FIELD

Maxillofacial Diagnostic and Surgical Science

Research outline

講座イメージ画像

Graduate School Graduate School of Medical and Dental Sciences
Course Advanced Therapeutics Course
Field Oral and Maxillofacial Rehabilitation
Department Maxillofacial Diagnostic and Surgical Science
Homepage http://w3.hal.kagoshima-u.ac.jp/dental/omfs1/

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Contact

TEL.+81-99-275-6232 / FAX.+81-99-275-6238

Research interests

  • Experimental and clinicopathological study on oral tumor
  • Study on genetic and epigenetic changes in oral squamous cell carcinoma
  • Clinicopathological study on odontogenic tumor
  • Immunohistochemical study on diseases of oral mucosa
  • Study on diagnosis and treatment of jaw deformity
  • Clinicopathological study on oral lesions in HIV infectionm
  • Electron microscopic study on oral diseases
  • Molecular genetic study on pathogenic oral Candida species
  • Study on cancer stem cells in oral malignant tumors and its clinical application
  • Study on cancer metastasis suppressor, tetraspanin CD82 and its application for anti- cancer metastasis therapy on oral malignant tumors
  • Study on regeneration method on salivary gland

Staff

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Professor
Name Tsuyoshi SUGIURA
Specialized field Oral Surgery、Oral Oncology、口腔再建学、口腔外科手術学、Tumor Biology、Molecular Biology、Cell Biology
Research interests
  • 口腔癌幹細胞を標的とした新規治療法の開発
  • 口腔癌特異的マイクロRNAを用いた転移早期診断法の開発
  • 口腔癌の予後予測因子の解析
  • 唾液腺の再生医療に関する研究
  • がん転移抑制遺伝子CD82を用いたがん転移抑制療法の開発

Researche

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Associate Professor
Name Yoshiaki KAMIKAWA
Specialized field Oral Surgery、Oral Medicine
Research interests
  • HIV関連口腔病変に関する基礎的臨床的研究
  • 口腔粘膜疾患と微量元素特に亜鉛についての臨床的研究
  • 口腔粘膜疾患と口腔カンジダ菌との関連に関する臨床的研究
  • 口腔カンジダ菌に関する基礎的研究
  • 口腔乾燥症に関する臨床的研究
  • 舌痛症に関する臨床的研究
  • 血液凝固能障害に関連する口腔疾患に関する研究

Researche Repository

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Assistant Professor
Name Haruyuki IMAMURA
Specialized field Oral Surgery
Research interests
  • Localization of superoxide dismutase on experimental oral cancer
  • Electron microscopical study of the effect of superoxide dismutase on carcinogenesis of oral cancer

Researche Repository

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 Assistant Professor
Name Kojiro YAMAGUCHI
Specialized field Oral Surgery、Imaging、Immunology、Oriental Herbal Medisine
Research interests
  • Clinical and imaging study of metastasis of the oral cancer
  • Immunological study of oral malignant tumor and precancerous lesions
  • Oriental herbal medical study of oral diseases
  • Clinical study of sleep apnea syndrome

Researche Repository

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 Assistant Professor
Name Ryoichi SAKAMOTO
Specialized field Oral Surgery、Oral Medicine、口腔癌、Oral Mucosal Disease
Research interests
  • Clinicopathological study on oral mucous membrane disease
  • Immunohistochemical study on oral disease
  • Study on invasion and metastasis of oral cancer

Researche Repository

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 Assistant Professor
Name Mayumi YAMASHITA
Specialized field Oral Surgery
Research interests 口腔癌における血管新生と所属リンパ節転移の関連

Researche Repository

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Name Tomofumi HAMADA
Specialized field Oral Surgery、Oral Oncology
Research interests
  • うがい液からのDNAメチル化異常検出による口腔癌発癌予測システムの開発
  • MUC1遺伝子スプライシング異常が口腔癌に及ぼす影響
  • 口腔癌におけるMUC1遺伝子スプライシングバリアントの発現とその意義
  • 含嗽液からのエピジェネティック異常検出による口腔癌スクリーニング法の確立

Researche Repository

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Name Tetsuya NITTA
Specialized field Oral Surgery
Research interests  

Researche Repository

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Name Yuichi GOTO
Specialized field Oral Surgery、Oral Oncology、Dysphagia Rehabilitation
Research interests 口腔扁平上皮癌におけるΔNp63が浸潤・転移に及ぼす影響

