FIELD

Research outline

歯科機能形態学

Graduate School Graduate School of Medical and Dental Sciences
Course Advanced Therapeutics Course
Field Neurology
Department Anatomy for Oral Science
Homepage http://w3.hal.kagoshima-u.ac.jp/dental/anatomy1/

Homepage

Contact

TEL.+81-99-275-6102 / FAX.+81-99-275-6108

Research interests

  • Regulation of bone metabolism by nervous system
  • Molecular mechanisms regulating tooth development
  • Biological Analysis for Biomaterials
  • Neural mechanism for pain control

Staff

後藤哲哉 Tetsuya GOTO

Professor
Name Tetsuya GOTO
Specialized field 解剖学、組織学、口腔組織学、口腔解剖学、骨の分子生物学
Research interests
  • 骨代謝に対する神経調節機構の解明
  • 口腔インプラントの細胞生物学的解析
  • 歯根膜細胞の骨代謝との関係
  • 三叉神経節における情報伝達システムの解析

Researche Repository


山中淳之 Atsushi YAMANAKA

Associate Professor
Name Atsushi YAMANAKA
Specialized field 発生学、口腔組織学
Research interests
  • 歯の形態形成を制御する分子メカニズムに関する研究
  • 哺乳類の歯の進化発生学的研究

Researche Repository


岩井治樹 Haruki IWAI

Assistant Professor
Name Haruki IWAI
Specialized field Neuroanatomy
Research interests
  • Neural Circuit of Taste
  • 三叉神経節における情報伝達システムの解析

Researche Repository


倉本恵梨子 Eriko KURAMOTO

Assistant Professor
Name Eriko KURAMOTO
Specialized field Neuroanatomy
Research interests
  • 視床-皮質投射
  • 大脳皮質と視床による痛覚感受性の調節機構

Researche Repository

Research results

Tetsuya GOTO
  1. Nagao S, Goto T, Kataoka S, Toyono T, Egusa H, Yatani H, Maki K.Expression of neuropeptide receptor mRNA during osteoblastic differentiation of mouse iPS cells. Neuropeptides 48, 399-406, 2014.
  2. 後藤哲哉:「インプラントと口腔周囲組織-生物学的幅径を考えるー」日本顎顔面インプラント学会雑誌
  3. Ozeki K, Goto T, Aoki F, and Masuzawa T: Fabrication of hydroxyapatite thin films on zirconia using a sputtering technique. Bio-Medical Materials and Engineering 24, 1793-1802, 2014.
  4. 田中謙光、高橋 哲、山内健介、宮崎敏樹、後藤哲哉:チタン表面へのグロー放電処理効果と持続性に関する研究。日本口腔インプラント学会誌、27巻12号、1-10, 2014.
  5. Kurata S, Goto T, K Gunjigake K, Kataoka S, N Kuroishi K, Ono K, Toyono T, Kobayashi S, Yamaguchi K. Nerve Growth Factor Involves Mutual Interaction between Neurons and Satellite Glial Cells in the Rat Trigeminal Ganglion.
    Acta Histochem Cytochem. ;46(2):65-73, 2013.
  6. Fukuda A, Goto T, Kuroishi KN, Gunjigake KK, Kataoka S, Kobayashi S, Yamaguchi K. Hemokinin-1 competitively inhibits substance P-induced stimulation of osteoclast formation and function. Neuropeptides. 47(4):251-9, 2013.
  7. Ozeki K, Goto T, Aoki H, Masuzawa T. Characterization of Sr-substituted hydroxyapatite thin film by sputtering technique from mixture targets of hydroxyapatite and strontium apatite. Biomed Mater Eng.24(2):1447-56, 2014.
  8. Ichiki T, Kuroishi KN, Gunjigake KK, Kobayashi S, Goto T.: Neurokinin B activates the formation and bone resorption activity of rat osteoclasts. Neuropeptides 45:239-244, 2011.
  9. Tanaka K, Goto T, Miyazaki T, Morita Y, Kobayashi S, Takahashi T. : Apatite-coated hyaluronan for bone regeneration. J Dent Res. 90:906-911, 2011.
  10. Nakao K., Goto T., Gunjigake K., Konoo T., Kobayashi S., and Yamaguchi K. : Intermittent force induces high RANKL expression in human periodontal ligament cells. J Dent Res 86, 623-628, 2007.
  11. Goto T., Nakao K., Gunjigake K.K., Kido M.A., Kobayashi S., and Tanaka T.: Substance P stimulates late-stage rat osteoblastic bone formation through neurokinin-1 receptor. Neuropeptides 41,25-23, 2007.
  12. Goto T., Kajiwara H., Yoshinari M., Fukuhara E., Kobayashi S., and Tanaka T. : In vitro assay of mineralized-tissue formation on titanium using fluorescent staining with calcein blue. Biomaterials 244, 2885-2892, 2003.
  13. Okumura A., Goto M., Goto T., Yoshinari M., Masuko S., Katsuki T., and Tanaka T.: Substrate affects the initial attachment and subsequent behavior of human osteoblastic cells (Saos-2). Biomaterials 22, 2263-2271, 2001.
  14. Goto T., and Brunette D.M. : Surface topography and serum concentration affect the appearance of tenascin in human gingival fibroblasts in vitro. Exp Cell Res 244, 474-480, 1998.
  15. Goto T., Yamaza T., Kido M.A., and Tanaka T.*: Light and electron microscopic study of the distribution of axons containing substance P and the localization of neurokinin-1 receptor in bone. Cell Tissue Res. 293, 87-93, 1998.
  16. Goto T., Tsukuba T., Kiyoshima T., Nishimura Y., Kato K., Yamamoto K., and Tanaka T.: Immunohistochemical localization of cathepsin B, D and L in the rat osteoclast. Histochemistry 99, 411-414, 1993.
  17. Goto T., Tsukuba T., Ayasaka N., Yamamoto K., and Tanaka T*.: Immunocytochemical localization of cathepsin D in the rat osteoclast.Histochemistry97,13-18,1992.

