• Research outline
• Research interests
• Staff
• Research results
• Research Grant List

Research outline

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Research interests

• Virulence factors and diversity of bacteria
• Molecular epidemiology of bacteria
• Genome analysis of bacteria
• Local network of infection control
• Epidemiological study on vaccine effectiveness

Staff

Professor

Researche Repository

Associate Professor

Researche Repository

Assistant Professor

Researche Repository

Research results

Junichiro NISHI

1. Kawabata T, Tenokuchi Y, Yamakuchi H, Sameshima H, Katayama H, Ota T, Tokunaga M, Takezaki T, Tamae S, Nakamura T, Chang B, Kodama Y, Imuta N, Ooka T, Okamoto Y, Suga S, Nishi J. Concurrent bacteremia due to non-vaccine serotype 24f pneumococcus in twins: a rapid increase in serotype 24f-invasive pneumococcal disease and its high invasive potential. Pediatr Infect Dis J 39(1):85-87, 2020
2. Otake S, Yamaguchi T, Imuta N, Nishi J, Kasai M. A case of polymicrobial bacteremia due to lung abscess after respiratory syncytial virus infection. Pediatr Int 62(8):994-996, 2020
3. Imashioya T, Kodama Y, Ooka T, Nakagawa S, Nishikawa T, Tanabe T, Okamoto Y, Imuta N, Kirishima M, Tanimoto A, Koriyama T, Nishi J, Kawano Y. Liver abscess due to Sterigmatomyces halophilus in a boy with acute lymphoblastic leukemia. J Infect Chemother 25(12):1047-1049, 2019
4. Kato H, Yamaguchi H, Ito Y, Imuta N, Nishi J, Kasai M. Escherichia coli O157 Enterocolitis Followed by Non-diarrheagenic Escherichia coli Bacteremia. Indian J Pediatr 86(8):750, 2019
5. Naito S, Takeuchi N, Ohkusu M, Takahashi-Nakaguchi A, Takahashi H, Imuta N, Nishi J, Shibayama K, Matsuoka M, Sasaki Y, Ishiwada N.　Clinical and Bacteriologic Analysis of Nontypeable Haemophilus influenzae Strains Isolated from Children with Invasive Diseases, Japan, 2008-2015. J Clin Microbiol 56(7), 2018

Tadasuke OOKA

　Original paper

1. Arai S, Ooka T, Shibata M, Nagai Y, Tokoi Y, Nagaoka H, Maeda R, Tsuchiya A, Kojima Y, Ohya K, Ohnishi T, Konishi N, Ohtsuka K, Hara-Kudo Y. Development of a novel real-time polymerase chain reaction assay to detect Escherichia albertii in chicken meat. Foodborne Pathog. Dis, 2022 in press.
2. Nakae K, Ooka T, Murakami K, Hara-Kudo Y, Imuta N, Gotoh Y, Ogura Y, Hayashi T, Okamoto Y, Nishi J. Diversification of Escherichia albertii H-Antigens and Development of H-Genotyping PCR. Front Microbiol. 2021 Nov 1;12:737979. doi: 10.3389/fmicb.2021.737979.
3. Ooka T, Seto K, Ogura Y, Nakamura K, Iguchi A, Gotoh Y, Honda M, Etoh Y, Ikeda T, Sugitani W, Konno T, Kawano K, Imuta N, Yoshiie K, Hara-Kudo Y, Murakami K, Hayashi T, Nishi J. O-antigen biosynthesis gene clusters of Escherichia albertii: their diversity and similarity to E. coli gene clusters and the development of an O-genotyping method. Microb. Genom, 5(11). doi: 10.1099/mgen.0.000314, 2019.
4. Masuda K, Ooka T, Akita H, Hiratsuka T, Takao S, Fukada M, Inoue K, Honda M, Toda J, Sugitani W, Narimatsu H, Ishioka T, Hirai S, Sekizuka T, Kuroda M, Morita Y, Hayashi T, Kimura H, Oishi K, Ohnishi M, Fujimoto S, Murakami K. Epidemiological Aspects of Escherichia albertii Outbreaks in Japan and Genetic Characteristics of the Causative Pathogen. Foodborne Pathog. Dis, doi: 10.1089/fpd.2019.2654. 2019.
5. Akter A,#, Ooka T#, Gotoh Y, Yamamoto S, Fujita H, Terasoma F, Kida K, Taira M, Nakadouzono F, Gokuden M, Hirano M, Miyashiro M, Inari K, Shimazu Y, Tabara K, Toyoda A, Yoshimura D, Itoh T, Kitano T, Sato MP, Katsura K, Mondal SI, Ogura Y, Ando S, Hayashi T: Extremely low genomic diversity of Rickettsia japonica distributed in Japan. Genome Biol. Evol, 9:124-133, 2016. (#: These authors contributed equally to this work.)
6. Ooka T, Ogura Y, Katsura K, Seto K, Kobayashi H, Kawano K, Tokuoka E, Furukawa M, Harada S, Yoshino S, Seto J, Ikeda T, Yamaguchi K, Murase K, Gotoh Y, Imuta N, Nishi J, Gomes TA, Beutin L, Hayashi T. Defining the genome features of Escherichia albertii, an emerging enteropathogen closely related to Escherichia coli. Genome Biol Evol 7:3170-3179, 2015
7. Ooka T, Tokuoka E, Furukawa M, Nagamura T, Ogura Y, Arisawa K, Harada S, Hayashi T. Human gastroenteritis outbreak associated with Escherichia albertii, Japan. Emerging infectious diseases 2013;19:144-146
8. Ooka T, Seto K, Kawano K, Kobayashi H, Etoh Y, Ichihara S, Kaneko A, Isobe J, Yamaguchi K, Horikawa K, Gomes TA, Linden A, Bardiau M, Mainil JG, Beutin L, Ogura Y, Hayashi T. Clinical significance of Escherichia albertii. Emerging infectious diseases 2012;18:488-492
9. Ooka T, Terajima J, Kusumoto M, Iguchi A, Kurokawa K, Ogura Y, Asadulghani M, Nakayama K, Murase K, Ohnishi M, Iyoda S, Watanabe H, Hayashi T. Development of a multiplex PCR-based rapid typing method for enterohemorrhagic Escherichia coli O157 strains. Journal of clinical f003-01 2009;47:2888-2894
10. Ooka T, Ogura Y, Asadulghani M, Ohnishi M, Nakayama K, Terajima J, Watanabe H, Hayashi T. Inference of the impact of insertion sequence (IS) elements on bacterial genome diversification through analysis of small-size structural polymorphisms in Escherichia coli O157 genomes. Genome res 2009;19:1809-1816