Researche

Research results

  • Mine M, Yamaguchi K, Sugiura T, Chigita S, Yoshihama N, Yoshihama R, Hiyake N, Kobayashi Y, Mori Y:
    miR-203 Inhibits Frizzled-2 Expression via CD82/KAI1 Expression in Human Lung Carcinoma Cells.
    PLoS One 2015, 10(7):e0131350.
  • Yoshihama N, Yamaguchi K, Chigita S, Mine M, Abe M, Ishii K, Kobayashi Y, Akimoto N, Mori Y, Sugiura T:
    A Novel Function of CD82/KAI1 in Sialyl Lewis Antigen-Mediated Adhesion of Cancer Cells: Evidence for an Anti-Metastasis Effect by Down-Regulation of Sialyl Lewis Antigens.
    PLoS One 2015, 10(4):e0124743.
  • Kamikawa Y, Fujisaki J, Nagayama T, Kawasak K, Hirabayashi D, Hamada T, Sakamoto R, Mukai H,Sugihara K.
    Use of Candida-specific chicken egg yolk antibodies to inhibit the adhering of Candida to denture base materials: prevention of denture stomatitis.
    Gerodontology:2015 No.12163
  • Yamaguchi　K.
    Traditional Japanese herbal medicines for treatment of odontopathy
    Frontiers in pharmacology:2015:6-14 doi : 10.3389/fphar2015.00176
  • Yoshihama R, Yamaguchi K, Imajyo I, Mine M, Hiyake N., Akimoto N., Kobayashi Y., Chigita S, Kumamaru W, Kiyoshima T, Mori Y, Sugiura, T.
    Expression levels of SOX2, KLF4 and branchyury trans cription factors are associated with metastasis and poor prognosis in oral squamous cell carcinoma
    Oncology letters 2015: 1-12 doi : 10.3892/ol.2015.4047
  • Yamada N, Hasegawa Y, Yue M, Hamada T, Nakagawa S, Ogawa Y
    Xist Exon 7 Contributes to the Stable Localization of Xist RNA on the Inactive X-Chromosome.
    PLoS Genetics2015. 5;11(8):e1005430.
  • Hayashi Y, Moriyama M, Maehara T, Goto Y, Kawano S, Ohta M, Tanaka A, Furukawa S, Hayashida JN, Kiyoshima T, Shimizu M, Chikui T, Nakamura S.
    A case of mantle cell lymphoma presenting as IgG4-related dacryoadenitis and sialoadenitis, so-called Mikulicz’s disease.
    World J Surg Oncol 2015. 13:225
  • Ohta M, Moriyama M, Goto Y,. Kawano S, Tanaka A, Maehara T, Furukawa S, Hayashida JN, Kiyoshima T, Shimizu M, Arinobu Y, Nakamura S.
    A case of marginal zone B cell lymphoma mimicking IgG4-related dacryoadenitis and sialoadenitis.
    World J Surg Oncol.2015:21(13):67
  • Maruse Y. Kawano S, Kiyoshima T, Goto Y, Matsubara R, Chikui T, Yoshiga D, Nakamura S..
    Case of mucoepidermoid carcinoma of the sublingual gland accompanied with extensive dystrophic calcification and intratumoral bone formation.
    Head & Neck. Mar 17.2015
  • Jinno T, Kawano S, Maruse Y, Matsubara R, Goto Y, Sakamoto T, Hashiguchi Y, Kaneko N, Tanaka H, Kitamura R, Toyoshima T, Jinno A, Moriyama M., Oobu K, Kiyoshima T,Nakamura S.
    Increased expression of interleukin-6 predicts poor response to chemoradiotherapy and unfavorable prognosis in oral squamous cell carcinoma.
    Oncol Rep.2015,33(5):2161-8

Research Grant List

Tsuyoshi SUGIURA
Project・Event / SpanResearch
平成27年度科学研究補助金
基盤研究（B）代表
平成27年度 1,014万円
平成27年4月1日～平成30年3月31日(予定)		 転移先臓器と癌幹細胞を標的とした機能性RNAによる口腔癌新規治療法の開発（課題番号15H05045）
Tomofumi HAMADA
Project・Event / SpanResearch
平成27年度科学研究補助金
基盤研究(C)　代表
130万円
平成27年4月1日～平成30年3月31日		 うがい液からのDNAメチル化異常検出による口腔癌発癌予測システムの開発（課題番号15K11297）
科学技術振興機構 A-STEP（研究成果最適展開支援プログラム） / ライフイノベーション分野　
代表 169万円		 うがい液からの口腔癌発癌予測システムの開発　（課題番号：AS262Z02191P）
Yuichi GOTO
Project・Event / SpanResearch
平成27年度科学研究補助金
若手研究（B）代表
104万円
平成25年4月1日～平成28年3月31日（予定）		 口腔扁平上皮癌におけるΔNp63を介した上皮-間葉転換の浸潤・転移における役割(課題番号25870492)

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