• 研究室概要
• 主要研究テーマ
• スタッフ
• 主な研究実績
• 主な研究費取得状況

 

研究室概要

連絡先

主要研究テーマ

スタッフ

特任教授

研究者総覧　リポジトリ

主な研究業績

1. Plasmid-transformed Bifidobacterium longum 105A secretingβ-glucuronidase for prodrug conversion of SN-38 glucuronide. Saisho A, Shimokawa M, Kubo R, Enomoto Y, Taniguchi S, Kobayashi H, Protein Expr. Purif. 239 (2026)
   https://doi.org/10.1016/j.pep.2025.106844
2. Activation of the inflammasome drives peritoneal deterioration in a mouse model of peritoneal fibrosis. Kadoya H, Hirano A, Umeno R, Kajimoto E, Iwakura T, Kondo M, Wada Y, Kidokoro K, Kishi S, Nagasu H, Sasaki T, Taniguchi S, Takahashi M, Kashihara N. FESEB J 37(9) e23129 (2023)
3. Identification and characterization of endo- and exo-hydrolases cleaving the α- and β-D-arabinofuranosidic bonds of lipoarabinomannan and arabinogalactan of Mycobacteria. Shimokwa M, Ishiwata A, Kashima T, Nakashima C, Li J, Fukushima R, Sawai N, Nakamori M, TanakaY, Kudo A, Morikami S, Iwanaga N, Akai G, Shimizu N, Arakawa T, Yamada C, Kitahara K, Tanaka K, Ito Y, Fushinobu S, Fujita K. Nat. Commun 14. 5803 (2023)
   https://doi.org/10.1038/s41467-023-41431-2
4. Gallbladder microbiota composition is associated with pancreaticobiliary and gallbladder cancer prognosis. Kirishima M, Yokoyama S, MatsuoK , Hamada T , Shimokawa M , Akahane T, Sugimoto T , Tsurumaru H , Ishibashi M , Mataki Y, Ootsuka T, Nomoto M, Hayashi C , Horiguchi A , Higashi M, Tanimoto A. BMC Microbiol. 22, 147. (2022)
   https://doi.org/10.1186/s12866-022-02557-3
5. An oncogenic splice variant of PDGFRα in adult glioblastoma as a therapeutic target for selective CDK4/6 inhibitors. Hamada T , Akahane T, Yokoyama S , HigaN , Kirishima M , Matsuo K , Shimokawa M , Yoshimoto K, Tanimoto A. Sci. Rep.12: 1275. (2022)
   https://doi.org/10.1038/s41598-022-05391-9
6. Endothelial Dysfunction Accelerates Impairment of Mitochondrial Function in Ageing Kidneys via Inflammasome Activation. Wada Y, Umeno R, Nagasu H, Kondo M, Tokuyama A, Kadoya H, Kidokoro K, Taniguchi S, Takahashi M, Sasaki T, Kashihara N. Int J Mol Sci. 22(17) 9269. (2021)
7. Potentiated antitumor effects of APS001F/5-FC combined with anti-PD-1 antibody in a CT26 syngeneic mouse model. Biosci Biotechnol Biochem. 85(2) 324-331 (2021)
8. In Situ Delivery and Production System (iDPS) of Anti-Cancer Molecules with Gene-Engineered Bifidobacterium Taniguchi S J Pers Med 11(6) (2021)
9. Cecal Tumorigenesis in Aryl Hydrocarbon Receptor-Deficient Mice Depends on Cecum-Specific Mitogen-Activated Protein Kinase Pathway Activation and Inflammation Matoba H, Takamoto M, Fujii C, Kawakubo M, Kasuga E, Matsumura T, Natori T, Misawa K, Taniguchi S, Nakayama J Am J Pathol 190(2) 453-468 (2020)

主な研究費取得状況