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Research outline

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Research interests

• Diabetic complication
• Pathogenesis and prevention of diabetic macroangiopathy
• Clinical staing and management of diabetic neuropathy
• Mechanism of appetite regulation of ghrelin
• Mechanism of insulin secretion amplified by incretin hormone
• Endocrinology, Metabolism and Clinical Nutrition

Staff

Professor

Researcher Repository

Lecturer

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Assistant Professor

Researcher Repository

Assistant Professor

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Research results

Assistant Professor

Researche Repository

主な研究実績

Yoshihiko NISHIO

1. Arimura H, Askoro R, Fujio S, Ummah FC, Takajo T, Nagano Y, Nishio Y, Arita K.
   A Thyroid-stimulating Hormone (TSH) Producing Adenoma in a Patient with Severe Hypothyroidism: Thyroxine Replacement Reduced the TSH Level and Tumor Size.
   NMC Case Rep J. 2019 Dec 18;7(1):17-21
2. Yamamoto K, Ito T, Nagasato T, Shinnakasu A, Kurano M, Arimura A, Arimura H, Hashiguchi H, Deguchi T, Maruyama I, Nishio Y.
   Effects of glycemic control and hypoglycemia on Thrombus formation assessed using automated microchip flow chamber system: an exploratory observational study.
   Thromb J. 2019 Sep 2;17:17
3. Kume S, Araki SI, Ugi S, Morino K, Koya D, Nishio Y, Haneda M, Kashiwagi A, Maegawa H.
   Secular changes in clinical manifestations of kidney disease among Japanese adults with type 2 diabetes from 1996 to 2014. J Diabetes Investig. 2019 Jul;10(4):1032-1040
4. Ghavidel Darestani S, Kurano M, Shinnakasu A, Yamamoto K, Dochi Y, Uemura K, Ikeda Y, Arimura A, Arimura H, Kikuchi A, Hashiguchi H, Deguchi T, Nishio Y. Association between changes in the mRNA expression of platelet-activating factor receptor in peripheral blood mononuclear cells and progression of diabetic nephropathy. Diabetol Int. 11(1):11-18,2019
5. Shayo SC, Kawade S, Ogiso K, Yoshihiko N.
   Strategies to ameliorate endothelial dysfunction associated with metabolic syndrome, where are we?
   Diabetes Metab Syndr. 2019 May-Jun;13(3):2164-2169.
6. Ogiso K, Koriyama N, Obo T, Tokito A, Ueno T, Nishio Y.
   Performance of a 2-step insulin infusion protocol with adjustment of insulin doses for Asians in the medical intensive care unit following cardiothoracic surgery. Diabetol Int. 2018 Jun 15;10(1):12-23
7. Kurano M, Darestani SG, Shinnakasu A, Yamamoto K, Dochi Y, Uemura K, Ikeda Y, Kikuchi A, Hashiguchi H, Deguchi T, Nishio Y. mRNA expression of platelet activating factor receptor (PAFR) in peripheral blood mononuclear cells is associated with albuminuria and vascular dysfunction in patients with type 2 diabetes. Diabetes Res Clin Pract. 136:124-133,2018
8. Shinnakasu A, Yamamoto K, Kurano M, Arimura H, Arimura A, Kikuti A, Hashiguchi H, Deguchi T, Nishio Y. The Combination Therapy of Fenofibrate and Ezetimibe Improved Lipid Profile and Vascular Function Compared with Statins in Patients with Type 2 Diabetes.
   J Atheroscler Thromb. 2017 Jul 1;24(7):735-748
9. Kondo K, Morino K, Nishio Y, Ishikado A, Arima H, Nakao K, Nakagawa F, Nikami F, Sekine O, Nemoto KI, Suwa M, Matsumoto M, Miura K, Makino T, Ugi S, Maegawa H.
   Fiber-rich diet with brown rice improves endothelial function in type 2 diabetes mellitus: A randomized controlled trial.
   PLoS One. 2017 Jun 29;12(6):e0179869.
10. Masuda T, Ueda M, Suenaga G, Misumi Y, Tasaki M, Izaki A, Yanagisawa Y, Inoue Y, Motokawa H, Matsumoto S, Mizukami M, Arimura A, Deguchi T, Nishio Y, Yamashita T, Inomata Y, Obayashi K, Ando Y.
    Early skin denervation in hereditary and iatrogenic transthyretin amyloid neuropathy.
    Neurology. 2017 Jun 6;88(23):2192-2197.
11. Kume S, Kondo M, Maeda S, Nishio Y, Yanagimachi T, Fujita Y, Haneda M, Kondo K, Sekine A, Araki SI, Araki H, Chin-Kanasaki M, Ugi S, Koya D, Kitahara S, Maeda K, Kashiwagi A, Uzu T, Maegawa H.
    Hypothalamic AMP-Activated Protein Kinase Regulates Biphasic Insulin Secretion from Pancreatic β Cells during Fasting and in Type 2 Diabetes.
    EBioMedicine. 2016 Nov;13:168-180
12. Ugi S, Maegawa H, Morino K, Nishio Y, Sato T, Okada S, Kikkawa Y, Watanabe T, Nakajima H, Kashiwagi A. Evaluation of a Novel Glucose Area Under the Curve (AUC) Monitoring System: Comparison with the AUC by Continuous Glucose Monitoring.
    Diabetes Metab J. 2016 Aug;40(4):326-33
13. Fujio S, Takano K, Arimura H, Habu M, Bohara M, Hirano H, Hanaya R, Nishio Y, Koriyama C, Kinoshita Y, Arita K.
    Treatable glomerular hyperfiltration in patients with active acromegaly. Eur J Endocrinol. 2016 Oct;175(4):325-33
14. Tanaka A, Murohara T, Taguchi I, Eguchi K, Suzuki M, Kitakaze M, Sato Y, Ishizu T, Higashi Y, Yamada H, Nanasato M, Shimabukuro M, Teragawa H, Ueda S, Kodera S, Matsuhisa M, Kadokami T, Kario K, Nishio Y, Inoue T, Maemura K, Oyama J, Ohishi M, Sata M, Tomiyama H, Node K; PROTECT Study Investigators.
    Rationale and design of a multicenter randomized controlled study to evaluate the preventive effect of ipragliflozin on carotid atherosclerosis: the PROTECT study.
    Cardiovasc Diabetol. 2016 Sep 13;15(1):133
15. Arimura H, Hashiguchi H, Yamamoto K, Shinnakasu A, Arimura A, Kikuchi A, Deguchi T, Habu M, Fujio S, Arita K, Nishio Y.
    Investigation of the clinical significance of the growth hormone-releasing peptide-2 test for the diagnosis of secondary adrenal failure.
    Endocr J. 2016 Jun 30;63(6):533-44

