FIELD

Research outline

講座イメージ画像

Graduate School Center for Innovation in Medical and Dental Education
Endowed Courses Molecular Frontier Surgery

Contact

TEL.+81-99-275-5361 / FAX.+81-99-265-7426

Research interests

  • Detection of CTC by CellSearch system and RT-PCR
  • Expression of biomarker regarding anticancer on CTC
  • Evaluation of Her2 expression on CTC
  • Evaluation of viability of CTC

Staff

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Professor(additional post)
Name Shoji NATSUGOE
Specialized field Digestive Surgery
Research interests
  • 消化器癌の微量癌細胞の着床・増殖機序の解明と臨床応用
  • N型糖鎖を用いた膵臓癌特異的癌腫瘍マーカーの開発

Researche Repository


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Associate Professor
Name Yoshikazu UENOSONO
Specialized field Digestive Surgery
Research interests
  • 消化器癌における血中循環癌細胞の検出
  • センチネルリンパ節理論の消化器癌への応用と微小転移診断

Researche Repository


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Guest Associate Professor
Name Takaaki ARIGAMI
Specialized field Digestive Surgery
Research interests
  • 消化器癌における免疫回避機構の解明とその制御に関する基礎的研究
  • 消化器癌の癌免疫機構における免疫補助刺激分子の臨床的意義と新たな臨床応用への展開

Researche Repository

Research results

Shoji NATSUGOE
  • Sawada G, Niida A, Hirata H, Komatsu H, Uchi R, Shimamura T, Takahashi Y, Kurashige J, Matsumura T, Ueo H, Takano Y, Ueda M, Sakimura S, Shinden Y, Eguchi H, Sudo T, Sugimachi K, Yamasaki M, Tanaka F, Tachimori Y, Kajiyama Y, Natsugoe S, Fujita H, Tanaka Y, Calin G, Miyano S, Doki Y, Mori M, Mimori K.: An Integrative Analysis to Identify Driver Genes in Esophageal Squamous Cell Carcinoma. PLoS One. 2015 Oct 14;10(10):e0139808. doi: 10.1371
  • Oki E, Emi Y, Miyamoto Y, Kabashima A, Higashi H, Ogata Y, Ikebe M, Saeki H, Tokunaga S, Shirabe K, Beppu T, Uchida S, Takatsuki M, Sakoda M, Eguchi S, Akagi Y, Kakeji Y, Baba H, Natsugoe S, Maehara Y; Kyushu Study Group of Clinical Cancer (KSCC).: Erratum to: Phase II Trial of S-1 and Oxaliplatin Plus Cetuximab for Colorectal Cancer Patients with Initially Unresectable or Not Optimally Resectable Liver Metastases (KSCC1002). Ann Surg Oncol. 2015 Sep 21.
  • Oki E, Emi Y, Miyamoto Y, Kabashima A, Higashi H, Ogata Y, Ikebe M, Saeki H, Tokunaga S, Shirabe K, Beppu T, Uchida S, Takatsuki M, Sakoda M, Eguchi S, Akagi Y, Kakeji Y, Baba H, Natsugoe S, Maehara Y; Kyushu Study Group of Clinical Cancer (KSCC).: Phase II Trial of S-1 and Oxaliplatin Plus Cetuximab for Colorectal Cancer Patients with Initially Unresectable or Not Optimally Resectable Liver Metastases (KSCC1002). Ann Surg Oncol. 2015 Sep 3.
  • Oki E, Tokunaga S, Emi Y, Kusumoto T, Yamamoto M, Fukuzawa K, Takahashi I, Ishigami S, Tsuji A, Higashi H, Nakamura T, Saeki H, Shirabe K, Kakeji Y, Sakai K, Baba H, Nishimaki T, Natsugoe S, Maehara Y; Kyushu Study Group of Clinical Cancer: Surgical treatment of liver metastasis of gastric cancer: a retrospective multicenter cohort study (KSCC1302). Gastric Cancer. 2015 Aug 11.
  • Okumura H, Uchikado Y, Matsumoto M, Omoto I, Sasaki K, Kita Y, Arigami T, Uenosono Y, Nakajo A, Owaki T, Mori S, Ishigami S, Natsugoe S.: Clinical significance of mediastinoscope-assisted transhiatal esophagectomy in patients with esophageal cancer. Langenbecks Arch Surg. 2015 Aug;400(6):699-706. doi: 10.1007/s00423-015-1330-y
  • Kitagawa Y, Takeuchi H, Takagi Y, Natsugoe S, Terashima M, Murakami N, Fujimura T, Tsujimoto H, Hayashi H, Yoshimizu N, Takagane A, Mohri Y, Nabeshima K, Uenosono Y, Kinami S, Sakamoto J, Morita S, Aikou T, Miwa K, Kitajima M.: Sentinel node mapping for gastric cancer: a prospective multicenter trial in Japan. J Clin Oncol. 2013 Oct 10;31(29):3704-10. doi: 10.1200/JCO.2013.50.3789