Atsushi YAMANAKA
  1. Yamanaka A, Iwai H, Uemura M, Goto T. Patterning of mammalian heterodont dentition within the upper and lower jaws. Evolution & Development 17: 127-138, 2015.
  2. Yamanaka A, Iwai H, Kuramoto E, Goto T. Three-dimensional gene expression pattern reconstructed from serial section in situ hybridization. 鹿児島大学歯学部紀要 35: 87-92, 2015.
  3. Uemura M, Sonomura T, Iwai H, Yamanaka A. Localization of masticatory motoneurons in the trigeminal motor nucleus of shrew and pig, with emphasis on the innervation ratio in the shrew. Journal of Oral Bioscience 55: 101-107, 2013.
  4. Sonomura T, Furuta T, Nakatani I, Yamamoto Y, Unzai T, Matsuda W, Iwai H, Yamanaka A, Uemura M, Kaneko T. Correlative analysis of immunoreactivity in confocal laser-scanning microscopy and scanning electron microscopy with focused ion beam milling. Frontiers in Neural Circuits 7: 1-7, 2013.
  5. Carlson KJ, Wrangham RW, Muller MN, Sumner DR, Morbeck ME, Nishida T, Yamanaka A, Boesch C. Comparison of limb structural properties in free-ranging chimpanzees from Kibale, Bombe, Mahale, and Tai communities. In: D'Aout K, Vereecke EE eds. Primate Locomotion: linking field and laboratory research. Springer, New York, pp. 155-182, 2012.
  6. Yamanaka A. Developmental mechanisms regulating heterodonty and diphyodonty of mammalian dentition. 鹿児島大学歯学部紀要 31: 71-80, 2011.
  7. 山中淳之, 花村肇. 歯の新知見. スンクスの生物学, 東京: 学会出版センター, pp.107-113, 2011.
  8. Yamanaka A, Uemura M. The house shrew, Suncus murinus, as a model organism to investigate mammalian basal condition of tooth development. Journal of Oral Bioscience 52: 215-224, 2010.
  9. Yamanaka A, Yasui K, Sonomura T, Iwai H, Uemura M. Development of deciduous and permanent dentitions in the upper jaw of the house shrew (Suncus murinus). Arch Oral Biol 55: 279-287, 2010.
  10. Yamanaka A, Yasui K, Sonomura T, Uemura M. Development of heterodont dentition in house shrew (Suncus murinus). European Journal of Oral Science 115: 433-440, 2007.
  11. Yamanaka A, Gunji H, Ishida H. Curvature, length, and cross-sectional geometry of the femur and humerus in anthropoid primates. American Journal of Physical Anthropology 127: 46-57, 2005.

