FIELD

Research outline

精神機能病学分野スタッフ写真

Graduate School Graduate School of Medical and Dental Sciences
Course Health Research Course
Field Social and Behavioral Medicine
Department Psychiatry
Homepage http://www.kufm.kagoshima-u.ac.jp/~np/

Homepage

Contact

TEL.+81-99-275-5346 / FAX.+81-99-265-7089

Research interests

  • Molecular genetical study of neuropsychiatryic disorders
  • Molecular biological study of neuropsychiatryic disorders
  • Clinical study of neuropsychiatryic disorders
  • Surveillance study of chorea-acanthocytosis

Staff

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Professor
Name Akira SANO
Specialized field Molecular pychiatry、臨床精神神経医学
Research interests
  • Molecular genetical and biological study of neuropsychiatric diseases
  • 有棘赤血球舞踏病の調査研究
  • Clinical study of neuropsychiatryic disorders

Researche Repository


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Associate Professor
Name Masayuki NAKAMURA
Specialized field biological psychiatry、臨床精神神経医学、老年精神医学
Research interests
  • Molecular genetical and biological study of neuropsychiatric diseases
  • 有棘赤血球舞踏病の調査研究
  • Clinical study of neuropsychiatryic disorders

Researche Repository


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Lecturer
Name Motofumi KASUGAI
Specialized field 臨床精神医学
Research interests
  • 司法精神医学
  • Clinical study of neuropsychiatryic disorders

Researche Repository


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Assistant Professor
Name Hiroshi KIMOTSUKI
Specialized field 臨床精神医学
Research interests リエゾン精神医学

Researche Repository


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Assistant Professor
Name Nari SHIOKAWA
Specialized field 臨床精神神経医学、Biological psychiatry
Research interests  

Researche Repository


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Assistant Professor
Name Takanori ISHIZUKA
Specialized field Biological psychiatry、臨床精神神経医学、老年精神医学
Research interests
  • 精神神経疾患の分子遺伝学・生物学的研究
  • Clinical study of neuropsychiatryic disorders

Researche Repository


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Assistant Professor
Name Takehiro HAYASHI
Specialized field Biological psychiatry、臨床精神神経医学
Research interests
  • 精神神経疾患の分子遺伝学・生物学的研究
  • Clinical study of neuropsychiatryic disorders

Researche Repository


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Assistant Professor
Name Yoko DAIMOU
Specialized field Biological psychiatry、臨床精神神経医学
Research interests
  • 精神神経疾患の分子遺伝学・生物学的研究
  • ミトコンドリア機能障害の調査研究
  • Clinical study of neuropsychiatryic disorders

Researche Repository


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Assistant Professor
Name Junko NAGATANI
Specialized field 臨床精神神経医学、精神腫瘍学
Research interests Clinical study of neuropsychiatryic disorders

Researche Repository


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Assistant Professor
Name Natsuki SASAKI
Specialized field Biological psychiatry、臨床精神神経医学
Research interests
  • 精神神経疾患の分子遺伝学・生物学的研究
  • Clinical study of neuropsychiatryic disorders

Researche Repository


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特任研究員
Name Hanae HIWATASHI
Specialized field  
Research interests  

Researche Repository

Research results

Akira SANO
  1. The gene encoding a newly discovered protein, chorein, is mutated in chorea-acanthocytosis. Nat Genet 28: 121-2, 2001
  2. A gene-targeted mouse model for chorea-acanthocytosis. J Neurochem 92: 759-66, 2005
  3. Neurologic phenotypes associated with acanthocytosis. Neurology 68: 92-8, 2007
  4. Exome sequencing identifies a novel missense variant in RRM2B associated with autosomal recessive progressive external ophthalmoplegia. Genome Biol 12: r92, 2011
  5. Heteroplasmic m.1624C>T mutation of the mitochondrial tRNA(Val) gene in a proband and his mother with repeated consciousness disturbances. Mitochondrion 12, 617-622, 2012

Masayuki NAKAMURA
  1. The human serotonin transporter gene linked polymorphism (5-HTTLPR) shows ten novel allelic variants, Mol Psychiatry 5: 32-38, 2000
  2. The silencer activity of the novel human serotonin transporter linked polymorphic regions, Neurosci Lett 327: 13-16, 2002
  3. N-terminal proteolysis of full-length mutant huntingtin in an inducible PC12 cell model of Huntington's disease. Cell Cycle 6: 2970-2981, 2007
  4. Familial Semantic Dementia with P301L Mutation in the Tau Gene. Dement Geriatr Cogn Disord 31: 334-340, 2011
  5. Chorein, the protein responsible for chorea-acanthocytosis, interacts with β-adducin and β-actin. Biochem Biophys Res Commun 441: 96-101, 2013

Hiroshi KIMOTSUKI
  1. Dexmedetomidine aggravates cerebral ischemia in rats. Circulation Control 25: 50-55,2004.
  2. Migration of neutrophils elicited by leukotriene B4 is inhibited by fasudil, a Rho-kinase inhibitor, in the microvasculature of hamster cheek pouch. Circulation Control 25: 267-271, 2004.
  3. 脳器質性変化を伴う高齢者のうつ病の診断と治療に関する実態調査―アルツハイマー病と脳血管障害. 老年精神医学雑誌 20: 445-452, 2009.
  4. 難治性気分障害の治療―エビデンスレビューアルツハイマー病または脳血管障害を伴ううつ病の治療ガイドライン. 臨床精神医学 38: 1083-1092, 2009.

