FIELD

Oral Microbiology

Research outline

口腔微生物学top

Graduate School Graduate School of Medical and Dental Sciences
Course Health Research Course
Field Developmental Medicine
Department Oral Microbiology
Homepage in Prep

Contact

TEL.+81-99-275-6150 / FAX.+81-99-275-6158

Research interests

  • Ecology of oral bacteria
  • Bacterial responses to environmental factors
  • Interaction between pathogenic bacteria and their hosts
  • Functions and regulatory mechanisms of virulence factors

Staff

写真中田匡宣教授

Professor
Name Masanobu NAKATA
Specialized field Bacteriology
Research interests

Bacterial responses to environmental factors
Structures and assembly mechanisms of  pili
Structures and functions of virulence factors

Research Repository

助教:大貝悠一

Lecturer
Name Yuichi OOGAI
Specialized field Bacteriology
Research interests Bacterial colonization factors in living organisms
Bacterial small RNAs

Research Repository

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Assistant Professor
Name Airi MATSUMOTO
Specialized field Bacteriology
Research interests Functions of bacterial virulence factors and membrane vesicles

Research Repository

Assistant Professor
Name Kenji KANBARA
Specialized field Virology, Immunology
Research interests ・Oral infections and systemic diseases

Researche Repository

Research results

Masanobu NAKATA
  1. Takebe K, Suzuki M, Sangawa T, Kreikemeyer B, Yamaguchi M, Uzawa N, Sumitomo T, Kawabata S, Nakata M. Analysis of FctB3 crystal structure and insight into its structural stabilization and pilin linkage mechanisms. Arch. Microbiol. 2024. 206: 4. 
  2. Kubota S, Nakata M, Hirose Y, Yamaguchi M, Kreikemeyer B, Uzawa N, Sumitomo T, Kawabata S. Involvement of ribonuclease Y in pilus production by M49 Streptococcus pyogenes strain via modulation of messenger RNA level of transcriptional regulator. Microbiol. Immunol. 2023. 67:319-333. 
  3. Nakata M, Kreikemeyer B. Genetics, Structure, and Function of Group A Streptococcal Pili. Front. Microbiol. 2021. 12:616508.
  4. Sumitomo, T., Nakata, M., Nagase, S., Takahara, Y., Honda-Ogawa, M., Mori, Y., Akamatsu, Y., Yamaguchi, M., Okamoto, S., Kawabata, S. GP96 Drives Exacerbation of Secondary Bacterial Pneumonia following Influenza A Virus Infection. mBio. 2021. 12(3): e0326920.
  5. Nakata M, Sumitomo T, Patenge N, Kreikemeyer B, Kawabata S. Thermosensitive pilus production by FCT type 3 Streptococcus pyogenes controlled by Nra regulator translational efficiency. Mol. Microbiol. 2020. 113:173-189.
  6. Kriebel K, Hieke C, Müller-Hilke B, Nakata M, Bernd Kreikemeyer. Oral biofilms from symbiotic to pathogenic interactions and associated disease – Connection of Periodontitis and Rheumatic arthritis by peptidylarginine deiminase. Front. Microbiol. 2018. 9:53.
  7. Sumioka R, Nakata M, Okahashi N, Li Y, Wada S, Yamaguchi M, Sumitomo T, Hayashi M, Kawabata S. Streptococcus sanguinis induces neutrophil cell death by production of hydrogen peroxide. PLoS One. 2017. 12: e0172223.
Yuichi OOGAI
  1. Ratman M F, Oogai Y, Matsumoto A, Nakata M. The ArcAB two-component system is associated with the susceptibility of Aggregatibacter actinomycetemcomitans to superoxide and hydrogen peroxide. mSphere. 2025 In press.
  2. Fujita A, Oogai Y, Kawada-Matsuo M, Nakata M, Noguchi K, Komatsuzawa H.
    Expression of virulence factors under different environmental conditions in Aggregatibacter actinomycetemcomitans. Microbiol Immunol. 2021 65:101-114.
  3. Oogai Y, Gotoh Y, Ogura Y, Kawada-Matsuo M, Hayashi T, Komatsuzawa H. Small RNA repertoires and their intraspecies variation in Aggregatibacter actinomycetemcomitans. DNA Res. 2018. 25:207-215.
  4. Oogai Y, Yamaguchi M, Kawada-Matsuo M, Sumitomo T, Kawabata S, Komatsuzawa H. Lysine and Threonine Biosynthesis from Aspartate Contributes to Staphylococcus aureus Growth in Calf Serum. Appl. Environ. Microbiol. 2016. 82:6150-6157.
  5. Oogai Y, Kawada-Matsuo M, Komatsuzawa H. Staphylococcus aureus SrrAB Affects Susceptibility to Hydrogen Peroxide and Co-Existence with Streptococcus sanguinis. PLoS One. 2016. 11:e0159768.
  6. Oogai Y, Matsuo M, Hashimoto M, Kato F, Sugai M and Komatsuzawa H. Expressions of virulence factors by Staphylococcus aureus grown in serum. Appl. Environ. Microbiol. 2011 77:8097-105.
Airi MATSUMOTO
  1. Tomoyasu T, Matsumoto A, Takao A, Tabata A, Nagamune H. A simple method to differentiate three classes of cholesterol-dependent cytolysins. J. Microbiol. Methods. 2023. 207:106696.
  2. Tabata A, Matsumoto A, Fujimoto A, Ohkura K, Ikeda T, Oda H, Yokohata S, Kobayashi M, Tomoyasu T, Takao A, Ohkuni H, Nagamune H. Dual functions of discoidinolysin, a cholesterol-dependent cytolysin with N-terminal discoidin domain produced from Streptococcus mitis strain Nm-76. J. Oral Microbiol. 2022. 14(1):2105013. 
  3. Matsumoto A, Tabata A, Ohkura K, Oda H, Kodama C, Ohkuni H, Takao A, Kikuchi K, Tomoyasu T, Nagamune H. Molecular characteristics of an adhesion molecule containing cholesterol-dependent cytolysin-motif produced by mitis group streptococci. Microbiol. Immunol. 2021. 65(2): 61-75.

Research Grant List

Masanobu NAKATA
Project・Event / Span Research
Kakenhi Grant-in-Aid for Scientific Research (B)
2022〜2025		 RNAサーモセンサーとタンパク質重合体を介するレンサ球菌感染機構の探索
Kakenhi Grant in Aid for Challenging Research (Exploratory)
2022〜2024		 口腔内の病原性共生細菌に対する一本鎖可変断片の創生と応用
Kakenhi Grant-in-Aid for Fund for the Promotion of Joint International Research
2016〜2019		 レンサ球菌が産生する線毛の付着機能と発現機構の解析
Yuichi OOGAI
Project・Event / Span Research
Kakenhi Grant-in-Aid for Scientific Research (C)
2023〜2025		 歯周病原因細菌の口腔から全身への定着に関与する因子の研究
Kakenhi Grant-in-Aid for Scientific Research (C)
2020〜2022		 歯周病原因菌の病原性因子及び挿入配列を制御するsmall RNAの解析
Kakenhi Grant-in-Aid for Scientific Research (C)
2017〜2019		 A. actinomycetemcomitansの産生する生理活性ペプチドの探索
Kakenhi　Grant in Aid for Young Scientists (B)
2015〜2016		 A. actinomycetemcomitans表層タンパクの同定及び病原性解析
松本愛理
事業・種目 / 期間 研究
Kakenhi　Grant in Aid for Young Scientists (B)
2023〜2025		 ミティス群レンサ球菌が産生する細胞外小胞と亜鉛メタロプロテアーゼの機能解明