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Research outline

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Research interests

• Molecular target therapy for musculoskeletal Sarcomas
• Virotherapy for cancer
• Molecular mechanisms of development and regeneration for bone and cartilage
• Regeneration for injured spinal cord

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Research results

Noboru TANIGUCH

1. Lee D, Taniguchi N, Sato K, Choijookhuu N, Hishikawa Y, Kataoka H, Morinaga H, Lotz M, Chosa E. HMGB2 is a novel adipogenic factor that regulates ectopic fat infiltration in skeletal muscles. Sci Rep. 2018 Jun 25;8(1):9601. 

2. Taniguchi N, D'Lima DD, Suenaga N, Chosa E. A new scale measuring translation of the humeral head as a prognostic factor for the treatment of large and massive rotator cuff tears.  J Shoulder Elbow Surg. 2018 Feb;27(2):196-203. 　

3. Taniguchi N, D'Lima DD, Suenaga N, Ishida Y, Lee D, Goya I, Chosa E. Translation of the humeral head scale is associated with success of rotator cuff repair for large-massive tears.  BMC Musculoskelet Disord. 2017 Dec 4;18(1):511. 

4. Taniguchi N, Kawakami Y, Maruyama I, Lotz M. HMGB proteins and arthritis. Hum Cell. 2018 Jan;31(1):1-9. Review.

5. Inoue K, Suenaga N, Oizumi N, Yamaguchi H, Miyoshi N, Taniguchi N, Munemoto M, Egawa T, Tanaka Y. Humeral bone resorption after anatomic shoulder arthroplasty using an uncemented stem. J Shoulder Elbow Surg. 2017 Nov;26(11):1984-1989.

6. Hasegawa A, Yonezawa T, Taniguchi N, Otabe K, Akasaki Y, Matsukawa T, Saito M, Neo M, Marmorstein L, Lotz M. Fibulin-3 in joint aging and osteoarthritis pathogenesis. Arthritis Rheumatol. 2017 Mar;69(3):576-585.

7. Taniguchi N, Suenaga N, Oizumi N, Miyoshi N, Yamaguchi H, Inoue K, Chosa E. Bone marrow stimulation at the footprint of arthroscopic surface-holding repair advances cuff repair integrity. J Shoulder Elbow Surg. 2015 Jun;24(6):860-6.

8. Taniguchi N, Suenaga N, Oizumi N, Miyoshi N, Araki N, Chosa E. Surface-holding repair: an original arthroscopic rotator cuff repair technique. J Shoulder Elbow Surg. 2014 May;23(5):620-7.

9. Grogan SP, Chen X, Sovani S, Taniguchi N, Colwell CW Jr, Lotz MK, D'Lima DD. Influence of cartilage extracellular matrix molecules on cell phenotype and neocartilage formation. Tissue Eng Part A. 2014 Jan;20(1-2):264-74.

10. Monemdjou R, Vasheghani F, Fahmi H, Perez G, Blati M, Taniguchi N, Lotz M, St-Arnaud R, Pelletier JP, Martel-Pelletier J, Beier F, Kapoor M. Association of cartilage-specific deletion of peroxisome proliferator-activated receptor γ with abnormal endochondral ossification and impaired cartilage growth and development in a murine model. Arthritis Rheum. 2012 May;64(5):1551-61.

11. Carames B, Hasegawa A, Taniguchi N, Miyaki S, Blanco FJ, Lotz M. Autophagy　activation by rapamycin reduces severity of experimental osteoarthritis. Ann Rheum Dis. 2012 Apr;71(4):575-81.

12. Carames B, Taniguchi N, Seino D, Blanco FJ, D'Lima D, Lotz M. Mechanical injury suppresses autophagy regulators and its pharmacological activation results in chondroprotection. Arthritis Rheum. 2012 Apr;64(4):1182-92.

13. Taniguchi N, Carames B, Hsu E, Cherqui S, Kawakami Y, Lotz M. Expression patterns and function of chromatin protein HMGB2 during Mesenchymal stem cell differentiation. J Biol Chem. 2011 Dec 2;286(48):41489-98.