Nari SHIOKAWA
  1. Chorein, the protein responsible for chorea-acanthocytosis, interacts with β-adducin and β-actin. Biochem Biophys Res Commun 441: 96-101, 2013

Takanori ISHIZUKA
  1. Familial semantic dementia with P301L mutation in the Tau gene. Dement Geriatr Cogn Disord 31: 334-40, 2011
  2. Different clinical phenotypes in siblings with a presenilin-1 P264L mutation. Dement Geriatr Cogn Disord 33: 132-40, 2012

Takehiro HAYASHI
  1. Adult-type metachromatic leukodystrophy with compound heterozygous ARSA mutations: A case report and phenotypic comparison with a previously reported case. Psychiatry Clin Neurosci 65: 105-8, 2011
  2. Quetiapine-induced frequent ventricular contraction. Gen Hosp Psychiatry 34: 211.e1-3, 2012
  3. Subcellular localization and putative role of VPS13A/chorein in dopaminergic cells. Biochem Biophys Res Commun 419: 511-6, 2012

Yoko DAIMOU
  1. A new phenotype of mitochondrial disease characterized by familial late-onset predominant axial myopathy and encephalopathy. Acta Neuropathologica 121: 775-783, 2011
  2. Heteroplasmic m.1624C>T mutation of the mitochondrial tRNAVal gene in a proband and his mother with repeated consciousness disturbances. Mitochondrion 12: 617-622, 2012

Natsuki SASAKI
  1. Chorein interacts with α-tubulin and histone deacetylase 6, and overexpression preserves cell viability during nutrient deprivation in human embryonic kidney 293 cells. FASEB J. 30: 3726-3732, 2016

Hanae HIWATASHI
  1. 2-Methyl-5-pyridyl 2-(Substituted-phenoxy)-ethyl Esters with Precocious Metamorphosis-Inducing Activity. J Psticide Sci 26: 390-2, 2001

Patents and copy Rights

title ヘムオキシゲナーゼの誘導または誘導促進剤としてのフラバノン誘導体
出願人・特許権者:杏林製薬株式会社 
inventor /
application number
発明者:宮地弘幸、永楽智彦、石黒英恵
特願2004-170090
application date 2004年06月08日

Research Grant List

Akira SANO
Project・Event / Span 基盤研究(B)平成29-32年度
Research 有棘赤血球舞踏病とマイトファジー 分子レベルの病態機序解明と神経変性予防法の開発
Project・Event / Span 基盤研究(B)平成23-25年度
Research 有棘赤血球舞踏病におけるオートファジー性神経変性の分子的機序の解明と治療的研究
Project・Event / Span 挑戦的萌芽研究 平成23-24年度
Research パーキン遺伝子と精神障害の関わり ーコピー数変異を含めた総合的分子遺伝学的研究ー
Project・Event / Span 基盤研究(B)平成20-22年度
Research 精神神経障害における神経有棘赤血球症遺伝子群の関わりに関する研究
Project・Event / Span 挑戦的萌芽研究 平成21-22年度
Research 精神神経障害における神経有棘赤血球症遺伝子群の関わりに関する研究
Project・Event / Span 特定領域研究(A)平成18-19年度
Research VPS13A遺伝子が関連する新たな細胞死カスケードの解明
Project・Event / Span 特定領域研究(A)平成17年度
Research モデルマウスを用いた機能性精神疾患の多因子性の機構解明
Project・Event / Span 基盤研究(B)平成16-17年度
Research 多因子性精神神経障害の分子遺伝学的アプローチ ーCHACモデルマウスを用いた多因子の解析ー
Project・Event / Span 基盤研究(B)平成14-15年度
Research 有棘赤血球舞踏病遺伝子と精神疾患 ーヒト精神疾患とモデルマウスを通じて
Masayuki NAKAMURA
Project・Event / Span 基盤研究(C)平成27-29年度
Research 特異な中間表現型を有した統合失調症多発家系から同定した責任遺伝子の解析
Project・Event / Span 基盤研究(C)平成24-26年度
Research choreinとミトコンドリア関連細胞死の関連について
Project・Event / Span 基盤研究(C)平成21-23年度
Research 精神疾患と有棘赤血球舞踏病病因遺伝子のコピー数多型解析
Project・Event / Span 基盤研究(C)平成19-20年度
Research 精神神経疾患におけるミトコンドリア遺伝子異常の解析
Takanori ISHIZUKA
Project・Event / Span 若手研究(B)平成27-28年度
Research 若年認知症関連遺伝子群の包括的変異解析と高齢初発てんかんの特異的臨床症状の抽出
Takehiro HAYASHI
 Project・Event / Span  若手研究(B)平成28-29年度
 Research  薬剤性パーキンソニズムにおけるシナプトタグミンファミリーの関与についての研究

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