口腔顎顔面領域の病変の診断と病理発生について研究しています。

 口腔癌の早期診断に欠かせない前がん病変の診断基準は、未だ確立されているとは云えず、診断にも有用な遺伝子変異の同定が急務です。多数例の人体例の検索と共に、舌癌化学発がん実験系を用いた発がん感受性遺伝子の解析や前がん病変モデル開発と早期遺伝子変異の同定を行い、ヒトに応用できる診断法の確立を目指しています。また、口腔顎顔面を構成する顎骨や間葉組織の病変は口腔顎顔面領域に特有の病変が多く、病理発生の背景にある組織発生や形態学的解析とともに遺伝子解析も行っています。

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研究室概要

部局 医歯学総合研究科 Graduate School of Medical and Dental Sciences
専攻 先進治療科学専攻 Advanced Therapeutics Course
大講座 腫瘍学 Oncology
分野 口腔病理解析学 Oral Pathology
分野サイト http://w3.hal.kagoshima-u.ac.jp/dental/op/index.html

分野サイト

連絡先

TEL.099-275-6142 / FAX.099-275-6148

主要研究テーマ

口腔粘膜前癌病変の病理診断基準の確立 Establishment of criteria for Pathological diagnosis of oral precancers
頭部中胚葉分化制御因子の解明 Analysis for mesenchymal differentiation factors in craniofacial region
多発性口腔扁平上皮癌におけるDNAメチル化に関する研究 Investigation of DNA methylation status in multiple oral cancers

スタッフ

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教授
氏名 仙波伊知郎 Ichiro SEMBA
専門分野 口腔病理学
研究テーマ ・口腔粘膜前癌病変の病理診断基準の確立
・頭部中胚葉分化制御因子の解明

研究者総覧 リポジトリ


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助教
氏名 嶋香織 Kaori SHIMA
専門分野 口腔病理学
研究テーマ ・多発性口腔扁平上皮癌におけるDNAメチル化に関する研究

研究者総覧 リポジトリ


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助教
氏名 近藤智之 Tomoyuki KONDO
専門分野 口腔病理学
研究テーマ ・腫瘍免疫に関する研究

