FIELD

Research outline

糖尿病・内分泌内科学 講座集合写真

Graduate School Graduate School of Medical and Dental Scinces
Course Health Research Course
Field Human and Environmental Sciences
Department Diabetes, Metabolism and Endocrinology
Homepage http://kadai-tounai.com/

糖尿病・内分泌内科学 糖尿病・内分泌内科学 糖尿病・内分泌内科学

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Contact

TEL.+81-99-275-6478 / FAX.+81-99-275-6479

Research interests

  • Diabetic complication
  • Pathogenesis and prevention of diabetic macroangiopathy
  • Clinical staing and management of diabetic neuropathy
  • Mechanism of appetite regulation of ghrelin
  • Mechanism of insulin secretion amplified by incretin hormone
  • Endocrinology, Metabolism and Clinical Nutrition

Staff

西尾善彦

Professor
Name Yoshihiko NISHIO
Specialized field Diabetology、Endocrinology、Metabolism
Research interests
  • Diabetic complications, its pathophysiology and treatment
  • 脂質異常症の病態、治療

Researcher Repository


出口尚寿

Assistant Professor
Name Takahisa DEGUCHI
Specialized field Diabetology、神経内科学、病態栄養学
Research interests
  • 糖尿病性神経障害の臨床病期と治療
  • 有痛性糖尿病神経障害の病態と治療

Researcher Repository


橋口裕

Assistant Professor
Name Hiroshi HASHIGUCHI
Specialized field Diabetology、Endocrinology
Research interests
  • インクレチンによるインスリン分泌機構
  • グレリンによる摂食促進機構

Researcher Repository


菊池晃

Assistant Professor
Name Akira KIKUCHI
Specialized field Diabetology
Research interests
  • 糖尿病の治療
  • 糖尿病合併症の病態と治療

Researcher Repository


staff dummy

Assistant Professor
Name Aiko ARIMURA
Specialized field Diabetology、Endocrinology
Research interests
  • 糖尿病における小径神経線維障害
  • 糖尿病性自律神経障害の進展機序

Researcher Repository

Research results

Yoshihiko NISHIO
  1. Kondo K, Morino K, Nishio Y, Kondo M, Nakao K, Nakagawa F, Ishikado A, Sekine O, Yoshizaki T, Kashiwagi A, Ugi S, Maegawa H. A fish-based diet intervention improves endothelial function in postmenopausal women with type 2 diabetes mellitus: a randomized crossover trial. Metabolism 63(7):930-940, 2014
  2. Kondo K, Ishikado A, Morino K, Nishio Y, Ugi S, Kajiwara S, Kurihara M, Iwakawa H, Nakao K, Uesaki S, Shigeta Y, Imanaka H, Yoshizaki T, Sekine O, Makino T, Maegawa H, King GL, Kashiwagi A. A high-fiber, low-fat diet improves periodontal disease markers in high-risk subjects: a pilot study. Nutr Res 34(6):491-498, 2014
  3. Nakagawa F, Morino K, Ugi S, Ishikado A, Kondo K, Sato D, Konno S, Nemoto K, Kusunoki C, Sekine O, Sunagawa A, Kawamura M, Inoue N, Nishio Y, Maegawa H. 4-Hydroxy hexenal derived from dietary n-3 polyunsaturated fatty acids induces anti-oxidative enzyme heme oxygenase-1 in multiple organs. Biochem Biophys Res Commun 443(3):991-996, 2014
  4. Ishikado A, Morino K, Nishio Y, Nakagawa F, Mukose A, Sono Y, Yoshioka N, Kondo K, Sekine O, Yoshizaki T, Ugi S, Uzu T, Kawai H, Makino T, Okamura T, Yamamoto M, Kashiwagi A, Maegawa H. 4-Hydroxy hexenal derived from docosahexaenoic acid protects endothelial cells via Nrf2 activation. PLoS One 8(7):e69415, 2013
  5. Kusunoki C, Yang L, Yoshizaki T, Nakagawa F, Ishikado A, Kondo M, Morino K, Sekine O, Ugi S, Nishio Y, Kashiwagi A, Maegawa H. Omega-3 polyunsaturated fatty acid has an anti-oxidant effect via the Nrf-2/HO-1 pathway in 3T3-L1 adipocytes. Biochem Biophys Res Commun. 430(1):225-230, 2013
  6. Yoshizaki T, Kusunoki C, Kondo M, Yasuda M, Kume S, Morino K, Sekine O, Ugi S, Uzu T, Nishio Y, Kashiwagi A, Maegawa H.Autophagy regulates inflammation in adipocytes. Biochem Biophys Res Commun. 417(1):352-357, 2012
  7. Kume S, Uzu T, Takagi C, Kondo M, Okabe T, Araki S, Isshiki K, Takeda N, Kondo K, Haneda M, Koya D, Nishio Y, Kashiwagi A, Maegawa H.
    Efficacy and tolerability of vildagliptin in type 2 diabetic patients on hemodialysis. J Diabetes Investig 3(3):298-301, 2012
  8. Miyazawa I, Araki S, Obata T, Yoshizaki T, Morino K, Kadota A, Ugi S, Kawai H, Uzu T, Nishio Y, Koya D, Haneda M, Kashiwagi A, Maegawa H. Association between serum soluble TNFα receptors and renal dysfunction in type 2 diabetic patients without proteinuria. Diabetes Res Clin Pract 92(2): 174-180, 2011
  9. Yagi A, Nishio Y, Ugi S, Kawai H, Uzu T, Imai M, Yamada N, Okawa M, Kashiwagi A, Maegawa H. The role of sleep disturbance and depression in patients with type 2 diabetes. Diabetol Int 2:79?85, 2011
  10. Yang X, Kume S, Tanaka Y, Isshiki K, Araki S, Chin-Kanasaki M, Sugimoto T, Koya D, Haneda M, Sugaya T, Li D, Han P, Nishio Y, Kashiwagi A, Maegawa H, Uzu T. GW501516, a PPARδ agonist, ameliorates tubulointerstitial inflammation in proteinuric kidney disease via inhibition of TAK1-NFκB pathway in mice. PLoS One 6(9):e25271, 2011
  11. Sekikawa A, Kadowaki T, El-Saed A, Okamura T, Sutton-Tyrrell K, Nakamura Y, Evans RW, Mitsunami K, Edmundowicz D, Nishio Y, Nakata K, Kadota A, Otake T, Miura K, Choo J, Abbott RD, Kuller LH, Curb JD, Ueshima H; ERA JUMP Study group. Differential association of docosahexaenoic and eicosapentaenoic acids with carotid intima-media thickness. Stroke 42(9):2538-2543, 2011
  12. Kondo M, Ugi S, Morino K, Fuke T, Obata T, Yoshizaki T, Nishio Y, Maeda S, Kashiwagi A, Maegawa H. Postprandial activation of protein kinase Cμ regulates the expression of adipocytokines via the transcription factor AP-2β. Int J Mol Med. 28(1):95-100, 2011
  13. Miyazawa I, Araki S, Obata T, Yoshizaki T, Morino K, Kadota A, Ugi S, Kawai H, Uzu T, Nishio Y, Koya D, Haneda M, Kashiwagi A, Maegawa H. Association between serum soluble TNFα receptors and renal dysfunction in type 2 diabetic patients without proteinuria. Diabetes Res Clin Pract 92(2):174-80, 2011

