FIELD

Physiology

Research outline

top 

Our brain and heart function using changes in membrane potential (electrical signals). How is the electrical signal generated and regulated? How do neurons in the brain use such electrical signals for their circuit formation during development? What happens if the regulation of membrane potentials goes wrong? We address these questions using state-of-the-art techniques in molecular biology, electrophysiology, and imaging.

Graduate School Graduate School of Medical and Dental Sciences
Course Advanced Therapeutics Course
Field Neurology
Department Physiology
Homepage http://www.kufm.kagoshima-u.ac.jp/~physiol2/

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Contact

TEL.+81-99-275-5234 / FAX.+81-99-275-5522

 Research interests

  • Activity-dependent formation of neural circuits in the cerebral cortex

  • Restoration of damaged circuits

  • Function and dysfunction of ion channels

Staff

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Professor
Name Yoshiaki TAGAWA
Specialized field Neuroscience
Research interests Neural circuits in the cerebral cortex

Researche Repository

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Lecturer
Name XU Jianjun
Specialized field Physiology of Ion channels, Molecular Biology
Research interests
  • Regulations of ion channels in nerve and muscle cells
  • Molecular and genetic studies on ion channels

Researche Repository

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Lecturer
Name Etsuko MINOBE
Specialized field Physiology of Ion channels, Molecular Biology
Research interests
  • Regulations of ion channels in nerve and muscle cells
  • Molecular and genetic studies on ion channels

Researche Repository

nakagawa

Assistant Professor
Name Nao NAKAGAWA
Specialized field Neuroscience
Research interests
  • Neural circuits in the cerebral cortex
  • Functional analysis of gap junction network in the developing neocortex 

Researche Repository

Research results

Yoshiaki TAGAWA

Control of spontaneous Ca2+ transients is critical for neuronal maturation in the developing neocortex. Cerebral Cortex, 26, 106-117 2016.

Neuronal activity is not required for the initial formation and maturation of visual selectivity. Nature Neuroscience, 18(12), 1780-1788 2015.

Dysfunction of KCNK potassium channels impairs neuronal migration in the developing mouse cerebral cortex. Cerebral Cortex, 24, 1017-1029 2014.

Evidence for activity-dependent cortical wiring: Formation of interhemispheric connections in neonatal mouse visual cortex requires projection neuron activity. Journal of Neuroscience 27(25), 6760-6770, 2007.

Multiple periods of functional ocular dominance plasticity in mouse visual cortex. Nature Neuroscience 8(3), 380-388, 2005.

XU Jianjun

PKA and phosphatases attached to the Cav1.2 channel regulate channel activity in cell-free patches. American Journal of Physiology Cell Physiology, 310(2), C136-141, 2015.

Calmodulin reverses rundown of L-type Ca2+ channels in guinea pig ventricular myocytes. American Journal of Physiology Cell Physiology, 287(6), C1717-24, 2004.

Etsuko MINOBE

Calmodulin and ATP support activity of the Cav1.2 channel through dynamic interactions with the channel. The Journal of Physiolgy, 595(8), 2465-2477, 2017.

A new phosphorylation site in cardiac L-type Ca2+ channels (Cav1.2) responsible for its cAMP-mediated modulation. American Journal of Physiology Cell Physiology, 307, C999-C1009, 2014.

Calpastatin domain L is a partial agonist of the calmodulin-binding site for channel activation in Cav1.2 Ca2+ channels. The Journal of Biological Chemistry, 286, 39013-39022, 2011.

A region of calpastatin domain L that reprimes cardiac L-type Ca2+ channels. Biochemical and Biophysical Research Communications, 348, 288-294, 2006.

Nao NAKAGAWA

Lattice system of functionally distinct cell types in the neocortex.Science 358(6363), 610-615. 2017

Schizophrenia-like phenotypes in mice with NMDA receptor ablation in intralaminar thalamic nucleus cells and gene therapy-based reversal in adults.Translational psychiatry 7(2) e1047. 2017

Identity of neocortical layer 4 neurons is specified through correct positioning into the cortex.eLife 5. pii: e10907. 2016

Collaborations

 Kyoto University, Kyusyu University, The University of Tokyo, National Institute of Genetics, Sumitomo Dainippon Phama

Research Grant List

Yoshiaki TAGAWA
Project・Event / SpanResearch
科研費　新学術領域研究公募　代表　2017~2019 自発神経活動に依存した大脳長距離軸索投射の形成・再編・再生
 科研費 基盤研究(C)　代表　2016~2019 同期・非同期の自発神経活動による大脳皮質神経回路の形成とその障害 同期・非同期の自発神経活動による大脳皮質神経回路の形成とその障害
 科研費 新学術領域研究公募　代表　2013~2015 哺乳期マウスの神経活動操作・記録実験による生後初期神経活動の役割の解明 哺乳期マウスの神経活動操作・記録実験による生後初期神経活動の役割の解明
 戦略的創造研究推進事業CREST　分担　2010~2016  大脳皮質の機能的神経回路の構築原理の解明
 科研費　基盤研究(C)　代表　2011~2014  活動依存的メカニズムに基づく大脳皮質長距離軸索投射の再建
 科研費　新学術領域研究公募　代表　2011~2013  皮質2／3層興奮性細胞の特徴的な形態・機能獲得における神経活動の役割
 科研費　若手研究(B)　代表　2009~2011  大脳皮質の層特異的回路網構築における神経活動の役割
 科研費　若手研究(B)　代表 2006~2009  Cross-modal可塑性における代謝型グルタミン酸受容体の役割の解明
XU Jianjun
Project・Event / SpanResearch
科研費　基盤研究（C）一般、分担
2007~2008		 L型CaチャネルのCa依存性促進と不活性化の分子機構
Etsuko MINOBE
Project・Event / SpanResearch
科研費　基盤研究（C）分担
2007～2008		 L型CaチャネルのCa依存性促進と不活性化の分子機構
科研費　若手研究（B）代表
2009～2010		 L型Caチャネルの活性制御におけるカルモジュリンの役割とその調節機構
科研費　基盤研究（B）分担
2009～2011		 心筋Caチャネルの調節機構間相互作用
科研費　若手研究（B）代表
2011～2012		 カルモジュリンをリンクさせた変異体を用いたL型Caチャネルの活性調節機構
科研費　基盤研究（C）代表
2013～2015		 カルモジュリンによるL型Caチャネルの活性制御の分子機構の解明
科研費　基盤研究（C）代表
2016～2018		 Cav1.2チャネルの活性とカルモジュリン結合部位との機能的相関の解明
Nao NAKAGAWA
Project・Event / SpanResearch
科研費　挑戦的萌芽研究　代表
2016～2018		 大脳新皮質第５層のgap junctionネットワークによる皮質内基本構造形成

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