研究者総覧 リポジトリ


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技術職員
氏名 加治屋由佳 Yuka KAJIYA

主な研究実績

仙波伊知郎
  • Semba I, JSOP Working Committee. Carcinoma in-situ of the oral mucosa: its pathological diagnostic concept based on the recognition of histological varieties proposed in the JSOP Oral CIS Catalog. J Oral Maxillofac Surg Med Pathol 2014; 26: 397-406
  • Toshiro Kibe, Takao Fuchigami, Michiko Kishida, Mikio Iijima, Kiyohide Ishihata, Hiroshi Hijioka, Akihiko Miyawaki, Ichiro Semba, Norifumi Nakamura, Tohru Kiyono, Shosei Kishida. A novel ameloblastoma cell line (AM-3) secretes MMP-9 in response to Wnt-3a and induces osteoclastogenesis. OS OM OP OR, 115:780-788, 2013.
  • 仙波伊知郎、嶋香織:歯原性腫瘍の病理診断 その他の歯原性腫瘍. 病理と臨床 31 (5): 515-20, 文光堂, 2013.
  • Hamada T, Hirano M, Semba I, Kamikawa Y, Sugihara K. Myofibroblastoma of the tongue: a case report with immunohistochemical findings. J Oral Maxillofac Surg Med Pathol. 24:180–183, 2012.
  • 久米健一、宮脇昭彦、比地岡浩志、石田喬之、仙波伊知郎、中村典史.上唇粘膜部に発生した腺房細胞癌の2例.日口外会誌, 58(9):526-530, 2012.
  • 宮脇昭彦、中村康典、野添悦郎、仙波伊知郎、中村典史.腎透析患者の上顎歯槽部に生じた異所性石灰化の1例.日口外会誌, 58(12):728-732, 2012.
  • Miyahara M, Tanuma J, Sugihara K, Semba I. Tumor lymphangiogenesis correlates with lymph node metastasis and clinicopathologic parameters in oral squamous cell carcinoma. Cancer, 110:1287-1294, 2007.
  • Takeda T, Sugihara K, Hirayama Y, Hirano M, Tanuma J-I, Semba I. Immunohistological evaluation of Ki-67, p63, CK19 and p53 expression in oral epithelial dysplasias. J Oral Pathol Med., 35:369-375, 2006.
  • Ogawa K, Tanuma J, Hirano M, Hirayama Y, Semba I, Shisa H, Kitano M. Selective loss of resistant alleles at p15INK4B and p16INK4A genes in chemically induced rat tongue cancers. Oral Oncol., 42:710-717, 2006.
  • Hirano M, Tanuma J, Hirayama Y, Ohyama M, Semba I, Shisa H, Hiai H, Kitano M. A speed congenic rat strain bearing the tongue cancer susceptibility locus Tscc1 from the dark-agouti rats. Cancer Letters, 231:185-191, 2006.
  • Kawatoko S, Sato T, Kawabata Y, Suenaga K, Suenaga S, Morita Y, Indo H, Kawano K, Iwashita Y, Majima HJ, Sugihara K, Semba I. A trial for histopathological subclassification of papillary cystadenoma lymphomatosum by 99Tcm-pretechnetate in a patient with multiple bilateral lesions of the parotid glands. Dentomaxillofac Radiol., 34:218-221, 2005.
  • Nagata E, Okayama H, Ito H-O, Semba I, Inoue M, Oho T. Experimental infective endocarditis induced by human supragingival dental plaque in rats. Eur J Oral Sci., 113:499-504, 2005.
  • Tanuma J, Hirano M, Hirayama Y, Semba I, Ogawa K, Shisa H, Hiai H, Kitano M. Genetic predispositionto 4NQO-induced tongue carcinogenesis in the rat. Med Princ Pract., 14:297-305, 2005.
  • Bandow K, Ohnishi T, Tamura M, Semba I, Daikuhara Y. Hepatocyte growth factor / scatter factor stimulates migration of muscle precursors in developing mouse tongue. J Cellular Physiol., 201: 236-243, 2004.
  • Hirayama T, Hamada T, Hasui K, Semba I, Murata F, Sugihara K. Immunohistochemical analysis of cell proliferation and suppression of ameloblastoma with special reference to plexiform and follicular ameloblastoma. Acta Histochem Cytochem. 37(6):391-398, 2004.
  • Ohyama M, Hirayama Y, Tanuma J, Hirano M, Semba I, Shisa H, Hiai H, Sugihara K, Kitano M. Expressions of junB and c-fos are enhanced in 4-nitroquinoline 1-oxide-induced rat tongue cancers. Pathol. Int., 54: 35-40, 2004.
  • Tanuma J, Hiai H, Shisa H, Hirano M, Semba I, Nagaoka S, Kitano M. Carcinogenesis modifier loci in rat tongue are subject to frequent loss of heterozygosity. Int. J. Cancer, 102: 638-642, 2002.
  • Kakimoto K, Machigashira M, Ohnishi T, Kajihara T, Semba I, Setoguchi T, Tamura M, Izumi Y, Daikuhara Y. Hepatocyte growth factor (HGF) levels in gingival crevicular fluid and distribution of HGF-activator in gingival tissue from adult periodontitis. Arch Oral Biol, 47: 655-663, 2002.
  • Yasui K, Saiga H, Wang Y, Zhang PJ, Semba I. Early expressed genes showing a dichotomous developing pattern in the lancelet embryo. Dev Growth Differ., 43: 185-194, 2001.
  • Semba I, Funakoshi S, Kitano M. Histomorphometrical analysis of age changes in the human inferior alveolar artery. Arch Oral Biol., 46(1):13-21, 2001.
  • Semba I, Nonaka K, Takahashi K, Takahashi I, Dashner R, Shum L, Nuckolls GH, Slavkin HC. Positionally dependent chondrogenesis induced by BMP4 is co-regulated by Sox9 and Msx2. Dev Dyn., 217:401-414, 2000.
  • Semba I, Ishigami T, Sugihara K, Kitano M. Osteoclastic Higher Demineralization and Highly Mineralized Cement Lines with Osteocalcin Deposition in a Mandibular Cortical Bone of Autosomal Dominant Osteopetrosis Type II: Ultrastructural and Undecalcified Histological Investigations. Bone, 27(3): 389-395, 2000.