　Reviews

1. 大岡唯祐. 新興下痢症起因菌 Escherichia albertiiの特徴. 食品衛生研究 10月号 2020
2. Gomes TA, Ooka T, Hernandes R, Yamamoto D, Hayashi T. Escherichia albertii pathogenesis. EcoSAL plus 9(1): doi: 10.1128/ecosalplus.ESP-0015-2019, 2020
3. 大岡唯祐.　個別菌ゲノム解析（PacBioの利用，annotationやその他の問題点を含む）. 化学療法の領域 33(7):44-50, 2017
4. 大岡唯祐. 新興下痢症原因菌 Escherichia albertii. 日本食品微生物学会誌34(3)：151-157, 2017

Naoko IMUTA

1. Imuta N, Ooka T, Seto K, Kawahara R, Koriyama T, Kojyo T, Iguchi A, Tokuda K, Kawamura H, Yoshiie K, Ogura Y, Hayashi T, Nishi J. Phylogenetic Analysis of Enteroaggregative Escherichia coli (EAEC) Isolates from Japan Reveals Emergence of CTX-M-14-Producing EAEC O25:H4 Clones Related to Sequence Type 131. J Clin Microbiol 54(8):2128-2134, 2016
2. Naito S, Takeuchi N, Ohkusu M, Takahashi-Nakaguchi A, Takahashi H, Imuta N, Nishi J, Shibayama K, Matsuoka M, Sasaki Y, Ishiwada N.　Clinical and Bacteriologic Analysis of Nontypeable Haemophilus influenzae Strains Isolated from Children with Invasive Diseases, Japan, 2008-2015. J Clin Microbiol 56(7), 2018
3. Kanno K, Yamaguchi H, Imuta N, Nishi J, Kasai M. Non-typeable Haemophilus influenzae purulent pericarditis in a healthy child. Pediatr Int 60(9):886-887, 2018
4. Kawamura H, Tokuda K, Imuta N, Kubota T, Koriyama T, Miyanohara H, Hashiguchi T, Kawano Y, Nishi J. Epidemiological Analysis of Nosocomial MRSA Outbreaks Using Phage Open-Reading Frame Typing in a Tertiary-Care Hospital. Jpn J Infect Dis 2016;69(6):523-524
5. Imuta N, Nishi J , Tokuda K, Fujiyama R, Manago K, Iwashita M, Sarantuya J, Kawano Y. Escherichia coli efflux pump TolC promotes aggregation of enteroaggregative E. coli 042. Infect Immun 2008;76(3):1247-1256
6. Wakimoto N, Nishi J, Sheikh J, Nataro JP, Sarantuya J, Iwashita M, Manago K, Tokuda K, Yoshinaga M, Kawano Y. Quantitative biofilm assay using microtiter plate to screen for enteroaggregative Escherichia coli. Am J Trop Med Hyg 2004;71(5):687-690

Research Grant List

Junichiro NISHI

Tadasuke OOKA

Naoko IMUTA

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