Takahisa DEGUCHI

1. Sugimoto K, Murakami H, Deguchi T, Arimura A, Daimon M, Suzuki S, Shimbo T, Yagihashi S.
   Cutaneous microangiopathy in patients with type 2 diabetes: Impaired vascular endothelial growth factor expression and its correlation with neuropathy, retinopathy and nephropathy.
   J Diabetes Investig 10:1318-1331,2019
2. Masuda T, Ueda M, Suenaga G, Misumi Y, Tasaki M, Izaki A, Yanagisawa Y, Inoue Y, Motokawa H, Matsumoto S, Mizukami M, Arimura A, Deguchi T, Nishio Y, Yamashita T, Inomata Y, Obayashi K, Ando Y.
   Early skin denervation in hereditary and iatrogenic transthyretin amyloid neuropathy.　Neurology　88（23）：2192-2197,2017
3. Horinouchi S, Deguchi T, Arimura K, Arimura A, Dochi Y, Uto T, Nakamura T, Arimura Y, Nishio Y, Takashima H. Median neuropathy at the wrist as an early manifestation of diabetic neuropathy. J Diabetes Invest 5: 709-713, 2014
4. Deguchi T, Nishio Y, Takashima H. Diabetes mellitus and autoimmune neuropathy. Brain Nerve 66(2):135-47, 2014
5. Deguchi T, Rosales R, Hashiguchi T, Arimura K. Antiplatelet Therapy, Diabetic Neuropathy and Peripheral Vascular Disease: A Unitary Approach. J Diabetes Metab S5: 005, 2012
6. Deguchi T, Hashiguchi T, Horinouchi S, Uto T, Oku H, Kimura K, Makisumi K, Arimura K. Serum VEGF increases in diabetic polyneuropathy, particularly in the neurologically active symptomatic stage. Diabetic Med 26(3): 247-252, 2009
7. Kimura K, Hashiguchi T, Deguchi T, Horinouchi S, Uto T, Oku H, Setoyama S, Maruyama I, Osame M, Arimura K.　Serum VEGF－As a prognostic factor of atherosclerosis. Atherosclerosis 194(1): 182-188, 2007

