研究テーマ（研究室紹介）

消化器疾患・生活習慣病学

消化器疾患・生活習慣病学イメージ

当分野では、肝再生の分子機構の解明や肝障害に対する肝細胞増殖因子（hepatocyte growth factor：HGF）の有効性の検証など，障害肝組織の再生・修復および炎症性発癌に関する研究を行ってまいりました。近年では、消化管，胆膵疾患や腎疾患の腫瘍や慢性炎症に対する基礎、臨床研究を積極的に行っています。

研究室概要

部局 大学院医歯学総合研究科 Graduate School of Medical and Dental Sciences
専攻 健康科学専攻 Health Research Course
大講座 人間環境学 Human and Environmental Sciences
分野 消化器疾患・生活習慣病学 Digestive and Lifestyle Diseases
分野サイト https://www3.kufm.kagoshima-u.ac.jp/intmed2/

分野サイト

連絡先

TEL.099-275-5326 / FAX.099-264-3504

主要研究テーマ

内科学 Internal Medicine
肝臓病学 Hepatology
消化器病学 Gastroenterology
腎臓病学 Nephrology

スタッフ

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准教授
氏名 上村修司 Shuji KANMURA
専門分野 消化器病学
研究テーマ 腸疾患の病態解明

研究者総覧 リポジトリ

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講師
氏名 馬渡誠一 Seiichi MAWATARI
専門分野 消化器病学、肝臓病学
研究テーマ 脂肪性肝疾患の病態解明、C型肝炎ウイルス薬剤耐性変異解析

研究者総覧 リポジトリ

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助教
氏名 前田英仁 Hidehito MAEDA
専門分野 消化器病学、消化器内視鏡学
研究テーマ 早期消化管癌の内視鏡診断及び内視鏡治療、内視鏡治療後潰瘍の病態解明