Haruki IWAI
  1. Tsukahara T, Masuhara M, Iwai H, Sonomura T, Sato T. The effect of repeated stress on KCC2 and NKCC1 immunoreactivity in the hippocampus of female mice. Data in Brief 6, 521-525, 2016.
  2. Tsukahara T, Masuhara M, Iwai H, Sonomura T, Sato T. Repeated stress-induced expression pattern alterations of the hippocampal chloride transporters KCC2 and NKCC1 associated with behavioral abnormalities in female mice. Biochemical and Biophysical Research Communications 17, 127-138, 2015
  3. Iwai H, Kuramoto E, Yamanaka A, Sonomura T, Uemura M, Goto T. Ascending parabrachio-thalamo-striatal pathways: Potential circuits for integration of gustatory and oral motor functions. Neuroscience 294, 1-13, 2015.
  4. Yamanaka A, Iwai H, Kuramoto E, Goto T. Three-dimensional gene expression pattern reconstructed from serial section in situ hybridization. 鹿児島大学歯学部紀要 35, 87- 92, 2015.
  5. Yamanaka A, Iwai H, Uemura M, Goto T. Patterning of mammalian heterodont dentition within the upper and lower jaws. Evolution and Development 17, 127-138, 2015.
  6. Uemura M, Sonomura T, Iwai H, Yamanaka A. Localization of masticatory motoneurons in the trigeminal motor nucleus of shrew and pig, with emphasis on the innervation ratio in the shrew. Journal of Oral Biosciences 55, 101-107, 2013.
  7. 植村正憲, 薗村貴弘, 岩井治樹, 山中淳之. 顎顔面の運動神経細胞の脳内分布, および味覚の神経回路. 鹿児島大学歯学部紀要 33, 3- 17, 2013.
  8. Sonomura T, Furuta T, Nakatani I, Yamamoto Y, Unzai T, Matsuda W, Iwai H, Yamanaka A, Uemura M, Kaneko T. Correlative Analysis of Immunoreactivity in Confocal Laser-Scanning Microscopy and Scanning Electron Microscopy with Focused Ion Beam Milling. Frontiers in Neural Circuits 7, Article 26,2013.
  9. Yamanaka A, Yasui K, Sonomura T, Iwai H, Uemura M. Development of deciduous and permanent dentitions in the upper jaw of the house shrew (Suncus murinus). Arch Oral Biol 55, 279-287, 2010.
  10. 田松裕一,岩井治樹,島田和幸. 表情筋は咀嚼にいかにかかわるか. 歯科臨床研究 3, 52-60, 2006.

Eriko KURAMOTO
  1. Unzai T, Kuramoto E, Kaneko T, Fujiyama F*. Quantitative analysis of the projection of individual neurons from the midline thalamic nuclei to the striosome and matrix compartments of the rat striatum.
    Cerebral Cortex; in press.
  2. Kanda T, Tsujino N, Kuramoto E, Koyama Y, Susaki AE, Chikahisa S, Funato H.(2016) Sleep as a biological problem: an overview of frontiers in sleep research. 2015, The Journal of Physiological Science 66: 1-13.
  3. Kuramoto E, Ohno S, Furuta T, Unzai T, Tanaka YR, Hioki H, Kaneko T.
    Ventral medial nucleus neurons send thalamocortical afferents more widely and more preferentially to layer 1 than neurons of the ventral anterior-ventral lateral nuclear complex in the rat.
    2015, Cerebral Cortex 25(1):221-235.
  4. Iwai H, Kuramoto E, Yamanaka A, Sonomura T, Uemura M, Goto T.
    Ascending parabrachio-thalamo-striatal pathways: Potential circuits for integration of gustatory and oral motor functions.
    2015, Neuroscience 294: 1-13.
  5. Hioki H, Okamoto S, Konno M, Kameda H, Sohn J, Kuramoto E, Fujiyama F, Kaneko T.
    Cell-type specific inhibitory inputs to dendritic and somatic compartments of parvalbumin-expressing neocortical interneuron.
    2013, Journal of Neuroscience 33(2): 544-555.
  6. Ohno S, Kuramoto E, Furuta F, Hioki H, Tanaka YR, Fujiyama F, Sonomura T, Uemura M, Sugiyama K, Kaneko T.
    A morphological analysis of thalamocortical axon fibers of rat posterior thalamic nuclei: A single neuron tracing study with viral vectors.
    2012, Cerebral Cortex 22(12):2840-2857.
  7. Kuramoto E, Furuta T, Hioki H, Fujiyama F, Kaneko T.
    Novel single-neuron-tracing method using Sindbis viral vectors.
    2011, Microscopy 46(2):125-131. 日本語の総説.
  8. Kuramoto E, Fujiyama F, Nakamura KC, Tanaka Y, Hioki H, Kaneko T.
    Complementary distribution of glutamatergic cerebellar and GABAergic basal ganglia afferents to the rat motor thalamic nuclei.
    2011, European Journal of Neuroscience 33(1):95-109.
  9. Ohira K, Furuta T, Hioki H, Nakamura KC, Kuramoto E, Tanaka Y, Funatsu N, Shimizu K, Oishi T, Hayashi M, Miyakawa T, Kaneko T, Nakamura S.
    Ischemia-induced neurogenesis of neocortical layer 1 progenitor cells.
    2010, Nature Neuroscience 13(2):173-179.
  10. Kuramoto E, Furuta T, Nakamura KC, Unzai T, Hioki H, Kaneko T.
    Two types of thalamocortical projections from the motor thalamic nuclei of the rat: a single neuron-tracing study using viral vectors.
    2009, Cerebral Cortex 9(9):2065-2077.
  11. Hioki H, Kuramoto E, Konno M, Kameda H, Takahashi Y, Nakano T, Nakamura KC, Kaneko T.
    High-level transgene expression in neurons by lentivirus with Tet-Off system.
    2009, Neuroscience Research 63(2):149-154.
  12. Kuramoto E, Fujiyama F, Unzai T, Nakamura K, Hioki H, Furuta T, Shigemoto R, Ferraguti F, Kaneko T.
    Metabotropic glutamate receptor 4-immunopositive terminals of medium-sized spiny neurons selectively form synapses with cholinergic interneurons in the rat neostriatum.
    2007, Journal of Comparative Neurology, 500(5):908-922.
  13. Fujiyama F, Kuramoto E, Okamoto K, Hioki H, Furuta T, Zhou L, Nomura S, Kaneko T.
    Presynaptic localization of an AMPA-type glutamate receptor in corticostriatal and thalamostriatal axon terminals.
    2004, European Journal of Neuroscience, 20(12): 3322-30.