嶋香織
  • Li T, Liao X, Lochhead P, Morikawa T, Yamauchi M, Nishihara R, Inamura K, Kim SA, Mima K, Sukawa Y, Kuchiba A, Imamura Y, Baba Y, Shima K, Meyerhardt JA, Chan AT, Fuchs, CS, Ogino S, Qian ZR. SMO Expression in Colorectal Cancer: Associations with Clinical, Pathological, and Molecular Features. Ann Surg Oncol., 21 (13): 4164-73, 2014.
  • Li S, Sheng J, Hu JK, Yu W, Kishikawa H, Hu MG, Shima K, Wu D, Xu Z, Xin W, Sims KB, Landers JE, Brown RH Jr, Hu GF. Ribonuclease 4 protects neuron degeneration by promoting angiogenesis, neurogenesis, and neuronal survival under stress. Angiogenesis. 16(2): 387-404, 2013.
  • Yamauchi M, Lochhead P, Imamura Y, Kuchiba A, Liao X, Qian ZR, Nishihara R, Morikawa T, Shima K, Wu K, Giovannucci E, Meyerhardt JA, Fuchs CS, Chan AT, Ogino S. Physical Activity, Tumor PTGS2 Expression, and Survival in Patients with Colorectal Cancer. Cancer Epidemiol Biomarkers Prev. 22(6): 1142-52, 2013.
  • Nishihara R, Morikawa T, Kuchiba A, Lochhead P, Yamauchi M, Liao X, Imamura Y, Nosho K, Shima K, Kawachi I, Qian ZR, Fuchs CS, Chan AT, Giovannucci E, Ogino S. A Prospective Study of Duration of Smoking Cessation and Colorectal Cancer Risk by Epigenetics-related Tumor Classification. Am J Epidemiol. 178(1): 84-100, 2013.
  • Kibe T, Fuchigami T, Kishida M, Iijima M, Ishihata K, Hijioka H, Miyawaki A, Semba I, Nakamura N, Kiyono T, Kishida S. A novel ameloblastoma cell line (AM-3) secretes MMP-9 in response to Wnt-3a and induces osteoclastogenesis. Oral Surg Oral Med Oral Pathol Oral Radiol. 115: 780-8, 2013.
  • Lin JH, Morikawa T, Chan AT, Kuchiba A, Shima K, Nosho K, et al. Postmenopausal hormone therapy is associated with a reduced risk of colorectal cancer lacking CDKN1A expression. Cancer Res. 72:3020-3028, 2012.
  • Morikawa T, Shima K, Kuchiba A, Yamauchi M, Tanaka N, Imamura Y, et al. No Evidence for Interference of H&E Staining in DNA Testing. Usefulness of DNA Extraction from H&E-Stained Archival Tissue Sections. Am J Clin Pathol. 138:122-129, 2012.
  • Liao X, Lochhead P, Nishihara R, Morikawa T, Kuchiba A, Yamauchi M, Shima K, et al. Aspirin use, tumor PIK3CA mutation, and colorectal-cancer survival. N Engl J Med. 367:1596-1606, 2012.
  • Waldron L, Ogino S, Hoshida Y, Shima K, McCart Reed AE, Simpson PT, et al. Expression Profiling of Archival Tumors for Long-term Health Studies. Clin Cancer Res. 18:6136-6146, 2012.
  • Shima K, Morikawa T, Yamauchi M, Kuchiba A, Imamura Y, Liao X, Meyerhardt JA, Fuchs CS, Ogino S. TGFBR2 and BAX Mononucleotide Tract Mutations, Microsatellite Instability, and Prognosis in 1072 Colorectal Cancers. PLoSOne. 6(9): e25062, 2011.
  • Shima K, Nosho K, Baba Y, Cantor M, Meyerhardt JA, Giovannucci EL, Fuchs CS, Ogino S. Prognostic significance of CDKN2A (p16) promoter methylation and loss of expression in 902 colorectal cancers: Cohort study and literature review. Int J Cancer. 128 (5): 1080-94, 2011.
  • Shima K, Morikawa T, Baba Y, Nosho K, Suzuki M, Yamauchi M, Hayashi M, Giovannucci E, Fuchs CS, Ogino S. MGMT promoter methylation, loss of expression and prognosis in 855 colorectal cancers. Cancer Causes Control. 22(2): 301-9, 2011.
  • Shima K, Muramatsu T, Abiko Y, Yamaoka Y, Sasaki H. Shimono M. Connexin 43 transfection in basaloid squamous cell carcinoma cells. Oncol Rep. 16 (2): 285-8, 2006.
  • Shima K, Hashimoto S, Muramatsu T, Takasaki Y, Kakizawa T, Inoue T, Shimono M. Expression of Ki-67, Osteocalcin and Osteopontin in Cementoblastoma. Oral Med Pathol. 9(3): 91-4, 2004.
  • Shima K, Kobayashi I, Saito I, Kiyoshima T, Matsuo K, Ozeki S, Ohishi M, Sakai H. Incidence of human papillomavirus 16 and 18 infection and p53 mutation in patients with oral squamous cell carcinoma in Japan. Br J Oral Maxillofac Surg. 38(5): 445-50, 2000.