Yoshikazu UENOSONO
  • Matsushita D, Uenosono Y, Arigami T, Yanagita S, Nishizono Y, Hagihara T, Hirata M, Haraguchi N, Arima H, Kijima Y, Kurahara H, Maemura K, Okumura H, Ishigami S, Natsugoe S.: Clinical Significance of Circulating Tumor Cells in Peripheral Blood of Patients with Esophageal Squamous Cell Carcinoma. Ann Surg Oncol. 2015 Oct;22(11):3674-80. doi: 10.1245/s10434-015-4392-8.
  • Yanagita S, Uenosono Y, Arigami T, Daisuke M, Okubo K, Kijima T, Arima H, Hirata M, Haraguchi N, Hagihara T, Nishizono Y, Ishigami S, Natsugoe S.: The clinical usefulness of the intraoperative detection of sentinel lymph node metastases by a rapid RT-PCR system in patients with gastric cancer. Cancer. 2015 Oct 19. doi: 10.1002/cncr.29740.
  • Uenosono Y, Arigami T, Kozono T, Yanagita S, Hagihara T, Haraguchi N, Matsushita D, Hirata M, Arima H, Funasako Y, Kijima Y, Nakajo A, Okumura H, Ishigami S, Hokita S,Ueno S, Natsugoe S. :Clinical significance of circulating tumor cells in peripheral blood from patients with gastric cancer.: Cancer. 2013 Nov 15;119(22):3984-91. doi: 10.1002/cncr.28309.

Takaaki ARIGAMI
  • Arigami T, Okumura H, Matsumoto M, Uchikado Y, Uenosono Y, Kita Y, Owaki T, Mori S, Kurahara H, Kijima Y, Ishigami S, Natsugoe S.: Analysis of the Fibrinogen and Neutrophil-Lymphocyte Ratio in Esophageal Squamous Cell Carcinoma: A Promising Blood Marker of Tumor Progression and Prognosis. Medicine (Baltimore). 2015 Oct;94(42):e1702. doi: 10.1097/MD.0000000000001702.
  • Arigami T, Uenosono Y, Ishigami S, Matsushita D, Hirahara T, Yanagita S, Okumura H, Uchikado Y, Nakajo A, Kijima Y, Natsugoe S.: Decreased density of CD3+ tumor-infiltrating lymphocytes during gastric cancer progression. J Gastroenterol Hepatol. 2014;29(7):1435-41.
  • Arigami T, Uenosono Y, Ishigami S, Yanagita S, Hagihara T, Haraguchi N, Matsushita D, Hirahara T, Okumura H, Uchikado Y, Nakajo A, Hokita S, Natsugoe S.: Clinical significance of stanniocalcin 2 expression as a predictor of tumor progression in gastric cancer. Oncol Rep. 2013 Dec;30(6):2838-44. doi: 10.3892/or.2013.2775

Research Grant List

Shoji NATSUGOE
研究名・財団名など / 期間詳細
科学研究費助成 挑戦的萌芽研究
April 1, 2015~March 31, 2017
N型糖鎖を用いた膵臓癌特異的癌腫瘍マーカーの開発
科学研究費助成 基盤研究(B)
April 1, 2014~March 31, 2017
消化器癌の微量癌細胞の着床・増殖機序の解明と臨床応用
Yoshikazu UENOSONO
研究名・財団名など / 期間詳細
科学研究費助成 基盤研究(C)
April 1, 2013~March 31, 2016
消化器癌における腹膜播種機構の解析と微小癌細胞における抗癌剤感受性検査法の確立
科学研究費助成 基盤研究(C)
April 1, 2010~March 31, 2013
微小癌細胞のNOGマウスによる生着モデルと抗癌剤感受性試験への手技の確立
Takaaki ARIGAMI
研究名・財団名など / 期間詳細
科学研究費助成 基盤研究(C)
April 1, 2013~March 31, 2016
消化器癌における免疫回避機構の解明とその制御に関する基礎的研究
科学研究費助成 基盤研究(C)
April 1, 2010~March 31, 2013
消化器癌の癌免疫機構における免疫補助刺激分子の
臨床的意義と新たな臨床応用への展開