FIELD

Research outline

医化学スタッフ

Graduate School Graduate School of Medical and Dental Sciences
Course Health Research Course
Field Developmental Medicine
Department Biochemistry and Genetics
Homepage http://www.kufm.kagoshima-u.ac.jp/~biochem1/

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Contact

TEL.+81-99-275-5242 / FAX.+81-99-264-6274

Research interests

  • The effects of Wnt signal on the invasiveness of glioma
  • Reciprocal cell-to-cell interactions between ameloblastoma derived cells and stromal fibroblasts via cytokines
  • Signal transduction

Staff

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Professor
Name Shosei KISHIDA
Specialized field Biochemistry、Cell Biology、Signal transduction
Research interests
  • Wnt siganling
  • neurotransmitter release

Researche Repository


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Lecturer
Name Hirofumi KOYAMA
Specialized field Molecular biology、Biochemistry
Research interests Wnt siganling

Researche Repository


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Assistant Professor
Name Mikio IIJIMA
Specialized field Cell Biology、Pathological biochemistry、Molecular biology
Research interests Wnt siganling

Researche Repository


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Assistant Professor
Name Michiko KISHIDA
Specialized field Cell Biology
Research interests Regulation of signal transduction by phosphorylation

Researche Repository

Research results

Shosei KISHIDA
  1. A conserved function in phosphatidylinositol metabolism for mammalian Vps13 family proteins.
    Park JS, Halegoua S, Kishida S, Neiman AM.
    PLoS One., (2015) Vol. 10, e0124836.
  2. Regulation of IL-6 and IL-8 production by reciprocal cell-to-cell interactions between tumor cells and stromal fibroblasts through IL-1α in ameloblastoma.
    Fuchigami T, Kibe T, Koyama H, Kishida S, Iijima M, Nishizawa Y, Hijioka H, Fujii T, Ueda M, Nakamura N, Kiyono T, Kishida M.
    Biochem. Biophys. Res. Commun., (2014) Vol. 451, 491-496.
  3. Ryk is essential for Wnt-5a-dependent invasiveness in human glioma.
    Habu M, Koyama H, Kishida M, Kamino M, Iijima M, Fuchigami T, Tokimura H, Ueda M, Tokudome M, Koriyama C, Hirano H, Arita K, Kishida S.
    J. Biochem., (2014) Vol. 156, 29-38.
  4. Immunoreactivity of Wnt5a, Fzd2, Fzd6, and Ryk in glioblastoma: evaluative methodology for DAB chromogenic immunostaining.
    Hirano H, Yonezawa H, Yunoue S, Habu M, Uchida H, Yoshioka T, Kishida S, Kishida M, Oyoshi T, Fujio S, Sugata S, Yamahata H, Hanaya R, Arita K.
    Brain Tumor Pathol., (2014) Vol. 31, 85-93.
  5. A novel ameloblastoma cell line (AM-3) secretes MMP-9 in response to Wnt-3a and induces osteoclastogenesis.
    Kibe T, Fuchigami T, Kishida M, Iijima M, Ishihata K, Hijioka H, Miyawaki A, Semba I, Nakamura N, Kiyono T, Kishida S.
    Oral Surg. Oral Med. Oral Pathol. Oral Radiol., (2013) Vol. 115, 780-788.

