KK, Kobayashi S, Goto T.: Neurokinin B activates the formation and bone resorption activity of rat osteoclasts. Neuropeptides 45:239-244, 2011.
10. Tanaka K, Goto T, Miyazaki T, Morita Y, Kobayashi S, Takahashi T. : Apatite-coated hyaluronan for bone regeneration. J Dent Res. 90:906-911, 2011.
11. Nakao K., Goto T., Gunjigake K., Konoo T., Kobayashi S., and Yamaguchi K. : Intermittent force induces high RANKL expression in human periodontal ligament cells. J Dent Res 86, 623-628, 2007.
12. Goto T., Nakao K., Gunjigake K.K., Kido M.A., Kobayashi S., and Tanaka T.: Substance P stimulates late-stage rat osteoblastic bone formation through neurokinin-1 receptor. Neuropeptides 41,25-23, 2007.
13. Goto T., Kajiwara H., Yoshinari M., Fukuhara E., Kobayashi S., and Tanaka T. : In vitro assay of mineralized-tissue formation on titanium using fluorescent staining with calcein blue. Biomaterials 244, 2885-2892, 2003.
14. Okumura A., Goto M., Goto T., Yoshinari M., Masuko S., Katsuki T., and Tanaka T.: Substrate affects the initial attachment and subsequent behavior of human osteoblastic cells (Saos-2). Biomaterials 22, 2263-2271, 2001.
15. Goto T., and Brunette D.M. : Surface topography and serum concentration affect the appearance of tenascin in human gingival fibroblasts in vitro. Exp Cell Res 244, 474-480, 1998.
16. Goto T., Yamaza T., Kido M.A., and Tanaka T.*: Light and electron microscopic study of the distribution of axons containing substance P and the localization of neurokinin-1 receptor in bone. Cell Tissue Res. 293, 87-93, 1998.
17. Goto T., Tsukuba T., Kiyoshima T., Nishimura Y., Kato K., Yamamoto K., and Tanaka T.: Immunohistochemical localization of cathepsin B, D and L in the rat osteoclast. Histochemistry 99, 411-414, 1993.
18. Goto T., Tsukuba T., Ayasaka N., Yamamoto K., and Tanaka T*.: Immunocytochemical localization of cathepsin D in the rat osteoclast.Histochemistry97,13-18,1992

Atsushi YAMANAKA

1. Yamanaka A, Iwai H, Uemura M, Goto T. Patterning of mammalian heterodont dentition within the upper and lower jaws. Evolution & Development 17: 127-138, 2015.
2. Yamanaka A, Iwai H, Kuramoto E, Goto T. Three-dimensional gene expression pattern reconstructed from serial section in situ hybridization. 鹿児島大学歯学部紀要 35: 87-92, 2015.
3. Uemura M, Sonomura T, Iwai H, Yamanaka A. Localization of masticatory motoneurons in the trigeminal motor nucleus of shrew and pig, with emphasis on the innervation ratio in the shrew. Journal of Oral Bioscience 55: 101-107, 2013.
4. Sonomura T, Furuta T, Nakatani I, Yamamoto Y, Unzai T, Matsuda W, Iwai H, Yamanaka A, Uemura M, Kaneko T. Correlative analysis of immunoreactivity in confocal laser-scanning microscopy and scanning electron microscopy with focused ion beam milling. Frontiers in Neural Circuits 7: 1-7, 2013.
5. Carlson KJ, Wrangham RW, Muller MN, Sumner DR, Morbeck ME, Nishida T, Yamanaka A, Boesch C. Comparison of limb structural properties in free-ranging chimpanzees from Kibale, Bombe, Mahale, and Tai communities. In: D'Aout K, Vereecke EE eds. Primate Locomotion: linking field and laboratory research. Springer, New York, pp. 155-182, 2012.
6. Yamanaka A. Developmental mechanisms regulating heterodonty and diphyodonty of mammalian dentition. 鹿児島大学歯学部紀要 31: 71-80, 2011.
7. 山中淳之, 花村肇. 歯の新知見. スンクスの生物学, 東京: 学会出版センター, pp.107-113, 2011.
8. Yamanaka A, Uemura M. The house shrew, Suncus murinus, as a model organism to investigate mammalian basal condition of tooth development. Journal of Oral Bioscience 52: 215-224, 2010.
9. Yamanaka A, Yasui K, Sonomura T, Iwai H, Uemura M. Development of deciduous and permanent dentitions in the upper jaw of the house shrew (Suncus murinus). Arch Oral Biol 55: 279-287, 2010.
10. Yamanaka A, Yasui K, Sonomura T, Uemura M. Development of heterodont dentition in house shrew (Suncus murinus). European Journal of Oral Science 115: 433-440, 2007.
11. Yamanaka A, Gunji H, Ishida H. Curvature, length, and cross-sectional geometry of the femur and humerus in anthropoid primates. American Journal of Physical Anthropology 127: 46-57, 2005.