研究者総覧 リポジトリ

主な研究実績

上村修司
  1. Kanmura S, Hamamoto H, Morinaga Y, Oda K, Fujita T, Arima S, Nasu Y, Sasaki F, Hashimoto S, Taguchi H, Setoyama H, Ido AFecal Human Neutrophil Peptide Levels Correlate with Intestinal Inflammation in Ulcerative Colitis.　Digestion.　93(4):300-308、2016
  2. Kanmura S,　Hamamoto H, Tanaka A, Arima S, Sasaki F, Tanoue S, Nasu Y, Hashimoto S, Higashi M, Ido A. Diagnostic utility of linked color imaging in the evaluation of colonic mucosal inflammation in ulcerative colitis: a pilot study. Endosc Int Open. 7(8): E937-E943 2019
  3. Ibusuki K, Sakiyama T, Kanmura S, Maeda T, Iwashita Y, Nasu Y, Sasaki F, Taguchi H, Hashimoto S, Numata M, Uto H, Tsubouchi H, Ido A. Human neutrophil peptides induce interleukin-8 in intestinal epithelial cells through the P2 receptor and ERK1/2 signaling pathways. Int J Mol Med 35(6): 1603-1609 2015
  4. Maeda T, Sakiyama T, Kanmura S, Hashimoto S, Ibusuki K, Tanoue S, Komaki Y, Arima S, Nasu Y, Sasaki F, Taguchi H, Numata M, Uto H, Tsubouchi H, Ido A. Int J Mol Med. 1777-1785 2016
  5. Ono Y, Kanmura S, Morinaga Y, Oda K, Kawabata K, Arima S, Sasaki F, Nasu Y, Tanoue S, Hashimoto S, Taguchi H, Uto H, Tsubouchi H, Ido A The utility of apoptosis inhibitor of macrophages as a possible diagnostic marker in patients with Crohn’s disease BMC Gastroenterol 17（1）： 40 2017
  6. Kawabata K, Kanmura S, Morinaga Y, Tanaka A, Makino T, Fujita T, Arima S, Sasaki F, Nasu Y, Tanoue S, Hashimoto S, Ido A. A high‑fructose diet induces epithelial barrier dysfunction and exacerbates the severity of dextran sulfate sodium‑induced colitis. Int J Mol Med 43(3): 1487-1496 2018
  7. Hiraishi N, Kanmura S, Oda K, Arima S, Kumagai K, Mawatari S, Tanoue S, Sasaki F, Hashimoto S, Ido A. Extract of Lactobacillus plantarum strain 06CC2 induces JNK/p38 MAPK pathway-mediated apoptosis through endoplasmic reticulum stress in Caco2 colorectal cancer cells. Biochem Biophys Rep. 100691 2019
  8. Tanaka A, Kanmura S, Morinaga Y, Kawabata K, Arima S, Sasaki F, Nasu Y, Tanoue S, Hashimoto S, Takeshita M, Takeda S, Ido A. Oral administration of Lactobacillus plantarum arum 06CC2 prevents experimental colitis in mice via an anti‑inflammatory response. Mol Med Rep. 1181-1191 2019
馬渡誠一
  1. Mawatari S,Uto H, Ido A, Nakashima K, Suzuki T, Kanmura S, Kumagai K, Oda K, Tabu K, Tamai T, Moriuchi A, Oketani M, Shimada Y, Sudoh M, Shoji I, Tsubouchi H. Hepatitis C virus NS3/4A Protease Inhibits Complement Activation by Cleaving Complement Component 4. PLoS One　8(12)　 e82094　2013
  2. Mawatari S, Uto H, Moriuchi A, Tabu K, Muromachi K, Tabu E, Oda K, Imanaka D, Oshige A, Nakazawa J, Kumagai K, Tamai T, Okamoto H, Tsubouchi H, Ido A. Horizontal transmission of de novo hepatitis B between spouses: A case report. Hepatol Res 45(8): 933-938 2015
  3. Mawatari S, Oda K, Tabu K, Ijuin S, Kumagai K, Inada Y, Uto H, Hiramine Y, Kure T, Fujisaki K, Hashiguchi M, Hori T, Oshige A, Imanaka D, Saishoji A, Taniyama O, Sakae H, Tamai T, Moriuchi A, Ido A. New resistance-associated substitutions and failure of dual oral therapy with daclatasvir and asunaprevir. J Gastroenterol. 52(7): 855-867 2017
  4. Mawatari S, Moriuchi A, Ohba F, Kawano T, Oda K,Takikawa Y, Takikawa H, Ido A, Tsubouchi H. The recovery of the PT-INR to less than 1.3 predicts survival in patients with severe acute liver injury. J Gastroenterol. 53(7): 861-872 2018
  5. Mawatari S, Oda K, Tabu K, Ijuin S, Kumagai K, Fujisaki K, Hashiguchi M, Inada Y, Uto H, Hiramine Y, Kure T, Hori T, Taniyama O, Kasai A, Tamai T, Moriuchi A, Ido A. The co-existence of NS5A and NS5B resistance-associated substitutions is associated with virologic failure in Hepatitis C Virus genotype 1 patients treated with sofosbuvir and ledipasvir. PLoS One. 13(6): e0198642 2018
