• Research outline
• Research interests
• Staff
• Research results
• Collaborations
• Research Grant List

Research outline

Our brain and heart function using changes in membrane potential (electrical signals). How is the electrical signal generated and regulated? How do neurons in the brain use such electrical signals for their circuit formation during development? What happens if the regulation of membrane potentials goes wrong? We address these questions using state-of-the-art techniques in molecular biology, electrophysiology, and imaging.

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 Research interests

• Activity-dependent formation of neural circuits in the cerebral cortex

• Restoration of damaged circuits

• Function and dysfunction of ion channels

Staff

Professor

Researche Repository

Lecturer

Researche Repository

Lecturer

Researche Repository

Assistant Professor

Researche Repository

Research results

Yoshiaki TAGAWA

Developmental stage-specific spontaneous activity contributes to callosal axon projections .  eLife11 ( e72435 ) 1 - 15   2022

Long-Range Interhemispheric Projection Neurons Show Biased Response Properties and Fine-Scale Local Subnetworks in Mouse Visual Cortex .  Cerebral Cortex31 ( 2 ) 1307 - 1315   2021

Involvement of Calcium-Dependent Pathway and β Subunit-Interaction in Neuronal Migration and Callosal Projection Deficits Caused by the Cav1.2 I1166T Mutation in Developing Mouse Neocortex. Frontiers in Neuroscience, 15, 747951, 2021

Long-range interhemispheric projection neurons show biased response properties and fine-scale local subnetworks in mouse visual cortex. Cerebral Cortex, 31(2), 1307–1315, 2020.

自発神経活動と視覚系神経回路のスクラップ＆ビルド　 生体の科学, 70, 23-27, 2019.

Control of spontaneous Ca²⁺ transients is critical for neuronal maturation in the developing neocortex. Cerebral Cortex, 26, 106-117 2016.

Neuronal activity is not required for the initial formation and maturation of visual selectivity. Nature Neuroscience, 18(12), 1780-1788 2015.

Dysfunction of KCNK potassium channels impairs neuronal migration in the developing mouse cerebral cortex. Cerebral Cortex, 24, 1017-1029 2014.

Evidence for activity-dependent cortical wiring: Formation of interhemispheric connections in neonatal mouse visual cortex requires projection neuron activity. Journal of Neuroscience 27(25), 6760-6770, 2007.

Multiple periods of functional ocular dominance plasticity in mouse visual cortex. Nature Neuroscience 8(3), 380-388, 2005.

XU Jianjun

Regulation of cardiac Cav1.2 channels by calmodulin. International Journal of Molecular Sciences, 24 (7) ( 6409 ), 1-28, 2023.

Ca2+ Dyshomeostasis Links Risk Factors to Neurodegeneration in Parkinson’s Disease. Front Cell Neurosci., 16:867385, 2022.

Purification of insoluble GST-fused and GST-cleaved Cav1.2 channel fragment by denaturation and renaturation. Protein Expr Purif.,160: 7-10, 2019.

PKA phosphorylation of Cav1.2 channel modulates the interaction of calmodulin with the C terminal tail of the channel. J Pharmacol Sci.,137(2):187-194, 2018.

A new interaction between proximal and distal C-terminus of Cav1.2 channels. J Pharmacol Sci.,133(4):240-246, 2017.

PKA and phosphatases attached to the Cav1.2 channel regulate channel activity in cell-free patches. American Journal of Physiology Cell Physiology, 310(2), C136-141, 2015.

Calmodulin reverses rundown of L-type Ca²⁺ channels in guinea pig ventricular myocytes. American Journal of Physiology Cell Physiology, 287(6), C1717-24, 2004.

Etsuko MINOBE

Regulation of cardiac Cav1.2 channels by calmodulin. International Journal of Molecular Sciences, 24 (7) ( 6409 ), 1-28, 2023.

Ca2+ Dyshomeostasis Links Risk Factors to Neurodegeneration in Parkinson’s Disease .  Frontiers in Cellular Neuroscience16 ( 867385 ) 1 - 15   2022

Properties of Calmodulin Binding to Nav1.2 IQ Motif and Its Autism-Associated Mutation R1902C .  Neurochemical Research46 ( 3 ) 523 – 534, 2021

Calmodulin and ATP support activity of the Cav1.2 channel through dynamic interactions with the channel. The Journal of Physiolgy, 595(8), 2465-2477, 2017.

A new phosphorylation site in cardiac L-type Ca²⁺ channels (Cav1.2) responsible for its cAMP-mediated modulation. American Journal of Physiology Cell Physiology, 307, C999-C1009, 2014.

Calpastatin domain L is a partial agonist of the calmodulin-binding site for channel activation in Cav1.2 Ca²⁺ channels. The Journal of Biological Chemistry, 286, 39013-39022, 2011.

A region of calpastatin domain L that reprimes cardiac L-type Ca²⁺ channels. Biochemical and Biophysical Research Communications, 348, 288-294, 2006.

Nao Nakagawa-Tamagawa

Complex activity and short-term plasticity of human cerebral organoids reciprocally connected with axons. Nature Communications 15, 2945, 2024

In Vivo Visualization of Spontaneous Activity in Neonatal Mouse Sensory Cortex at a Single-neuron Resolution .  Journal of Visualized Experiments ( 201 )   2023

In vivo two-photon calcium imaging of cortical neurons in neonatal mice .  STAR protocols 4(102245)   2023

Involvement of Calcium-Dependent Pathway and β Subunit-Interaction in Neuronal Migration and Callosal Projection Deficits Caused by the Cav1.2 I1166T Mutation in Developing Mouse Neocortex. Frontiers in Neuroscience, 15, 747951, 2021

Slow Dynamics in Microcolumnar Gap Junction Network of Developing Neocortical Pyramidal Neurons. Neuroscience 406(2019) 554-562, 2019

Lattice system of functionally distinct cell types in the neocortex.Science 358(6363), 610-615. 2017

Schizophrenia-like phenotypes in mice with NMDA receptor ablation in intralaminar thalamic nucleus cells and gene therapy-based reversal in adults.Translational psychiatry 7(2) e1047. 2017

Identity of neocortical layer 4 neurons is specified through correct positioning into the cortex.eLife 5. pii: e10907. 2016

Collaborations

 Kyoto University, Kyusyu University, The University of Tokyo, National Institute of Genetics, Sumitomo Dainippon Phama

Research Grant List

Yoshiaki TAGAWA

XU Jianjun

Etsuko MINOBE

Nao Nakagawa-Tamagawa

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