Haruki IWAI

1. Shiozaki K, Kawabe M, Karasuyama K, Kurachi T, Hayashi A, Ataka K, Iwai H, Takeno H, Hayasaka O, Kotani T, Komatsu M, Inui A. Neuropeptide Y deficiency induces anxiety-like behaviours in zebrafish (Danio rerio). Sci Rep.10(1):5913, 2020.
2. Suzuki H, Ataka K, Asakawa A, Cheng KC, Ushikai M, Iwai H, Yagi T, Arai T, Yahiro K, Yamamoto K, Yokoyama Y, Kojima M, Yada T, Hirayama T, Nakamura N, Inui A. Helicobacter pylori Vacuolating Cytotoxin A Causes Anorexia and Anxiety via Hypothalamic Urocortin 1 in Mice. Sci Rep. 9(1):6011, 2019.
3. Tsukahara T, Masuhara M, Iwai H, Sonomura T, Sato T. The effect of repeated stress on KCC2 and NKCC1 immunoreactivity in the hippocampus of female mice. Data in Brief 6, 521-525, 2016.
4. Tsukahara T, Masuhara M, Iwai H, Sonomura T, Sato T. Repeated stress-induced expression pattern alterations of the hippocampal chloride transporters KCC2 and NKCC1 associated with behavioral abnormalities in female mice. Biochemical and Biophysical Research Communications 17, 127-138, 2015
5. Iwai H, Kuramoto E, Yamanaka A, Sonomura T, Uemura M, Goto T. Ascending parabrachio-thalamo-striatal pathways: Potential circuits for integration of gustatory and oral motor functions. Neuroscience 294, 1-13, 2015.
6. Yamanaka A, Iwai H, Kuramoto E, Goto T. Three-dimensional gene expression pattern reconstructed from serial section in situ hybridization. 鹿児島大学歯学部紀要 35, 87- 92, 2015.
7. Yamanaka A, Iwai H, Uemura M, Goto T. Patterning of mammalian heterodont dentition within the upper and lower jaws. Evolution and Development 17, 127-138, 2015.
8. Uemura M, Sonomura T, Iwai H, Yamanaka A. Localization of masticatory motoneurons in the trigeminal motor nucleus of shrew and pig, with emphasis on the innervation ratio in the shrew. Journal of Oral Biosciences 55, 101-107, 2013.
9. Sonomura T, Furuta T, Nakatani I, Yamamoto Y, Unzai T, Matsuda W, Iwai H, Yamanaka A, Uemura M, Kaneko T. Correlative Analysis of Immunoreactivity in Confocal Laser-Scanning Microscopy and Scanning Electron Microscopy with Focused Ion Beam Milling. Frontiers in Neural Circuits 7, Article 26，2013.
10. Yamanaka A, Yasui K, Sonomura T, Iwai H, Uemura M. Development of deciduous and permanent dentitions in the upper jaw of the house shrew (Suncus murinus). Arch Oral Biol 55, 279-287, 2010.