Takahisa DEGUCHI
  1. Horinouchi S, Deguchi T, Arimura K, Arimura A, Dochi Y, Uto T, Nakamura T, Arimura Y, Nishio Y, Takashima H.? Median neuropathy at the wrist as an early manifestation of diabetic neuropathy.? J Diabetes Invest 5: 709?713, 2014
  2. Deguchi T, Nishio Y, Takashima H. Diabetes mellitus and autoimmune neuropathy. Brain Nerve 66(2):135-47, 2014
  3. Deguchi T, Rosales R, Hashiguchi T, Arimura K. Antiplatelet Therapy, Diabetic Neuropathy and Peripheral Vascular Disease: A Unitary Approach. J Diabetes Metab S5: 005, 2012
  4. Deguchi T, Hashiguchi T, Horinouchi S, Uto T, Oku H, Kimura K, Makisumi K, Arimura K.? Serum VEGF increases in diabetic polyneuropathy, particularly in the neurologically active symptomatic stage.? Diabetic Med 26(3): 247-252, 2009
  5. Kimura K, Hashiguchi T, Deguchi T, Horinouchi S, Uto T, Oku H, Setoyama S, Maruyama I, Osame M, Arimura K. Serum VEGF-As a prognostic factor of atherosclerosis. Atherosclerosis 194(1): 182-188, 2007

Hiroshi HASHIGUCHI
  1. Hashiguchi H, Nakazaki M, Koriyama N, Fukudome M, Aso K, Tei C. Cyclic AMP/cAMP-GEF pathway amplifies insulin exocytosis induced by Ca2+ and ATP in rat islet beta-cells. Diabetes Metab Res Rev 22(1): 64-71,2006

Aiko ARIMURA
  1. Arimura A, Deguchi T, Sugimoto K, Uto T, Nakamura T, Arimura Y, Arimura K, Yagihashi S, Nishio Y, Takashima H. Intraepidermal nerve fiber density and nerve conduction study parameters correlate with clinical staging of diabetic polyneuropathy.Diabetes Res Clin Pract 99(1): 24-29, 2013

Research Grant List

Yoshihiko NISHIO
Project・EventResearchSpan
基盤(C) 多価不飽和脂肪酸を用いた血管内皮抗酸化システムの活性化戦略の意義を明らかにする。 2011~2014
基盤(C) 非アルコール性脂肪肝炎発症におけるマクロファージ活性化の意義の解明 2011~2014
基盤(C) ヒト肝SREBP-1c遺伝子発現を調節する新しい核蛋白の同定とその機能解析 2008~2010
Takahisa DEGUCHI
Project・EventResearchSpan
厚生労働科学研究費補助金
糖尿病戦略等研究事業(分担)
糖尿病多発神経障害の臨床病期分類の確立と病期に基づいた治療ガイドラインの作成 2008~2010

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