楠山穣二
  • Bandow K, Kusuyama J, Kakimoto K, Ohnishi T, Matsuguchi T. AMP-activated protein kinase (AMPK) activity negatively regulates chondrogenic differentiation. Bone. 2015.
  • Maeda A, Bandow K, Kusuyama J, Kakimoto K, Ohnishi T, Miyawaki S, Matsuguchi T. Induction of CXCL2 and CCL2 by pressure force requires IL-1β-MyD88 axis in osteoblasts. Bone. 2015.
  • Kusuyama J, Bandow K, Shamoto M, Kakimoto K, Ohnishi T, Matsuguchi T. Low Intensity Pulsed Ultrasound (LIPUS) Influences the Multilineage Differentiation of Mesenchymal Stem and Progenitor Cell Lines through ROCK-Cot/Tpl2-MEK-ERK Signaling Pathway. J Biol Chem., 289; 10330-10344, 2014.

主な研究費取得状況

仙波伊知郎
事業・種目 / 期間研究
科学研究費補助金
基盤研究(B)海外調査
平成24~28年度(連携)
WHO国際分類改訂に向けたアジアにおける歯原性腫瘍の戦略的大規模調査
科学研究費補助金
基盤研究(C)一般
平成21~23年度 代表
口腔粘膜前癌病変の初期遺伝子変異の解明
科学研究費補助金
基盤研究(C)企画
平成18年 分担
口腔粘膜悪性境界病変の病理組織学的診断基準の策定
科学研究費補助金
基盤研究(C)
平成16年 分担
口腔粘膜癌とその境界病変の病理組織学的診断基準のグローバル化策定
科学研究費補助金
基盤研究(B)代表
平成12~14年度
DNAマイクロアレイによる舌癌感受性遺伝子の解析-ラットからヒトへ
科学研究費補助金
基盤研究(B)分担
平成11~13年度
コンジェニックラットの作成とそれによる舌癌感受性及び抵抗性遺伝子の解析
嶋香織
事業・種目 / 期間研究
科学研究費補助金
基盤研究(C)代表
平成25~27年度
多発性口腔扁平上皮癌におけるDNAメチル化に関する研究

分野サイト