Collaborations

  • 茨城大学工学部(尾関研究室):新規インプラント材の生物学的親和性に関する研究。
  • University of California, San Francisco (UCSF) Dr. Ophir Klein lab.

Research Grant List

Tetsuya GOTO
Project・Event / SpanResearch
日本学術振興会
基盤研究(C)、4,940千円
2014~2017年
ATPによる象牙芽細胞からの神経伝達機構の解明
日本学術振興会
基盤研究(C)、4,550千円
2010~2012年
歯周組織におけるオステオアクチビンの作用機序の解明
日本学術振興会
基盤研究(C)、3,900千円
2007~2009年
三叉神経節を介した上下顎骨の協調的骨代謝調節機構の解明
日本学術振興会
基盤研究(C)、3,500千円
2003~2004年
神経ペプチドによる骨代謝調節機構の解明
日本学術振興会
萌芽研究、1,700千円
2001~2002年
遺伝子導入法を用いたヒト破骨細胞の形態・機能解析法の確立
日本学術振興会
基盤研究(B)、11,800千円
1999~2001年
神経ペプチド、サブスタンスPによる骨代謝調節機構の解明
日本学術振興会
奨励研究、1,800千円
1997~1998年
破骨細胞の骨吸収サイクルに関する経時的、細胞形態学的研究
Atsushi YAMANAKA
Project・Event / SpanResearch
日本学術振興会
若手研究(B)、4,420千円
2009~2010年
実験動物スンクスを用いた歯の代生と加生の分子メカニズムの探究
日本学術振興会
若手研究(B)、3,600千円
2007~2008年
異形歯性歯列のパターン形成におけるFGFシグナルとBMPシグナルの拮抗的な役割
日本学術振興会
若手研究(B)、3,500千円
2002~2004年
有限要素解析を応用したヒトの大腿骨の形態進化シミュレーション
Haruki IWAI
Project・Event / SpanResearch
日本学術振興会
若手研究(B)、4,030千円
2014~2017年
食行動の基本原理の解明:単一味覚ニューロン標識法による大脳皮質味覚マッピング
日本学術振興会
若手研究(B)、4,420千円
2012~2014年
単一ニューロン記録法・標識法を用いた食行動を呼び起こす味覚神経回路の解析
Eriko KURAMOTO
Project・Event / SpanResearch
成茂神経科学研究助成
350千円
2015年
痛覚抑制系におけるノルアドレナリン作動性ニューロンの形態と機能
中冨健康科学振興財団
研究助成金 1,500千円
2015年
下行性の痛覚抑制メカニズムの解明-新しい疼痛治療法の開発を目指して
日本学術振興会
若手研究(B)、直接経費3,200千円
2013~2014年
梨状葉皮質の興奮性ニューロンからパルブアルブミン陽性ニューロンへの出力の形態計測
日本学術振興会
若手研究(B)、直接経費3,300千円
2011~2012年
視床運動核から皮質パルブアルブミン陽性ニューロンへの出力を形態学的に解析する
日本学術振興会特別研究員
奨励費、直接経費 1,200千円
2009~2010年
ラット視床から大脳皮質運動関連領野への投射を単一ニューロンレベルで解析する

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