Hiroshi HASHIGUCHI

1. Direct versus indirect actions of ghrelin on hypothalamic NPY neurons
   Hashiguchi H, Sheng Z, Routh V, Gerzanich V, Simard JM, Bryan J.
   PLoS One. 2017 Sep 6;12(9):e0184261.
2. Investigation of the clinical significance of the growth hormone-releasing peptide-2 test for the diagnosis of secondary adrenal failure. Arimura H, Hashiguchi H, Yamamoto K, Shinnakasu A, Arimura A, Kikuchi A, Deguchi T, Habu M, Fujio S, Arita K, Nishio Y. Endocr J. 2016 Jun 30;63(6):533-44.
3. リラグルチドの有効性に関する多施設共同観察研究(原著論文)
   野田 智穂, 上野 浩晶, 山口 秀樹, 村瀬 邦崇, 野見山 崇, 橋口 裕, 山口 美幸, 鳥本 桂一, 森 博子, 岡田 洋右, 安西 慶三, 西尾 善彦, 柳瀬 敏彦, 中里 雅光
   Diabetes Frontier (0915-6593)27巻3号 Page388-391(2016.06)
4. .ABCC8:Physiology and pathology. Ortiz D.,Nakamura Y.,Hashiguchi H.,Bryan J., & Aguilar-Bryan,L. In The ABC Transporters of Human Physiology and Disease : Genetics and Biochemistry of ATP Binding
   Cassette Transporters.(2011:311-346).World Scientific Publishing Co.
5. αリポ酸が誘因と推察されたインスリン自己免疫症候群の1例(原著論文/症例報告)
   中島 千鶴, 橋口 裕, 福留 美千代, 池田 優子, 中崎 満浩, 鄭 忠和
   糖尿病 (0021-437X)50巻8号 Page623-626(2007.08)
6. Cyclic AMP/cAMP-GEF pathway amplifies insulin exocytosis induced by Ca2+ and ATP in rat islet beta-cells Hashiguchi H , Nakazaki M, Koriyama N, Fukudome M, Aso K, Tei C. Diabetes Metab Res Rev.2006 Jan-Feb;22(1):64-71.

Aiko ARIMURA

1. Arimura A, Deguchi T, Sugimoto K, Uto T, Nakamura T, Arimura Y, Arimura K, Yagihashi S, Nishio Y, Takashima H. Intraepidermal nerve fiber density and nerve conduction study parameters correlate with clinical staging of diabetic polyneuropathy.Diabetes Res Clin Pract 99(1): 24-29, 2013

Mihoko KURANO

1. Ghavidel Darestani S, Kurano M, Shinnakasu A, Yamamoto K, Dochi Y, Uemura K, Ikeda Y, Arimura A, Arimura H, Kikuchi A, Hashiguchi H, Deguchi T, Nishio Y. Association between changes in the mRNA expression of platelet-activating factor receptor in peripheral blood mononuclear cells and progression of diabetic nephropathy. Diabetol Int. 11(1):11-18,2019
2. Kurano M, Darestani SG, Shinnakasu A, Yamamoto K, Dochi Y, Uemura K, Ikeda Y, Kikuchi A, Hashiguchi H, Deguchi T, Nishio Y. mRNA expression of platelet activating factor receptor (PAFR) in peripheral blood mononuclear cells is associated with albuminuria and vascular dysfunction in patients with type 2 diabetes. Diabetes Res Clin Pract. 136:124-133,2018

Research Grant List

Yoshihiko NISHIO

Takahisa DEGUCHI

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