14. Itou J*, Taniguchi N*, Oishi I*, Kawakami H, Lotz M and Kawakami Y. HMGB factors are required for posterior digit development through integrating signaling pathway activities. Dev Dyn. 2011 May;240(5):1151-62. (*; equal contributed)

15. Carames B, Taniguchi N, Otsuki S, Blanco FJ, Lotz MK. Autophagy is a protective mechanism in normal cartilage and its aging-related loss is linked with cell death and 　　osteoarthritis. Arthritis Rheum 2010;62(3):791-801.

16. Taniguchi N, Carames B, Kawakami Y, Amendt B, Komiya S, Lotz M. Chromatin   protein HMGB2 regulates articular cartilage surface maintenance via beta-catenin pathways. Proc Natl Acad Sci U S A 2009;106(39):16817-22.

17. Taniguchi N, Carames B, Ronfani L, Ulmer U, Komiya S, Bianchi ME, Lotz M. Aging-related loss of the chromatin protein HMGB2 in articular cartilage is linked to reduced cellularity and osteoarthritis. Proc Natl Acad Sci U S A 2009;106(4):1181-6.

18. Taniguchi N, Yoshida K, Ito T, Tsuda M, Mishima Y, Furumatsu T, Ronfani L, Abeyama K, Kawahara K, Komiya S, Maruyama I, Lotz M, Bianchi ME, Asahara H. Stage-specific secretion of HMGB1 in cartilage regulates endochondral ossification. Mol Cell Biol 2007;27(16):5650-63.

19. Ijiri K, Zerbini LF, Peng H, Correa RG, Lu B, Walsh N, Zhao Y, Taniguchi N, Huang XL, Otu H, Wang H, Wang JF, Komiya S, Ducy P, Rahman MU, Flavell RA, Gravallese EM, Oettgen P, Libermann TA, Goldring MB. A novel role for GADD45beta as a mediator of MMP-13 gene expression during chondrocyte terminal differentiation. J Biol Chem 2005;280(46):38544-55.

20. Furumatsu T, Tsuda M, Yoshida K, Taniguchi N, Ito T, Hashimoto M, Ito T, Asahara H. Sox9 and p300 cooperatively regulate chromatin-mediated transcription. J Biol Chem 2005;280(42):35203-8.

21. Ijiri K, Tsuruga H, Sakakima H, Tomita K, Taniguchi N, Shimoonoda K, Komiya S, Goldring MB, Majima HJ, Matsuyama T. Increased expression of humanin peptide in diffuse-type pigmented villonodular synovitis: implication of its mitochondrial abnormality. Ann Rheum Dis 2005;64(6):816-23.

22. Abeyama K, Stern DM, Ito Y, Kawahara KI, Yoshimoto Y, Tanaka M, Uchimura T, Ida N, Yamazaki Y, Yamada S, Yamamoto Y, Yamamoto H, Iino S, Taniguchi N, Maruyama I. The N-terminal domain of thrombomodulin sequesters high-mobility group-B1 protein, a novel antiinflammatory mechanism. J Clin Invest 2005;115(5):1267-1274.

23. Kawakami Y, Tsuda M, Takahashi S, Taniguchi N, Esteban C.R, Zemmyo M, Furumatsu T, Lotz M, Belmonte J.C, Asahara H.  PGC-1a regulates chondrogenesis via association with Sox9. Proc Natl Acad Sci USA 2005;102:2414-9.

24. Furumatsu T, Tsuda M, Taniguchi N, Tajima Y, Asahara H.  Smad3 induces chondrogenesis through the activation of SOX9 via CBP/p300 recruitment. J Biol Chem 2005;280:8843-350.

25. Taniguchi N, Kawahara K, Yone K, Hashiguchi T, Yamakuchi M, Goto M, Inoue K, Yamada S, Ijiri K, Matsunaga S, Nakajima T, Komiya S, Maruyama I. High mobility group box chromosomal protein 1 plays a role in the pathogenesis of rheumatoid arthritis as a novel cytokine. Arthritis Rheum 2003;48:971-81.

Research Grant List

Noboru TANIGUCH

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