• 研究室概要
• 主要研究テーマ
• スタッフ
• 主な研究実績
• 主な研究費取得状況

　歯科二大疾患のう蝕と歯周病は主に細菌に起因することから，歯学領域における細菌学の研究は重要です．近年，社会的問題となってきたコロナウイルス感染症，インフルエンザ，麻疹，細菌性肺炎等は口腔を含む上気道を侵入経路とする微生物による感染症です．

　当分野では，歯科領域に関連する口腔内細菌とともに口腔を侵入門戸として全身に病気を起こす病原性細菌について病態発症機構の解析を行い，新規の治療・予防法を開発するための基盤となる研究を進めています．

研究室概要

連絡先

主要研究テーマ

スタッフ

教授

研究者総覧 リポジトリ

助教

研究者総覧 リポジトリ

助教

研究者総覧 リポジトリ

助教

研究者総覧 リポジトリ

主な研究実績

中田匡宣

1. Takebe K, Suzuki M, Sangawa T, Kreikemeyer B, Yamaguchi M, Uzawa N, Sumitomo T, Kawabata S, Nakata M. Analysis of FctB3 crystal structure and insight into its structural stabilization and pilin linkage mechanisms. Arch. Microbiol. 2024. 206: 4. 
2. Kubota S, Nakata M, Hirose Y, Yamaguchi M, Kreikemeyer B, Uzawa N, Sumitomo T, Kawabata S. Involvement of ribonuclease Y in pilus production by M49 Streptococcus pyogenes strain via modulation of messenger RNA level of transcriptional regulator. Microbiol. Immunol. 2023. 67:319-333. 
3. Nakata M, Kreikemeyer B. Genetics, Structure, and Function of Group A Streptococcal Pili. Front. Microbiol. 2021. 12:616508.
4. Sumitomo, T., Nakata, M., Nagase, S., Takahara, Y., Honda-Ogawa, M., Mori, Y., Akamatsu, Y., Yamaguchi, M., Okamoto, S., Kawabata, S. GP96 Drives Exacerbation of Secondary Bacterial Pneumonia following Influenza A Virus Infection. mBio. 2021. 12(3): e0326920.
5. Nakata M, Sumitomo T, Patenge N, Kreikemeyer B, Kawabata S. Thermosensitive pilus production by FCT type 3 Streptococcus pyogenes controlled by Nra regulator translational efficiency. Mol. Microbiol. 2020. 113:173-189.
6. Kriebel K, Hieke C, Müller-Hilke B, Nakata M, Bernd Kreikemeyer. Oral biofilms from symbiotic to pathogenic interactions and associated disease – Connection of Periodontitis and Rheumatic arthritis by peptidylarginine deiminase. Front. Microbiol. 2018. 9:53.
7. Sumioka R, Nakata M, Okahashi N, Li Y, Wada S, Yamaguchi M, Sumitomo T, Hayashi M, Kawabata S. Streptococcus sanguinis induces neutrophil cell death by production of hydrogen peroxide. PLoS One. 2017. 12: e0172223.

大貝悠一

1. Oogai Y, Gotoh Y, Ogura Y, Kawada-Matsuo M, Hayashi T, Komatsuzawa H. Small RNA repertoires and their intraspecies variation in Aggregatibacter actinomycetemcomitans. DNA Res. 2018. 25:207-215.
2. Oogai Y, Yamaguchi M, Kawada-Matsuo M, Sumitomo T, Kawabata S, Komatsuzawa H. Lysine and Threonine Biosynthesis from Aspartate Contributes to Staphylococcus aureus Growth in Calf Serum. Appl. Environ. Microbiol. 2016. 82:6150-6157.
3. Oogai Y, Kawada-Matsuo M, Komatsuzawa H. Staphylococcus aureus SrrAB Affects Susceptibility to Hydrogen Peroxide and Co-Existence with Streptococcus sanguinis. PLoS One. 2016. 11:e0159768.
4. Oogai Y, Matsuo M, Hashimoto M, Kato F, Sugai M and Komatsuzawa H. Expressions of virulence factors by Staphylococcus aureus grown in serum. Appl. Environ. Microbiol. 2011 77:8097-105

松本愛理

1. Tomoyasu T, Matsumoto A, Takao A, Tabata A, Nagamune H. A simple method to differentiate three classes of cholesterol-dependent cytolysins. J. Microbiol. Methods. 2023. 207:106696.
2. Tabata A, Matsumoto A, Fujimoto A, Ohkura K, Ikeda T, Oda H, Yokohata S, Kobayashi M, Tomoyasu T, Takao A, Ohkuni H, Nagamune H. Dual functions of discoidinolysin, a cholesterol-dependent cytolysin with N-terminal discoidin domain produced from Streptococcus mitis strain Nm-76. J. Oral Microbiol. 2022. 14(1):2105013. 
3. Matsumoto A, Tabata A, Ohkura K, Oda H, Kodama C, Ohkuni H, Takao A, Kikuchi K, Tomoyasu T, Nagamune H. Molecular characteristics of an adhesion molecule containing cholesterol-dependent cytolysin-motif produced by mitis group streptococci. Microbiol. Immunol. 2021. 65(2): 61-75.

主な研究費取得状況

中田匡宣

大貝悠一

松本愛理