  6. Kure T, Mawatari S, Imamura Y, Oda K, Kumagai K, Hiramine Y, Miyahara H, Kanmura S, Moriuchi A, Uto H, Horiuchi M, Ido A. Nonalcoholic fatty liver disease is associated with both subcutaneous and visceral adiposity -A cross-sectional study-Medicine (Baltimore). 98(46): e17879. 2019
  7. Tabu K, Mawatari S, Oda K, Kumagai K, Inada Y, Uto H, Saisyoji A, Hiramine Y, Hashiguchi M, Tamai T, Hori T, Fujisaki K, Imanaka D, Kure T, Taniyama O, Toyodome A, Ijuin S, Sakae H, Sakurai K, Moriuchi A, Kanmura S, Ido A. Hypovascular tumors developed into hepatocellular carcinoma at a high rate despite the elimination of hepatitis C virus by direct-acting antivirals. PLoS One. 15(8): e0237475 2020
  8. Mawatari S, Oda K, Kumagai K, Tabu K, Ijuin S, Fujisaki K, Inada Y, Uto H, Saisyoji A, Hiramine Y, Hori T, Taniyama O, Toyodome A, Sakae H, Hashiguchi M, Kure T, Sakurai K, Tamai T, Moriuchi A, Ido A. Viral and host factors are associated with retreatment failure in hepatitis C patients receiving all-oral direct antiviral therapy Hepatol Res. 50(4) 453-465 2020
前田英仁
  1. Maeda H, Sasaki F, Koyoshi N, Uehara S, Sakae T, Tanaka A, Hinokuchi M, Arima S, Hashimoto S, Kanmura S. Impact of waiting time for treatment on the progression of superficial esophageal squamous cell carcinoma: a single-center retrospective study. Esophagus. doi: 10.1007/s10388-025-01156-1. 2025
  2. Yano H, Sasaki F, Maeda H, Uehara S, Kabayama M, Fujino Y, Tanaka A, Hinokuchi M, Arima S, Hashimoto S, Kanmura S, Ito S, Nishifuchi A, Taguchi T, Ido A. Effect of sprayable, highly adhesive hydrophobized gelatin microparticles on esophageal stenosis after endoscopic submucosal dissection: an experimental study in a swine model. Esophagus. 22(1):95-104. 2025
  3. Maeda H, Sasaki F, Doi T, Uehara S, Yano H, Sameshima Y, Fukuda Y, Nasu Y, Fujino Y, Shigeta K, Fujita H, Tanaka A, Kanmura S, Ido A. Trends of Early Helicobacter pylori-Uninfected Gastric Cancer in an Aging Regional Area. Journal of Clinical Medicine.13(6):1827. 2024
  4. Maeda H, Sasaski F, Sakae T, Tanaka A, Kanmura S, Tamai T, Ido A. A case of early gastric cancer with esophagogastric varices safely treated with endoscopic submucosal dissection after percutaneous transhepatic obliteration and partial splenic embolization.VIDEO GIE. 9(7):312-316. 2024
  5. Kabayama M, Sasaki F, Maeda H, Fujino Y, Yano H, Tanaka A, Arima S, Tanoue S, Hahimoto S, Kanmura S, Hirade H, Nishiguchi A, Taguchi T, Ido A. Effects of Sprayable, Highly Adhesive Hydrophobized Gelatin Microparticles on Endoscopic Submucosal Dissection: A Swine Model. Digestion.104(2):137-147. 2023
  6. Maeda H, Sasaki F, Kabayama M, Iwaya H, Komaki Y, Arima S, Tanoue S, Hashimoto S, Kanmura S, Miyashita K, Ohori J, Yamashita M, Ido A. Efficacy of endoscopic ultrasonography in evaluating tumor thickness in patients with superficial pharyngeal carcinoma: A pilot study. Auris Nasus Larynx. 49(3):495-503. 2022
  7. Maeda H, Sasaki F, Morinaga Y, Kabayama M, Iwaya H, Komaki Y, Arima S, Nasu Y, Tanoue S, Hashimoto S, Kanmura S, Nishiguchi A, Taguchi T, Ido A. Covering post-endoscopic submucosal dissection ulcers in miniature swine with hexanoyl (Hx:C6) group–modified alkaline-treated gelatin porous film (HAG) induces proper healing by decreasing inflammation and fibrosis. Digestion.102(3):415-427. 2021
  8. Maeda H, Hashimoto S, Nakazawa J, Arima S, Taguchi H, Nasu Y, Sasaki H, Kanmura S, Setoyama H, Kadono J, Higashi M, Ido A. JPS SELECTED ABSTRACT 6 Magnifying Observation With Narrow-Band Imaging for the Main Pancreatic Duct Via a Gastric Fistula in a Patient With Intraductal Papillary Mucinous Carcinoma: A Case Report. Pancreas. 46:833-834. 2017

 

 

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