Eriko KURAMOTO

1. Kuramoto E. Method for labeling and reconstruction of single neurons using Sindbis virus vectors. J Chem Neuroanat. 100:101648, 2019.
2. Kawasaki Y, Saito M, Won J, Bae JY, Sato H, Toyoda H, Kuramoto E, Kogo M, Tanaka T, Kaneko T, Oh SB, Bae YC, Kang Y. Inhibition of GluR Current in Microvilli of Sensory Neurons via Na⁺-Microdomain Coupling Among GluR, HCN Channel, and Na⁺/K⁺ Pump. Front Cell Neurosci. 12:113, 2018.
3. Nishimura K, Ohta M, Saito M, Morita-Isogai Y, Sato H, Kuramoto E, Yin DX, Maeda Y, Kaneko T, Yamashiro T, Takada K, Oh SB, Toyoda H, Kang Y. Electrophysiological and Morphological Properties of α and γ Motoneurons in the Rat Trigeminal Motor Nucleus. Front Cell Neurosci. 12:9, 2018.
4. Kuramoto E, Iwai H, Yamanaka A, Ohno S, Seki H, Tanaka YR, Furuta T, Hioki H, Goto T. Dorsal and ventral parts of thalamic nucleus submedius project to different areas of rat orbitofrontal cortex: A single neuron-tracing study using virus vectors. J Comp Neurol. 525(18):3821-3839, 2017.
5. Unzai T, Kuramoto E, Kaneko T, Fujiyama F. Quantitative Analyses of the Projection of Individual Neurons from the Midline Thalamic Nuclei to the Striosome and Matrix Compartments of the Rat Striatum. Cereb Cortex. 27(2):1164-1181, 2017.
6. Kanda T, Tsujino N, Kuramoto E, Koyama Y, Susaki AE, Chikahisa S, Funato H.(2016) Sleep as a biological problem: an overview of frontiers in sleep research. J Physiol Sci 66: 1-13, 2015.
7. Kuramoto E, Ohno S, Furuta T, Unzai T, Tanaka YR, Hioki H, Kaneko T. Ventral medial nucleus neurons send thalamocortical afferents more widely and more preferentially to layer 1 than neurons of the ventral anterior-ventral lateral nuclear complex in the rat. Cerebral Cortex 25(1):221-235, 2015.
8. Hioki H, Okamoto S, Konno M, Kameda H, Sohn J, Kuramoto E, Fujiyama F, Kaneko T.Cell-type specific inhibitory inputs to dendritic and somatic compartments of parvalbumin-expressing neocortical interneuron. J Neurosci. 33(2): 544-555, 2013.
9. Ohno S, Kuramoto E, Furuta F, Hioki H, Tanaka YR, Fujiyama F, Sonomura T, Uemura M, Sugiyama K, Kaneko T.A morphological analysis of thalamocortical axon fibers of rat posterior thalamic nuclei: A single neuron tracing study with viral vectors. 2012, Cereb Cortex 22(12):2840-2857, 2012.
10. Kuramoto E, Fujiyama F, Nakamura KC, Tanaka Y, Hioki H, Kaneko T.Complementary distribution of glutamatergic cerebellar and GABAergic basal ganglia afferents to the rat motor thalamic nuclei. EurJ Neurosci 33(1):95-109, 2011.
11. Ohira K, Furuta T, Hioki H, Nakamura KC, Kuramoto E, Tanaka Y, Funatsu N, Shimizu K, Oishi T, Hayashi M, Miyakawa T, Kaneko T, Nakamura S.Ischemia-induced neurogenesis of neocortical layer 1 progenitor cells.2010, Nature Neuroscience 13(2):173-179, 2010.
12. Kuramoto E, Furuta T, Nakamura KC, Unzai T, Hioki H, Kaneko T.Two types of thalamocortical projections from the motor thalamic nuclei of the rat: a single neuron-tracing study using viral vectors. Cereb Cortex 9(9):2065-2077, 2009.
13. Kuramoto E, Fujiyama F, Unzai T, Nakamura K, Hioki H, Furuta T, Shigemoto R, Ferraguti F, Kaneko T. Metabotropic glutamate receptor 4-immunopositive terminals of medium-sized spiny neurons selectively form synapses with cholinergic interneurons in the rat neostriatum. 2007, J Comp Neurol 500(5):908-922, 2007.

Collaborations

• 医学系：鹿児島大学医学部 免疫学分野、心身内科学分野、統合分子生理学分野／名古屋市立大学医学部　病態生化学分野／九州大学医学部 神経解剖学分野
• 歯学系：鹿児島大学歯科麻酔全身管理学分野、歯科矯正学分野、生理学分野
• 理学系：京都大学大学院理学研究科 自然人類学研究室 生理学研究所 大脳神経回路論研究部門
• 工学系：茨城大学工学部機械工学科尾関研究室、物質・材料研究機構
• 海　外：University of California, San Francisco, Klein Lab University of Hong Kong, Biomedical Sciences, R C-C Chang Lab

Research Grant List

Tetsuya Goto

Atsushi YAMANAKA

Haruki IWAI

Eriko KURAMOTO

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