Hirofumi KOYAMA
  1. The Wnt5a-Ror2 axis promotes the signaling circuit between interleukin-12 and interferon-γ in colitis.
    Sato A, Kayama H, Shojima K, Matsumoto S, Koyama H, Minami Y, Nojima S, Morii E, Honda H, Takeda K, Kikuchi A.
    Sci. Rep., (2015) Vol. 5, 10536.
  2. Reprogramming suppresses premature senescence phenotypes of Werner syndrome cells and maintains chromosomal stability over long-term culture.
    Shimamoto A, Kagawa H, Zensho K, Sera Y, Kazuki Y, Osaki M, Oshimura M, Ishigaki Y, Hamasaki K, Kodama Y, Yuasa S, Fukuda K, Hirashima K, Seimiya H, Koyama H, Shimizu T, Takemoto M, Yokote K, Goto M, Tahara H.
    PLoS One., (2014) Vol. 9, e112900.
  3. Regulation of IL-6 and IL-8 production by reciprocal cell-to-cell interactions between tumor cells and stromal fibroblasts through IL-1α in ameloblastoma.
    Fuchigami T, Kibe T, Koyama H, Kishida S, Iijima M, Nishizawa Y, Hijioka H, Fujii T, Ueda M, Nakamura N, Kiyono T, Kishida M.
    Biochem. Biophys. Res. Commun., (2014) Vol. 451, 491-496.
  4. Ryk is essential for Wnt-5a-dependent invasiveness in human glioma.
    Habu M, Koyama H, Kishida M, Kamino M, Iijima M, Fuchigami T, Tokimura H, Ueda M, Tokudome M, Koriyama C, Hirano H, Arita K, Kishida S.
    J. Biochem., (2014) Vol. 156, 29-38.
  5. Antioxidants improve the phenotypes of dilated cardiomyopathy and muscle fatigue in mitochondrial superoxide dismutase-deficient mice.
    Koyama H, Nojiri H, Kawakami S, Sunagawa T, Shirasawa T, Shimizu T.
    Molecules. (2013) Vol. 18, 1383-1393.

Mikio IIJIMA
  1. Regulation of IL-6 and IL-8 production by reciprocal cell-to-cell interactions between tumor cells and stromal fibroblasts through IL-1α in ameloblastoma.
    Fuchigami T, Kibe T, Koyama H, Kishida S, Iijima M, Nishizawa Y, Hijioka H, Fujii T, Ueda M, Nakamura N, Kiyono T, Kishida M.
    Biochem. Biophys. Res. Commun., (2014) Vol. 451, 491-496.
  2. Ryk is essential for Wnt-5a-dependent invasiveness in human glioma.
    Habu M, Koyama H, Kishida M, Kamino M, Iijima M, Fuchigami T, Tokimura H, Ueda M, Tokudome M, Koriyama C, Hirano H, Arita K, Kishida S.
    J. Biochem., (2014) Vol. 156, 29-38.
  3. A novel ameloblastoma cell line (AM-3) secretes MMP-9 in response to Wnt-3a and induces osteoclastogenesis.
    Kibe T, Fuchigami T, Kishida M, Iijima M, Ishihata K, Hijioka H, Miyawaki A, Semba I, Nakamura N, Kiyono T, Kishida S.
    Oral Surg. Oral Med. Oral Pathol. Oral Radiol., (2013) Vol. 115, 780-788.
  4. Subcellular localization and putative role of VPS13A/chorein in dopaminergic neuronal cells.
    Hayashi T, Kishida M, Nishizawa Y, Iijima M, Koriyama C, Nakamura M, Sano A, Kishida S.
    Biochem. Biophys. Res. Commun., (2012) Vol. 419, 511-516.
  5. Wnt-5a signaling is correlated with infiltrative activity in human glioma by inducing cellular migration and MMP-2.
    Kamino M, Kishida M, Kibe T, Ikoma K, Iijima M, Hirano H, Tokudome M, Chen L, Koriyama C, Yamada K, Arita K, Kishida S.
    Cancer Sci., (2011) Vol. 102, 540-548.

Michiko KISHIDA
  1. Regulation of IL-6 and IL-8 production by reciprocal cell-to-cell interactions between tumor cells and stromal fibroblasts through IL-1α in ameloblastoma.
    Fuchigami T, Kibe T, Koyama H, Kishida S, Iijima M, Nishizawa Y, Hijioka H, Fujii T, Ueda M, Nakamura N, Kiyono T, Kishida M.
    Biochem. Biophys. Res. Commun., (2014) Vol. 451, 491-496.
  2. Ryk is essential for Wnt-5a-dependent invasiveness in human glioma.
    Habu M, Koyama H, Kishida M, Kamino M, Iijima M, Fuchigami T, Tokimura H, Ueda M, Tokudome M, Koriyama C, Hirano H, Arita K, Kishida S.
    J. Biochem., (2014) Vol. 156, 29-38.
  3. Immunoreactivity of Wnt5a, Fzd2, Fzd6, and Ryk in glioblastoma: evaluative methodology for DAB chromogenic immunostaining.
    Hirano H, Yonezawa H, Yunoue S, Habu M, Uchida H, Yoshioka T, Kishida S, Kishida M, Oyoshi T, Fujio S, Sugata S, Yamahata H, Hanaya R, Arita K.
    Brain Tumor Pathol., (2014) Vol. 31, 85-93.
  4. A novel ameloblastoma cell line (AM-3) secretes MMP-9 in response to Wnt-3a and induces osteoclastogenesis.
    Kibe T, Fuchigami T, Kishida M, Iijima M, Ishihata K, Hijioka H, Miyawaki A, Semba I, Nakamura N, Kiyono T, Kishida S.
    Oral Surg. Oral Med. Oral Pathol. Oral Radiol., (2013) Vol. 115, 780-788.
  5. Subcellular localization and putative role of VPS13A/chorein in dopaminergic neuronal cells.
    Hayashi T, Kishida M, Nishizawa Y, Iijima M, Koriyama C, Nakamura M, Sano A, Kishida S.
    Biochem. Biophys. Res. Commun., (2012) Vol. 419, 511-516.

Research Grant List

Shosei KISHIDA
Project・Event / SpanResearch
文部科学省
基盤研究(C)分担
平成25-27年度
自己免疫性脳炎の病態解析および新規抗原の解明
文部科学省
基盤研究(C)分担
平成25-27年度
口蓋裂術後の瘢痕拘縮分子メカニズムの解明と新規創傷被覆材開発への展開
文部科学省
基盤研究(C)代表
平成21-23年度
腫瘍の病態におけるWntシグナルの役割
文部科学省
基盤研究(C)代表
平成19、20年度
シナプス形成におけるWntシグナル伝達経路の役割
文部科学省
基盤研究(C)代表
平成17、18年度
Wntシグナルによる細胞極性の制御機構の解析
Hirofumi KOYAMA
Project・Event / SpanResearch
文部科学省
挑戦的萌芽研究 分担
平成26、27年度
デスアシルグレリン受容体を介した新しい食欲制御機構の解明
文部科学省
挑戦的萌芽研究 分担
平成26-28年度
食欲を調節するアドロピンやオーグリンのシグナル伝達の解明
Mikio IIJIMA
Project・Event / SpanResearch
文部科学省
挑戦的萌芽研究 代表
平成26、27年度
デスアシルグレリン受容体を介した新しい食欲制御機構の解明
文部科学省
基盤研究(C)代表
平成23-25年度
イムノクロマト法によるシトリン欠損症迅速簡便診断法の開発と臨床応用
文部科学省
挑戦的萌芽研究 代表
平成19-21年度
骨異常と片眼性異常が認められたアスパラギン酸グルタミン酸輸送体欠損マウス
文部科学省
基盤研究(C)代表
平成14、15年度
変異citrinタンパク質は肝細胞を細胞死させるか
文部科学省
基盤研究(C)代表
平成12、13年度
新規遺伝子citrinとaralarの機能解析
Michiko KISHIDA
Project・Event / SpanResearch
文部科学省
基盤研究(C)分担
平成23-25年度
エナメル上皮腫による骨破壊・浸潤に関わる細胞間シグナルの解明と治療戦略への展開
文部科学省
挑戦的萌芽研究 分担
平成23、24年度
神経ペプチドグレリンの新規受容体の同定と作用機構の解明
文部科学省
基盤研究(C)代表
平成21-23年度
腫瘍の病態におけるWntシグナルの役割
文部科学省
基盤研究(C)代表
平成20-22年度
悪性グリオーマにおけるWntシグナル活性化の検討と診断・治療への応用
文部科学省
若手研究(B)代表
平成19、20年度
Wnt-11蛋白質の精製とその生理機能の解析

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